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Protein

Phenazine biosynthesis protein PhzG

Gene

phzG

Organism
Pseudomonas fluorescens
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in the biosynthesis of the antibiotic phenazine, a nitrogen-containing heterocyclic molecule having important roles in virulence, competition and biological control. Probably catalyzes the final step in the conversion of trans-2,3-dihydro-3-hydroxyanthranilic acid (DHHA) to phenazine-1-carboxylic acid (PCA).

Cofactori

FMN1 PublicationNote: Binds 1 FMN per subunit.1 Publication

Pathwayi: phenazine biosynthesis

This protein is involved in the pathway phenazine biosynthesis, which is part of Antibiotic biosynthesis.
View all proteins of this organism that are known to be involved in the pathway phenazine biosynthesis and in Antibiotic biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei95FMN1 Publication1
Binding sitei117FMN1 Publication1
Binding sitei153FMN1 Publication1
Binding sitei205FMN1 Publication1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi73 – 76FMN1 Publication4
Nucleotide bindingi88 – 89FMN1 Publication2

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
Biological processAntibiotic biosynthesis, Virulence
LigandFlavoprotein, FMN

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-16114
UniPathwayi
UPA00099

Names & Taxonomyi

Protein namesi
Recommended name:
Phenazine biosynthesis protein PhzG (EC:1.4.-.-)
Gene namesi
Name:phzG
OrganismiPseudomonas fluorescens
Taxonomic identifieri294 [NCBI]
Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas

Pathology & Biotechi

Chemistry databases

DrugBankiDB03247 Riboflavin Monophosphate

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001677901 – 222Phenazine biosynthesis protein PhzGAdd BLAST222

Interactioni

Subunit structurei

Homodimer.1 Publication

Structurei

Secondary structure

1222
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

ProteinModelPortaliQ51793
SMRiQ51793
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ51793

Family & Domainsi

Sequence similaritiesi

Family and domain databases

Gene3Di2.30.110.10, 1 hit
InterProiView protein in InterPro
IPR000659 Pyridox_Oxase
IPR019740 Pyridox_Oxase_CS
IPR011576 Pyridox_Oxase_put
IPR019576 Pyridoxamine_oxidase_dimer_C
IPR012349 Split_barrel_FMN-bd
PANTHERiPTHR10851 PTHR10851, 1 hit
PfamiView protein in Pfam
PF10590 PNP_phzG_C, 1 hit
PF01243 Putative_PNPOx, 1 hit
PIRSFiPIRSF000190 Pyd_amn-ph_oxd, 1 hit
PROSITEiView protein in PROSITE
PS01064 PYRIDOX_OXIDASE, 1 hit

Sequencei

Sequence statusi: Complete.

Q51793-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MNGSIQGKPL LGKGMSESLT GTLDAPFPEY QTLPADPMSV LHNWLERARR
60 70 80 90 100
VGIREPRALA LATADSQGRP STRIVVISEI SDAGVVFSTH AGSQKGRELL
110 120 130 140 150
HNPWASGVLY WRETSQQIIL NGQAVRLPNA KADDAWLKRP YATHPMSSVS
160 170 180 190 200
RQSEELQDVQ AMRNAARQLA ELQGPLPRPE GYCVFELRLE SLEFWGNGQE
210 220
RLHERLRYDR SDTGWNVRRL QP
Length:222
Mass (Da):24,935
Last modified:November 1, 1997 - v1
Checksum:i732F3DB6AB029AD4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L48616 Genomic DNA Translation: AAC18906.1
RefSeqiWP_043050176.1, NZ_JXCQ01000041.1

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
L48616 Genomic DNA Translation: AAC18906.1
RefSeqiWP_043050176.1, NZ_JXCQ01000041.1

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1TY9X-ray1.80A/B1-222[»]
4HMSX-ray1.33A/B1-222[»]
4HMTX-ray1.42A/B1-222[»]
4HMUX-ray1.56A/B1-222[»]
4HMVX-ray1.45A/B1-222[»]
ProteinModelPortaliQ51793
SMRiQ51793
ModBaseiSearch...
MobiDBiSearch...

Chemistry databases

DrugBankiDB03247 Riboflavin Monophosphate

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Enzyme and pathway databases

UniPathwayi
UPA00099

BioCyciMetaCyc:MONOMER-16114

Miscellaneous databases

EvolutionaryTraceiQ51793

Family and domain databases

Gene3Di2.30.110.10, 1 hit
InterProiView protein in InterPro
IPR000659 Pyridox_Oxase
IPR019740 Pyridox_Oxase_CS
IPR011576 Pyridox_Oxase_put
IPR019576 Pyridoxamine_oxidase_dimer_C
IPR012349 Split_barrel_FMN-bd
PANTHERiPTHR10851 PTHR10851, 1 hit
PfamiView protein in Pfam
PF10590 PNP_phzG_C, 1 hit
PF01243 Putative_PNPOx, 1 hit
PIRSFiPIRSF000190 Pyd_amn-ph_oxd, 1 hit
PROSITEiView protein in PROSITE
PS01064 PYRIDOX_OXIDASE, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiPHZG_PSEFL
AccessioniPrimary (citable) accession number: Q51793
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: October 10, 2018
This is version 86 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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Main funding by: National Institutes of Health

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