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UniProtKB - Q51956 (PCAF_PSEPU)

Entry version 88 (12 Aug 2020)
Sequence version 1 (01 Nov 1996)
Previous versions | rss
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Protein

Beta-ketoadipyl-CoA thiolase

Gene

pcaF

Organism
Pseudomonas putida (Arthrobacter siderocapsulatus)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes thiolytic cleavage of beta-ketoadipyl-CoA to succinyl-CoA and acetyl-CoA.

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: beta-ketoadipate pathway

This protein is involved in step 2 of the subpathway that synthesizes acetyl-CoA and succinyl-CoA from 3-oxoadipate.
Proteins known to be involved in the 2 steps of the subpathway in this organism are:
  1. 3-oxoadipate CoA-transferase (HB4184_23470), 3-oxoadipate CoA-transferase (E6B08_15545), 3-oxoadipate CoA-transferase (WP8W18C01_41040), 3-oxoadipate CoA-transferase (B7H17_10750), 3-oxoadipate CoA-transferase (HA62_14360), 3-oxoadipate CoA-transferase (HA62_14355), 3-oxoadipate CoA-transferase (BIW19_17495), 3-oxoadipate CoA-transferase (EGT09_23945), 3-oxoadipate CoA-transferase (EFK07_18155), 3-oxoadipate CoA-transferase (B7H17_10755), 3-oxoadipate CoA-transferase (EFJ98_29850), 3-oxoadipate CoA-transferase (SAMN03097715_04398), 3-oxoadipate CoA-transferase (PU99_06900), 3-oxoadipate CoA-transferase (gctA), 3-oxoadipate CoA-transferase (camF1), 3-oxoadipate CoA-transferase (SAMN03097715_00583), 3-oxoadipate CoA-transferase (HA62_19760), 3-oxoadipate CoA-transferase (BGP80_13965), 3-oxoadipate CoA-transferase (AO269_11515), 3-oxoadipate CoA-transferase (pcaJ), 3-oxoadipate CoA-transferase (DKY63_09830), 3-oxoadipate CoA-transferase (WP8W18C01_20710), 3-oxoadipate CoA-transferase (pcaJ), 3-oxoadipate CoA-transferase (B7H17_16125), 3-oxoadipate CoA-transferase (EFJ98_00745), 3-oxoadipate CoA-transferase (DI560_05760), 3-oxoadipate CoA-transferase (catJ), 3-oxoadipate CoA-transferase (catI), 3-oxoadipate CoA-transferase (DKY63_26185), 3-oxoadipate CoA-transferase (catI), 3-oxoadipate CoA-transferase (catJ_1), 3-oxoadipate CoA-transferase (BGP80_13970), 3-oxoadipate CoA-transferase (B7H19_21030), 3-oxoadipate CoA-transferase (EGT09_23950), 3-oxoadipate CoA-transferase (QV12_06600), 3-oxoadipate CoA-transferase (HB4184_03995), 3-oxoadipate CoA-transferase (E2H86_01870), 3-oxoadipate CoA-transferase subunit A (pcaI), 3-oxoadipate CoA-transferase (E2H86_15025), 3-oxoadipate CoA-transferase (pcaJ), 3-oxoadipate CoA-transferase (B7H19_21025), 3-oxoadipate CoA-transferase (AYO28_20035), 3-oxoadipate CoA-transferase (QV12_18345), 3-oxoadipate CoA-transferase (CR511_14690), 3-oxoadipate CoA-transferase (B7H17_16120), 3-oxoadipate CoA-transferase (AO269_31845), 3-oxoadipate CoA-transferase (pcaI), 3-oxoadipate CoA-transferase (AWT69_001010), 3-oxoadipate CoA-transferase (scoA), 3-oxoadipate CoA-transferase (AWT69_001009), 3-oxoadipate CoA-transferase (WP8W18C01_20700), 3-oxoadipate CoA-transferase (EGT09_07970), 3-oxoadipate CoA-transferase (E6B08_17335), 3-oxoadipate CoA-transferase (pcaI), 3-oxoadipate CoA-transferase (BL240_14625), 3-oxoadipate CoA-transferase (AYO08_08005), 3-oxoadipate CoA-transferase (pcaJ), 3-oxoadipate CoA-transferase (CRX57_22530), 3-oxoadipate CoA-transferase (E4195_03750), 3-oxoadipate CoA-transferase (AYO28_17945), 3-oxoadipate CoA-transferase (B8W72_11560), 3-oxoadipate CoA-transferase (AYO08_15105), 3-oxoadipate CoA-transferase (AYO28_20040), 3-oxoadipate CoA-transferase (DI560_05755), 3-oxoadipate CoA-transferase (E6B08_16565), 3-oxoadipate CoA-transferase (WP8W18C01_23110), 3-oxoadipate CoA-transferase (scoB), 3-oxoadipate CoA-transferase (CRX57_05090), 3-oxoadipate CoA-transferase (pcaJ), 3-oxoadipate CoA-transferase (BGP84_10815), 3-oxoadipate CoA-transferase (lpsI), 3-oxoadipate CoA-transferase (HB4184_04000), 3-oxoadipate CoA-transferase (HA62_20000), 3-oxoadipate CoA-transferase (scoB), 3-oxoadipate CoA-transferase (A3L25_016270), 3-oxoadipate CoA-transferase (B8W72_11555), 3-oxoadipate CoA-transferase (E4195_01610), 3-oxoadipate CoA-transferase (CR511_14055), 3-oxoadipate CoA-transferase (B8W72_30675), 3-oxoadipate CoA-transferase (EGT09_07975), 3-oxoadipate CoA-transferase (E4195_03745), 3-oxoadipate CoA-transferase (BGP84_11455), 3-oxoadipate CoA-transferase (QV12_06595), 3-oxoadipate CoA-transferase (B8W72_29715), 3-oxoadipate CoA-transferase (CR512_12370), 3-oxoadipate CoA-transferase (PU99_11090), 3-oxoadipate CoA-transferase (CR511_14685), 3-oxoadipate CoA-transferase (C2H86_09535), 3-oxoadipate CoA-transferase (B7H18_27035), 3-oxoadipate CoA-transferase (pcaI), 3-oxoadipate CoA-transferase (AWT69_002763), 3-oxoadipate CoA-transferase (lpsI), 3-oxoadipate CoA-transferase (B7H18_15425), 3-oxoadipate CoA-transferase (HB4184_23475), 3-oxoadipate CoA-transferase (D0O09_03725), 3-oxoadipate CoA-transferase (KF715C_ch36990), 3-oxoadipate CoA-transferase (C2H86_09540), 3-oxoadipate CoA-transferase (PU99_23085), 3-oxoadipate CoA-transferase (CR511_14060), 3-oxoadipate CoA-transferase (E6B08_17330), 3-oxoadipate CoA-transferase (A3L25_016275), 3-oxoadipate CoA-transferase (E2H86_01875), 3-oxoadipate CoA-transferase (A3L25_015050), 3-oxoadipate CoA-transferase (BIW19_04370), 3-oxoadipate CoA-transferase subunit B (pcaJ), 3-oxoadipate CoA-transferase (HA62_20005), 3-oxoadipate CoA-transferase (pcaI), 3-oxoadipate CoA-transferase (QV12_18350), 3-oxoadipate CoA-transferase (DKY63_30410), 3-oxoadipate CoA-transferase (PU99_06895), 3-oxoadipate CoA-transferase (BGP80_22620), 3-oxoadipate CoA-transferase (scoA), 3-oxoadipate CoA-transferase (KF715C_ch28880), 3-oxoadipate CoA-transferase (DKY63_09825), 3-oxoadipate CoA-transferase (B7H17_17330), 3-oxoadipate CoA-transferase (BGP84_10820), 3-oxoadipate CoA-transferase (camF2), 3-oxoadipate CoA-transferase (SAMN03097715_00582), 3-oxoadipate CoA-transferase (catJ_2), 3-oxoadipate CoA-transferase (BGP82_15680), 3-oxoadipate CoA-transferase (BGP80_22625), 3-oxoadipate CoA-transferase (BIW19_17490), 3-oxoadipate CoA-transferase (scoB), 3-oxoadipate CoA-transferase (A3L25_020075), 3-oxoadipate CoA-transferase (scoA), 3-oxoadipate CoA-transferase (DKY63_26180), 3-oxoadipate CoA-transferase (E6B08_16560), 3-oxoadipate CoA-transferase (DKY63_30405), 3-oxoadipate CoA-transferase (HA62_22170), 3-oxoadipate CoA-transferase (HA62_22165), 3-oxoadipate CoA-transferase (BL240_22795), 3-oxoadipate CoA-transferase (B7H19_19895), 3-oxoadipate CoA-transferase (KF715C_ch28870), 3-oxoadipate CoA-transferase (A3K88_10685), 3-oxoadipate CoA-transferase (C2H86_10190), 3-oxoadipate CoA-transferase (B7H17_17325), 3-oxoadipate CoA-transferase (PU99_23090), 3-oxoadipate CoA-transferase (AYO28_17950), 3-oxoadipate CoA-transferase (AWT69_002764), 3-oxoadipate CoA-transferase (pcaI), 3-oxoadipate CoA-transferase (GPM17_17465), 3-oxoadipate CoA-transferase (KF715C_ch27090), 3-oxoadipate CoA-transferase (CRX57_22525), 3-oxoadipate CoA-transferase (DI560_10095), 3-oxoadipate CoA-transferase (CRX57_05095), 3-oxoadipate CoA-transferase (scoB), 3-oxoadipate CoA-transferase (A3L25_020070), 3-oxoadipate CoA-transferase (E2H86_15020), 3-oxoadipate CoA-transferase (EQ845_29740), 3-oxoadipate CoA-transferase (IEC33019_1799), 3-oxoadipate CoA-transferase (BGP84_11450), 3-oxoadipate CoA-transferase (DI560_10100), 3-oxoadipate CoA-transferase (B8W72_25095)
  2. 3-oxoadipyl-CoA thiolase (paaJ), 3-oxoadipyl-CoA thiolase (BGP82_26200), 3-oxoadipyl-CoA thiolase (WP8W18C01_41030), 3-oxoadipyl-CoA thiolase (BIW19_04360), 3-oxoadipyl-CoA thiolase (pcaF), 3-oxoadipyl-CoA thiolase (pcaF), 3-oxoadipyl-CoA thiolase (AWT69_001011), 3-oxoadipyl-CoA thiolase (BL240_22785), 3-oxoadipyl-CoA thiolase (pcaF), 3-oxoadipyl-CoA thiolase, 3-oxoadipyl-CoA thiolase (pcaF), 3-oxoadipyl-CoA thiolase (AYO08_09350), 3-oxoadipyl-CoA thiolase (pcaF), 3-oxoadipyl-CoA thiolase (pcaF), 3-oxoadipyl-CoA thiolase (BGP84_23530), 3-oxoadipyl-CoA thiolase (PU99_15200), 3-oxoadipyl-CoA thiolase (KF715C_ch48130), 3-oxoadipyl-CoA thiolase (pcaF), 3-oxoadipyl-CoA thiolase (pcaF_1), 3-oxoadipyl-CoA thiolase (B8W72_22255), 3-oxoadipyl-CoA thiolase (HB13667_24550), 3-oxoadipyl-CoA thiolase (pcaF), 3-oxoadipyl-CoA thiolase (AYO28_06670), 3-oxoadipyl-CoA thiolase (pcaF), 3-oxoadipyl-CoA thiolase (pcaF), 3-oxoadipyl-CoA thiolase (HA62_25055), 3-oxoadipyl-CoA thiolase (AWT69_002573), 3-oxoadipyl-CoA thiolase (QV12_06605), 3-oxoadipyl-CoA thiolase (pcaF), 3-oxoadipyl-CoA thiolase (pcaF), 3-oxoadipyl-CoA thiolase (pcaF), 3-oxoadipyl-CoA thiolase (B7H18_15000), 3-oxoadipyl-CoA thiolase (pcaF), 3-oxoadipyl-CoA thiolase (pcaF), 3-oxoadipyl-CoA thiolase (AYO08_26170), 3-oxoadipyl-CoA thiolase (paaJ), 3-oxoadipyl-CoA thiolase (pcaF), 3-oxoadipyl-CoA thiolase (HB4184_23910), 3-oxoadipyl-CoA thiolase (pcaF), 3-oxoadipyl-CoA thiolase (pcaF), 3-oxoadipyl-CoA thiolase (HB4184_11850), 3-oxoadipyl-CoA thiolase (pcaF_1), 3-oxoadipyl-CoA thiolase (pcaF), 3-oxoadipyl-CoA thiolase (pcaF), 3-oxoadipyl-CoA thiolase (pcaF), 3-oxoadipyl-CoA thiolase (pcaF), 3-oxoadipyl-CoA thiolase (BGP80_22615), 3-oxoadipyl-CoA thiolase (B7H19_03525), 3-oxoadipyl-CoA thiolase (pcaF), 3-oxoadipyl-CoA thiolase (pcaF), 3-oxoadipyl-CoA thiolase (pcaF), 3-oxoadipyl-CoA thiolase (B7H17_10760), 3-oxoadipyl-CoA thiolase (BL240_14135), 3-oxoadipyl-CoA thiolase (DW66_2949), 3-oxoadipyl-CoA thiolase (pcaF), 3-oxoadipyl-CoA thiolase (pcaF), 3-oxoadipyl-CoA thiolase (BGP82_07895), 3-oxoadipyl-CoA thiolase (pcaF), 3-oxoadipyl-CoA thiolase (SAMN03097715_04399), 3-oxoadipyl-CoA thiolase (HA62_22175), 3-oxoadipyl-CoA thiolase (pcaF), 3-oxoadipyl-CoA thiolase (KF715C_ch27640), 3-oxoadipyl-CoA thiolase (pcaF), 3-oxoadipyl-CoA thiolase (PU99_08945), 3-oxoadipyl-CoA thiolase (pcaF), 3-oxoadipyl-CoA thiolase (CBP06_23785), 3-oxoadipyl-CoA thiolase (B8W72_30115), 3-oxoadipyl-CoA thiolase (pcaF), 3-oxoadipyl-CoA thiolase (BGP84_13110), 3-oxoadipyl-CoA thiolase (pcaF), 3-oxoadipyl-CoA thiolase (QV12_18715), 3-oxoadipyl-CoA thiolase (pcaF), 3-oxoadipyl-CoA thiolase (B7H19_18390), 3-oxoadipyl-CoA thiolase (pcaF), Beta-ketoadipyl-CoA thiolase (pcaF), 3-oxoadipyl-CoA thiolase (paaE), 3-oxoadipyl-CoA thiolase (pcaF), 3-oxoadipyl-CoA thiolase (AYO28_21685), 3-oxoadipyl-CoA thiolase (A3K88_05345)
This subpathway is part of the pathway beta-ketoadipate pathway, which is itself part of Aromatic compound metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes acetyl-CoA and succinyl-CoA from 3-oxoadipate, the pathway beta-ketoadipate pathway and in Aromatic compound metabolism.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei90Acyl-thioester intermediateBy similarity1
Active sitei356Proton acceptorPROSITE-ProRule annotation1
Active sitei386Proton acceptorPROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAcyltransferase, Transferase
Biological processAromatic hydrocarbons catabolism

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...BioCyci		MetaCyc:MONOMER-3207

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...UniPathwayi		UPA00157;UER00263

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Beta-ketoadipyl-CoA thiolase (EC:2.3.1.174)
Alternative name(s):
3-oxoadipyl-CoA thiolase
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:pcaF
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPseudomonas putida (Arthrobacter siderocapsulatus)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri303 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteria › Proteobacteria › Gammaproteobacteria › Pseudomonadales › Pseudomonadaceae › Pseudomonas ›

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002064221 – 400Beta-ketoadipyl-CoA thiolaseAdd BLAST400

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		1240350.AMZE01000001_gene2841

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q51956

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi192 – 198Poly-Ala7

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the thiolase-like superfamily. Thiolase family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		COG0183, Bacteria

Family and domain databases

Conserved Domains Database

More...CDDi		cd00751, thiolase, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		3.40.47.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR012793, PcaF
IPR002155, Thiolase
IPR016039, Thiolase-like
IPR020615, Thiolase_acyl_enz_int_AS
IPR020610, Thiolase_AS
IPR020617, Thiolase_C
IPR020613, Thiolase_CS
IPR020616, Thiolase_N

Pfam protein domain database

More...Pfami		View protein in Pfam
PF02803, Thiolase_C, 1 hit
PF00108, Thiolase_N, 1 hit

PIRSF; a whole-protein classification database

More...PIRSFi		PIRSF000429, Ac-CoA_Ac_transf, 1 hit

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF53901, SSF53901, 2 hits

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR01930, AcCoA-C-Actrans, 1 hit
TIGR02430, pcaF, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00098, THIOLASE_1, 1 hit
PS00737, THIOLASE_2, 1 hit
PS00099, THIOLASE_3, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q51956-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRDVFICDAI RTPIGRFGGA LAGVRADDLA AVPLKALIEP NPAVQWDQVD 
        60         70         80         90        100
EVFFGCANQA GEDNRNVARM ALLLAGLPES IPGVTLNRLC ASGMDAIGTA 
       110        120        130        140        150
FRAIASGEME LAIAGGVESM SRAPFVMGKA ESGYSRNMKL EDTTIGWRFI 
       160        170        180        190        200
NPLMKSQYGV DSMPETADNV ADDYQVSRAD QDAFALRSQQ KAAAAQAAGF 
       210        220        230        240        250
FAEEIVPVRI AHKKGETIVE RDEHLRPETT LEALTKLKPV NGPDKTVTAG 
       260        270        280        290        300
NASGVNDGAA ALILASAEAV KKHGLTPRAR VLGMASGGVA PRVMGIGPVP 
       310        320        330        340        350
AVRKLTERLG VAVSDFDVIE LNEAFASQGL AVLRELGVAD DAPQVNPNGG 
       360        370        380        390        400
AIALGHPLGM SGARLVLTAL HQLEKSGGRK GLATMCVGVG QGLALAIERV
Length:400
Mass (Da):41,781
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i856336E2E48152B2
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
U10895 Genomic DNA Translation: AAA85138.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U10895 Genomic DNA Translation: AAA85138.1

3D structure databases

SMRiQ51956
ModBaseiSearch...

Protein-protein interaction databases

STRINGi1240350.AMZE01000001_gene2841

Phylogenomic databases

eggNOGiCOG0183, Bacteria

Enzyme and pathway databases

UniPathwayiUPA00157;UER00263
BioCyciMetaCyc:MONOMER-3207

Family and domain databases

CDDicd00751, thiolase, 1 hit
Gene3Di3.40.47.10, 2 hits
InterProiView protein in InterPro
IPR012793, PcaF
IPR002155, Thiolase
IPR016039, Thiolase-like
IPR020615, Thiolase_acyl_enz_int_AS
IPR020610, Thiolase_AS
IPR020617, Thiolase_C
IPR020613, Thiolase_CS
IPR020616, Thiolase_N
PfamiView protein in Pfam
PF02803, Thiolase_C, 1 hit
PF00108, Thiolase_N, 1 hit
PIRSFiPIRSF000429, Ac-CoA_Ac_transf, 1 hit
SUPFAMiSSF53901, SSF53901, 2 hits
TIGRFAMsiTIGR01930, AcCoA-C-Actrans, 1 hit
TIGR02430, pcaF, 1 hit
PROSITEiView protein in PROSITE
PS00098, THIOLASE_1, 1 hit
PS00737, THIOLASE_2, 1 hit
PS00099, THIOLASE_3, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPCAF_PSEPU
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q51956
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1999
Last sequence update: November 1, 1996
Last modified: August 12, 2020
This is version 88 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
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