We will be switching to the new UniProt website soon. Please explore and share your feedback.
Take me to the new website.
UniProtKB - Q51956 (PCAF_PSEPU)
Protein
Beta-ketoadipyl-CoA thiolase
Gene
pcaF
Organism
Pseudomonas putida (Arthrobacter siderocapsulatus)
Status
Functioni
Catalyzes thiolytic cleavage of beta-ketoadipyl-CoA to succinyl-CoA and acetyl-CoA.
Catalytic activityi
- EC:2.3.1.174
: beta-ketoadipate pathway Pathwayi
This protein is involved in step 2 of the subpathway that synthesizes acetyl-CoA and succinyl-CoA from 3-oxoadipate. This subpathway is part of the pathway beta-ketoadipate pathway, which is itself part of Aromatic compound metabolism.View all proteins of this organism that are known to be involved in the subpathway that synthesizes acetyl-CoA and succinyl-CoA from 3-oxoadipate, the pathway beta-ketoadipate pathway and in Aromatic compound metabolism.
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 90 | Acyl-thioester intermediateBy similarity | 1 | |
Active sitei | 356 | Proton acceptorPROSITE-ProRule annotation | 1 | |
Active sitei | 386 | Proton acceptorPROSITE-ProRule annotation | 1 |
GO - Molecular functioni
- 3-oxoadipyl-CoA thiolase activity Source: UniProtKB-EC
GO - Biological processi
- 3,4-dihydroxybenzoate catabolic process Source: InterPro
- beta-ketoadipate pathway Source: UniProtKB-UniPathway
Keywordsi
Molecular function | Acyltransferase, Transferase |
Biological process | Aromatic hydrocarbons catabolism |
Enzyme and pathway databases
UniPathwayi | UPA00157;UER00263 |
Names & Taxonomyi
Protein namesi | Recommended name: Beta-ketoadipyl-CoA thiolase (EC:2.3.1.174)Alternative name(s): 3-oxoadipyl-CoA thiolase |
Gene namesi | Name:pcaF |
Organismi | Pseudomonas putida (Arthrobacter siderocapsulatus) |
Taxonomic identifieri | 303 [NCBI] |
Taxonomic lineagei | Bacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas › |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000206422 | 1 – 400 | Beta-ketoadipyl-CoA thiolaseAdd BLAST | 400 |
Family & Domainsi
Sequence similaritiesi
Phylogenomic databases
eggNOGi | COG0183, Bacteria |
Family and domain databases
CDDi | cd00751, thiolase, 1 hit |
Gene3Di | 3.40.47.10, 1 hit |
InterProi | View protein in InterPro IPR012793, PcaF IPR002155, Thiolase IPR016039, Thiolase-like IPR020615, Thiolase_acyl_enz_int_AS IPR020610, Thiolase_AS IPR020617, Thiolase_C IPR020613, Thiolase_CS IPR020616, Thiolase_N |
Pfami | View protein in Pfam PF02803, Thiolase_C, 1 hit PF00108, Thiolase_N, 1 hit |
PIRSFi | PIRSF000429, Ac-CoA_Ac_transf, 1 hit |
SUPFAMi | SSF53901, SSF53901, 2 hits |
TIGRFAMsi | TIGR01930, AcCoA-C-Actrans, 1 hit TIGR02430, pcaF, 1 hit |
PROSITEi | View protein in PROSITE PS00098, THIOLASE_1, 1 hit PS00737, THIOLASE_2, 1 hit PS00099, THIOLASE_3, 1 hit |
i Sequence
Sequence statusi: Complete.
Q51956-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MRDVFICDAI RTPIGRFGGA LAGVRADDLA AVPLKALIEP NPAVQWDQVD
60 70 80 90 100
EVFFGCANQA GEDNRNVARM ALLLAGLPES IPGVTLNRLC ASGMDAIGTA
110 120 130 140 150
FRAIASGEME LAIAGGVESM SRAPFVMGKA ESGYSRNMKL EDTTIGWRFI
160 170 180 190 200
NPLMKSQYGV DSMPETADNV ADDYQVSRAD QDAFALRSQQ KAAAAQAAGF
210 220 230 240 250
FAEEIVPVRI AHKKGETIVE RDEHLRPETT LEALTKLKPV NGPDKTVTAG
260 270 280 290 300
NASGVNDGAA ALILASAEAV KKHGLTPRAR VLGMASGGVA PRVMGIGPVP
310 320 330 340 350
AVRKLTERLG VAVSDFDVIE LNEAFASQGL AVLRELGVAD DAPQVNPNGG
360 370 380 390 400
AIALGHPLGM SGARLVLTAL HQLEKSGGRK GLATMCVGVG QGLALAIERV
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U10895 Genomic DNA Translation: AAA85138.1 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | U10895 Genomic DNA Translation: AAA85138.1 |
3D structure databases
SMRi | Q51956 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 1240350.AMZE01000001_gene2841 |
Phylogenomic databases
eggNOGi | COG0183, Bacteria |
Enzyme and pathway databases
UniPathwayi | UPA00157;UER00263 |
Family and domain databases
CDDi | cd00751, thiolase, 1 hit |
Gene3Di | 3.40.47.10, 1 hit |
InterProi | View protein in InterPro IPR012793, PcaF IPR002155, Thiolase IPR016039, Thiolase-like IPR020615, Thiolase_acyl_enz_int_AS IPR020610, Thiolase_AS IPR020617, Thiolase_C IPR020613, Thiolase_CS IPR020616, Thiolase_N |
Pfami | View protein in Pfam PF02803, Thiolase_C, 1 hit PF00108, Thiolase_N, 1 hit |
PIRSFi | PIRSF000429, Ac-CoA_Ac_transf, 1 hit |
SUPFAMi | SSF53901, SSF53901, 2 hits |
TIGRFAMsi | TIGR01930, AcCoA-C-Actrans, 1 hit TIGR02430, pcaF, 1 hit |
PROSITEi | View protein in PROSITE PS00098, THIOLASE_1, 1 hit PS00737, THIOLASE_2, 1 hit PS00099, THIOLASE_3, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | PCAF_PSEPU | |
Accessioni | Q51956Primary (citable) accession number: Q51956 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 15, 1999 |
Last sequence update: | November 1, 1996 | |
Last modified: | February 23, 2022 | |
This is version 91 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Prokaryotic Protein Annotation Program |
Miscellaneousi
Documents
- PATHWAY comments
Index of metabolic and biosynthesis pathways - SIMILARITY comments
Index of protein domains and families