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Entry version 132 (17 Jun 2020)
Sequence version 1 (24 May 2005)
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Protein

Leucine-rich repeats and immunoglobulin-like domains protein 2

Gene

Lrig2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Leucine-rich repeats and immunoglobulin-like domains protein 2
Short name:
LIG-2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Lrig2
Synonyms:Kiaa0806
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:2443718 Lrig2

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei807 – 827HelicalSequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 39Sequence analysisAdd BLAST39
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_000001483040 – 1054Leucine-rich repeats and immunoglobulin-like domains protein 2Add BLAST1015

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi90N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi120N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi172N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi188N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi273N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi440N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi467N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi513N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the PTM / Processing":/help/ptm_processing_section section describes the positions of cysteine residues participating in disulfide bonds.<p><a href='/help/disulfid' target='_top'>More...</a></p>Disulfide bondi518 ↔ 579PROSITE-ProRule annotation
Glycosylationi570N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi588N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi622 ↔ 674PROSITE-ProRule annotation
Glycosylationi686N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi716 ↔ 765PROSITE-ProRule annotation
Glycosylationi727N-linked (GlcNAc...) asparagineSequence analysis1
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei905PhosphotyrosineCombined sources1
Glycosylationi1024N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q52KR2

PRoteomics IDEntifications database

More...
PRIDEi
Q52KR2

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q52KR2

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q52KR2

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000032913 Expressed in pituitary gland and 240 other tissues

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q52KR2 MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
234657, 1 interactor

Protein interaction database and analysis system

More...
IntActi
Q52KR2, 1 interactor

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000035999

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q52KR2 protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q52KR2

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini40 – 74LRRNTAdd BLAST35
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati75 – 96LRR 1Add BLAST22
Repeati97 – 118LRR 2Add BLAST22
Repeati120 – 141LRR 3Add BLAST22
Repeati144 – 165LRR 4Add BLAST22
Repeati167 – 188LRR 5Add BLAST22
Repeati192 – 213LRR 6Add BLAST22
Repeati215 – 236LRR 7Add BLAST22
Repeati239 – 260LRR 8Add BLAST22
Repeati263 – 284LRR 9Add BLAST22
Repeati287 – 308LRR 10Add BLAST22
Repeati311 – 332LRR 11Add BLAST22
Repeati335 – 356LRR 12Add BLAST22
Repeati359 – 381LRR 13Add BLAST23
Repeati386 – 407LRR 14Add BLAST22
Repeati410 – 431LRR 15Add BLAST22
Domaini442 – 493LRRCTAdd BLAST52
Domaini497 – 596Ig-like C2-type 1Add BLAST100
Domaini601 – 690Ig-like C2-type 2Add BLAST90
Domaini695 – 784Ig-like C2-type 3Add BLAST90

Keywords - Domaini

Immunoglobulin domain, Leucine-rich repeat, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG4194 Eukaryota
COG4886 LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00940000158791

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000288_18_24_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q52KR2

Database of Orthologous Groups

More...
OrthoDBi
161719at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q52KR2

TreeFam database of animal gene trees

More...
TreeFami
TF325380

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.40.10, 3 hits
3.80.10.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000483 Cys-rich_flank_reg_C
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF07679 I-set, 2 hits
PF13855 LRR_8, 4 hits
PF01463 LRRCT, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00409 IG, 3 hits
SM00408 IGc2, 3 hits
SM00369 LRR_TYP, 12 hits
SM00082 LRRCT, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48726 SSF48726, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50835 IG_LIKE, 3 hits
PS51450 LRR, 15 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform. This section is only present in reviewed entries, i.e. in UniProtKB/Swiss-Prot.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q52KR2-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MAAAPRGIWE QRRLGCGLGP LARLLILAQA LRLLPAARAG LCPAPCACRL
60 70 80 90 100
PLLDCSRRKL PAPSWRALSG PLPSDISSLD LSHNRLSNWN NTLESQTLQE
110 120 130 140 150
VKMNYNELTE IPYFGEPTPN ITLLSLVHNL IPEINAEAFE LYSALESLDL
160 170 180 190 200
SSNIISEIKT SSFPRMSLKY LNLSNNRIST LEAGCFDNLS DSLLVVKLNR
210 220 230 240 250
NRISMIPPKV FKLPHLQFLE LKRNRIKIVE GLTFQGLDSL RSLKMQRNGI
260 270 280 290 300
SKLKDGAFFG LNNMEELELE HNNLTGVNKG WLYGLRMLQQ LYMSQNAIEK
310 320 330 340 350
ISPDAWEFCQ RLSELDLSYN QLTRLDESAF VGLSLLERLN LGDNRVTHIA
360 370 380 390 400
DGVFRFLSNL QTLDLRNNDI SWAIEDASEA FSGLKSLTKL ILQGNRIKSV
410 420 430 440 450
TQKAFIGLES LEYLDLNNNA IMSIQENAFS QTHLKGLVLN TSSLLCDCHL
460 470 480 490 500
KWLLQWLVDN NFHHSVNVSC AHPEWLAGQS ILNVDLKDFV CDDFLKPQIR
510 520 530 540 550
THPESTIALR GVNVTLTCTA VSSSDSPMST IWRKDSEILY DVDIENFVRY
560 570 580 590 600
RQQDGEALEY TSVLRLFSVN FTDEGKYQCI VTNHFGSNYS QKAKLTVNEM
610 620 630 640 650
PSFLKTPMDL TIRTGAMARL ECAAEGHPTP QISWQKDGGT DFPAARERRM
660 670 680 690 700
HVMPEDDVFF IANVKIEDMG IYSCMAQNIA GGLSANASLT VLETPSFIRP
710 720 730 740 750
LEDKTVTRGE TAVLQCIAGG SPAPRLNWTK DDGPLLVTER HFFAAANQLL
760 770 780 790 800
IIVDAGLEDA GKYTCLMSNT LGTERGHIYL NVISSPNCDS SQSSIGHEDD
810 820 830 840 850
GWTTVGIVII VVVCCVVGTS LIWVIVIYHM RRKNEDYSIT NTEELNLPAD
860 870 880 890 900
IPSYLSSQGT LSEPQEGYSN SEAGSHQQLM PPANGYTHRG TDGGAGTRVI
910 920 930 940 950
CSDCYDNANI YSRTREYCPY TYIAEEDVLD QALSSLMVQM PKETFLSHPP
960 970 980 990 1000
QDAANLESLI PSAEREPAAF PTNHERMTEN LPFSQRSSEI FQRPLWNMNR
1010 1020 1030 1040 1050
ELGLLPFSQQ PVLESPELTE RDPNCSSPVT CRRLHDHAFD FSRTRIIQDG

TEGT
Length:1,054
Mass (Da):117,863
Last modified:May 24, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i334B7250E2DF168E
GO
Isoform 2 (identifier: Q52KR2-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     79-436: Missing.
     843-849: Missing.

Note: May be due to a competing acceptor splice site.Curated
Show »
Length:689
Mass (Da):76,339
Checksum:i7E25E58E1ADEDBEA
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
B2RRI5B2RRI5_MOUSE
Leucine-rich repeats and immunoglob...
Lrig2
1,047Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0G2JG33A0A0G2JG33_MOUSE
Leucine-rich repeats and immunoglob...
Lrig2
47Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAD32308 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_01499379 – 436Missing in isoform 2. 1 PublicationAdd BLAST358
Alternative sequenceiVSP_057113843 – 849Missing in isoform 2. 1 Publication7

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK173030 mRNA Translation: BAD32308.1 Different initiation.
BC094228 mRNA Translation: AAH94228.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS17701.1 [Q52KR2-1]

NCBI Reference Sequences

More...
RefSeqi
NP_001020238.1, NM_001025067.2 [Q52KR2-1]
NP_001297627.1, NM_001310698.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000046316; ENSMUSP00000035999; ENSMUSG00000032913 [Q52KR2-1]
ENSMUST00000199070; ENSMUSP00000142373; ENSMUSG00000032913 [Q52KR2-2]

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
269473

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:269473

UCSC genome browser

More...
UCSCi
uc008que.1 mouse [Q52KR2-1]
uc012cvk.1 mouse [Q52KR2-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK173030 mRNA Translation: BAD32308.1 Different initiation.
BC094228 mRNA Translation: AAH94228.1
CCDSiCCDS17701.1 [Q52KR2-1]
RefSeqiNP_001020238.1, NM_001025067.2 [Q52KR2-1]
NP_001297627.1, NM_001310698.1

3D structure databases

SMRiQ52KR2
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi234657, 1 interactor
IntActiQ52KR2, 1 interactor
STRINGi10090.ENSMUSP00000035999

PTM databases

iPTMnetiQ52KR2
PhosphoSitePlusiQ52KR2

Proteomic databases

PaxDbiQ52KR2
PRIDEiQ52KR2

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
2748 136 antibodies

Genome annotation databases

EnsembliENSMUST00000046316; ENSMUSP00000035999; ENSMUSG00000032913 [Q52KR2-1]
ENSMUST00000199070; ENSMUSP00000142373; ENSMUSG00000032913 [Q52KR2-2]
GeneIDi269473
KEGGimmu:269473
UCSCiuc008que.1 mouse [Q52KR2-1]
uc012cvk.1 mouse [Q52KR2-2]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
9860
MGIiMGI:2443718 Lrig2

Rodent Unidentified Gene-Encoded large proteins database

More...
Rougei
Search...

Phylogenomic databases

eggNOGiKOG4194 Eukaryota
COG4886 LUCA
GeneTreeiENSGT00940000158791
HOGENOMiCLU_000288_18_24_1
InParanoidiQ52KR2
OrthoDBi161719at2759
PhylomeDBiQ52KR2
TreeFamiTF325380

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

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BioGRID-ORCSi
269473 1 hit in 12 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
Lrig2 mouse

Protein Ontology

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PROi
PR:Q52KR2
RNActiQ52KR2 protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
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Gene expression databases

BgeeiENSMUSG00000032913 Expressed in pituitary gland and 240 other tissues
GenevisibleiQ52KR2 MM

Family and domain databases

Gene3Di2.60.40.10, 3 hits
3.80.10.10, 2 hits
InterProiView protein in InterPro
IPR000483 Cys-rich_flank_reg_C
IPR007110 Ig-like_dom
IPR036179 Ig-like_dom_sf
IPR013783 Ig-like_fold
IPR013098 Ig_I-set
IPR003599 Ig_sub
IPR003598 Ig_sub2
IPR001611 Leu-rich_rpt
IPR003591 Leu-rich_rpt_typical-subtyp
IPR032675 LRR_dom_sf
PfamiView protein in Pfam
PF07679 I-set, 2 hits
PF13855 LRR_8, 4 hits
PF01463 LRRCT, 1 hit
SMARTiView protein in SMART
SM00409 IG, 3 hits
SM00408 IGc2, 3 hits
SM00369 LRR_TYP, 12 hits
SM00082 LRRCT, 1 hit
SUPFAMiSSF48726 SSF48726, 3 hits
PROSITEiView protein in PROSITE
PS50835 IG_LIKE, 3 hits
PS51450 LRR, 15 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
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MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
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<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLRIG2_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q52KR2
Secondary accession number(s): Q69ZY8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2005
Last sequence update: May 24, 2005
Last modified: June 17, 2020
This is version 132 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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