Kctd8

Functionⁱ

Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating onset and promoting desensitization.1 Publication

GO - Biological processⁱ

protein homooligomerization Source: InterPro
regulation of G protein-coupled receptor signaling pathway
Source: MGI
Inferred from genetic interactionⁱ
- 20400944

View the complete GO annotation on QuickGO ...

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: BTB/POZ domain-containing protein KCTD8
Gene namesⁱ	Name:Kctd8
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 5

Organism-specific databases

MGIⁱ	MGI:2443804 Kctd8

Keywords - Cellular componentⁱ

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000251482	1 – 476	BTB/POZ domain-containing protein KCTD8Add BLAST		476

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	78	PhosphoserineCombined sources	1
Modified residueⁱ	80	Omega-N-methylarginineCombined sources	1
Modified residueⁱ	413	PhosphoserineCombined sources	1

Keywords - PTMⁱ

Methylation, Phosphoprotein

Proteomic databases

PaxDbⁱ	Q50H33
PeptideAtlas More...PeptideAtlasⁱ	Q50H33
PRIDEⁱ	Q50H33

PTM databases

iPTMnetⁱ	Q50H33
PhosphoSitePlusⁱ	Q50H33

Expressionⁱ

Gene expression databases

Bgeeⁱ	ENSMUSG00000037653 Expressed in 108 organ(s), highest expression level in habenula
Genevisibleⁱ	Q50H33 MM

Interactionⁱ

Subunit structureⁱ

Protein-protein interaction databases

CORUMⁱ	Q50H33
STRINGⁱ	10090.ENSMUSP00000055326

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q50H33
SMRⁱ	Q50H33
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	44 – 122	BTBAdd BLAST		79

Phylogenomic databases

eggNOGⁱ	KOG2723 Eukaryota ENOG410Z155 LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000119013
HOGENOMⁱ	HOG000041197
HOVERGENⁱ	HBG052218
InParanoidⁱ	Q50H33
KEGG Orthology (KO) More...KOⁱ	K21918
OMAⁱ	DHEERKH
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G0P3F
PhylomeDBⁱ	Q50H33
TreeFamⁱ	TF315332

Family and domain databases

InterProⁱ	View protein in InterPro IPR000210 BTB/POZ_dom IPR011333 SKP1/BTB/POZ_sf IPR003131 T1-type_BTB
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02214 BTB_2, 1 hit
SMARTⁱ	View protein in SMART SM00225 BTB, 1 hit
SUPFAMⁱ	SSF54695 SSF54695, 1 hit

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

Isoform 1 (identifier: Q50H33-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MALKDTGSGG STILPISEMV SASSSPGAPL AAAPGPCAPS PFPEVVELNV 
        60         70         80         90        100
GGQVYVTKHS TLLSVPDSTL ASMFSPSSPR GGARRRGDLP RDSRARFFID 
       110        120        130        140        150
RDGFLFRYVL DYLRDKQLAL PEHFPEKERL LREAEFFQLT DLVKLLSPKV 
       160        170        180        190        200
TKQNSLNDEC CQSDLEDNVS QGSSDALLLR GAAAGAPSGS GAHGVSGVVG 
       210        220        230        240        250
GGSAPDKRSG FLTLGYRGSY TTVRDNQADA KFRRVARIMV CGRIALAKEV 
       260        270        280        290        300
FGDTLNESRD PDRQPEKYTS RFYLKFTYLE QAFDRLSEAG FHMVACNSSG 
       310        320        330        340        350
TAAFVNQYRD DKIWSSYTEY IFFRPPQKIV SPKQEHEDRK RDKVTDKGSE 
       360        370        380        390        400
SGTSCNELST SSCDSHSEAS TPQDNPANTQ QAAAHQPNTL TLDRPSRKAP 
       410        420        430        440        450
VQWMPPPDKR RNSELFQSLI SKSRETNLSK KKVCEKLSVE EEMKKCIQDF 
       460        470 
KKIHIPDCFP ERKRQWQSEL LQKYGL

Length:476

Mass (Da):52,768

Last modified:June 7, 2005 - v1

Checksum:ⁱ26EC9C5A673A53DF

GO

Isoform 2 (identifier: Q50H33-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
325-346: PPQKIVSPKQEHEDRKRDKVTD → KETAQRNCFSHFIHHMRVDGKA
347-476: Missing.

« Hide

        10         20         30         40         50
MALKDTGSGG STILPISEMV SASSSPGAPL AAAPGPCAPS PFPEVVELNV 
        60         70         80         90        100
GGQVYVTKHS TLLSVPDSTL ASMFSPSSPR GGARRRGDLP RDSRARFFID 
       110        120        130        140        150
RDGFLFRYVL DYLRDKQLAL PEHFPEKERL LREAEFFQLT DLVKLLSPKV 
       160        170        180        190        200
TKQNSLNDEC CQSDLEDNVS QGSSDALLLR GAAAGAPSGS GAHGVSGVVG 
       210        220        230        240        250
GGSAPDKRSG FLTLGYRGSY TTVRDNQADA KFRRVARIMV CGRIALAKEV 
       260        270        280        290        300
FGDTLNESRD PDRQPEKYTS RFYLKFTYLE QAFDRLSEAG FHMVACNSSG 
       310        320        330        340 
TAAFVNQYRD DKIWSSYTEY IFFRKETAQR NCFSHFIHHM RVDGKA

Note: No experimental confirmation available.

Show »

Length:346

Mass (Da):37,981

Checksum:ⁱC6F5A0693E660312

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	45	V → I in BAC31296 (PubMed:16141072).Curated	1
Sequence conflictⁱ	82 – 83	GA → RAP in BAC31296 (PubMed:16141072).Curated	2
Sequence conflictⁱ	149	K → E in BAC38532 (PubMed:16141072).Curated	1
Sequence conflictⁱ	159	E → K in BAC30262 (PubMed:16141072).Curated	1
Sequence conflictⁱ	206	D → Y in BAC32368 (PubMed:16141072).Curated	1
Sequence conflictⁱ	359	S → Y in BAC32368 (PubMed:16141072).Curated	1
Sequence conflictⁱ	412	N → K in BAC31527 (PubMed:16141072).Curated	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_020761	325 – 346	PPQKI…DKVTD → KETAQRNCFSHFIHHMRVDG KA in isoform 2. 1 PublicationAdd BLAST		22
Alternative sequenceⁱVSP_020762	347 – 476	Missing in isoform 2. 1 PublicationAdd BLAST		130

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY615967 mRNA Translation: AAU25822.1 AK039167 mRNA Translation: BAC30262.2 AK042569 mRNA Translation: BAC31296.1 AK043351 mRNA Translation: BAC31527.1 AK045439 mRNA Translation: BAC32368.1 AK082563 mRNA Translation: BAC38532.1 BC116940 mRNA Translation: AAI16941.1 BC116942 mRNA Translation: AAI16943.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS19320.1 [Q50H33-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_780728.3, NM_175519.5 [Q50H33-1]
UniGeneⁱ	Mm.234821

Genome annotation databases

Ensemblⁱ	ENSMUST00000054095; ENSMUSP00000055326; ENSMUSG00000037653 [Q50H33-1] ENSMUST00000087231; ENSMUSP00000084484; ENSMUSG00000037653 [Q50H33-2]
GeneIDⁱ	243043
KEGGⁱ	mmu:243043
UCSC genome browser More...UCSCⁱ	uc008xqj.1 mouse [Q50H33-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q50H33	BTB/POZ domain-containing protein KCTD8		HUMAN		473	UniRef90_Q50H33
BTB/POZ domain-containing protein KCTD8		ERIEU		481
BTB/POZ domain-containing protein KCTD8		NEOSC		479
BTB/POZ domain-containing protein KCTD8		LEPWE		477
BTB/POZ domain-containing protein KCTD8		MESAU		477
+83

Protein	Similar proteins		Species	Score	Length	Source
Q50H33	BTB/POZ domain-containing protein KCTD8		HUMAN		473	UniRef50_Q50H33
BTB/POZ domain-containing protein KCTD8		ERIEU		481
BTB/POZ domain-containing protein KCTD8		NEOSC		479
BTB/POZ domain-containing protein KCTD8		MESAU		477
BTB/POZ domain-containing protein KCTD8		LEPWE		477
+119
Q50H33-2	BTB/POZ domain-containing protein KCTD16 (Fragment)		MERNU		256	UniRef50_Q50H33-2
Potassium channel tetramerization domain containing 16		HORSE		258
Uncharacterized protein		ANOCA		284
BTB/POZ domain-containing protein KCTD12-like		ALLSI		340
Btb poz domain-containing protein kctd12		Limosa lapponica baueri		296
+165

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	AY615967 mRNA Translation: AAU25822.1 AK039167 mRNA Translation: BAC30262.2 AK042569 mRNA Translation: BAC31296.1 AK043351 mRNA Translation: BAC31527.1 AK045439 mRNA Translation: BAC32368.1 AK082563 mRNA Translation: BAC38532.1 BC116940 mRNA Translation: AAI16941.1 BC116942 mRNA Translation: AAI16943.1
CCDSⁱ	CCDS19320.1 [Q50H33-1]
RefSeqⁱ	NP_780728.3, NM_175519.5 [Q50H33-1]
UniGeneⁱ	Mm.234821

3D structure databases

ProteinModelPortalⁱ	Q50H33
SMRⁱ	Q50H33
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

CORUMⁱ	Q50H33
STRINGⁱ	10090.ENSMUSP00000055326

PTM databases

iPTMnetⁱ	Q50H33
PhosphoSitePlusⁱ	Q50H33

Proteomic databases

PaxDbⁱ	Q50H33
PeptideAtlasⁱ	Q50H33
PRIDEⁱ	Q50H33

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000054095; ENSMUSP00000055326; ENSMUSG00000037653 [Q50H33-1] ENSMUST00000087231; ENSMUSP00000084484; ENSMUSG00000037653 [Q50H33-2]
GeneIDⁱ	243043
KEGGⁱ	mmu:243043
UCSCⁱ	uc008xqj.1 mouse [Q50H33-1]

Organism-specific databases

CTDⁱ	386617
MGIⁱ	MGI:2443804 Kctd8

Phylogenomic databases

eggNOGⁱ	KOG2723 Eukaryota ENOG410Z155 LUCA
GeneTreeⁱ	ENSGT00760000119013
HOGENOMⁱ	HOG000041197
HOVERGENⁱ	HBG052218
InParanoidⁱ	Q50H33
KOⁱ	K21918
OMAⁱ	DHEERKH
OrthoDBⁱ	EOG091G0P3F
PhylomeDBⁱ	Q50H33
TreeFamⁱ	TF315332

Miscellaneous databases

Protein Ontology More...PROⁱ	PR:Q50H33
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000037653 Expressed in 108 organ(s), highest expression level in habenula
Genevisibleⁱ	Q50H33 MM

Family and domain databases

InterProⁱ	View protein in InterPro IPR000210 BTB/POZ_dom IPR011333 SKP1/BTB/POZ_sf IPR003131 T1-type_BTB
Pfamⁱ	View protein in Pfam PF02214 BTB_2, 1 hit
SMARTⁱ	View protein in SMART SM00225 BTB, 1 hit
SUPFAMⁱ	SSF54695 SSF54695, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	KCTD8_MOUSE
Accessionⁱ	Q50H33Primary (citable) accession number: Q50H33 Secondary accession number(s): Q8BR74 , Q8C4C2, Q8C906, Q8C9B0, Q8CAA9
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	October 3, 2006
	Last sequence update:	June 7, 2005
	Last modified:	November 7, 2018
	This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

UniParc

Help

UniRef

Proteomes

Annotation systems

Supporting data

UniProtKB - Q50H33 (KCTD8_MOUSE)

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BTB/POZ domain-containing protein KCTD8

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Plasma membrane

Plasma Membrane

Other locations

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Phylogenomic databases

Family and domain databases

Experimental Info

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Documents

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Functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ