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Protein

Alcohol dehydrogenase

Gene

Adh

Organism
Drosophila ananassae (Fruit fly)
Status
Reviewed-Annotation score: -Protein inferred from homologyi

Functioni

Catalytic activityi

A primary alcohol + NAD+ = an aldehyde + NADH.PROSITE-ProRule annotationCurated
A secondary alcohol + NAD+ = a ketone + NADH.PROSITE-ProRule annotationCurated

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei140SubstrateBy similarity1
Active sitei153Proton acceptorPROSITE-ProRule annotationBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi12 – 41NADBy similarityAdd BLAST30

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionOxidoreductase
LigandNAD

Names & Taxonomyi

Protein namesi
Recommended name:
Alcohol dehydrogenaseBy similarity (EC:1.1.1.1)
Gene namesi
Name:AdhImported
ORF Names:GF14888
OrganismiDrosophila ananassae (Fruit fly)
Taxonomic identifieri7217 [NCBI]
Taxonomic lineageiEukaryotaMetazoaEcdysozoaArthropodaHexapodaInsectaPterygotaNeopteraHolometabolaDipteraBrachyceraMuscomorphaEphydroideaDrosophilidaeDrosophilaSophophora
Proteomesi
  • UP000007801 Componenti: Unassembled WGS sequence

Organism-specific databases

FlyBaseiFBgn0012113 Dana\Adh

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedBy similarity
ChainiPRO_00003527522 – 256Alcohol dehydrogenaseBy similarityAdd BLAST255

Expressioni

Gene expression databases

BgeeiFBgn0012113

Interactioni

Subunit structurei

Homodimer.Curated

Protein-protein interaction databases

STRINGi7217.FBpp0118080

Structurei

3D structure databases

ProteinModelPortaliQ50L96
SMRiQ50L96
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG4169 Eukaryota
COG1028 LUCA
InParanoidiQ50L96
KOiK00001
OMAiWSKHWDS
OrthoDBiEOG091G0OC9
PhylomeDBiQ50L96

Family and domain databases

InterProiView protein in InterPro
IPR002425 ADH_Drosophila-type
IPR002424 ADH_insect
IPR036291 NAD(P)-bd_dom_sf
IPR020904 Sc_DH/Rdtase_CS
IPR002347 SDR_fam
PfamiView protein in Pfam
PF00106 adh_short, 1 hit
PRINTSiPR01168 ALCDHDRGNASE
PR01167 INSADHFAMILY
PR00080 SDRFAMILY
SUPFAMiSSF51735 SSF51735, 1 hit
PROSITEiView protein in PROSITE
PS00061 ADH_SHORT, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q50L96-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MALSLTNKNV VFVAGLGGIG LDTTKELLKR DLKNLVILDR IDNPVVIAEL
60 70 80 90 100
KTINPKVTVT FIPYDVTVPI TETKKLLKTI FDKLKTVDIL INGAGILDDH
110 120 130 140 150
QIERTIAVNY TGLVNTTTAI LDFWDKRKGG PGGIICNIGS VTGFNAIYQV
160 170 180 190 200
PVYSGTKAAV VNFTSSLAKL APITGVTAYT VNPGITRTTL VHKFNSWLDV
210 220 230 240 250
EPQVAEKLLA HPTQSSQACG ENFVKAIELN QNGAIWKLDR GTLEAIQWSK

HWDSGI
Length:256
Mass (Da):27,854
Last modified:June 7, 2005 - v1
Checksum:iD9702C0DA79765E0
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB194426 Genomic DNA Translation: BAD98197.1
EU877943 Genomic DNA Translation: ACF95828.1
CH902620 Genomic DNA Translation: EDV30743.1
AF459754 Genomic DNA Translation: AAM28691.1
RefSeqiXP_001961522.1, XM_001961486.2

Genome annotation databases

EnsemblMetazoaiFBtr0119588; FBpp0118080; FBgn0012113
GeneIDi6492907
KEGGidan:Dana_GF14888

Similar proteinsi

Entry informationi

Entry nameiADH_DROAN
AccessioniPrimary (citable) accession number: Q50L96
Secondary accession number(s): Q8N0A0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 14, 2008
Last sequence update: June 7, 2005
Last modified: November 22, 2017
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programDrosophila annotation project

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Drosophila
    Drosophila: entries, gene names and cross-references to FlyBase
  2. SIMILARITY comments
    Index of protein domains and families

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