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UniProtKB - Q50LE4 (RDRP_HPBVH)
Protein
Potential RNA-dependent RNA polymerase
Gene
Segment-2
Organism
Human picobirnavirus (strain Human/Thailand/Hy005102/-) (PBV)
Status
Functioni
RNA-directed RNA polymerase that is involved in both transcription and genome replication.
CuratedCatalytic activityi
- EC:2.7.7.48
GO - Molecular functioni
- nucleotide binding Source: UniProtKB-KW
- RNA binding Source: UniProtKB-KW
- RNA-directed 5'-3' RNA polymerase activity Source: UniProtKB-KW
GO - Biological processi
- transcription, DNA-templated Source: InterPro
Keywordsi
Molecular function | Nucleotidyltransferase, RNA-binding, RNA-directed RNA polymerase, Transferase |
Biological process | Viral RNA replication |
Ligand | Nucleotide-binding |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:Segment-2 ORF Names:ORF3 |
Organismi | Human picobirnavirus (strain Human/Thailand/Hy005102/-) (PBV) |
Taxonomic identifieri | 647332 [NCBI] |
Taxonomic lineagei | Viruses › Riboviria › Orthornavirae › Pisuviricota › Duplopiviricetes › Durnavirales › Picobirnaviridae › Picobirnavirus › |
Virus hosti | Homo sapiens (Human) [TaxID: 9606] |
Proteomesi |
|
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000379525 | 1 – 534 | Potential RNA-dependent RNA polymeraseAdd BLAST | 534 |
Proteomic databases
PRIDEi | Q50LE4 |
Structurei
Secondary structure
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details3D structure databases
SMRi | Q50LE4 |
ModBasei | Search... |
PDBe-KBi | Search... |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 255 – 373 | RdRp catalyticAdd BLAST | 119 |
Family and domain databases
InterProi | View protein in InterPro IPR043502, DNA/RNA_pol_sf IPR001205, RNA-dir_pol_C |
Pfami | View protein in Pfam PF00680, RdRP_1, 1 hit |
SUPFAMi | SSF56672, SSF56672, 1 hit |
i Sequence
Sequence statusi: Complete.
Q50LE4-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MQVAPNVWSK YFNIPNPGLR AYFSNVVSGQ PEVYRTPFYK GMSLESICDE
60 70 80 90 100
WYKKLVSIDT QWPTLMEFED DLRKKVGPMS VMLPLKERMS DIDSYYDSIS
110 120 130 140 150
KDQVPFDTKA ISAAKSEWKG VSRLRLRSEV NTVAVMKKST NSGSPYFSKR
160 170 180 190 200
KAVVSKTIPC DVYMDGRYCV MRQNGREWSG AAVLGWRGQE GGPKPTDVKQ
210 220 230 240 250
RVVWMFPFAV NIRELQVYQP LILTFQRLGL VPAWVSMEAV DRRITKMFDT
260 270 280 290 300
KGPRDVVVCT DFSKFDQHFN PTCQSVAKEL LADLLTGQEA VDWLERVFPI
310 320 330 340 350
KYAIPLAYNW GEIRYGIHGM GSGSGGTNAD ETLVHRVLQH EAAISHHTTL
360 370 380 390 400
NPNSQCLGDD GVLTYPGISA EDVMQSYSRH GLDMNLEKQY VSKQDCTYLR
410 420 430 440 450
RWHHTDYRVD GMCVGVYSTM RALGRLAMQE RYYDPDVWGE KMVTLRYLSI
460 470 480 490 500
IENVKYHPLK EEFLDFCIKG DKTRLGLGIP GFLDNIAGEA QKAIDMMPDF
510 520 530
LGYTKSLQYD GDLRRNAAAG IENWWVVQAL KSRR
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB186898 Genomic RNA Translation: BAD98236.1 |
RefSeqi | YP_239361.1, NC_007027.1 |
Genome annotation databases
GeneIDi | 5075908 |
KEGGi | vg:5075908 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AB186898 Genomic RNA Translation: BAD98236.1 |
RefSeqi | YP_239361.1, NC_007027.1 |
3D structure databases
Select the link destinations: PDBei RCSB PDBi PDBji Links Updated | PDB entry | Method | Resolution (Å) | Chain | Positions | PDBsum |
5I61 | X-ray | 2.40 | A/B | 2-534 | [»] | |
5I62 | X-ray | 2.00 | A | 2-534 | [»] | |
SMRi | Q50LE4 | |||||
ModBasei | Search... | |||||
PDBe-KBi | Search... |
Proteomic databases
PRIDEi | Q50LE4 |
Genome annotation databases
GeneIDi | 5075908 |
KEGGi | vg:5075908 |
Family and domain databases
InterProi | View protein in InterPro IPR043502, DNA/RNA_pol_sf IPR001205, RNA-dir_pol_C |
Pfami | View protein in Pfam PF00680, RdRP_1, 1 hit |
SUPFAMi | SSF56672, SSF56672, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | RDRP_HPBVH | |
Accessioni | Q50LE4Primary (citable) accession number: Q50LE4 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | July 7, 2009 |
Last sequence update: | June 7, 2005 | |
Last modified: | September 29, 2021 | |
This is version 47 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Viral Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
3D-structure, Reference proteomeDocuments
- PDB cross-references
Index of Protein Data Bank (PDB) cross-references