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Protein

BTB/POZ domain-containing protein KCTD8

Gene

Kctd8

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating onset and promoting desensitization.1 Publication

GO - Biological processi

  • protein homooligomerization Source: InterPro
  • regulation of G protein-coupled receptor signaling pathway Source: MGI

Names & Taxonomyi

Protein namesi
Recommended name:
BTB/POZ domain-containing protein KCTD8
Gene namesi
Name:Kctd8
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:2443804 Kctd8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Postsynaptic cell membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002514821 – 476BTB/POZ domain-containing protein KCTD8Add BLAST476

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei78PhosphoserineCombined sources1
Modified residuei80Omega-N-methylarginineCombined sources1
Modified residuei413PhosphoserineCombined sources1

Keywords - PTMi

Methylation, Phosphoprotein

Proteomic databases

PaxDbiQ50H33
PeptideAtlasiQ50H33
PRIDEiQ50H33

PTM databases

iPTMnetiQ50H33
PhosphoSitePlusiQ50H33

Expressioni

Gene expression databases

BgeeiENSMUSG00000037653 Expressed in 108 organ(s), highest expression level in habenula
GenevisibleiQ50H33 MM

Interactioni

Subunit structurei

Interacts as a tetramer with GABRB1 and GABRB2.1 Publication

Protein-protein interaction databases

CORUMiQ50H33
STRINGi10090.ENSMUSP00000055326

Structurei

3D structure databases

ProteinModelPortaliQ50H33
SMRiQ50H33
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini44 – 122BTBAdd BLAST79

Phylogenomic databases

eggNOGiKOG2723 Eukaryota
ENOG410Z155 LUCA
GeneTreeiENSGT00760000119013
HOGENOMiHOG000041197
HOVERGENiHBG052218
InParanoidiQ50H33
KOiK21918
OMAiDHEERKH
OrthoDBiEOG091G0P3F
PhylomeDBiQ50H33
TreeFamiTF315332

Family and domain databases

InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR011333 SKP1/BTB/POZ_sf
IPR003131 T1-type_BTB
PfamiView protein in Pfam
PF02214 BTB_2, 1 hit
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SUPFAMiSSF54695 SSF54695, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q50H33-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MALKDTGSGG STILPISEMV SASSSPGAPL AAAPGPCAPS PFPEVVELNV
60 70 80 90 100
GGQVYVTKHS TLLSVPDSTL ASMFSPSSPR GGARRRGDLP RDSRARFFID
110 120 130 140 150
RDGFLFRYVL DYLRDKQLAL PEHFPEKERL LREAEFFQLT DLVKLLSPKV
160 170 180 190 200
TKQNSLNDEC CQSDLEDNVS QGSSDALLLR GAAAGAPSGS GAHGVSGVVG
210 220 230 240 250
GGSAPDKRSG FLTLGYRGSY TTVRDNQADA KFRRVARIMV CGRIALAKEV
260 270 280 290 300
FGDTLNESRD PDRQPEKYTS RFYLKFTYLE QAFDRLSEAG FHMVACNSSG
310 320 330 340 350
TAAFVNQYRD DKIWSSYTEY IFFRPPQKIV SPKQEHEDRK RDKVTDKGSE
360 370 380 390 400
SGTSCNELST SSCDSHSEAS TPQDNPANTQ QAAAHQPNTL TLDRPSRKAP
410 420 430 440 450
VQWMPPPDKR RNSELFQSLI SKSRETNLSK KKVCEKLSVE EEMKKCIQDF
460 470
KKIHIPDCFP ERKRQWQSEL LQKYGL
Length:476
Mass (Da):52,768
Last modified:June 7, 2005 - v1
Checksum:i26EC9C5A673A53DF
GO
Isoform 2 (identifier: Q50H33-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     325-346: PPQKIVSPKQEHEDRKRDKVTD → KETAQRNCFSHFIHHMRVDGKA
     347-476: Missing.

Note: No experimental confirmation available.
Show »
Length:346
Mass (Da):37,981
Checksum:iC6F5A0693E660312
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti45V → I in BAC31296 (PubMed:16141072).Curated1
Sequence conflicti82 – 83GA → RAP in BAC31296 (PubMed:16141072).Curated2
Sequence conflicti149K → E in BAC38532 (PubMed:16141072).Curated1
Sequence conflicti159E → K in BAC30262 (PubMed:16141072).Curated1
Sequence conflicti206D → Y in BAC32368 (PubMed:16141072).Curated1
Sequence conflicti359S → Y in BAC32368 (PubMed:16141072).Curated1
Sequence conflicti412N → K in BAC31527 (PubMed:16141072).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_020761325 – 346PPQKI…DKVTD → KETAQRNCFSHFIHHMRVDG KA in isoform 2. 1 PublicationAdd BLAST22
Alternative sequenceiVSP_020762347 – 476Missing in isoform 2. 1 PublicationAdd BLAST130

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY615967 mRNA Translation: AAU25822.1
AK039167 mRNA Translation: BAC30262.2
AK042569 mRNA Translation: BAC31296.1
AK043351 mRNA Translation: BAC31527.1
AK045439 mRNA Translation: BAC32368.1
AK082563 mRNA Translation: BAC38532.1
BC116940 mRNA Translation: AAI16941.1
BC116942 mRNA Translation: AAI16943.1
CCDSiCCDS19320.1 [Q50H33-1]
RefSeqiNP_780728.3, NM_175519.5 [Q50H33-1]
UniGeneiMm.234821

Genome annotation databases

EnsembliENSMUST00000054095; ENSMUSP00000055326; ENSMUSG00000037653 [Q50H33-1]
ENSMUST00000087231; ENSMUSP00000084484; ENSMUSG00000037653 [Q50H33-2]
GeneIDi243043
KEGGimmu:243043
UCSCiuc008xqj.1 mouse [Q50H33-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY615967 mRNA Translation: AAU25822.1
AK039167 mRNA Translation: BAC30262.2
AK042569 mRNA Translation: BAC31296.1
AK043351 mRNA Translation: BAC31527.1
AK045439 mRNA Translation: BAC32368.1
AK082563 mRNA Translation: BAC38532.1
BC116940 mRNA Translation: AAI16941.1
BC116942 mRNA Translation: AAI16943.1
CCDSiCCDS19320.1 [Q50H33-1]
RefSeqiNP_780728.3, NM_175519.5 [Q50H33-1]
UniGeneiMm.234821

3D structure databases

ProteinModelPortaliQ50H33
SMRiQ50H33
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

CORUMiQ50H33
STRINGi10090.ENSMUSP00000055326

PTM databases

iPTMnetiQ50H33
PhosphoSitePlusiQ50H33

Proteomic databases

PaxDbiQ50H33
PeptideAtlasiQ50H33
PRIDEiQ50H33

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000054095; ENSMUSP00000055326; ENSMUSG00000037653 [Q50H33-1]
ENSMUST00000087231; ENSMUSP00000084484; ENSMUSG00000037653 [Q50H33-2]
GeneIDi243043
KEGGimmu:243043
UCSCiuc008xqj.1 mouse [Q50H33-1]

Organism-specific databases

CTDi386617
MGIiMGI:2443804 Kctd8

Phylogenomic databases

eggNOGiKOG2723 Eukaryota
ENOG410Z155 LUCA
GeneTreeiENSGT00760000119013
HOGENOMiHOG000041197
HOVERGENiHBG052218
InParanoidiQ50H33
KOiK21918
OMAiDHEERKH
OrthoDBiEOG091G0P3F
PhylomeDBiQ50H33
TreeFamiTF315332

Miscellaneous databases

PROiPR:Q50H33
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000037653 Expressed in 108 organ(s), highest expression level in habenula
GenevisibleiQ50H33 MM

Family and domain databases

InterProiView protein in InterPro
IPR000210 BTB/POZ_dom
IPR011333 SKP1/BTB/POZ_sf
IPR003131 T1-type_BTB
PfamiView protein in Pfam
PF02214 BTB_2, 1 hit
SMARTiView protein in SMART
SM00225 BTB, 1 hit
SUPFAMiSSF54695 SSF54695, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiKCTD8_MOUSE
AccessioniPrimary (citable) accession number: Q50H33
Secondary accession number(s): Q8BR74
, Q8C4C2, Q8C906, Q8C9B0, Q8CAA9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 3, 2006
Last sequence update: June 7, 2005
Last modified: November 7, 2018
This is version 84 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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