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Protein

Glutaredoxin domain-containing cysteine-rich protein 1

Gene

Grxcr1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play a role in actin filament architecture in developing stereocilia of sensory cells.1 Publication

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processHearing

Names & Taxonomyi

Protein namesi
Recommended name:
Glutaredoxin domain-containing cysteine-rich protein 1
Gene namesi
Name:Grxcr1
Synonyms:pi
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:3577767 Grxcr1

Subcellular locationi

Keywords - Cellular componenti

Cell projection, Cilium

Pathology & Biotechi

Involvement in diseasei

Defects in Grxcr1 are the cause of the pirouette (pi) phenotype which is characterized by vestibular defects and profound deafness with affected mice displaying abnormally thin and slightly shortened sterocilia.2 Publications

Keywords - Diseasei

Deafness

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003491901 – 290Glutaredoxin domain-containing cysteine-rich protein 1Add BLAST290

Proteomic databases

PaxDbiQ50H32
PRIDEiQ50H32

PTM databases

PhosphoSitePlusiQ50H32

Expressioni

Tissue specificityi

In the inner ear, expressed predominantly in sensory hair cells and their stereocilia bundles with higher levels in outer hair cells (OHC) at P1 and in inner hair cells (IHC) at P5. At P1, expression is prominent in each row of stereocilia within bundles including immature shorter stereocilia. Expression is also observed in apical microvilli of sensory cells at P1 and in kinocilia at P1 and P5. In the adult, expression is localized throughout the length of the stereocilia of both OHC and IHC (at protein level).1 Publication

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000092305

Structurei

3D structure databases

ProteinModelPortaliQ50H32
SMRiQ50H32
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini127 – 234GlutaredoxinPROSITE-ProRule annotationAdd BLAST108

Sequence similaritiesi

Belongs to the GRXCR1 family.Curated

Phylogenomic databases

eggNOGiKOG2824 Eukaryota
ENOG4111HAI LUCA
HOGENOMiHOG000112811
HOVERGENiHBG095477
InParanoidiQ50H32
KOiK17479
PhylomeDBiQ50H32

Family and domain databases

InterProiView protein in InterPro
IPR002109 Glutaredoxin
IPR036249 Thioredoxin-like_sf
PfamiView protein in Pfam
PF00462 Glutaredoxin, 1 hit
SUPFAMiSSF52833 SSF52833, 1 hit
PROSITEiView protein in PROSITE
PS51354 GLUTAREDOXIN_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q50H32-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MLRRETKPES DRPRKVRFRI ASSHSGRVLK EVYEDGQAPG SLDSECASIC
60 70 80 90 100
AIDGLSDSEG QQNGHIGSED NEQEKDQDNL LVLARTASEK AFGTRRVNIL
110 120 130 140 150
SKNGTVRGVK YKVSAGQALF NNLTKVLQQP SADLEFDRVV IYTTCLRVVR
160 170 180 190 200
TTFERCELVR KIFQNHRVKF EEKNIALNGD YGKELDERCR RVSEAPSLPV
210 220 230 240 250
VFIDGHYLGG AEKILSMNES GELQDLLTKI ERVQHPHECP SCGGFGFLPC
260 270 280 290
SVCHGSKMSV FRNCFTDAFK ALKCTACNEN GLQRCKNCTC
Length:290
Mass (Da):32,402
Last modified:June 7, 2005 - v1
Checksum:i410ABE24FA7D27B9
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
G3X9N2G3X9N2_MOUSE
Glutaredoxin domain-containing cyst...
Grxcr1
296Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY616753 mRNA Translation: AAU84851.1
BC147268 mRNA Translation: AAI47269.1
BC147269 mRNA Translation: AAI47270.1
RefSeqiNP_001018019.2, NM_001018019.2
UniGeneiMm.332422

Genome annotation databases

GeneIDi433899
KEGGimmu:433899

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY616753 mRNA Translation: AAU84851.1
BC147268 mRNA Translation: AAI47269.1
BC147269 mRNA Translation: AAI47270.1
RefSeqiNP_001018019.2, NM_001018019.2
UniGeneiMm.332422

3D structure databases

ProteinModelPortaliQ50H32
SMRiQ50H32
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000092305

PTM databases

PhosphoSitePlusiQ50H32

Proteomic databases

PaxDbiQ50H32
PRIDEiQ50H32

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi433899
KEGGimmu:433899

Organism-specific databases

CTDi389207
MGIiMGI:3577767 Grxcr1

Phylogenomic databases

eggNOGiKOG2824 Eukaryota
ENOG4111HAI LUCA
HOGENOMiHOG000112811
HOVERGENiHBG095477
InParanoidiQ50H32
KOiK17479
PhylomeDBiQ50H32

Miscellaneous databases

PROiPR:Q50H32
SOURCEiSearch...

Family and domain databases

InterProiView protein in InterPro
IPR002109 Glutaredoxin
IPR036249 Thioredoxin-like_sf
PfamiView protein in Pfam
PF00462 Glutaredoxin, 1 hit
SUPFAMiSSF52833 SSF52833, 1 hit
PROSITEiView protein in PROSITE
PS51354 GLUTAREDOXIN_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiGRCR1_MOUSE
AccessioniPrimary (citable) accession number: Q50H32
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: June 7, 2005
Last modified: February 28, 2018
This is version 94 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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