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Entry version 74 (12 Aug 2020)
Sequence version 1 (07 Jun 2005)
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Protein
Submitted name:

Peptide synthetase 3

Gene

dptD

Organism
Streptomyces filamentosus (Streptomyces roseosporus)
Status
Unreviewed-Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein predictedi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

pantetheine 4'-phosphateARBA annotation

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Protein family/group databases

ESTHER database of the Alpha/Beta-hydrolase fold superfamily of proteins

More...
ESTHERi
strfl-q50ec8, Thioesterase

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Submitted name:
Peptide synthetase 3Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:dptDImported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiStreptomyces filamentosus (Streptomyces roseosporus)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri67294 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaActinobacteriaStreptomycetalesStreptomycetaceaeStreptomyces

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei1002O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1
Modified residuei2071O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

PhosphopantetheinePROSITE-ProRule annotationARBA annotation, PhosphoproteinARBA annotation

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini967 – 1042CarrierInterPro annotationAdd BLAST76
Domaini2036 – 2111CarrierInterPro annotationAdd BLAST76

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni2018 – 2037DisorderedSequence analysisAdd BLAST20

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1200.10, 1 hit
3.30.559.10, 2 hits
3.40.50.12780, 2 hits
3.40.50.1820, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR010071, AA_adenyl_domain
IPR029058, AB_hydrolase
IPR036736, ACP-like_sf
IPR025110, AMP-bd_C
IPR020845, AMP-binding_CS
IPR000873, AMP-dep_Synth/Lig
IPR042099, AMP-dep_Synthh-like_sf
IPR023213, CAT-like_dom_sf
IPR001242, Condensatn
IPR020806, PKS_PP-bd
IPR020802, PKS_thioesterase
IPR009081, PP-bd_ACP
IPR006162, Ppantetheine_attach_site
IPR001031, Thioesterase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00501, AMP-binding, 2 hits
PF13193, AMP-binding_C, 2 hits
PF00668, Condensation, 2 hits
PF00550, PP-binding, 2 hits
PF00975, Thioesterase, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00823, PKS_PP, 2 hits
SM00824, PKS_TE, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47336, SSF47336, 2 hits
SSF53474, SSF53474, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01733, AA-adenyl-dom, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00455, AMP_BINDING, 2 hits
PS50075, CARRIER, 2 hits
PS00012, PHOSPHOPANTETHEINE, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q50EC8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTQRAMEDIL PLTPLQEGLL FHSVYDEQSV DVYTVQVVVD LEGPVDPEAL
60 70 80 90 100
RAAAAALLRR HANLRAAFRY ERLQRPVQII PREVAVPWEH TDVAKLEGAE
110 120 130 140 150
QKAEIERLLH DQRWRRFDLT APPLLRFLLV RTGHDRHRFA LTFHHILMDG
160 170 180 190 200
WSMPVLLREL ITLYRTGDET ALPWVRPYRD YLAWISRRDR DEAGRAWSKA
210 220 230 240 250
LAGVDEATLV APGADRAAEP PLWTESRLEP DLAATLAARA REFGVTLNTL
260 270 280 290 300
VQAAWALVLG RLTGRDDVVF GVTVSGRPPE LAGVEDMVGL FINTVPLRAE
310 320 330 340 350
LLPHESLRDF TVRLQREQIQ LLDHQYERLA VIQRLAGRTE LFDTVMVFEN
360 370 380 390 400
YPVAAASSAG ADGPAAEPRV ADVHVRDAMH YPLGLLVLPG PPLRLRFGHR
410 420 430 440 450
PSALPAERVT TIRDSLVRAL ELMADQPDLA VGRADILGEE EKQHLLTGLN
460 470 480 490 500
DTHRDVPPLT VPGMIEAQAA RTPGRPAVHA RDGELSYAEL NARANRLARH
510 520 530 540 550
LAAAGVGPEQ YVTLLLPLSA RMVVAALAVM KTGAAYVPVD PEYPADRIAY
560 570 580 590 600
MLGDIGPALV LTDSRSAAAM PAGPARVLTL DDDALDTGVR ALPEHDLGTD
610 620 630 640 650
GIAPLPDQPA YVIYTSGSTG RPKGVVILHR SVTGYLLRTI EEYPEAAGKA
660 670 680 690 700
FVHSPVSFDL TVGALYAPLV SGGCLRLGSF TDDKILDLGE DSPTFMKATP
710 720 730 740 750
SHLAVLDSLP DEISPTGAIT LGGEQLLSET LDPWRARHPG VTVFNVYGPT
760 770 780 790 800
ETTINCAEHR IAPGTTLPPG PVPIGRPLWN TRLYVLDGGL RVVPTGVAGE
810 820 830 840 850
LYVAGAGLAR GYLGRPGLTA ERFVACPFGA PGERMYRTGD LVRWRTDGTL
860 870 880 890 900
EFVGRVDDQV KVRGFRIELG EVEATVAATP GVARAIVAVR EDRPGDQRLV
910 920 930 940 950
AYVTPADVDP TGGLPSAVTA HAAARLPAYM VPSAVVVLHE VPLTPNGKIN
960 970 980 990 1000
RAALPAPEAV SGAGFRAPGT AREEVLCGLF AEVLGLERVG TADDFFELGG
1010 1020 1030 1040 1050
HSLLATRLVS RVRSVLGVEL GVRALFDAPT PGRLDRLLGE RSGAPVRAPL
1060 1070 1080 1090 1100
TARERTGRDP LSYAQQRLWF LHELEGHGAT YNIPLALRLT GPLDVTALEA
1110 1120 1130 1140 1150
ALTDVVARHE SLRTLIARDG TGTAWQHILP TGDPRARITL EAVPLHRDEL
1160 1170 1180 1190 1200
AGRLAEAARH PFDLTAEIPV RATVFRTERD DHTLLVVTHH IASDRWSREP
1210 1220 1230 1240 1250
FLRDLSAAYA ARRAHSAPEL PPLSVQYADY AAWQRDVLGT EDDGTSEMAG
1260 1270 1280 1290 1300
QLAHWRGRLA GLPQGLDLPT DRPRRPDVGR RGGRCRLEIP AALHRDIVTL
1310 1320 1330 1340 1350
ARVTSTTVFM VVQAALAGLL SRLGAGTDIP IGTPIAGRTD EATEHLIGFF
1360 1370 1380 1390 1400
VNTLVLRTDV SGDPTFAELL ARVRATDLDA YAHQDVPFER LVEVLNPERS
1410 1420 1430 1440 1450
LLRHPLFQIL LAFQNTEDRS ISDRPGTLLP DLQVTEQPLD AGTAKFDLAF
1460 1470 1480 1490 1500
AFTERPPEKG EPSGITGIVE YHADLYDEGT VRQIADCFVQ FLDAAVHAPG
1510 1520 1530 1540 1550
TRVDAVGLLP EHTLHKLLTR SRGTVTGLPP ATLPELFEAR VAAHPGHIAV
1560 1570 1580 1590 1600
EVAGRRPATT TYDALNRRAN RLARLLTDRG VRPEQRVAIA LPRSADLVTA
1610 1620 1630 1640 1650
WLGILKAGAV CVPVDPAYPD DRIAHMAADA APALLIASAA TRDRMLPTGI
1660 1670 1680 1690 1700
PVLDLDDPAV TAALAAAPDG NPRGTGLLPA HPAYVIYTSG STGTPKGVVV
1710 1720 1730 1740 1750
THEGIPALAA TQQEALRAGP GDRVLQLVST SFDASVWDLC SALLSGATLV
1760 1770 1780 1790 1800
LAPDADLFGD ELAAALTAHR ITHVTLPPAA LAAVPAGAAP PRLTVTVTGD
1810 1820 1830 1840 1850
VCGPQLVDRW AGGERRILNG YGPTEVTVGA TYAVCERTGD GAPVPIGAPW
1860 1870 1880 1890 1900
PDQRVYVLEH RLRPVPAGCV GEIYVAGAGL ARGYLGRPGQ TAERFVADPF
1910 1920 1930 1940 1950
GAPGERMYRT GDLARRRSDG HLLFEGRADT QVKIRGFRVE LAEIEAALAS
1960 1970 1980 1990 2000
HPGVEDAVVT VYDDGLGDQR LVAYVTGGPG TPSAAALRAH LASRLPRHMV
2010 2020 2030 2040 2050
PGDVLTLDAL PLTANGKVDR TALPGPGTQT AAPGRAPQSP QERVLCALFA
2060 2070 2080 2090 2100
DVLGRETVGV DEGFFDLGGH SLLATRLAAR VRAALGVEIS VRTLFEAPTP
2110 2120 2130 2140 2150
ALLASACTAD AAAYDPFETV LPLRRTGSRP PLFCVHAGMG LSWAYAGLLS
2160 2170 2180 2190 2200
HLDADVPVYG LQARRLTAPG GLPGSVEEMA EDYAGEIRRL CPDGPYRLLG
2210 2220 2230 2240 2250
WSFGGTVAHA VATRLQQQGH TVELLAVLDA YPVTGARPDA EVDEQRIVAD
2260 2270 2280 2290 2300
YLAQLGSPVA PERLEGDAWL PEFLEFVRRT DGPARDFDAG RILAMKDVFL
2310 2320 2330 2340 2350
NNARLTRRFT PGVFTGDMVF FASARPGSEQ AAERVGLWHP HVTGDLDLHL
2360 2370
IDCAHEEMTD PAALTRIGPV LAARLGAGT
Length:2,379
Mass (Da):255,669
Last modified:June 7, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8102F753F50752F0
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AY787762 Genomic DNA Translation: AAX31559.1

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY787762 Genomic DNA Translation: AAX31559.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein family/group databases

ESTHERistrfl-q50ec8, Thioesterase

Family and domain databases

Gene3Di1.10.1200.10, 1 hit
3.30.559.10, 2 hits
3.40.50.12780, 2 hits
3.40.50.1820, 1 hit
InterProiView protein in InterPro
IPR010071, AA_adenyl_domain
IPR029058, AB_hydrolase
IPR036736, ACP-like_sf
IPR025110, AMP-bd_C
IPR020845, AMP-binding_CS
IPR000873, AMP-dep_Synth/Lig
IPR042099, AMP-dep_Synthh-like_sf
IPR023213, CAT-like_dom_sf
IPR001242, Condensatn
IPR020806, PKS_PP-bd
IPR020802, PKS_thioesterase
IPR009081, PP-bd_ACP
IPR006162, Ppantetheine_attach_site
IPR001031, Thioesterase
PfamiView protein in Pfam
PF00501, AMP-binding, 2 hits
PF13193, AMP-binding_C, 2 hits
PF00668, Condensation, 2 hits
PF00550, PP-binding, 2 hits
PF00975, Thioesterase, 1 hit
SMARTiView protein in SMART
SM00823, PKS_PP, 2 hits
SM00824, PKS_TE, 1 hit
SUPFAMiSSF47336, SSF47336, 2 hits
SSF53474, SSF53474, 1 hit
TIGRFAMsiTIGR01733, AA-adenyl-dom, 2 hits
PROSITEiView protein in PROSITE
PS00455, AMP_BINDING, 2 hits
PS50075, CARRIER, 2 hits
PS00012, PHOSPHOPANTETHEINE, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ50EC8_STRFL
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q50EC8
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: June 7, 2005
Last sequence update: June 7, 2005
Last modified: August 12, 2020
This is version 74 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)
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