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Entry version 110 (02 Jun 2021)
Sequence version 1 (01 Nov 1996)
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Protein

p-cumate 2,3-dioxygenase system, large oxygenase component

Gene

cmtAb

Organism
Pseudomonas putida (Arthrobacter siderocapsulatus)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Component of the p-cumate 2,3-dioxygenase multicomponent enzyme system which catalyzes the incorporation of both atoms of molecular oxygen into p-cumate to form cis-2,3-dihydroxy-2,3-dihydro-p-cumate. The alpha subunit has a catalytic role in the holoenzyme. Also able to catalyze the cis-dihydroxylation of indole-2-carboxylate and indole-3-carboxylate (PubMed:7592495).

1 Publication2 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Protein has several cofactor binding sites:

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: p-cumate degradation

This protein is involved in the subpathway that synthesizes acetaldehyde and pyruvate from p-cumate.1 Publication This subpathway is part of the pathway p-cumate degradation, which is itself part of Aromatic compound metabolism.
View all proteins of this organism that are known to be involved in the pathway p-cumate degradation and in Aromatic compound metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi84Iron-sulfur (2Fe-2S)PROSITE-ProRule annotationBy similarity1
Metal bindingi86Iron-sulfur (2Fe-2S); via pros nitrogenPROSITE-ProRule annotationBy similarity1
Metal bindingi104Iron-sulfur (2Fe-2S)PROSITE-ProRule annotationBy similarity1
Metal bindingi107Iron-sulfur (2Fe-2S); via pros nitrogenPROSITE-ProRule annotationBy similarity1
Metal bindingi211IronBy similarity1
Metal bindingi216IronBy similarity1
Metal bindingi365IronBy similarity1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionDioxygenase, Oxidoreductase
Biological processAromatic hydrocarbons catabolism
Ligand2Fe-2S, Iron, Iron-sulfur, Metal-binding, NAD

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

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BioCyci
MetaCyc:MONOMER-342

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
1.14.12.25, 5092

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
p-cumate 2,3-dioxygenase system, large oxygenase component1 Publication (EC:1.14.12.251 Publication)
Alternative name(s):
Large terminal subunit of p-cumate dioxygenase1 Publication
p-cumate 2,3-dioxygenase large subunit1 Publication
p-cumate 2,3-dioxygenase subunit alpha1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:cmtAb1 Publication
ORF Names:CBP06_10605Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPseudomonas putida (Arthrobacter siderocapsulatus)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri303 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000195461 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004422821 – 434p-cumate 2,3-dioxygenase system, large oxygenase componentAdd BLAST434

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Induced by p-cumate and repressed by CymR.1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

The p-cumate 2,3-dioxygenase multicomponent enzyme system is composed of an electron transfer component and a dioxygenase component (iron sulfur protein (ISP)). The electron transfer component is composed of a ferredoxin reductase (CmtAa) and a ferredoxin (CmtAd), and the dioxygenase component is formed of a large alpha subunit (CmtAb) and a small beta subunit (CmtAc).

1 Publication

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini43 – 153RieskePROSITE-ProRule annotationAdd BLAST111

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.102.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR044637, RHO
IPR017941, Rieske_2Fe-2S
IPR036922, Rieske_2Fe-2S_sf
IPR015881, Ring-hydroxy_dOase_2Fe2S_BS
IPR015879, Ring_hydroxy_dOase_asu_C_dom
IPR001663, Rng_hydr_dOase-A

The PANTHER Classification System

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PANTHERi
PTHR43756, PTHR43756, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00355, Rieske, 1 hit
PF00848, Ring_hydroxyl_A, 1 hit

Protein Motif fingerprint database; a protein domain database

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PRINTSi
PR00090, RNGDIOXGNASE

Superfamily database of structural and functional annotation

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SUPFAMi
SSF50022, SSF50022, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51296, RIESKE, 1 hit
PS00570, RING_HYDROXYL_ALPHA, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q51974-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNNDKNLVEI DDENLLFRVA RESFVSEEVL AEEYEKIFDR CWLYVGHTSE
60 70 80 90 100
FKKPGDFVTR TVARRNLLVT MGTDRTINAF FNTCPHRGAT VCRERSGNSK
110 120 130 140 150
NFQCFYHGWV FGCDGNLKSQ PGKERYCADF ITGGAGNLVP VPRFDIYAGF
160 170 180 190 200
CFVSFNAEVE PLPDYLAGAK EYLELVSKYS ESGMGITTGT QEYAIRANWK
210 220 230 240 250
LLVENSIDGY HAVSTHASYL DYLKNINDGF SGAKLEGKST DLGNGHAVIE
260 270 280 290 300
FSAPWGRPIA SWVPIWGEEG KQEIDQIYAR LVELHGAEMA DRMAYKNRNL
310 320 330 340 350
LIFPNLIIND IMAITVRTFY PQAPNYMHVN GWSLAPNEES DWARKYRLSN
360 370 380 390 400
FLEFLGPGGF ATPDDVEALE SCQNGFSNYR LVPWSDISKG MGKETANYDD
410 420 430
ELQMRAFWTR WNQFIGGAPT PDSGVQYIPT IALA
Length:434
Mass (Da):48,968
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i820ABF7E578F4BCC
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U24215 Genomic DNA Translation: AAB62285.1
AB042508 Genomic DNA Translation: BAB17771.1
DQ157469 Genomic DNA Translation: ABA10794.1
GQ884177 Genomic DNA Translation: ADI95383.1
NHBC01000013 Genomic DNA Translation: OUS88312.1

NCBI Reference Sequences

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RefSeqi
WP_012052617.1, NZ_NHBC01000013.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
OUS88312; OUS88312; CBP06_10605

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U24215 Genomic DNA Translation: AAB62285.1
AB042508 Genomic DNA Translation: BAB17771.1
DQ157469 Genomic DNA Translation: ABA10794.1
GQ884177 Genomic DNA Translation: ADI95383.1
NHBC01000013 Genomic DNA Translation: OUS88312.1
RefSeqiWP_012052617.1, NZ_NHBC01000013.1

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Genome annotation databases

EnsemblBacteriaiOUS88312; OUS88312; CBP06_10605

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-342
BRENDAi1.14.12.25, 5092

Family and domain databases

Gene3Di2.102.10.10, 1 hit
InterProiView protein in InterPro
IPR044637, RHO
IPR017941, Rieske_2Fe-2S
IPR036922, Rieske_2Fe-2S_sf
IPR015881, Ring-hydroxy_dOase_2Fe2S_BS
IPR015879, Ring_hydroxy_dOase_asu_C_dom
IPR001663, Rng_hydr_dOase-A
PANTHERiPTHR43756, PTHR43756, 1 hit
PfamiView protein in Pfam
PF00355, Rieske, 1 hit
PF00848, Ring_hydroxyl_A, 1 hit
PRINTSiPR00090, RNGDIOXGNASE
SUPFAMiSSF50022, SSF50022, 1 hit
PROSITEiView protein in PROSITE
PS51296, RIESKE, 1 hit
PS00570, RING_HYDROXYL_ALPHA, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCMTAB_PSEPU
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q51974
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 22, 2017
Last sequence update: November 1, 1996
Last modified: June 2, 2021
This is version 110 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
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