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Entry version 95 (07 Oct 2020)
Sequence version 1 (01 Nov 1996)
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Protein
Submitted name:

IgA1 protease

Gene

iga

Organism
Neisseria meningitidis
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionHydrolase, Protease, Serine proteaseARBA annotation

Enzyme and pathway databases

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
3.4.21.72, 3593

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
IgA1 proteaseImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:igaImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiNeisseria meningitidisImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri487 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaProteobacteriaBetaproteobacteriaNeisserialesNeisseriaceaeNeisseria

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

PeriplasmARBA annotation

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section denotes the presence of an N-terminal signal peptide.<p><a href='/help/signal' target='_top'>More...</a></p>Signal peptidei1 – 27Sequence analysisAdd BLAST27
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_500424793328 – 1561Sequence analysisAdd BLAST1534

Keywords - PTMi

ZymogenARBA annotation

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini28 – 322Peptidase S6InterPro annotationAdd BLAST295
Domaini1309 – 1561AutotransporterInterPro annotationAdd BLAST253

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni975 – 1239DisorderedSequence analysisAdd BLAST265

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi985 – 1005PolarSequence analysisAdd BLAST21
Compositional biasi1025 – 1182PolyampholyteSequence analysisAdd BLAST158
Compositional biasi1210 – 1224AcidicSequence analysisAdd BLAST15
Compositional biasi1225 – 1239PolyampholyteSequence analysisAdd BLAST15

Keywords - Domaini

SignalSequence analysis

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.160.20.20, 1 hit
2.40.128.130, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR005546, Autotransporte_beta
IPR036709, Autotransporte_beta_dom_sf
IPR012332, P22_tailspike-like_C_sf
IPR011050, Pectin_lyase_fold/virulence
IPR000710, Peptidase_S6
IPR030396, Peptidase_S6_dom
IPR004899, Pertactin_central

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03797, Autotransporter, 1 hit
PF02395, Peptidase_S6, 1 hit
PF03212, Pertactin, 1 hit

Protein Motif fingerprint database; a protein domain database

More...
PRINTSi
PR00921, IGASERPTASE

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00869, Autotransporter, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF103515, SSF103515, 1 hit
SSF51126, SSF51126, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51208, AUTOTRANSPORTER, 1 hit
PS51691, PEPTIDASE_S6, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q51169-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MKTKRFKINA ISLSIFLAYA LTPYSEAALV RDDVDYQIFR DFAENKGKFF
60 70 80 90 100
VGATDLSVKN KQGQNIGNAL SNVPMIDFSV ADVNKRIATV VDPQYAVSVK
110 120 130 140 150
HAKAEVHTFY YGQYNGHNDV ADKENEYRVV EQNNYEPHKA WSASNLGRLE
160 170 180 190 200
DYNMARFNKF VTEVAPIAPT DAGGGLDTYK DKNRFSSFVR VGAGRQLVYE
210 220 230 240 250
KGAYHQEGNE KGYDLRDLSQ AYRYAIAGTP YKDINIDQTM NTEGLIGFGN
260 270 280 290 300
HNTHYSAEEL KQALSQDALT NYGVLGDSGS PLFAFDKQKN QWVFLGTYDY
310 320 330 340 350
WAGYGKKSWQ EWNIYKKEFA DKIKQRDNAG TIKGYGEHHW KTTGTNSHIG
360 370 380 390 400
STAVRLANNE RDANNGQNVT FENNGTLVLD QNINQGAGGL FFKGDYTVKG
410 420 430 440 450
ANNDITWLGA GIDVADGKKV VWQVKNPNGD RLAKIGKGTL EINGTGVNQG
460 470 480 490 500
ELKVGDGTVI LNQKADSNQK VSAFSQVGIV SGRGTLVLNS SNQINPDNLY
510 520 530 540 550
FGFRGGRLDA NGNDLTFEHI RNVDEGARIV NHNTSHASTI TLTGKSLITN
560 570 580 590 600
PNSLSVHSIQ NDYDEDDYSY YYRPRRPIPQ GKDLYYKNYR YYALKSGGSV
610 620 630 640 650
NAPMPENGQT ENNDWILMGS TQEEAKKNAM NHKNNQRISG FSGFFGEENG
660 670 680 690 700
KGHNGALNLN FNGKSAQNRF LLTGGTNLNG KISVTQGNVL LSGRPTPHAR
710 720 730 740 750
DFVNKSSARK DARFSKNNEV VFEDDWINRT FKAAEIAVNQ SASFSSGRNV
760 770 780 790 800
SNITANITAT DNAKVNLGYK NGDEVCVRSD YTGYVTCNTD NLSDKALNSF
810 820 830 840 850
DATQINGNVN LNQNAALVLG KAALWGQIQG QGNSSVSLNQ HSKWHLTSDS
860 870 880 890 900
QVHNLSLADS HIHLNNASDA QSANKYHTLK INHLSGNGHF HYLTHLAKNL
910 920 930 940 950
GDKVLVKESA SGHYQLHVQD KTGEPNQEGL NLFDASSVQD RSRLSVSLAN
960 970 980 990 1000
NHVDLGALRY TIKTENGITR LYNPYAENRR RVKPAPSPAT NTASQAQTDS
1010 1020 1030 1040 1050
AQIAKPQNIV VAPPSPQANQ AEEAKRQQAK AEQVKRQQAE AEKVAHQKAE
1060 1070 1080 1090 1100
EAKRQQDALA RQQAEQERQR LEAERQAAEI AKQKAEAEEA KRRAAEIAEQ
1110 1120 1130 1140 1150
KAAAEEAKRQ AAELARQQEE ARKAAELAAK QKAETERKAA EIAEQKAEAE
1160 1170 1180 1190 1200
REAAELAKQK AEEEGRQAAQ SQPKRRNRRA IPPELSSDAT TRALPRIARN
1210 1220 1230 1240 1250
SNPDASDYEE IPLDALEDED VSESVDTSDK QPQDNTELHE KVETVSLQPR
1260 1270 1280 1290 1300
AAQPRAQAAA QPQAQAVAQA DAVSTNTNSA LSDAMASTQS ILLDTGASLT
1310 1320 1330 1340 1350
RHIAQKSRAD AEKNSVWMSN IGYGRDYASA QYRRFSSKRT QTQIGIDRSL
1360 1370 1380 1390 1400
SENMQIGGVL TYSDSQHTFD QASGKNTFVQ ANLYGKYYLN DAWYVAGDIG
1410 1420 1430 1440 1450
AGSLRSRLQT QQKANFNRTS IQTGLTLGNT LKINQFEIVP SAGIRYSRLS
1460 1470 1480 1490 1500
SADYKLGNDS VKVSSMSVKT LTAGLDFAYR FKVGNLTVKP LLSAAYFANY
1510 1520 1530 1540 1550
GKGGVNVGGN SFAYKADNQQ QYSAGAALLY RNVTLNVNGS ITKGKQLEKQ
1560
KSGQIKIQIR F
Length:1,561
Mass (Da):171,849
Last modified:November 1, 1996 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i1C96E291A00017D5
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
X82474 Genomic DNA Translation: CAA57857.1

Protein sequence database of the Protein Information Resource

More...
PIRi
S61314

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X82474 Genomic DNA Translation: CAA57857.1
PIRiS61314

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Enzyme and pathway databases

BRENDAi3.4.21.72, 3593

Family and domain databases

Gene3Di2.160.20.20, 1 hit
2.40.128.130, 1 hit
InterProiView protein in InterPro
IPR005546, Autotransporte_beta
IPR036709, Autotransporte_beta_dom_sf
IPR012332, P22_tailspike-like_C_sf
IPR011050, Pectin_lyase_fold/virulence
IPR000710, Peptidase_S6
IPR030396, Peptidase_S6_dom
IPR004899, Pertactin_central
PfamiView protein in Pfam
PF03797, Autotransporter, 1 hit
PF02395, Peptidase_S6, 1 hit
PF03212, Pertactin, 1 hit
PRINTSiPR00921, IGASERPTASE
SMARTiView protein in SMART
SM00869, Autotransporter, 1 hit
SUPFAMiSSF103515, SSF103515, 1 hit
SSF51126, SSF51126, 1 hit
PROSITEiView protein in PROSITE
PS51208, AUTOTRANSPORTER, 1 hit
PS51691, PEPTIDASE_S6, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ51169_NEIME
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q51169
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: November 1, 1996
Last sequence update: November 1, 1996
Last modified: October 7, 2020
This is version 95 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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