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Entry version 125 (31 Jul 2019)
Sequence version 1 (01 Nov 1996)
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Protein
Submitted name:

Catabolite repression control protein

Gene

crc

Organism
Pseudomonas aeruginosa
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolaseImported

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Catabolite repression control proteinImported
Submitted name:
ExodeoxyribonucleaseImported (EC:3.1.11.2Imported)
Submitted name:
Exodeoxyribonuclease IIIImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:crcImported
Synonyms:exoAImported, exoA_2Imported
ORF Names:ALP65_01013Imported, C0044_39460Imported, CAZ10_32350Imported, DT376_09125Imported, DZ934_17220Imported, DZ962_18070Imported, ECC04_031800Imported, EFK68_33360Imported, EGV95_32765Imported, EQH76_27390Imported, IPC3_28120Imported, IPC669_00200Imported, PAERUG_E15_London_28_01_14_10555Imported, PAMH19_3299Imported, RW109_RW109_06940Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiPseudomonas aeruginosaImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri287 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaGammaproteobacteriaPseudomonadalesPseudomonadaceaePseudomonas
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000043988 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Unassembled WGS sequence
  • UP000253594 Componenti: Unassembled WGS sequence
  • UP000278438 Componenti: Unassembled WGS sequence
  • UP000194857 Componenti: Unassembled WGS sequence
  • UP000258262 Componenti: Unassembled WGS sequence
  • UP000283839 Componenti: Unassembled WGS sequence
  • UP000285404 Componenti: Unassembled WGS sequence
  • UP000269133 Componenti: Chromosome
  • UP000233777 Componenti: Chromosome mainomosome
  • UP000261121 Componenti: Unassembled WGS sequence
  • UP000287066 Componenti: Unassembled WGS sequence
  • UP000247072 Componenti: Unassembled WGS sequence

Organism-specific databases

Pseudomonas genome database

More...
PseudoCAPi
PA5332

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
287.DR97_2703

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Database of comparative protein structure models

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ModBasei
Search...

SWISS-MODEL Interactive Workspace

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SWISS-MODEL-Workspacei
Submit a new modelling project...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini5 – 233Endo/exonuclease/phosphataseInterPro annotationAdd BLAST229

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG4105CGK Bacteria
COG0708 LUCA

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000034586

KEGG Orthology (KO)

More...
KOi
K01142

Database of Orthologous Groups

More...
OrthoDBi
1893707at2

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.60.10.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR004808 AP_endonuc_1
IPR036691 Endo/exonu/phosph_ase_sf
IPR005135 Endo/exonuclease/phosphatase

The PANTHER Classification System

More...
PANTHERi
PTHR22748 PTHR22748, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03372 Exo_endo_phos, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF56219 SSF56219, 1 hit

TIGRFAMs; a protein family database

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TIGRFAMsi
TIGR00633 xth, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51435 AP_NUCLEASE_F1_4, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q51380-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRIISVNVNG IQAAAERGLL SWLQAQNADV ICLQDTRASA FDLDDPSFQL
60 70 80 90 100
DGYFLYACDA ELPEQGGVAL YSRLQPKAVI SGLGFETADR YGRYLQADFD
110 120 130 140 150
KVSIATLLLP SGQSGDESLN QKFKFMDDFT HYLSKQRRKR REYIYCGSLY
160 170 180 190 200
VAHQKMDVKN WRECQQMPGF LAPERAWLDE VFGNLGYADA LREVSREGDQ
210 220 230 240 250
FSWWPDSEQA EMLNLGWRFD YQVLTPGLRR FVRNAKLPRQ PRFSQHAPLI

VDYDWQLSI
Length:259
Mass (Da):29,845
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iF17989CC51EBCD10
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U38241 Genomic DNA Translation: AAC44428.1
CP033684 Genomic DNA Translation: AYW75988.1
CDAZ01000010 Genomic DNA Translation: CEI14943.1
CVWF01000850 Genomic DNA Translation: CRR74403.1
NFFZ01000026 Genomic DNA Translation: OTI55751.1
QHLU01003228 Genomic DNA Translation: PXB83472.1
QORE01000222 Genomic DNA Translation: RCI75149.1
QVCN01000029 Genomic DNA Translation: RFI51636.1
QVBL01000022 Genomic DNA Translation: RFJ70316.1
RBSQ01001239 Genomic DNA Translation: RMS46370.1
RJAF01000006 Genomic DNA Translation: RNF56866.1
NSVB01000001 Genomic DNA Translation: RPY79033.1
NTBB01000021 Genomic DNA Translation: RQJ36172.1
SBJW01000024 Genomic DNA Translation: RWY18963.1
LT969520 Genomic DNA Translation: SOV32786.1
RHMD02000002 Genomic DNA Translation: TGB23670.1

Protein sequence database of the Protein Information Resource

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PIRi
B82978

NCBI Reference Sequences

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RefSeqi
NP_254019.1, NC_002516.2
WP_003098313.1, NZ_UWWR01000001.1

Genome annotation databases

Ensembl bacterial and archaeal genome annotation project

More...
EnsemblBacteriai
CEI14943; CEI14943; PAMH19_3299
CRO79474; CRO79474; PAERUG_P32_London_17_VIM_2_10_11_03067
CRR74403; CRR74403; PAERUG_E15_London_28_01_14_10555
KSH11287; KSH11287; AO964_10135

Database of genes from NCBI RefSeq genomes

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GeneIDi
878037

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
pae:PA5332
paeb:NCGM1900_6175

Pathosystems Resource Integration Center (PATRIC)

More...
PATRICi
fig|287.1477.peg.5829

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U38241 Genomic DNA Translation: AAC44428.1
CP033684 Genomic DNA Translation: AYW75988.1
CDAZ01000010 Genomic DNA Translation: CEI14943.1
CVWF01000850 Genomic DNA Translation: CRR74403.1
NFFZ01000026 Genomic DNA Translation: OTI55751.1
QHLU01003228 Genomic DNA Translation: PXB83472.1
QORE01000222 Genomic DNA Translation: RCI75149.1
QVCN01000029 Genomic DNA Translation: RFI51636.1
QVBL01000022 Genomic DNA Translation: RFJ70316.1
RBSQ01001239 Genomic DNA Translation: RMS46370.1
RJAF01000006 Genomic DNA Translation: RNF56866.1
NSVB01000001 Genomic DNA Translation: RPY79033.1
NTBB01000021 Genomic DNA Translation: RQJ36172.1
SBJW01000024 Genomic DNA Translation: RWY18963.1
LT969520 Genomic DNA Translation: SOV32786.1
RHMD02000002 Genomic DNA Translation: TGB23670.1
PIRiB82978
RefSeqiNP_254019.1, NC_002516.2
WP_003098313.1, NZ_UWWR01000001.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4F1RX-ray2.20A1-259[»]
4JG3X-ray1.80A1-259[»]
6O1Kelectron microscopy3.13A/B1-259[»]
6O1Lelectron microscopy3.37A/B/R1-259[»]
6O1Melectron microscopy3.15A/B/R/S1-259[»]
ModBaseiSearch...
SWISS-MODEL-WorkspaceiSubmit a new modelling project...

Protein-protein interaction databases

STRINGi287.DR97_2703

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCEI14943; CEI14943; PAMH19_3299
CRO79474; CRO79474; PAERUG_P32_London_17_VIM_2_10_11_03067
CRR74403; CRR74403; PAERUG_E15_London_28_01_14_10555
KSH11287; KSH11287; AO964_10135
GeneIDi878037
KEGGipae:PA5332
paeb:NCGM1900_6175
PATRICifig|287.1477.peg.5829

Organism-specific databases

PseudoCAPiPA5332

Phylogenomic databases

eggNOGiENOG4105CGK Bacteria
COG0708 LUCA
HOGENOMiHOG000034586
KOiK01142
OrthoDBi1893707at2

Family and domain databases

Gene3Di3.60.10.10, 1 hit
InterProiView protein in InterPro
IPR004808 AP_endonuc_1
IPR036691 Endo/exonu/phosph_ase_sf
IPR005135 Endo/exonuclease/phosphatase
PANTHERiPTHR22748 PTHR22748, 1 hit
PfamiView protein in Pfam
PF03372 Exo_endo_phos, 1 hit
SUPFAMiSSF56219 SSF56219, 1 hit
TIGRFAMsiTIGR00633 xth, 1 hit
PROSITEiView protein in PROSITE
PS51435 AP_NUCLEASE_F1_4, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ51380_PSEAI
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q51380
Secondary accession number(s): Q7DC41
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: July 31, 2019
This is version 125 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteomeImported
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