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Protein

Cyclin-L1

Gene

Ccnl1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in pre-mRNA splicing. Functions in association with cyclin-dependent kinases (CDKs). May play a role in the regulation of RNA polymerase II (pol II). Inhibited by the CDK-specific inhibitor CDKN1A/p21.By similarity

GO - Molecular functioni

  • cyclin-dependent protein serine/threonine kinase regulator activity Source: GO_Central

GO - Biological processi

Keywordsi

Molecular functionCyclin
Biological processTranscription, Transcription regulation

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-L1
Short name:
Cyclin-L
Alternative name(s):
Cyclin Ania-6a
Gene namesi
Name:Ccnl1
Synonyms:Ania6a, Ccn1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:1922664 Ccnl1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000804811 – 532Cyclin-L1Add BLAST532

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei331PhosphothreonineBy similarity1
Modified residuei341PhosphoserineCombined sources1
Modified residuei344PhosphoserineCombined sources1
Cross-linki345Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Cross-linki353Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei358PhosphoserineCombined sources1
Modified residuei361PhosphoserineBy similarity1
Cross-linki368Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity
Modified residuei380PhosphoserineBy similarity1
Modified residuei451PhosphoserineBy similarity1

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ52KE7
PaxDbiQ52KE7
PeptideAtlasiQ52KE7
PRIDEiQ52KE7

PTM databases

iPTMnetiQ52KE7
PhosphoSitePlusiQ52KE7

Expressioni

Tissue specificityi

Widely expressed (at protein level).1 Publication

Gene expression databases

BgeeiENSMUSG00000027829 Expressed in 270 organ(s), highest expression level in cochlea
CleanExiMM_CCNL1
ExpressionAtlasiQ52KE7 baseline and differential
GenevisibleiQ52KE7 MM

Interactioni

Subunit structurei

Interacts with POLR2A via its hyperphosphorylated C-terminal domain (CTD) (By similarity). Interacts with CDK11A, CDK11B, CDK12 and CDK13. May form a ternary complex with CDK11B and casein kinase II (CKII). Interacts with pre-mRNA-splicing factors, including at least SRSF1, SRSF2 AND SRSF7/SLU7 (By similarity) (PubMed:17261272).By similarity1 Publication

Protein-protein interaction databases

ComplexPortaliCPX-351 Cyclin L1-CDK11B(p110) complex
CPX-352 Cyclin L1-CDK11B(p58) complex
IntActiQ52KE7, 1 interactor
MINTiQ52KE7
STRINGi10090.ENSMUSP00000029416

Structurei

3D structure databases

ProteinModelPortaliQ52KE7
SMRiQ52KE7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni94 – 196Cyclin-like 1Add BLAST103
Regioni209 – 293Cyclin-like 2Add BLAST85
Regioni396 – 438RSAdd BLAST43

Domaini

Contains a RS region (arginine-serine dipeptide repeat) within the C-terminal domain which is the hallmark of the SR family of splicing factors. This region probably plays a role in protein-protein interactions (By similarity).By similarity

Sequence similaritiesi

Belongs to the cyclin family. Cyclin L subfamily.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiKOG0835 Eukaryota
COG5333 LUCA
GeneTreeiENSGT00760000119191
HOGENOMiHOG000231292
HOVERGENiHBG056044
InParanoidiQ52KE7
OMAiSWNFMND
OrthoDBiEOG091G0BW9
PhylomeDBiQ52KE7
TreeFamiTF101011

Family and domain databases

CDDicd00043 CYCLIN, 2 hits
InterProiView protein in InterPro
IPR013763 Cyclin-like
IPR036915 Cyclin-like_sf
IPR004367 Cyclin_C-dom
IPR015431 Cyclin_L1
IPR006671 Cyclin_N
PANTHERiPTHR10026:SF64 PTHR10026:SF64, 1 hit
PfamiView protein in Pfam
PF02984 Cyclin_C, 1 hit
PF00134 Cyclin_N, 1 hit
SMARTiView protein in SMART
SM00385 CYCLIN, 2 hits
SM01332 Cyclin_C, 1 hit
SUPFAMiSSF47954 SSF47954, 2 hits

Sequences (2+)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q52KE7-1) [UniParc]FASTAAdd to basket
Also known as: Cyclin L alpha

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MASGPHPTST AAAAAAAAAS ASSAAPSAGG SSSGTTTTTT TTTGGILIGD
60 70 80 90 100
RLYSEVSLTI DHSLIPEERL SPTPSMQDGL DLPSETDLRI LGCELIQAAG
110 120 130 140 150
ILLRLPQVAM ATGQVLFHRF FYSKSFVKHS FEIVAMACIN LASKIEEAPR
160 170 180 190 200
RIRDVINVFH HLRQLRGKRT PSPLILDQNY INTKNQVIKA ERRVLKELGF
210 220 230 240 250
CVHVKHPHKI IVMYLQVLEC ERNQTLVQTA WNYMNDSLRT NVFVRFQPET
260 270 280 290 300
IACACIYLAA RALQIPLPTR PHWFLLFGTT EEEIQEICIE TLRLYTRKKP
310 320 330 340 350
NYELLEKEVE KRKVALQEAK LKAKGLNLDG TPALSTLGGF SPASKPSSPR
360 370 380 390 400
EVKAEEKSPV SINVKTVKKE PEDRQQASKS PYNGVRKDSK RSRTSRSASR
410 420 430 440 450
SRSRTRSRSR SHSPRRHYNN RRSRSGTYSS RSRSRSRSHS ESPRRHHNHG
460 470 480 490 500
SPHLKAKHTR EDLKSSNRHG HKRKKSRSRS QSKTRDHSDV TKKHRHERGH
510 520 530
HRDRRERSRS FERSHKGKHH GGSRSGHGRH RR
Note: Found in the nucleus, with a speckled pattern of expression.
Length:532
Mass (Da):60,133
Last modified:May 24, 2005 - v1
Checksum:iECBE41C070D0CA18
GO
Isoform 2 (identifier: Q52KE7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     210-252: IIVMYLQVLE...FVRFQPETIA → VSCKVQTLQF...SFLLDVDICF
     253-532: Missing.

Note: Found both in the nucleus and cytoplasm.
Show »
Length:252
Mass (Da):27,441
Checksum:i9643A9CC56E56E2B
GO

Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F6WST0F6WST0_MOUSE
Cyclin-L1
Ccnl1
146Annotation score:
F6WYR6F6WYR6_MOUSE
Cyclin-L1
Ccnl1
178Annotation score:
F7BI63F7BI63_MOUSE
Cyclin-L1
Ccnl1
22Annotation score:
F7BER3F7BER3_MOUSE
Cyclin-L1
Ccnl1
11Annotation score:

Sequence cautioni

The sequence AAD43568 differs from that shown. Reason: Frameshift at positions 29 and 51.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti93 – 94CE → WQ in AAL75565 (PubMed:11683997).Curated2
Sequence conflicti147E → G in BAB27744 (PubMed:16141072).Curated1
Sequence conflicti283E → G in BAB27744 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_016126210 – 252IIVMY…PETIA → VSCKVQTLQFVSIRAFSEIL NSVWRVKLTGVFKSFLLDVD ICF in isoform 2. 1 PublicationAdd BLAST43
Alternative sequenceiVSP_016127253 – 532Missing in isoform 2. 1 PublicationAdd BLAST280

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF159159 mRNA Translation: AAD43568.1 Frameshift.
AF467251 mRNA Translation: AAL75565.1
AK051380 mRNA Translation: BAC34619.1
AK011629 mRNA Translation: BAB27744.3
BC094383 mRNA Translation: AAH94383.1
CCDSiCCDS17390.1 [Q52KE7-1]
RefSeqiNP_064321.2, NM_019937.3 [Q52KE7-1]
UniGeneiMm.175612

Genome annotation databases

EnsembliENSMUST00000029416; ENSMUSP00000029416; ENSMUSG00000027829 [Q52KE7-1]
GeneIDi56706
KEGGimmu:56706
UCSCiuc008pku.1 mouse [Q52KE7-1]
uc008pkx.1 mouse [Q52KE7-2]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF159159 mRNA Translation: AAD43568.1 Frameshift.
AF467251 mRNA Translation: AAL75565.1
AK051380 mRNA Translation: BAC34619.1
AK011629 mRNA Translation: BAB27744.3
BC094383 mRNA Translation: AAH94383.1
CCDSiCCDS17390.1 [Q52KE7-1]
RefSeqiNP_064321.2, NM_019937.3 [Q52KE7-1]
UniGeneiMm.175612

3D structure databases

ProteinModelPortaliQ52KE7
SMRiQ52KE7
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

ComplexPortaliCPX-351 Cyclin L1-CDK11B(p110) complex
CPX-352 Cyclin L1-CDK11B(p58) complex
IntActiQ52KE7, 1 interactor
MINTiQ52KE7
STRINGi10090.ENSMUSP00000029416

PTM databases

iPTMnetiQ52KE7
PhosphoSitePlusiQ52KE7

Proteomic databases

EPDiQ52KE7
PaxDbiQ52KE7
PeptideAtlasiQ52KE7
PRIDEiQ52KE7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000029416; ENSMUSP00000029416; ENSMUSG00000027829 [Q52KE7-1]
GeneIDi56706
KEGGimmu:56706
UCSCiuc008pku.1 mouse [Q52KE7-1]
uc008pkx.1 mouse [Q52KE7-2]

Organism-specific databases

CTDi57018
MGIiMGI:1922664 Ccnl1

Phylogenomic databases

eggNOGiKOG0835 Eukaryota
COG5333 LUCA
GeneTreeiENSGT00760000119191
HOGENOMiHOG000231292
HOVERGENiHBG056044
InParanoidiQ52KE7
OMAiSWNFMND
OrthoDBiEOG091G0BW9
PhylomeDBiQ52KE7
TreeFamiTF101011

Miscellaneous databases

PROiPR:Q52KE7
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000027829 Expressed in 270 organ(s), highest expression level in cochlea
CleanExiMM_CCNL1
ExpressionAtlasiQ52KE7 baseline and differential
GenevisibleiQ52KE7 MM

Family and domain databases

CDDicd00043 CYCLIN, 2 hits
InterProiView protein in InterPro
IPR013763 Cyclin-like
IPR036915 Cyclin-like_sf
IPR004367 Cyclin_C-dom
IPR015431 Cyclin_L1
IPR006671 Cyclin_N
PANTHERiPTHR10026:SF64 PTHR10026:SF64, 1 hit
PfamiView protein in Pfam
PF02984 Cyclin_C, 1 hit
PF00134 Cyclin_N, 1 hit
SMARTiView protein in SMART
SM00385 CYCLIN, 2 hits
SM01332 Cyclin_C, 1 hit
SUPFAMiSSF47954 SSF47954, 2 hits
ProtoNetiSearch...

Entry informationi

Entry nameiCCNL1_MOUSE
AccessioniPrimary (citable) accession number: Q52KE7
Secondary accession number(s): Q8BQ75
, Q8R5H9, Q922K0, Q9CSZ3, Q9WV44
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: May 24, 2005
Last modified: November 7, 2018
This is version 114 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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