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Protein

Zinc finger and BTB domain-containing protein 45

Gene

Zbtb45

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

May be involved in transcriptional regulation (Probable). In the central nervous system, may play a role in glial cell differentiation (PubMed:21131782).Curated1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri412 – 434C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri440 – 462C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri468 – 490C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri495 – 517C2H2-type 4PROSITE-ProRule annotationAdd BLAST23

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding
Biological processNeurogenesis, Transcription, Transcription regulation
LigandMetal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger and BTB domain-containing protein 451 Publication
Alternative name(s):
Zinc finger protein 499Curated
Gene namesi
Name:Zbtb451 PublicationImported
Synonyms:Gm157Imported, Zfp499Imported
OrganismiMus musculus (Mouse)Imported
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:2685003 Zbtb45

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00004398791 – 520Zinc finger and BTB domain-containing protein 45Add BLAST520

Proteomic databases

MaxQBiQ52KG4
PaxDbiQ52KG4
PRIDEiQ52KG4

PTM databases

iPTMnetiQ52KG4
PhosphoSitePlusiQ52KG4

Expressioni

Developmental stagei

Detected in embryonic forebrain at stages E12.5 and E14.5 where it is ubiquitously expressed.1 Publication

Gene expression databases

BgeeiENSMUSG00000049600 Expressed in 209 organ(s), highest expression level in prefrontal cortex
ExpressionAtlasiQ52KG4 baseline and differential

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000056086

Structurei

3D structure databases

ProteinModelPortaliQ52KG4
SMRiQ52KG4
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini33 – 96BTBPROSITE-ProRule annotationAdd BLAST64

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi128 – 197Pro-richPROSITE-ProRule annotationAdd BLAST70
Compositional biasi302 – 373Pro-richPROSITE-ProRule annotationAdd BLAST72

Sequence similaritiesi

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri412 – 434C2H2-type 1PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri440 – 462C2H2-type 2PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri468 – 490C2H2-type 3PROSITE-ProRule annotationAdd BLAST23
Zinc fingeri495 – 517C2H2-type 4PROSITE-ProRule annotationAdd BLAST23

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00760000119063
HOGENOMiHOG000136747
HOVERGENiHBG060183
InParanoidiQ52KG4
KOiK10516
OMAiPDCALAG
OrthoDBiEOG091G0EMJ
PhylomeDBiQ52KG4
TreeFamiTF335684

Family and domain databases

InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR011333 SKP1/BTB/POZ_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00651 BTB, 1 hit
PF00096 zf-C2H2, 4 hits
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SM00355 ZnF_C2H2, 4 hits
SUPFAMiSSF54695 SSF54695, 1 hit
SSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 4 hits
PS50157 ZINC_FINGER_C2H2_2, 4 hits

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q52KG4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAATEAVHHI HLQNFSRSLL ETLNGQRLGG HFCDVTVRIR EASLRAHRCV
60 70 80 90 100
LAAGSPFFQD KLLLGHSEIR VPPVVPAQTV RQLVEFLYSG SLVVAQGEAL
110 120 130 140 150
QVLTAASVLR IQTVIDECTQ IIARARVPNT PAPAPLPPPV PPPLAPAQLR
160 170 180 190 200
HRLRHLLAAR PPGHPNAAHS RKQRQPARLQ LPAPPAPIKA EGPDAEPALT
210 220 230 240 250
AAPEDRGEED DDEETDEETD AEEGEGGGGG PGEGQAPPAF PDCAGGFLTT
260 270 280 290 300
AADSAREDPP ASTGITDYGG AGRDFLRGTG VTEDVFPDSY VSAWHEESSG
310 320 330 340 350
GPESCPVETS APPDCALAGP RPTGVKTPGP PVALFPFHLG APGPPAPTPP
360 370 380 390 400
TPSGPAPAPP PTFYPTLQPD AAPSAQLGET QAVPAAPAAQ ATAISGTPVR
410 420 430 440 450
APGGQGAEQP AYECSHCRKT FSSRKNYTKH MFIHSGEKPH QCAVCWRSFS
460 470 480 490 500
LRDYLLKHMV THTGVRAFQC AVCAKRFTQK SSLNVHMRTH RPERAPCPAC
510 520
GKVFSHRALL ERHLAAHPAP
Length:520
Mass (Da):55,012
Last modified:May 24, 2005 - v1
Checksum:i3B239179EE6E92D3
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A1B0GRT4A0A1B0GRT4_MOUSE
Zinc finger and BTB domain-containi...
Zbtb45
168Annotation score:
A0A1B0GS85A0A1B0GS85_MOUSE
Zinc finger and BTB domain-containi...
Zbtb45
27Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti304S → G in BAE38743 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK166382 mRNA Translation: BAE38743.1
AC121301 Genomic DNA No translation available.
CH466634 Genomic DNA Translation: EDL38083.1
CH466634 Genomic DNA Translation: EDL38084.1
BC094359 mRNA Translation: AAH94359.1
CCDSiCCDS20822.1
RefSeqiNP_001019870.1, NM_001024699.1
XP_006539865.1, XM_006539802.1
XP_006539866.1, XM_006539803.1
XP_006539867.1, XM_006539804.2
UniGeneiMm.279272

Genome annotation databases

EnsembliENSMUST00000051390; ENSMUSP00000056086; ENSMUSG00000049600
ENSMUST00000172240; ENSMUSP00000130439; ENSMUSG00000049600
ENSMUST00000210282; ENSMUSP00000147298; ENSMUSG00000049600
GeneIDi232879
KEGGimmu:232879
UCSCiuc009fez.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK166382 mRNA Translation: BAE38743.1
AC121301 Genomic DNA No translation available.
CH466634 Genomic DNA Translation: EDL38083.1
CH466634 Genomic DNA Translation: EDL38084.1
BC094359 mRNA Translation: AAH94359.1
CCDSiCCDS20822.1
RefSeqiNP_001019870.1, NM_001024699.1
XP_006539865.1, XM_006539802.1
XP_006539866.1, XM_006539803.1
XP_006539867.1, XM_006539804.2
UniGeneiMm.279272

3D structure databases

ProteinModelPortaliQ52KG4
SMRiQ52KG4
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000056086

PTM databases

iPTMnetiQ52KG4
PhosphoSitePlusiQ52KG4

Proteomic databases

MaxQBiQ52KG4
PaxDbiQ52KG4
PRIDEiQ52KG4

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000051390; ENSMUSP00000056086; ENSMUSG00000049600
ENSMUST00000172240; ENSMUSP00000130439; ENSMUSG00000049600
ENSMUST00000210282; ENSMUSP00000147298; ENSMUSG00000049600
GeneIDi232879
KEGGimmu:232879
UCSCiuc009fez.1 mouse

Organism-specific databases

CTDi84878
MGIiMGI:2685003 Zbtb45

Phylogenomic databases

eggNOGiKOG1721 Eukaryota
COG5048 LUCA
GeneTreeiENSGT00760000119063
HOGENOMiHOG000136747
HOVERGENiHBG060183
InParanoidiQ52KG4
KOiK10516
OMAiPDCALAG
OrthoDBiEOG091G0EMJ
PhylomeDBiQ52KG4
TreeFamiTF335684

Miscellaneous databases

PROiPR:Q52KG4
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000049600 Expressed in 209 organ(s), highest expression level in prefrontal cortex
ExpressionAtlasiQ52KG4 baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR011333 SKP1/BTB/POZ_sf
IPR036236 Znf_C2H2_sf
IPR013087 Znf_C2H2_type
PfamiView protein in Pfam
PF00651 BTB, 1 hit
PF00096 zf-C2H2, 4 hits
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SM00355 ZnF_C2H2, 4 hits
SUPFAMiSSF54695 SSF54695, 1 hit
SSF57667 SSF57667, 2 hits
PROSITEiView protein in PROSITE
PS50097 BTB, 1 hit
PS00028 ZINC_FINGER_C2H2_1, 4 hits
PS50157 ZINC_FINGER_C2H2_2, 4 hits
ProtoNetiSearch...

Entry informationi

Entry nameiZBT45_MOUSE
AccessioniPrimary (citable) accession number: Q52KG4
Secondary accession number(s): Q3TLP9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 10, 2017
Last sequence update: May 24, 2005
Last modified: November 7, 2018
This is version 128 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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