UniProtKB - Q50H33 (KCTD8_MOUSE)
Protein
BTB/POZ domain-containing protein KCTD8
Gene
Kctd8
Organism
Mus musculus (Mouse)
Status
Functioni
Auxiliary subunit of GABA-B receptors that determine the pharmacology and kinetics of the receptor response. Increases agonist potency and markedly alter the G-protein signaling of the receptors by accelerating onset and promoting desensitization.1 Publication
GO - Biological processi
- protein homooligomerization Source: InterPro
- regulation of G protein-coupled receptor signaling pathway Source: MGI
Names & Taxonomyi
Protein namesi | Recommended name: BTB/POZ domain-containing protein KCTD8 |
Gene namesi | Name:Kctd8 |
Organismi | Mus musculus (Mouse) |
Taxonomic identifieri | 10090 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus |
Proteomesi |
|
Organism-specific databases
MGIi | MGI:2443804, Kctd8 |
Subcellular locationi
Plasma membrane
- presynaptic cell membrane By similarity
- postsynaptic cell membrane By similarity
Plasma Membrane
- postsynaptic membrane Source: UniProtKB-SubCell
- presynaptic membrane Source: UniProtKB-SubCell
Other locations
- cell projection Source: UniProtKB-KW
- receptor complex Source: MGI
Keywords - Cellular componenti
Cell junction, Cell membrane, Cell projection, Membrane, Postsynaptic cell membrane, SynapsePTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000251482 | 1 – 476 | BTB/POZ domain-containing protein KCTD8Add BLAST | 476 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 78 | PhosphoserineCombined sources | 1 | |
Modified residuei | 80 | Omega-N-methylarginineCombined sources | 1 | |
Modified residuei | 413 | PhosphoserineCombined sources | 1 |
Keywords - PTMi
Methylation, PhosphoproteinProteomic databases
PaxDbi | Q50H33 |
PeptideAtlasi | Q50H33 |
PRIDEi | Q50H33 |
PTM databases
iPTMneti | Q50H33 |
PhosphoSitePlusi | Q50H33 |
Expressioni
Gene expression databases
Bgeei | ENSMUSG00000037653, Expressed in habenula and 132 other tissues |
Genevisiblei | Q50H33, MM |
Interactioni
Subunit structurei
Interacts as a tetramer with GABRB1 and GABRB2.
1 PublicationProtein-protein interaction databases
BioGRIDi | 232480, 2 interactors |
CORUMi | Q50H33 |
STRINGi | 10090.ENSMUSP00000055326 |
Miscellaneous databases
RNActi | Q50H33, protein |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 44 – 122 | BTBAdd BLAST | 79 |
Phylogenomic databases
eggNOGi | KOG2723, Eukaryota |
GeneTreei | ENSGT00940000161041 |
HOGENOMi | CLU_057051_1_0_1 |
InParanoidi | Q50H33 |
OMAi | FINQYRD |
OrthoDBi | 1579292at2759 |
PhylomeDBi | Q50H33 |
TreeFami | TF315332 |
Family and domain databases
InterProi | View protein in InterPro IPR000210, BTB/POZ_dom IPR011333, SKP1/BTB/POZ_sf IPR003131, T1-type_BTB |
Pfami | View protein in Pfam PF02214, BTB_2, 1 hit |
SMARTi | View protein in SMART SM00225, BTB, 1 hit |
SUPFAMi | SSF54695, SSF54695, 1 hit |
s (2)i Sequence
Sequence statusi: Complete.
This entry describes 2 produced by isoformsialternative splicing. AlignAdd to basketIsoform 1 (identifier: Q50H33-1) [UniParc]FASTAAdd to basket
This isoform has been chosen as the sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry. canonicali
10 20 30 40 50
MALKDTGSGG STILPISEMV SASSSPGAPL AAAPGPCAPS PFPEVVELNV
60 70 80 90 100
GGQVYVTKHS TLLSVPDSTL ASMFSPSSPR GGARRRGDLP RDSRARFFID
110 120 130 140 150
RDGFLFRYVL DYLRDKQLAL PEHFPEKERL LREAEFFQLT DLVKLLSPKV
160 170 180 190 200
TKQNSLNDEC CQSDLEDNVS QGSSDALLLR GAAAGAPSGS GAHGVSGVVG
210 220 230 240 250
GGSAPDKRSG FLTLGYRGSY TTVRDNQADA KFRRVARIMV CGRIALAKEV
260 270 280 290 300
FGDTLNESRD PDRQPEKYTS RFYLKFTYLE QAFDRLSEAG FHMVACNSSG
310 320 330 340 350
TAAFVNQYRD DKIWSSYTEY IFFRPPQKIV SPKQEHEDRK RDKVTDKGSE
360 370 380 390 400
SGTSCNELST SSCDSHSEAS TPQDNPANTQ QAAAHQPNTL TLDRPSRKAP
410 420 430 440 450
VQWMPPPDKR RNSELFQSLI SKSRETNLSK KKVCEKLSVE EEMKKCIQDF
460 470
KKIHIPDCFP ERKRQWQSEL LQKYGL
Experimental Info
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Sequence conflicti | 45 | V → I in BAC31296 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 82 – 83 | GA → RAP in BAC31296 (PubMed:16141072).Curated | 2 | |
Sequence conflicti | 149 | K → E in BAC38532 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 159 | E → K in BAC30262 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 206 | D → Y in BAC32368 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 359 | S → Y in BAC32368 (PubMed:16141072).Curated | 1 | |
Sequence conflicti | 412 | N → K in BAC31527 (PubMed:16141072).Curated | 1 |
Alternative sequence
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Alternative sequenceiVSP_020761 | 325 – 346 | PPQKI…DKVTD → KETAQRNCFSHFIHHMRVDG KA in isoform 2. 1 PublicationAdd BLAST | 22 | |
Alternative sequenceiVSP_020762 | 347 – 476 | Missing in isoform 2. 1 PublicationAdd BLAST | 130 |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY615967 mRNA Translation: AAU25822.1 AK039167 mRNA Translation: BAC30262.2 AK042569 mRNA Translation: BAC31296.1 AK043351 mRNA Translation: BAC31527.1 AK045439 mRNA Translation: BAC32368.1 AK082563 mRNA Translation: BAC38532.1 BC116940 mRNA Translation: AAI16941.1 BC116942 mRNA Translation: AAI16943.1 |
CCDSi | CCDS19320.1 [Q50H33-1] |
RefSeqi | NP_780728.3, NM_175519.5 [Q50H33-1] |
Genome annotation databases
Ensembli | ENSMUST00000054095; ENSMUSP00000055326; ENSMUSG00000037653 [Q50H33-1] ENSMUST00000087231; ENSMUSP00000084484; ENSMUSG00000037653 [Q50H33-2] |
GeneIDi | 243043 |
KEGGi | mmu:243043 |
UCSCi | uc008xqj.1, mouse [Q50H33-1] |
Keywords - Coding sequence diversityi
Alternative splicingSimilar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AY615967 mRNA Translation: AAU25822.1 AK039167 mRNA Translation: BAC30262.2 AK042569 mRNA Translation: BAC31296.1 AK043351 mRNA Translation: BAC31527.1 AK045439 mRNA Translation: BAC32368.1 AK082563 mRNA Translation: BAC38532.1 BC116940 mRNA Translation: AAI16941.1 BC116942 mRNA Translation: AAI16943.1 |
CCDSi | CCDS19320.1 [Q50H33-1] |
RefSeqi | NP_780728.3, NM_175519.5 [Q50H33-1] |
3D structure databases
SMRi | Q50H33 |
ModBasei | Search... |
Protein-protein interaction databases
BioGRIDi | 232480, 2 interactors |
CORUMi | Q50H33 |
STRINGi | 10090.ENSMUSP00000055326 |
PTM databases
iPTMneti | Q50H33 |
PhosphoSitePlusi | Q50H33 |
Proteomic databases
PaxDbi | Q50H33 |
PeptideAtlasi | Q50H33 |
PRIDEi | Q50H33 |
Protocols and materials databases
Antibodypediai | 23721, 82 antibodies |
Genome annotation databases
Ensembli | ENSMUST00000054095; ENSMUSP00000055326; ENSMUSG00000037653 [Q50H33-1] ENSMUST00000087231; ENSMUSP00000084484; ENSMUSG00000037653 [Q50H33-2] |
GeneIDi | 243043 |
KEGGi | mmu:243043 |
UCSCi | uc008xqj.1, mouse [Q50H33-1] |
Organism-specific databases
CTDi | 386617 |
MGIi | MGI:2443804, Kctd8 |
Phylogenomic databases
eggNOGi | KOG2723, Eukaryota |
GeneTreei | ENSGT00940000161041 |
HOGENOMi | CLU_057051_1_0_1 |
InParanoidi | Q50H33 |
OMAi | FINQYRD |
OrthoDBi | 1579292at2759 |
PhylomeDBi | Q50H33 |
TreeFami | TF315332 |
Miscellaneous databases
BioGRID-ORCSi | 243043, 0 hits in 17 CRISPR screens |
ChiTaRSi | Kctd8, mouse |
PROi | PR:Q50H33 |
RNActi | Q50H33, protein |
SOURCEi | Search... |
Gene expression databases
Bgeei | ENSMUSG00000037653, Expressed in habenula and 132 other tissues |
Genevisiblei | Q50H33, MM |
Family and domain databases
InterProi | View protein in InterPro IPR000210, BTB/POZ_dom IPR011333, SKP1/BTB/POZ_sf IPR003131, T1-type_BTB |
Pfami | View protein in Pfam PF02214, BTB_2, 1 hit |
SMARTi | View protein in SMART SM00225, BTB, 1 hit |
SUPFAMi | SSF54695, SSF54695, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | KCTD8_MOUSE | |
Accessioni | Q50H33Primary (citable) accession number: Q50H33 Secondary accession number(s): Q8BR74 Q8CAA9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | October 3, 2006 |
Last sequence update: | June 7, 2005 | |
Last modified: | December 2, 2020 | |
This is version 96 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot