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Protein

Protein lin-52 homolog

Gene

LIN52

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Biological processi

Enzyme and pathway databases

ReactomeiR-HSA-1362277 Transcription of E2F targets under negative control by DREAM complex
R-HSA-1362300 Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1
R-HSA-1538133 G0 and Early G1
R-HSA-156711 Polo-like kinase mediated events
R-HSA-539107 Activation of E2F1 target genes at G1/S
R-HSA-69202 Cyclin E associated events during G1/S transition
R-HSA-69656 Cyclin A:Cdk2-associated events at S phase entry

Names & Taxonomyi

Protein namesi
Recommended name:
Protein lin-52 homolog
Gene namesi
Name:LIN52
Synonyms:C14orf46
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

EuPathDBiHostDB:ENSG00000205659.10
HGNCiHGNC:19856 LIN52
neXtProtiNX_Q52LA3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi91750
OpenTargetsiENSG00000205659
PharmGKBiPA162394039

Polymorphism and mutation databases

BioMutaiLIN52
DMDMi74754720

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002521541 – 116Protein lin-52 homologAdd BLAST116

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei28PhosphoserineCombined sources1
Modified residuei53PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ52LA3
MaxQBiQ52LA3
PaxDbiQ52LA3
PeptideAtlasiQ52LA3
PRIDEiQ52LA3
ProteomicsDBi62420

PTM databases

iPTMnetiQ52LA3
PhosphoSitePlusiQ52LA3

Expressioni

Gene expression databases

BgeeiENSG00000205659 Expressed in 200 organ(s), highest expression level in secondary oocyte
CleanExiHS_LIN52
ExpressionAtlasiQ52LA3 baseline and differential
GenevisibleiQ52LA3 HS

Organism-specific databases

HPAiHPA000900
HPA001777

Interactioni

Subunit structurei

Component of the DREAM complex (also named LINC complex) at least composed of E2F4, E2F5, LIN9, LIN37, LIN52, LIN54, MYBL1, MYBL2, RBL1, RBL2, RBBP4, TFDP1 and TFDP2. The complex exists in quiescent cells where it represses cell cycle-dependent genes. It dissociates in S phase when LIN9, LIN37, LIN52 and LIN54 form a subcomplex that binds to MYBL2.2 Publications

Protein-protein interaction databases

BioGridi124874, 10 interactors
CORUMiQ52LA3
IntActiQ52LA3, 8 interactors
STRINGi9606.ENSP00000451812

Structurei

Secondary structure

1116
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ52LA3
SMRiQ52LA3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the lin-52 family.Curated

Phylogenomic databases

eggNOGiKOG4402 Eukaryota
ENOG4111VPU LUCA
GeneTreeiENSGT00390000008402
HOGENOMiHOG000006570
HOVERGENiHBG081917
InParanoidiQ52LA3
KOiK21775
OMAiMNIMTTE
OrthoDBiEOG091G0WNJ
PhylomeDBiQ52LA3
TreeFamiTF320091

Family and domain databases

InterProiView protein in InterPro
IPR018737 DREAM_LIN52
PANTHERiPTHR31489 PTHR31489, 1 hit
PfamiView protein in Pfam
PF10044 LIN52, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q52LA3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGWKMASPTD GTDLEASLLS FEKLDRASPD LWPEQLPGVA EFAASFKSPI
60 70 80 90 100
TSSPPKWMAE IERDDIDMLK ELGSLTTANL MEKVRGLQNL AYQLGLDESR
110
EMTRGKFLNI LEKPKK
Length:116
Mass (Da):13,001
Last modified:May 24, 2005 - v1
Checksum:iF9D1F2CA524975D0
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3V5T8G3V5T8_HUMAN
Protein lin-52 homolog
LIN52
97Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC094003 mRNA Translation: AAH94003.1
BC094005 mRNA Translation: AAH94005.1
CCDSiCCDS32120.1
RefSeqiNP_001019845.1, NM_001024674.2
UniGeneiHs.612866

Genome annotation databases

EnsembliENST00000555028; ENSP00000451812; ENSG00000205659
GeneIDi91750
KEGGihsa:91750
UCSCiuc001xpp.3 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC094003 mRNA Translation: AAH94003.1
BC094005 mRNA Translation: AAH94005.1
CCDSiCCDS32120.1
RefSeqiNP_001019845.1, NM_001024674.2
UniGeneiHs.612866

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4YOOX-ray2.40X15-34[»]
6C48X-ray2.32B/E52-116[»]
ProteinModelPortaliQ52LA3
SMRiQ52LA3
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124874, 10 interactors
CORUMiQ52LA3
IntActiQ52LA3, 8 interactors
STRINGi9606.ENSP00000451812

PTM databases

iPTMnetiQ52LA3
PhosphoSitePlusiQ52LA3

Polymorphism and mutation databases

BioMutaiLIN52
DMDMi74754720

Proteomic databases

EPDiQ52LA3
MaxQBiQ52LA3
PaxDbiQ52LA3
PeptideAtlasiQ52LA3
PRIDEiQ52LA3
ProteomicsDBi62420

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000555028; ENSP00000451812; ENSG00000205659
GeneIDi91750
KEGGihsa:91750
UCSCiuc001xpp.3 human

Organism-specific databases

CTDi91750
DisGeNETi91750
EuPathDBiHostDB:ENSG00000205659.10
GeneCardsiLIN52
HGNCiHGNC:19856 LIN52
HPAiHPA000900
HPA001777
neXtProtiNX_Q52LA3
OpenTargetsiENSG00000205659
PharmGKBiPA162394039
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4402 Eukaryota
ENOG4111VPU LUCA
GeneTreeiENSGT00390000008402
HOGENOMiHOG000006570
HOVERGENiHBG081917
InParanoidiQ52LA3
KOiK21775
OMAiMNIMTTE
OrthoDBiEOG091G0WNJ
PhylomeDBiQ52LA3
TreeFamiTF320091

Enzyme and pathway databases

ReactomeiR-HSA-1362277 Transcription of E2F targets under negative control by DREAM complex
R-HSA-1362300 Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1
R-HSA-1538133 G0 and Early G1
R-HSA-156711 Polo-like kinase mediated events
R-HSA-539107 Activation of E2F1 target genes at G1/S
R-HSA-69202 Cyclin E associated events during G1/S transition
R-HSA-69656 Cyclin A:Cdk2-associated events at S phase entry

Miscellaneous databases

GenomeRNAii91750
PROiPR:Q52LA3

Gene expression databases

BgeeiENSG00000205659 Expressed in 200 organ(s), highest expression level in secondary oocyte
CleanExiHS_LIN52
ExpressionAtlasiQ52LA3 baseline and differential
GenevisibleiQ52LA3 HS

Family and domain databases

InterProiView protein in InterPro
IPR018737 DREAM_LIN52
PANTHERiPTHR31489 PTHR31489, 1 hit
PfamiView protein in Pfam
PF10044 LIN52, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiLIN52_HUMAN
AccessioniPrimary (citable) accession number: Q52LA3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: May 24, 2005
Last modified: November 7, 2018
This is version 100 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  3. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
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