UniProtKB - Q52KE7 (CCNL1_MOUSE)
Cyclin-L1
Ccnl1
Functioni
GO - Molecular functioni
- cyclin-dependent protein serine/threonine kinase regulator activity Source: GO_Central
GO - Biological processi
- regulation of transcription by RNA polymerase II Source: GO_Central
- RNA processing Source: InterPro
Keywordsi
Molecular function | Cyclin |
Biological process | Transcription, Transcription regulation |
Names & Taxonomyi
Protein namesi | Recommended name: Cyclin-L1Short name: Cyclin-L Alternative name(s): Cyclin Ania-6a |
Gene namesi | Name:Ccnl1 Synonyms:Ania6a, Ccn1 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:1922664, Ccnl1 |
Subcellular locationi
Nucleus
- Nucleus speckle 1 Publication
- nucleoplasm By similarity
Note: Found in nuclear intrachromatin granules clusters (IGC), also called nuclear speckles, which are storage compartments for nuclear proteins involved in mRNA processing.
Nucleus
- nuclear speck Source: MGI
- nucleus Source: MGI
- transcription elongation factor complex Source: MGI
Other locations
- cytoplasm Source: UniProtKB-SubCell
Keywords - Cellular componenti
Cytoplasm, NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000080481 | 1 – 532 | Cyclin-L1Add BLAST | 532 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 331 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 341 | PhosphoserineCombined sources | 1 | |
Modified residuei | 344 | PhosphoserineCombined sources | 1 | |
Cross-linki | 345 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Cross-linki | 353 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Modified residuei | 358 | PhosphoserineCombined sources | 1 | |
Modified residuei | 361 | PhosphoserineBy similarity | 1 | |
Cross-linki | 368 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity | ||
Modified residuei | 380 | PhosphoserineBy similarity | 1 | |
Modified residuei | 451 | PhosphoserineBy similarity | 1 |
Keywords - PTMi
Isopeptide bond, Phosphoprotein, Ubl conjugationProteomic databases
EPDi | Q52KE7 |
jPOSTi | Q52KE7 |
PaxDbi | Q52KE7 |
PeptideAtlasi | Q52KE7 |
PRIDEi | Q52KE7 |
PTM databases
iPTMneti | Q52KE7 |
PhosphoSitePlusi | Q52KE7 |
Expressioni
Tissue specificityi
Gene expression databases
Bgeei | ENSMUSG00000027829, Expressed in granulocyte and 287 other tissues |
Genevisiblei | Q52KE7, MM |
Interactioni
Subunit structurei
Interacts with POLR2A via its hyperphosphorylated C-terminal domain (CTD) (By similarity).
Interacts with CDK11A, CDK11B, CDK12 and CDK13. May form a ternary complex with CDK11B and casein kinase II (CKII).
Interacts with pre-mRNA-splicing factors, including at least SRSF1, SRSF2 AND SRSF7/SLU7 (By similarity) (PubMed:17261272).
By similarity1 PublicationProtein-protein interaction databases
BioGRIDi | 208134, 6 interactors |
ComplexPortali | CPX-351, Cyclin L1-CDK11B(p110) complex CPX-352, Cyclin L1-CDK11B(p58) complex |
IntActi | Q52KE7, 1 interactor |
MINTi | Q52KE7 |
STRINGi | 10090.ENSMUSP00000029416 |
Miscellaneous databases
RNActi | Q52KE7, protein |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 94 – 196 | Cyclin-like 1Add BLAST | 103 | |
Regioni | 209 – 293 | Cyclin-like 2Add BLAST | 85 | |
Regioni | 396 – 438 | RSAdd BLAST | 43 |
Domaini
Sequence similaritiesi
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG0835, Eukaryota |
GeneTreei | ENSGT00940000159135 |
HOGENOMi | CLU_022000_6_1_1 |
InParanoidi | Q52KE7 |
OMAi | INFIYQA |
OrthoDBi | 1519153at2759 |
PhylomeDBi | Q52KE7 |
TreeFami | TF101011 |
Family and domain databases
CDDi | cd00043, CYCLIN, 2 hits |
InterProi | View protein in InterPro IPR013763, Cyclin-like IPR036915, Cyclin-like_sf IPR043198, Cyclin/Ssn8 IPR004367, Cyclin_C-dom IPR015431, Cyclin_L1 IPR006671, Cyclin_N |
PANTHERi | PTHR10026, PTHR10026, 1 hit PTHR10026:SF64, PTHR10026:SF64, 1 hit |
Pfami | View protein in Pfam PF02984, Cyclin_C, 1 hit PF00134, Cyclin_N, 1 hit |
SMARTi | View protein in SMART SM00385, CYCLIN, 2 hits SM01332, Cyclin_C, 1 hit |
SUPFAMi | SSF47954, SSF47954, 2 hits |
s (2+)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketThis entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MASGPHPTST AAAAAAAAAS ASSAAPSAGG SSSGTTTTTT TTTGGILIGD
60 70 80 90 100
RLYSEVSLTI DHSLIPEERL SPTPSMQDGL DLPSETDLRI LGCELIQAAG
110 120 130 140 150
ILLRLPQVAM ATGQVLFHRF FYSKSFVKHS FEIVAMACIN LASKIEEAPR
160 170 180 190 200
RIRDVINVFH HLRQLRGKRT PSPLILDQNY INTKNQVIKA ERRVLKELGF
210 220 230 240 250
CVHVKHPHKI IVMYLQVLEC ERNQTLVQTA WNYMNDSLRT NVFVRFQPET
260 270 280 290 300
IACACIYLAA RALQIPLPTR PHWFLLFGTT EEEIQEICIE TLRLYTRKKP
310 320 330 340 350
NYELLEKEVE KRKVALQEAK LKAKGLNLDG TPALSTLGGF SPASKPSSPR
360 370 380 390 400
EVKAEEKSPV SINVKTVKKE PEDRQQASKS PYNGVRKDSK RSRTSRSASR
410 420 430 440 450
SRSRTRSRSR SHSPRRHYNN RRSRSGTYSS RSRSRSRSHS ESPRRHHNHG
460 470 480 490 500
SPHLKAKHTR EDLKSSNRHG HKRKKSRSRS QSKTRDHSDV TKKHRHERGH
510 520 530
HRDRRERSRS FERSHKGKHH GGSRSGHGRH RR
Computationally mapped potential isoform sequencesi
There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketF6WST0 | F6WST0_MOUSE | Cyclin-L1 | Ccnl1 | 146 | Annotation score: | ||
F6WYR6 | F6WYR6_MOUSE | Cyclin-L1 | Ccnl1 | 178 | Annotation score: | ||
F7BI63 | F7BI63_MOUSE | Cyclin-L1 | Ccnl1 | 22 | Annotation score: | ||
F7BER3 | F7BER3_MOUSE | Cyclin-L1 | Ccnl1 | 11 | Annotation score: |
Sequence cautioni
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 93 – 94 | CE → WQ in AAL75565 (PubMed:11683997).Curated | 2 | |
Sequence conflicti | 147 | E → G in BAB27744 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 283 | E → G in BAB27744 (PubMed:16141072).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_016126 | 210 – 252 | IIVMY…PETIA → VSCKVQTLQFVSIRAFSEIL NSVWRVKLTGVFKSFLLDVD ICF in isoform 2. 1 PublicationAdd BLAST | 43 | |
Alternative sequenceiVSP_016127 | 253 – 532 | Missing in isoform 2. 1 PublicationAdd BLAST | 280 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF159159 mRNA Translation: AAD43568.1 Frameshift. AF467251 mRNA Translation: AAL75565.1 AK051380 mRNA Translation: BAC34619.1 AK011629 mRNA Translation: BAB27744.3 BC094383 mRNA Translation: AAH94383.1 |
CCDSi | CCDS17390.1 [Q52KE7-1] |
RefSeqi | NP_064321.2, NM_019937.3 [Q52KE7-1] |
Genome annotation databases
Ensembli | ENSMUST00000029416; ENSMUSP00000029416; ENSMUSG00000027829 [Q52KE7-1] |
GeneIDi | 56706 |
KEGGi | mmu:56706 |
UCSCi | uc008pku.1, mouse [Q52KE7-1] uc008pkx.1, mouse [Q52KE7-2] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AF159159 mRNA Translation: AAD43568.1 Frameshift. AF467251 mRNA Translation: AAL75565.1 AK051380 mRNA Translation: BAC34619.1 AK011629 mRNA Translation: BAB27744.3 BC094383 mRNA Translation: AAH94383.1 |
CCDSi | CCDS17390.1 [Q52KE7-1] |
RefSeqi | NP_064321.2, NM_019937.3 [Q52KE7-1] |
3D structure databases
SMRi | Q52KE7 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 208134, 6 interactors |
ComplexPortali | CPX-351, Cyclin L1-CDK11B(p110) complex CPX-352, Cyclin L1-CDK11B(p58) complex |
IntActi | Q52KE7, 1 interactor |
MINTi | Q52KE7 |
STRINGi | 10090.ENSMUSP00000029416 |
PTM databases
iPTMneti | Q52KE7 |
PhosphoSitePlusi | Q52KE7 |
Proteomic databases
EPDi | Q52KE7 |
jPOSTi | Q52KE7 |
PaxDbi | Q52KE7 |
PeptideAtlasi | Q52KE7 |
PRIDEi | Q52KE7 |
Protocols and materials databases
Antibodypediai | 18411, 214 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000029416; ENSMUSP00000029416; ENSMUSG00000027829 [Q52KE7-1] |
GeneIDi | 56706 |
KEGGi | mmu:56706 |
UCSCi | uc008pku.1, mouse [Q52KE7-1] uc008pkx.1, mouse [Q52KE7-2] |
Organism-specific databases
CTDi | 57018 |
MGIi | MGI:1922664, Ccnl1 |
Phylogenomic databases
eggNOGi | KOG0835, Eukaryota |
GeneTreei | ENSGT00940000159135 |
HOGENOMi | CLU_022000_6_1_1 |
InParanoidi | Q52KE7 |
OMAi | INFIYQA |
OrthoDBi | 1519153at2759 |
PhylomeDBi | Q52KE7 |
TreeFami | TF101011 |
Miscellaneous databases
BioGRID-ORCSi | 56706, 4 hits in 16 CRISPR screens |
ChiTaRSi | Ccnl1, mouse |
PROi | PR:Q52KE7 |
RNActi | Q52KE7, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000027829, Expressed in granulocyte and 287 other tissues |
Genevisiblei | Q52KE7, MM |
Family and domain databases
CDDi | cd00043, CYCLIN, 2 hits |
InterProi | View protein in InterPro IPR013763, Cyclin-like IPR036915, Cyclin-like_sf IPR043198, Cyclin/Ssn8 IPR004367, Cyclin_C-dom IPR015431, Cyclin_L1 IPR006671, Cyclin_N |
PANTHERi | PTHR10026, PTHR10026, 1 hit PTHR10026:SF64, PTHR10026:SF64, 1 hit |
Pfami | View protein in Pfam PF02984, Cyclin_C, 1 hit PF00134, Cyclin_N, 1 hit |
SMARTi | View protein in SMART SM00385, CYCLIN, 2 hits SM01332, Cyclin_C, 1 hit |
SUPFAMi | SSF47954, SSF47954, 2 hits |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | CCNL1_MOUSE | |
Accessioni | Q52KE7Primary (citable) accession number: Q52KE7 Secondary accession number(s): Q8BQ75 Q9WV44 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | November 22, 2005 |
Last sequence update: | May 24, 2005 | |
Last modified: | December 2, 2020 | |
This is version 126 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot - SIMILARITY comments
Index of protein domains and families