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Entry version 132 (18 Sep 2019)
Sequence version 1 (24 May 2005)
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Protein

Zinc finger protein 585B

Gene

ZNF585B

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in transcriptional regulation.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri158 – 180C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri186 – 208C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri214 – 236C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri242 – 264C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri270 – 292C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri298 – 320C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri354 – 376C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri382 – 404C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri410 – 432C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri438 – 460C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri466 – 488C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri494 – 516C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri522 – 544C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri550 – 572C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri578 – 600C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri606 – 628C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri634 – 656C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri662 – 684C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri690 – 712C2H2-type 19PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri718 – 740C2H2-type 20PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri746 – 768C2H2-type 21PROSITE-ProRule annotationAdd BLAST23

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTranscription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-212436 Generic Transcription Pathway

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger protein 585B
Alternative name(s):
zinc finger protein 41-like protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZNF585B
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:30948 ZNF585B

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q52M93

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Open Targets

More...
OpenTargetsi
ENSG00000245680

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134925877

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ZNF585B

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74762154

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000476791 – 769Zinc finger protein 585BAdd BLAST769

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q52M93

MassIVE - Mass Spectrometry Interactive Virtual Environment

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MassIVEi
Q52M93

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q52M93

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q52M93

PeptideAtlas

More...
PeptideAtlasi
Q52M93

PRoteomics IDEntifications database

More...
PRIDEi
Q52M93

ProteomicsDB human proteome resource

More...
ProteomicsDBi
62431

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q52M93

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q52M93

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000245680 Expressed in 172 organ(s), highest expression level in corpus callosum

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q52M93 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q52M93 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
124927, 4 interactors

Protein interaction database and analysis system

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IntActi
Q52M93, 5 interactors

Molecular INTeraction database

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MINTi
Q52M93

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000433773

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q52M93

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini27 – 97KRABPROSITE-ProRule annotationAdd BLAST71

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri158 – 180C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri186 – 208C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri214 – 236C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri242 – 264C2H2-type 4PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri270 – 292C2H2-type 5PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri298 – 320C2H2-type 6PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri354 – 376C2H2-type 7PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri382 – 404C2H2-type 8PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri410 – 432C2H2-type 9PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri438 – 460C2H2-type 10PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri466 – 488C2H2-type 11PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri494 – 516C2H2-type 12PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri522 – 544C2H2-type 13PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri550 – 572C2H2-type 14PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri578 – 600C2H2-type 15PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri606 – 628C2H2-type 16PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri634 – 656C2H2-type 17PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri662 – 684C2H2-type 18PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri690 – 712C2H2-type 19PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri718 – 740C2H2-type 20PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri746 – 768C2H2-type 21PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1721 Eukaryota
COG5048 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000161781

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000234617

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q52M93

KEGG Orthology (KO)

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KOi
K09228

Identification of Orthologs from Complete Genome Data

More...
OMAi
RKIIGYK

Database of Orthologous Groups

More...
OrthoDBi
1318335at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q52M93

TreeFam database of animal gene trees

More...
TreeFami
TF343410

Family and domain databases

Conserved Domains Database

More...
CDDi
cd07765 KRAB_A-box, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 19 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 21 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 12 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 21 hits
PS50157 ZINC_FINGER_C2H2_2, 23 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 9 potential isoforms that are computationally mapped.Show allAlign All

Q52M93-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MPASWTSPQK SSALAPEDHG SSYEGSVSFR DVAIDFSREE WRHLDLSQRN
60 70 80 90 100
LYRDVMLETY SHLLSVGYQV PKPEVVMLEQ GKEPWALQGE RPRHSCPGEK
110 120 130 140 150
LWDHNQHRKI IGYKPASSQD QKIYSGEKSY ECAEFGKSFT WKSQFKVHLK
160 170 180 190 200
VPTGEKLYVC IECGRAFVQK PEFITHQKTH MREKPYKCNE CGKSFFQVSS
210 220 230 240 250
LFRHHRIHTG EKLYECSECG KGFPYNSDLS IHEKIHTGER HHECTDCGKA
260 270 280 290 300
FTQKSTLKIH QKIHTGERSY ICIECGQAFI QKTQLIAHRR IHSGEKPYEC
310 320 330 340 350
NNCGKSFISK SQLQVHQRVH TRVKPYICTE YGKVFSNNSN LITHEKIQSR
360 370 380 390 400
EKSSICTECG KAFTYRSELI IHQRIHTGEK PYECSDCGRA FTQKSALTVH
410 420 430 440 450
QRIHTGEKSY ICMKCGLAFI RKAHLITHQI IHTGEKPYKC GHCGKLFTSK
460 470 480 490 500
SQLHVHKRIH TGEKPYVCNK CGKAFTNRSN LITHQKTHTG EKSYICSKCG
510 520 530 540 550
KAFTQRSDLI THQRIHTGEK PYECNTCGKA FTQKSNLNIH QKIHTGERQY
560 570 580 590 600
ECHECGKAFN QKSILIVHQK IHTGEKPYVC TECGRAFIRK SNFITHQRIH
610 620 630 640 650
TGEKPYECSD CGKSFTSKSQ LLVHQPVHTG EKPYVCAECG KAFSGRSNLS
660 670 680 690 700
KHQKTHTGEK PYICSECGKT FRQKSELITH HRIHTGEKPY ECSDCGKSFT
710 720 730 740 750
KKSQLQVHQR IHTGEKPYVC AECGKAFSNR SNLNKHQTTH TGDKPYKCGI
760
CGKGFVQKSV FSVHQSSHA
Length:769
Mass (Da):88,066
Last modified:May 24, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEA70D74DE81536FF
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 9 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F2Z3L4F2Z3L4_HUMAN
Zinc finger protein 585B
ZNF585B
157Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EJK4K7EJK4_HUMAN
KRAB domain-containing protein
120Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
Q8N7B4Q8N7B4_HUMAN
cDNA FLJ25829 fis, clone TST08126
148Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PQH3E9PQH3_HUMAN
Zinc finger protein 585B
ZNF585B
714Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EL12K7EL12_HUMAN
Zinc finger protein 585B
ZNF585B
137Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PQ00E9PQ00_HUMAN
Zinc finger protein 585B
ZNF585B
35Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EPG8K7EPG8_HUMAN
Zinc finger protein 585B
ZNF585B
84Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
E9PNT4E9PNT4_HUMAN
Zinc finger protein 585B
ZNF585B
56Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
K7EP93K7EP93_HUMAN
Zinc finger protein 585B
ZNF585B
60Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAB55400 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti186Y → P in AAN61169 (Ref. 1) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_059923467V → I. Corresponds to variant dbSNP:rs1657509Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AY147015 mRNA Translation: AAN61169.1
BC093625 mRNA Translation: AAH93625.1
AK027834 mRNA Translation: BAB55400.1 Different initiation.

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS12500.1

NCBI Reference Sequences

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RefSeqi
NP_689492.3, NM_152279.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000532828; ENSP00000433773; ENSG00000245680

Database of genes from NCBI RefSeq genomes

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GeneIDi
92285

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:92285

UCSC genome browser

More...
UCSCi
uc002ofq.3 human

Keywords - Coding sequence diversityi

Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY147015 mRNA Translation: AAN61169.1
BC093625 mRNA Translation: AAH93625.1
AK027834 mRNA Translation: BAB55400.1 Different initiation.
CCDSiCCDS12500.1
RefSeqiNP_689492.3, NM_152279.3

3D structure databases

SMRiQ52M93
ModBaseiSearch...

Protein-protein interaction databases

BioGridi124927, 4 interactors
IntActiQ52M93, 5 interactors
MINTiQ52M93
STRINGi9606.ENSP00000433773

PTM databases

iPTMnetiQ52M93
PhosphoSitePlusiQ52M93

Polymorphism and mutation databases

BioMutaiZNF585B
DMDMi74762154

Proteomic databases

jPOSTiQ52M93
MassIVEiQ52M93
MaxQBiQ52M93
PaxDbiQ52M93
PeptideAtlasiQ52M93
PRIDEiQ52M93
ProteomicsDBi62431

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
92285
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000532828; ENSP00000433773; ENSG00000245680
GeneIDi92285
KEGGihsa:92285
UCSCiuc002ofq.3 human

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
92285

GeneCards: human genes, protein and diseases

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GeneCardsi
ZNF585B
HGNCiHGNC:30948 ZNF585B
neXtProtiNX_Q52M93
OpenTargetsiENSG00000245680
PharmGKBiPA134925877

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00940000161781
HOGENOMiHOG000234617
InParanoidiQ52M93
KOiK09228
OMAiRKIIGYK
OrthoDBi1318335at2759
PhylomeDBiQ52M93
TreeFamiTF343410

Enzyme and pathway databases

ReactomeiR-HSA-212436 Generic Transcription Pathway

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
92285

Pharos

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Pharosi
Q52M93

Protein Ontology

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PROi
PR:Q52M93

Gene expression databases

BgeeiENSG00000245680 Expressed in 172 organ(s), highest expression level in corpus callosum
ExpressionAtlasiQ52M93 baseline and differential
GenevisibleiQ52M93 HS

Family and domain databases

CDDicd07765 KRAB_A-box, 1 hit
InterProiView protein in InterPro
IPR001909 KRAB
IPR036051 KRAB_dom_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF01352 KRAB, 1 hit
PF00096 zf-C2H2, 19 hits
SMARTiView protein in SMART
SM00349 KRAB, 1 hit
SM00355 ZnF_C2H2, 21 hits
SUPFAMiSSF109640 SSF109640, 1 hit
SSF57667 SSF57667, 12 hits
PROSITEiView protein in PROSITE
PS50805 KRAB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 21 hits
PS50157 ZINC_FINGER_C2H2_2, 23 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZ585B_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q52M93
Secondary accession number(s): Q8IZD3, Q96JW6
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 25, 2005
Last sequence update: May 24, 2005
Last modified: September 18, 2019
This is version 132 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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