UniProtKB - Q52LJ0 (FA98B_HUMAN)
Protein
Protein FAM98B
Gene
FAM98B
Organism
Homo sapiens (Human)
Status
Functioni
Positively stimulates PRMT1-induced protein arginine dimethylated arginine methylation (PubMed:28040436). Promotes colorectal cancer cell malignancy (PubMed:28040436).1 Publication
GO - Molecular functioni
- identical protein binding Source: UniProtKB
- protein methyltransferase activity Source: UniProtKB
- RNA binding Source: UniProtKB
GO - Biological processi
- positive regulation of cell population proliferation Source: UniProtKB
- positive regulation of gene expression Source: UniProtKB
- protein methylation Source: UniProtKB
- tRNA splicing, via endonucleolytic cleavage and ligation Source: Reactome
Enzyme and pathway databases
BioCyci | MetaCyc:ENSG00000171262-MONOMER |
PathwayCommonsi | Q52LJ0 |
Reactomei | R-HSA-6784531, tRNA processing in the nucleus |
Names & Taxonomyi
Protein namesi | Recommended name: Protein FAM98B |
Gene namesi | Name:FAM98B |
Organismi | Homo sapiens (Human) |
Taxonomic identifieri | 9606 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Proteomesi |
|
Organism-specific databases
EuPathDBi | HostDB:ENSG00000171262.11 |
HGNCi | HGNC:26773, FAM98B |
MIMi | 616142, gene |
neXtProti | NX_Q52LJ0 |
Subcellular locationi
Nucleus
- nucleoplasm Source: HPA
- nucleus Source: UniProtKB
Other locations
- cytoplasm Source: UniProtKB
- intracellular membrane-bounded organelle Source: HPA
- tRNA-splicing ligase complex Source: UniProtKB
Keywords - Cellular componenti
Cytoplasm, NucleusPathology & Biotechi
Organism-specific databases
DisGeNETi | 283742 |
OpenTargetsi | ENSG00000171262 |
PharmGKBi | PA142671778 |
Miscellaneous databases
Pharosi | Q52LJ0, Tdark |
Polymorphism and mutation databases
BioMutai | FAM98B |
DMDMi | 74735811 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000187188 | 1 – 433 | Protein FAM98BAdd BLAST | 433 |
Proteomic databases
EPDi | Q52LJ0 |
jPOSTi | Q52LJ0 |
MassIVEi | Q52LJ0 |
MaxQBi | Q52LJ0 |
PaxDbi | Q52LJ0 |
PeptideAtlasi | Q52LJ0 |
PRIDEi | Q52LJ0 |
ProteomicsDBi | 2137 62424 [Q52LJ0-1] |
PTM databases
iPTMneti | Q52LJ0 |
MetOSitei | Q52LJ0 |
PhosphoSitePlusi | Q52LJ0 |
SwissPalmi | Q52LJ0 |
Expressioni
Tissue specificityi
Expressed strongly in colorectal cancer tissues compared to wild-type colon samples (at protein level) (PubMed:28040436). Expressed strongly in colorectal cancer tissues compared to wild-type colon samples (PubMed:28040436).1 Publication
Gene expression databases
Bgeei | ENSG00000171262, Expressed in metanephros and 224 other tissues |
ExpressionAtlasi | Q52LJ0, baseline and differential |
Genevisiblei | Q52LJ0, HS |
Organism-specific databases
HPAi | ENSG00000171262, Low tissue specificity |
Interactioni
Subunit structurei
GO - Molecular functioni
- identical protein binding Source: UniProtKB
Protein-protein interaction databases
BioGRIDi | 129661, 74 interactors |
CORUMi | Q52LJ0 |
DIPi | DIP-50585N |
IntActi | Q52LJ0, 14 interactors |
MINTi | Q52LJ0 |
STRINGi | 9606.ENSP00000380734 |
Miscellaneous databases
RNActi | Q52LJ0, protein |
Family & Domainsi
Sequence similaritiesi
Belongs to the FAM98 family.Curated
Phylogenomic databases
eggNOGi | KOG3973, Eukaryota |
GeneTreei | ENSGT00440000037341 |
HOGENOMi | CLU_038408_1_1_1 |
InParanoidi | Q52LJ0 |
OMAi | NDQQWIS |
OrthoDBi | 800008at2759 |
PhylomeDBi | Q52LJ0 |
TreeFami | TF320308 |
Family and domain databases
InterProi | View protein in InterPro IPR018797, FAM98 |
PANTHERi | PTHR31353, PTHR31353, 1 hit |
Pfami | View protein in Pfam PF10239, DUF2465, 1 hit |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 1 potential isoform that is computationally mapped.Show allAlign All
Isoform 2 (identifier: Q52LJ0-2) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MRGPEPGPQP TMEGDVLDTL EALGYKGPLL EEQALTKAAE GGLSSPEFSE
60 70 80 90 100
LCIWLGSQIK SLCNLEESIT SAGRDDLESF QLEISGFLKE MACPYSVLIS
110 120 130 140 150
GDIKDRLKKK EDCLKLLLFL STELQASQIL QNKKHKNSQL DKNSEVYQEV
160 170 180 190 200
QAMFDTLGIP KSTTSDIPHM LNQVESKVKD ILSKVQKNHV GKPLLKMDLN
210 220 230 240 250
SEQAEQLERI NDALSCEYEC RRRMLMKRLD VTVQSFGWSD RAKVKTDDIA
260 270 280 290 300
RIYQPKRYAL SPKTTITMAH LLAAREDLSK IIRTSSGTSR EKTACAINKV
310 320 330 340 350
LMGRVPDRGG RPNEIEPPPP EMPPWQKRQE GGGGRGGWGG GGGGGGRGGG
360 370 380 390 400
GGGGGRGGWG GGGGGWGGGG GGGGGWGGGG GGGRGGFQGR GDYGGRGGYG
410 420 430
GRGGYGGRGY GDPYGGGGGG GGGGGGGGGY RRY
Computationally mapped potential isoform sequencesi
There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basketH0YNA1 | H0YNA1_HUMAN | Protein FAM98B | FAM98B | 101 | Annotation score: |
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 22 | A → T in BAC04621 (PubMed:14702039).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_060151 | 301 – 330 | LMGRV…QKRQE → GVSFSTVENELMISYLMFLQ ILVYFSFMSW in isoform 1. Add BLAST | 30 | |
Alternative sequenceiVSP_060152 | 331 – 433 | Missing in isoform 1. Add BLAST | 103 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK095745 mRNA Translation: BAC04621.1 AC109631 Genomic DNA No translation available. AC116158 Genomic DNA No translation available. BC093898 mRNA Translation: AAH93898.1 |
CCDSi | CCDS10047.2 [Q52LJ0-2] |
RefSeqi | NP_775882.2, NM_173611.3 [Q52LJ0-2] |
Genome annotation databases
Ensembli | ENST00000397609; ENSP00000380734; ENSG00000171262 [Q52LJ0-2] ENST00000491535; ENSP00000453166; ENSG00000171262 [Q52LJ0-1] |
GeneIDi | 283742 |
KEGGi | hsa:283742 |
UCSCi | uc001zkb.3, human [Q52LJ0-2] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AK095745 mRNA Translation: BAC04621.1 AC109631 Genomic DNA No translation available. AC116158 Genomic DNA No translation available. BC093898 mRNA Translation: AAH93898.1 |
CCDSi | CCDS10047.2 [Q52LJ0-2] |
RefSeqi | NP_775882.2, NM_173611.3 [Q52LJ0-2] |
3D structure databases
SMRi | Q52LJ0 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 129661, 74 interactors |
CORUMi | Q52LJ0 |
DIPi | DIP-50585N |
IntActi | Q52LJ0, 14 interactors |
MINTi | Q52LJ0 |
STRINGi | 9606.ENSP00000380734 |
PTM databases
iPTMneti | Q52LJ0 |
MetOSitei | Q52LJ0 |
PhosphoSitePlusi | Q52LJ0 |
SwissPalmi | Q52LJ0 |
Polymorphism and mutation databases
BioMutai | FAM98B |
DMDMi | 74735811 |
Proteomic databases
EPDi | Q52LJ0 |
jPOSTi | Q52LJ0 |
MassIVEi | Q52LJ0 |
MaxQBi | Q52LJ0 |
PaxDbi | Q52LJ0 |
PeptideAtlasi | Q52LJ0 |
PRIDEi | Q52LJ0 |
ProteomicsDBi | 2137 62424 [Q52LJ0-1] |
Protocols and materials databases
Antibodypediai | 2032, 101 antibodies |
DNASUi | 283742 |
Genome annotation databases
Ensembli | ENST00000397609; ENSP00000380734; ENSG00000171262 [Q52LJ0-2] ENST00000491535; ENSP00000453166; ENSG00000171262 [Q52LJ0-1] |
GeneIDi | 283742 |
KEGGi | hsa:283742 |
UCSCi | uc001zkb.3, human [Q52LJ0-2] |
Organism-specific databases
CTDi | 283742 |
DisGeNETi | 283742 |
EuPathDBi | HostDB:ENSG00000171262.11 |
GeneCardsi | FAM98B |
HGNCi | HGNC:26773, FAM98B |
HPAi | ENSG00000171262, Low tissue specificity |
MIMi | 616142, gene |
neXtProti | NX_Q52LJ0 |
OpenTargetsi | ENSG00000171262 |
PharmGKBi | PA142671778 |
GenAtlasi | Search... |
Phylogenomic databases
eggNOGi | KOG3973, Eukaryota |
GeneTreei | ENSGT00440000037341 |
HOGENOMi | CLU_038408_1_1_1 |
InParanoidi | Q52LJ0 |
OMAi | NDQQWIS |
OrthoDBi | 800008at2759 |
PhylomeDBi | Q52LJ0 |
TreeFami | TF320308 |
Enzyme and pathway databases
BioCyci | MetaCyc:ENSG00000171262-MONOMER |
PathwayCommonsi | Q52LJ0 |
Reactomei | R-HSA-6784531, tRNA processing in the nucleus |
Miscellaneous databases
BioGRID-ORCSi | 283742, 228 hits in 853 CRISPR screens |
ChiTaRSi | FAM98B, human |
GenomeRNAii | 283742 |
Pharosi | Q52LJ0, Tdark |
PROi | PR:Q52LJ0 |
RNActi | Q52LJ0, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSG00000171262, Expressed in metanephros and 224 other tissues |
ExpressionAtlasi | Q52LJ0, baseline and differential |
Genevisiblei | Q52LJ0, HS |
Family and domain databases
InterProi | View protein in InterPro IPR018797, FAM98 |
PANTHERi | PTHR31353, PTHR31353, 1 hit |
Pfami | View protein in Pfam PF10239, DUF2465, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | FA98B_HUMAN | |
Accessioni | Q52LJ0Primary (citable) accession number: Q52LJ0 Secondary accession number(s): A8MUW5, Q8N935 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | December 6, 2005 |
Last sequence update: | May 8, 2019 | |
Last modified: | December 2, 2020 | |
This is version 137 of the entry and version 2 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program | |
Disclaimer | Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families - Human chromosome 15
Human chromosome 15: entries, gene names and cross-references to MIM