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Entry version 103 (12 Aug 2020)
Sequence version 2 (18 May 2010)
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Protein

Coiled-coil domain-containing protein 184

Gene

CCDC184

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q52MB2

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Coiled-coil domain-containing protein 184
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:CCDC184
Synonyms:C12orf68
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 12

Organism-specific databases

Eukaryotic Pathogen Database Resources

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EuPathDBi
HostDB:ENSG00000177875.4

Human Gene Nomenclature Database

More...
HGNCi
HGNC:33749, CCDC184

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q52MB2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000177875

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162377998

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q52MB2, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
CCDC184

Domain mapping of disease mutations (DMDM)

More...
DMDMi
296434453

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003356811 – 194Coiled-coil domain-containing protein 184Add BLAST194

Proteomic databases

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q52MB2

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q52MB2

PeptideAtlas

More...
PeptideAtlasi
Q52MB2

PRoteomics IDEntifications database

More...
PRIDEi
Q52MB2

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
62432

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q52MB2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q52MB2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000177875, Expressed in prefrontal cortex and 132 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q52MB2, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000177875, Tissue enhanced (brain)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
132471, 9 interactors

Protein interaction database and analysis system

More...
IntActi
Q52MB2, 13 interactors

Molecular INTeraction database

More...
MINTi
Q52MB2

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000320849

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q52MB2, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili39 – 68Sequence analysisAdd BLAST30

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi136 – 146Poly-GluAdd BLAST11

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domaini

Coiled coil

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502RNYW, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000002978

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_125035_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q52MB2

Identification of Orthologs from Complete Genome Data

More...
OMAi
TSHCERS

Database of Orthologous Groups

More...
OrthoDBi
1296471at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q52MB2

TreeFam database of animal gene trees

More...
TreeFami
TF337201

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR031458, DUF4677

The PANTHER Classification System

More...
PANTHERi
PTHR31554, PTHR31554, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15726, DUF4677, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q52MB2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEDGLLEIMT KDGGDMPAPL EVSTVPAVGD VISGEYNGGM KELMEHLKAQ
60 70 80 90 100
LQALFEDVRA MRGALDEQAS HIQVLSDDVC ANQRAIVSMC QIMTTAPRQG
110 120 130 140 150
GLGVVGGKGS FQSDPQEPET PSPGIGDSGL LGRDPEDEEE EEEEKEMPSP
160 170 180 190
ATPSSHCERP ESPCAGLLGG DGPLVEPLDM PDITLLQLEG EASL
Length:194
Mass (Da):20,484
Last modified:May 18, 2010 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7281438BCDB2E313
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti78D → G in BAB71071 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_060278140E → D2 PublicationsCorresponds to variant dbSNP:rs10783231Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK056003 mRNA Translation: BAB71071.1
AK056783 mRNA Translation: BAB71283.1
AC074029 Genomic DNA No translation available.
CH471111 Genomic DNA Translation: EAW57977.1
BC036801 mRNA Translation: AAH36801.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS31785.1

NCBI Reference Sequences

More...
RefSeqi
NP_001013657.3, NM_001013635.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000316554; ENSP00000320849; ENSG00000177875

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
387856

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:387856

UCSC genome browser

More...
UCSCi
uc001rrj.3, human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK056003 mRNA Translation: BAB71071.1
AK056783 mRNA Translation: BAB71283.1
AC074029 Genomic DNA No translation available.
CH471111 Genomic DNA Translation: EAW57977.1
BC036801 mRNA Translation: AAH36801.1
CCDSiCCDS31785.1
RefSeqiNP_001013657.3, NM_001013635.3

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi132471, 9 interactors
IntActiQ52MB2, 13 interactors
MINTiQ52MB2
STRINGi9606.ENSP00000320849

PTM databases

iPTMnetiQ52MB2
PhosphoSitePlusiQ52MB2

Polymorphism and mutation databases

BioMutaiCCDC184
DMDMi296434453

Proteomic databases

MassIVEiQ52MB2
PaxDbiQ52MB2
PeptideAtlasiQ52MB2
PRIDEiQ52MB2
ProteomicsDBi62432

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
25636, 68 antibodies

The DNASU plasmid repository

More...
DNASUi
387856

Genome annotation databases

EnsembliENST00000316554; ENSP00000320849; ENSG00000177875
GeneIDi387856
KEGGihsa:387856
UCSCiuc001rrj.3, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
387856
EuPathDBiHostDB:ENSG00000177875.4

GeneCards: human genes, protein and diseases

More...
GeneCardsi
CCDC184
HGNCiHGNC:33749, CCDC184
HPAiENSG00000177875, Tissue enhanced (brain)
neXtProtiNX_Q52MB2
OpenTargetsiENSG00000177875
PharmGKBiPA162377998

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502RNYW, Eukaryota
GeneTreeiENSGT00390000002978
HOGENOMiCLU_125035_0_0_1
InParanoidiQ52MB2
OMAiTSHCERS
OrthoDBi1296471at2759
PhylomeDBiQ52MB2
TreeFamiTF337201

Enzyme and pathway databases

PathwayCommonsiQ52MB2

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
387856, 12 hits in 855 CRISPR screens

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
387856
PharosiQ52MB2, Tdark

Protein Ontology

More...
PROi
PR:Q52MB2
RNActiQ52MB2, protein

Gene expression databases

BgeeiENSG00000177875, Expressed in prefrontal cortex and 132 other tissues
GenevisibleiQ52MB2, HS

Family and domain databases

InterProiView protein in InterPro
IPR031458, DUF4677
PANTHERiPTHR31554, PTHR31554, 1 hit
PfamiView protein in Pfam
PF15726, DUF4677, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCC184_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q52MB2
Secondary accession number(s): Q96MK5, Q96N39
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: May 18, 2010
Last modified: August 12, 2020
This is version 103 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
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