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Entry version 122 (12 Aug 2020)
Sequence version 1 (01 Nov 1996)
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Protein

Tungsten-containing aldehyde ferredoxin oxidoreductase

Gene

aor

Organism
Pyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the oxidation of aldehydes to their corresponding carboxylic acids. May have a pyroglycolytic (saccharolytic) role.

Miscellaneous

A significant amount of formaldehyde ferredoxin oxidoreductase activity has been observed.

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Protein has several cofactor binding sites:

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Inhibited by arsenite, iodoacetate and cyanide.

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

Significant activity only with aliphatic and aromatic aldehydes and only at low concentration (0.5 mM).
  1. KM=0.72 mM for formaldehyde1 Publication
  1. Vmax=295 µmol/min/mg enzyme with formaldehyde as substrate1 Publication

pH dependencei

Optimum pH is above 10.1 Publication

Temperature dependencei

Optimum temperature is above 90 degrees Celsius.1 Publication

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi288Iron-sulfur (4Fe-4S)1
Metal bindingi291Iron-sulfur (4Fe-4S)1
Metal bindingi295Iron-sulfur (4Fe-4S)1
Metal bindingi494Iron-sulfur (4Fe-4S)1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionOxidoreductase
Ligand4Fe-4S, Iron, Iron-sulfur, Metal-binding, Tungsten

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
PFUR186497:G1FZR-361-MONOMER

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
1.2.7.5, 5243

SABIO-RK: Biochemical Reaction Kinetics Database

More...
SABIO-RKi
Q51739

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Tungsten-containing aldehyde ferredoxin oxidoreductase (EC:1.2.7.5)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:aor
Ordered Locus Names:PF0346
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPyrococcus furiosus (strain ATCC 43587 / DSM 3638 / JCM 8422 / Vc1)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri186497 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiArchaeaEuryarchaeotaThermococciThermococcalesThermococcaceaePyrococcus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000001013 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000646061 – 605Tungsten-containing aldehyde ferredoxin oxidoreductaseAdd BLAST605

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q51739

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Homodimer.

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
186497.PF0346

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1605
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q51739

Database of comparative protein structure models

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ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

Miscellaneous databases

Relative evolutionary importance of amino acids within a protein sequence

More...
EvolutionaryTracei
Q51739

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the AOR/FOR family.Curated

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
arCOG00706, Archaea

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_020364_1_0_2

KEGG Orthology (KO)

More...
KOi
K03738

Identification of Orthologs from Complete Genome Data

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OMAi
AMAMEMT

Database of Orthologous Groups

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OrthoDBi
9593at2157

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.569.10, 1 hit
1.10.599.10, 1 hit
3.60.9.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013984, Ald_Fedxn_OxRdtase_dom2
IPR013985, Ald_Fedxn_OxRdtase_dom3
IPR013983, Ald_Fedxn_OxRdtase_N
IPR036503, Ald_Fedxn_OxRdtase_N_sf
IPR001203, OxRdtase_Ald_Fedxn_C
IPR036021, Tungsten_al_ferr_oxy-like_C

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01314, AFOR_C, 1 hit
PF02730, AFOR_N, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00790, AFOR_N, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF48310, SSF48310, 1 hit
SSF56228, SSF56228, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q51739-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MYGNWGRFIR VNLSTGDIKV EEYDEELAKK WLGSRGLAIY LLLKEMDPTV
60 70 80 90 100
DPLSPENKLI IAAGPLTGTS APTGGRYNVV TKSPLTGFIT MANSGGYFGA
110 120 130 140 150
ELKFAGYDAI VVEGKAEKPV YIYIKDEHIE IRDASHIWGK KVSETEATIR
160 170 180 190 200
KEVGSEKVKI ASIGPAGENL VKFAAIMNDG HRAAGRGGVG AVMGSKNLKA
210 220 230 240 250
IAVEGSKTVP IADKQKFMLV VREKVNKLRN DPVAGGGLPK YGTAVLVNII
260 270 280 290 300
NENGLYPVKN FQTGVYPYAY EQSGEAMAAK YLVRNKPCYA CPIGCGRVNR
310 320 330 340 350
LPTVGETEGP EYESVWALGA NLGINDLASI IEANHMCDEL GLDTISTGGT
360 370 380 390 400
LATAMELYEK GHIKDEELGD APPFRWGNTE VLHYYIEKIA KREGFGDKLA
410 420 430 440 450
EGSYRLAESY GHPELSMTVK KLELPAYDPR GAEGHGLGYA TNNRGGCHIK
460 470 480 490 500
NYMISPEILG YPYKMDPHDV SDDKIKMLIL FQDLTALIDS AGLCLFTTFG
510 520 530 540 550
LGADDYRDLL NAALGWDFTT EDYLKIGERI WNAERLFNLK AGLDPARDDT
560 570 580 590 600
LPKRFLEEPM PEGPNKGHTV RLKEMLPRYY KLRGWTEDGK IPKEKLEELG

IAEFY
Length:605
Mass (Da):66,631
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i86254EDF6756C00D
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X79777 Genomic DNA Translation: CAA56170.1
AE009950 Genomic DNA Translation: AAL80470.1

NCBI Reference Sequences

More...
RefSeqi
WP_011011461.1, NZ_CP023154.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
AAL80470; AAL80470; PF0346

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
41712141

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
pfu:PF0346

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|186497.12.peg.360

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X79777 Genomic DNA Translation: CAA56170.1
AE009950 Genomic DNA Translation: AAL80470.1
RefSeqiWP_011011461.1, NZ_CP023154.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1AORX-ray2.30A/B1-605[»]
SMRiQ51739
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

STRINGi186497.PF0346

Proteomic databases

PRIDEiQ51739

Genome annotation databases

EnsemblBacteriaiAAL80470; AAL80470; PF0346
GeneIDi41712141
KEGGipfu:PF0346
PATRICifig|186497.12.peg.360

Phylogenomic databases

eggNOGiarCOG00706, Archaea
HOGENOMiCLU_020364_1_0_2
KOiK03738
OMAiAMAMEMT
OrthoDBi9593at2157

Enzyme and pathway databases

BioCyciPFUR186497:G1FZR-361-MONOMER
BRENDAi1.2.7.5, 5243
SABIO-RKiQ51739

Miscellaneous databases

EvolutionaryTraceiQ51739

Family and domain databases

Gene3Di1.10.569.10, 1 hit
1.10.599.10, 1 hit
3.60.9.10, 1 hit
InterProiView protein in InterPro
IPR013984, Ald_Fedxn_OxRdtase_dom2
IPR013985, Ald_Fedxn_OxRdtase_dom3
IPR013983, Ald_Fedxn_OxRdtase_N
IPR036503, Ald_Fedxn_OxRdtase_N_sf
IPR001203, OxRdtase_Ald_Fedxn_C
IPR036021, Tungsten_al_ferr_oxy-like_C
PfamiView protein in Pfam
PF01314, AFOR_C, 1 hit
PF02730, AFOR_N, 1 hit
SMARTiView protein in SMART
SM00790, AFOR_N, 1 hit
SUPFAMiSSF48310, SSF48310, 1 hit
SSF56228, SSF56228, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiAOR_PYRFU
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q51739
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: November 1, 1996
Last modified: August 12, 2020
This is version 122 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structure, Direct protein sequencing, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families
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