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Entry version 117 (07 Apr 2021)
Sequence version 3 (27 Jul 2011)
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Protein

Cytosolic phospholipase A2 delta

Gene

Pla2g4d

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Calcium-dependent phospholipase A2 that selectively hydrolyzes glycerophospholipids in the sn-2 position (PubMed:15866882). Compared to its human ortholog, may have no preference for the fatty acid found at the sn-2 position (PubMed:15866882).1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Ca2+PROSITE-ProRule annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section describes regulatory mechanisms for enzymes, transporters or microbial transcription factors, and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/activity_regulation' target='_top'>More...</a></p>Activity regulationi

Stimulated by cytosolic Ca2+.1 Publication

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

    1. Vmax=13.4 pmol/min/mg enzyme with 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphocholine as substrate (at 37 degrees Celsius)1 Publication
    2. Vmax=8.1 pmol/min/mg enzyme with 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphocholine as substrate (at 37 degrees Celsius)1 Publication
    3. Vmax=14.5 pmol/min/mg enzyme with 1-hexadecanoyl-2-(5Z,8Z,11Z,14Z-eicosatetraenoyl)-sn-glycero-3-phosphoethanolamine as substrate (at 37 degrees Celsius)1 Publication
    4. Vmax=19.9 pmol/min/mg enzyme with 1-hexadecanoyl-2-(9Z,12Z-octadecadienoyl)-sn-glycero-3-phosphoethanolamine as substrate (at 37 degrees Celsius)1 Publication
    5. Vmax=16.4 pmol/min/mg enzyme with 1-hexadecanoyl-sn-glycero-3-phosphocholine as substrate (at 37 degrees Celsius)1 Publication

    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: fatty acid metabolism

    This protein is involved in the pathway fatty acid metabolism, which is part of Lipid metabolism.1 Publication
    View all proteins of this organism that are known to be involved in the pathway fatty acid metabolism and in Lipid metabolism.

    Sites

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section indicates at which position the protein binds a given metal ion. The nature of the metal is indicated in the 'Description' field.<p><a href='/help/metal' target='_top'>More...</a></p>Metal bindingi47Calcium 1PROSITE-ProRule annotation1
    Metal bindingi47Calcium 2PROSITE-ProRule annotation1
    Metal bindingi53Calcium 1PROSITE-ProRule annotation1
    Metal bindingi103Calcium 1PROSITE-ProRule annotation1
    Metal bindingi103Calcium 2PROSITE-ProRule annotation1
    Metal bindingi105Calcium 1PROSITE-ProRule annotation1
    Metal bindingi105Calcium 2PROSITE-ProRule annotation1
    Metal bindingi111Calcium 2PROSITE-ProRule annotation1
    <p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei370NucleophileBy similarity1
    Active sitei654Proton acceptorBy similarity1

    <p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

    GO - Biological processi

    <p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

    Molecular functionHydrolase
    Biological processLipid degradation, Lipid metabolism
    LigandCalcium, Metal-binding

    Enzyme and pathway databases

    Reactome - a knowledgebase of biological pathways and processes

    More...
    Reactomei
    R-MMU-1482788, Acyl chain remodelling of PC
    R-MMU-1482801, Acyl chain remodelling of PS
    R-MMU-1482839, Acyl chain remodelling of PE
    R-MMU-1482922, Acyl chain remodelling of PI
    R-MMU-1482925, Acyl chain remodelling of PG
    R-MMU-1483115, Hydrolysis of LPC
    R-MMU-1483166, Synthesis of PA

    UniPathway: a resource for the exploration and annotation of metabolic pathways

    More...
    UniPathwayi
    UPA00199

    <p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
    Recommended name:
    Cytosolic phospholipase A2 deltaCurated (EC:3.1.1.41 Publication)
    Short name:
    cPLA2-delta1 Publication
    Alternative name(s):
    Phospholipase A2 group IVD
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
    Name:Pla2g4dImported
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
    <p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
    • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

    Organism-specific databases

    Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

    More...
    MGIi
    MGI:1925640, Pla2g4d

    <p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

    Keywords - Cellular componenti

    Cytoplasm, Membrane

    <p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002470241 – 825Cytosolic phospholipase A2 deltaAdd BLAST825

    Proteomic databases

    PaxDb, a database of protein abundance averages across all three domains of life

    More...
    PaxDbi
    Q50L43

    PRoteomics IDEntifications database

    More...
    PRIDEi
    Q50L43

    ProteomicsDB: a multi-organism proteome resource

    More...
    ProteomicsDBi
    294370

    PTM databases

    iPTMnet integrated resource for PTMs in systems biology context

    More...
    iPTMneti
    Q50L43

    Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

    More...
    PhosphoSitePlusi
    Q50L43

    <p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

    <p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

    Weakly or not expressed in most tissues. Detected in placenta of 17.5 dpc embryos.1 Publication

    Gene expression databases

    Bgee dataBase for Gene Expression Evolution

    More...
    Bgeei
    ENSMUSG00000070719, Expressed in oocyte and 47 other tissues

    Genevisible search portal to normalized and curated expression data from Genevestigator

    More...
    Genevisiblei
    Q50L43, MM

    <p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

    Protein-protein interaction databases

    STRING: functional protein association networks

    More...
    STRINGi
    10090.ENSMUSP00000092252

    Miscellaneous databases

    RNAct, Protein-RNA interaction predictions for model organisms.

    More...
    RNActi
    Q50L43, protein

    <p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

    3D structure databases

    SWISS-MODEL Repository - a database of annotated 3D protein structure models

    More...
    SMRi
    Q50L43

    Database of comparative protein structure models

    More...
    ModBasei
    Search...

    <p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini14 – 133C2PROSITE-ProRule annotationAdd BLAST120
    Domaini281 – 825PLA2cPROSITE-ProRule annotationAdd BLAST545

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni339 – 340Substrate bindingBy similarity2

    <p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

    The N-terminal C2 domain mediates the association with lipid membranes upon calcium binding. An additional second C2 domain may stand in between the C2 domain and the PLA2c domain.By similarity

    Phylogenomic databases

    evolutionary genealogy of genes: Non-supervised Orthologous Groups

    More...
    eggNOGi
    KOG1028, Eukaryota
    KOG1325, Eukaryota

    Ensembl GeneTree

    More...
    GeneTreei
    ENSGT01000000214525

    The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

    More...
    HOGENOMi
    CLU_011663_0_0_1

    InParanoid: Eukaryotic Ortholog Groups

    More...
    InParanoidi
    Q50L43

    Identification of Orthologs from Complete Genome Data

    More...
    OMAi
    NSSHPVW

    Database of Orthologous Groups

    More...
    OrthoDBi
    302848at2759

    TreeFam database of animal gene trees

    More...
    TreeFami
    TF325228

    Family and domain databases

    Conserved Domains Database

    More...
    CDDi
    cd04036, C2_cPLA2, 1 hit

    Gene3D Structural and Functional Annotation of Protein Families

    More...
    Gene3Di
    2.60.40.150, 1 hit

    Integrated resource of protein families, domains and functional sites

    More...
    InterProi
    View protein in InterPro
    IPR016035, Acyl_Trfase/lysoPLipase
    IPR041847, C2_cPLA2
    IPR000008, C2_dom
    IPR035892, C2_domain_sf
    IPR040723, cPLA2_C2
    IPR002642, LysoPLipase_cat_dom

    Pfam protein domain database

    More...
    Pfami
    View protein in Pfam
    PF00168, C2, 1 hit
    PF18695, cPLA2_C2, 1 hit
    PF01735, PLA2_B, 1 hit

    Simple Modular Architecture Research Tool; a protein domain database

    More...
    SMARTi
    View protein in SMART
    SM00239, C2, 1 hit
    SM00022, PLAc, 1 hit

    Superfamily database of structural and functional annotation

    More...
    SUPFAMi
    SSF52151, SSF52151, 1 hit

    PROSITE; a protein domain and family database

    More...
    PROSITEi
    View protein in PROSITE
    PS50004, C2, 1 hit
    PS51210, PLA2C, 1 hit

    <p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

    <p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

    Q50L43-1 [UniParc]FASTAAdd to basket
    « Hide
            10         20         30         40         50
    MWSGDRRVGM ESLSPERLHG HPYQEEASVF CRLTVKILEA RSLPRADLLS
    60 70 80 90 100
    QADPYVTVQL PTASGMKFKT QTVTNSSHPV WNETFSFLIQ SQVKNILELT
    110 120 130 140 150
    IYDEDVITKD DICFKVSYDV SEILPGQLLQ KTFSLNPQGP EELDVELLME
    160 170 180 190 200
    RTWDPPENLI TNNVLVAREL SHLDVSLDRA GNTAMAAGQD KLELELMLKG
    210 220 230 240 250
    SYEDTQTFFP DTAFTFSFHY MRGQDTELNG YLRGPRNSGW NSDTSVTPFN
    260 270 280 290 300
    VPLMSLAAGK EMTIDIPAMK APEGKLQLKT DCCPKELSVR LSYGLCPEEQ
    310 320 330 340 350
    AFLSRRKKVV AAALKQALQL DEDLNEDEVP VVGINAEGGG MRAMISLYGH
    360 370 380 390 400
    LLALQKLGLL DCVTYFSGIS GSTWTMAHLY RDPEWSQRDL EGPISHAREH
    410 420 430 440 450
    VAKTLLKEFL PEHLASYRQT LKLREEQGYT VTVADLWGLV LESKLHGQVT
    460 470 480 490 500
    DQKLSGQRAA LERGQNPLPL YLSLNVKENH LETLHFKEWV EFSPYEVGFL
    510 520 530 540 550
    KYGGFVPSEL FGSEFFMGRL MKRLPESQIC FLEGIWSNLF SVNLMDIWYD
    560 570 580 590 600
    ITYGKDSNNF PVDVRNSEKE FSGSAGTSSG VEAPWLESGT ALAQALKGFL
    610 620 630 640 650
    TGRPFHQRSA NFLHGLQLHR DYCNQRHFST WADCNLDDTP NQLTPQDPQL
    660 670 680 690 700
    CLIDAGCFMN SSCPSLFRPG RQVDLIISFN YNQSLPFKGL QQSEKYSRAR
    710 720 730 740 750
    GLPFPRVEPS PEDHSQPQEC YLFSDPTCPE APVVLHFPLV NDSFRDHSAP
    760 770 780 790 800
    GVRRSPDELK AGQVNLTGAA SPYFMYNMTY KNEDFDRLLQ LSDYNVQNNQ
    810 820
    GTILQALRTV LKRRASETRP LGVKT
    Length:825
    Mass (Da):93,042
    Last modified:July 27, 2011 - v3
    <p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i257668A34FFA841B
    GO

    Experimental Info

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    <p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti222R → G in BAE39570 (PubMed:16141072).Curated1
    Sequence conflicti222R → G in BAE26807 (PubMed:16141072).Curated1
    Sequence conflicti482E → G in BAE39570 (PubMed:16141072).Curated1
    Sequence conflicti482E → G in BAE26807 (PubMed:16141072).Curated1

    Sequence databases

    Select the link destinations:

    EMBL nucleotide sequence database

    More...
    EMBLi

    GenBank nucleotide sequence database

    More...
    GenBanki

    DNA Data Bank of Japan; a nucleotide sequence database

    More...
    DDBJi
    Links Updated
    AB195276 mRNA Translation: BAD98152.1
    AK167492 mRNA Translation: BAE39570.1
    AK145985 mRNA Translation: BAE26807.1
    AL844608 Genomic DNA No translation available.

    The Consensus CDS (CCDS) project

    More...
    CCDSi
    CCDS16617.1

    NCBI Reference Sequences

    More...
    RefSeqi
    NP_001019308.1, NM_001024137.1

    Genome annotation databases

    Ensembl eukaryotic genome annotation project

    More...
    Ensembli
    ENSMUST00000094665; ENSMUSP00000092252; ENSMUSG00000070719

    Database of genes from NCBI RefSeq genomes

    More...
    GeneIDi
    78390

    KEGG: Kyoto Encyclopedia of Genes and Genomes

    More...
    KEGGi
    mmu:78390

    UCSC genome browser

    More...
    UCSCi
    uc008lvh.1, mouse

    <p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

    <p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    AB195276 mRNA Translation: BAD98152.1
    AK167492 mRNA Translation: BAE39570.1
    AK145985 mRNA Translation: BAE26807.1
    AL844608 Genomic DNA No translation available.
    CCDSiCCDS16617.1
    RefSeqiNP_001019308.1, NM_001024137.1

    3D structure databases

    SMRiQ50L43
    ModBaseiSearch...

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000092252

    PTM databases

    iPTMnetiQ50L43
    PhosphoSitePlusiQ50L43

    Proteomic databases

    PaxDbiQ50L43
    PRIDEiQ50L43
    ProteomicsDBi294370

    Protocols and materials databases

    Antibodypedia a portal for validated antibodies

    More...
    Antibodypediai
    23488, 72 antibodies

    Genome annotation databases

    EnsembliENSMUST00000094665; ENSMUSP00000092252; ENSMUSG00000070719
    GeneIDi78390
    KEGGimmu:78390
    UCSCiuc008lvh.1, mouse

    Organism-specific databases

    Comparative Toxicogenomics Database

    More...
    CTDi
    283748
    MGIiMGI:1925640, Pla2g4d

    Phylogenomic databases

    eggNOGiKOG1028, Eukaryota
    KOG1325, Eukaryota
    GeneTreeiENSGT01000000214525
    HOGENOMiCLU_011663_0_0_1
    InParanoidiQ50L43
    OMAiNSSHPVW
    OrthoDBi302848at2759
    TreeFamiTF325228

    Enzyme and pathway databases

    UniPathwayiUPA00199
    ReactomeiR-MMU-1482788, Acyl chain remodelling of PC
    R-MMU-1482801, Acyl chain remodelling of PS
    R-MMU-1482839, Acyl chain remodelling of PE
    R-MMU-1482922, Acyl chain remodelling of PI
    R-MMU-1482925, Acyl chain remodelling of PG
    R-MMU-1483115, Hydrolysis of LPC
    R-MMU-1483166, Synthesis of PA

    Miscellaneous databases

    BioGRID ORCS database of CRISPR phenotype screens

    More...
    BioGRID-ORCSi
    78390, 1 hit in 52 CRISPR screens

    Protein Ontology

    More...
    PROi
    PR:Q50L43
    RNActiQ50L43, protein

    The Stanford Online Universal Resource for Clones and ESTs

    More...
    SOURCEi
    Search...

    Gene expression databases

    BgeeiENSMUSG00000070719, Expressed in oocyte and 47 other tissues
    GenevisibleiQ50L43, MM

    Family and domain databases

    CDDicd04036, C2_cPLA2, 1 hit
    Gene3Di2.60.40.150, 1 hit
    InterProiView protein in InterPro
    IPR016035, Acyl_Trfase/lysoPLipase
    IPR041847, C2_cPLA2
    IPR000008, C2_dom
    IPR035892, C2_domain_sf
    IPR040723, cPLA2_C2
    IPR002642, LysoPLipase_cat_dom
    PfamiView protein in Pfam
    PF00168, C2, 1 hit
    PF18695, cPLA2_C2, 1 hit
    PF01735, PLA2_B, 1 hit
    SMARTiView protein in SMART
    SM00239, C2, 1 hit
    SM00022, PLAc, 1 hit
    SUPFAMiSSF52151, SSF52151, 1 hit
    PROSITEiView protein in PROSITE
    PS50004, C2, 1 hit
    PS51210, PLA2C, 1 hit

    ProtoNet; Automatic hierarchical classification of proteins

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    ProtoNeti
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    MobiDB: a database of protein disorder and mobility annotations

    More...
    MobiDBi
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    <p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

    <p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPA24D_MOUSE
    <p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q50L43
    Secondary accession number(s): A2AQJ1, Q3TJC5
    <p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2006
    Last sequence update: July 27, 2011
    Last modified: April 7, 2021
    This is version 117 of the entry and version 3 of the sequence. See complete history.
    <p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    <p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

    Keywords - Technical termi

    Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PATHWAY comments
      Index of metabolic and biosynthesis pathways
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