We will be switching to the new UniProt website soon. Please explore and share your feedback.
Take me to the new website.
UniProtKB - Q50LE5 (CAPSD_HPBVH)
Protein
Capsid protein precursor
Gene
Segment-1
Organism
Human picobirnavirus (strain Human/Thailand/Hy005102/-) (PBV)
Status
Functioni
The capsid protein self-assembles to form an icosahedral capsid with a T=2 symmetry made of 120 subunits.
1 PublicationMiscellaneous
Picobirnavirus particles are capable of disrupting biological membranes in vitro.
Protein family/group databases
MEROPSi | N05.001 |
Names & Taxonomyi
Protein namesi | Recommended name: Capsid protein precursorCleaved into the following 2 chains: |
Gene namesi | Name:Segment-1 ORF Names:ORF2 |
Organismi | Human picobirnavirus (strain Human/Thailand/Hy005102/-) (PBV) |
Taxonomic identifieri | 647332 [NCBI] |
Taxonomic lineagei | Viruses › Riboviria › Orthornavirae › Pisuviricota › Duplopiviricetes › Durnavirales › Picobirnaviridae › Picobirnavirus › |
Virus hosti | Homo sapiens (Human) [TaxID: 9606] |
Proteomesi |
|
Subcellular locationi
- Virion 1 Publication
- Virion 1 Publication
Keywords - Cellular componenti
Capsid protein, T=3 icosahedral capsid protein, VirionPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000379521 | 1 – 552 | Capsid protein precursorAdd BLAST | 552 | |
ChainiPRO_0000379522 | 1 – 65 | 7 kDa polypeptideAdd BLAST | 65 | |
ChainiPRO_0000379523 | 66 – 552 | Capsid proteinAdd BLAST | 487 |
Post-translational modificationi
The 7 kDa polypeptide is acetylated.1 Publication
Autocatalytic proteolysis releases a post-translationally modified peptide that remains associated with nucleic acid within the virion. This peptide is observed only when nucleic acid is packaged in the capsid.1 Publication
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sitei | 65 – 66 | Cleavage | 2 |
Keywords - PTMi
AcetylationProteomic databases
PRIDEi | Q50LE5 |
Interactioni
Subunit structurei
Homodimer.
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q50LE5 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 41 | DisorderedSequence analysisAdd BLAST | 41 |
i Sequence
Sequence statusi: Complete.
: The displayed sequence is further processed into a mature form. Sequence processingi
Q50LE5-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MKQNDTKKTT QRRNSKKYSS KTNRGTKRAP RDQEVGTGAQ ESTRNDVAWY
60 70 80 90 100
ARYPHILEEA TRLPFAYPIG QYYDTGYSVA SATEWSKYVD TSLTIPGVMC
110 120 130 140 150
VNFTPTPGES YNKNSPINIA AQNVYTYVRH MNSGHANYEQ ADLMMYLLAM
160 170 180 190 200
DSLYIFHSYV RKILAISKLY TPVNKYFPRA LLVALGVDPE DVFANQAQWE
210 220 230 240 250
YFVNMVAYRA GAFAAPASMT YYERHAWMSN GLYVDQDVTR AQIYMFKPTM
260 270 280 290 300
LWKYENLGTT GTKLVPLMMP KAGDNRKLVD FQVLFNNLVS TMLGDEDFGI
310 320 330 340 350
MSGDVFKAFG ADGLVKLLAV DSTTMTLPTY DPLILAQIHS ARAVGAPILE
360 370 380 390 400
TSTLTGFPGR QWQITQNPDV NNGAIIFHPS FGYDGQDHEE LSFRAMCSNM
410 420 430 440 450
ILNLPGEAHS AEMIIEATRL ATMFQVKAVP AGDTSKPVLY LPNGFGTEVV
460 470 480 490 500
NDYTMISVDK ATPHDLTIHT FFNNILVPNA KENYVANLEL LNNIIQFDWA
510 520 530 540 550
PQLYLTYGIA QESFGPFAQL NDWTILTGET LARMHEVCVT SMFDVPQMGF
NK
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB186897 Genomic RNA Translation: BAD98235.1 |
RefSeqi | YP_239360.1, NC_007026.1 |
Genome annotation databases
GeneIDi | 5075907 |
KEGGi | vg:5075907 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB186897 Genomic RNA Translation: BAD98235.1 |
RefSeqi | YP_239360.1, NC_007026.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
6Z8D | electron microscopy | 2.63 | A/B | 1-552 | [»] | |
6Z8E | electron microscopy | 2.80 | A/B | 1-552 | [»] | |
6Z8F | electron microscopy | 2.80 | A/B | 41-552 | [»] | |
SMRi | Q50LE5 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Protein family/group databases
MEROPSi | N05.001 |
Proteomic databases
PRIDEi | Q50LE5 |
Genome annotation databases
GeneIDi | 5075907 |
KEGGi | vg:5075907 |
Family and domain databases
MobiDBi | Search... |
Entry informationi
Entry namei | CAPSD_HPBVH | |
Accessioni | Q50LE5Primary (citable) accession number: Q50LE5 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 7, 2009 |
Last sequence update: | June 7, 2005 | |
Last modified: | June 2, 2021 | |
This is version 33 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Viral Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references