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Entry version 125 (07 Apr 2021)
Sequence version 1 (07 Jun 2005)
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Protein

Leucine-rich repeat-containing protein 47

Gene

Lrrc47

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Leucine-rich repeat-containing protein 47
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Lrrc47
Synonyms:Kiaa1185
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

More...
MGIi
MGI:1920196, Lrrc47

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002239271 – 581Leucine-rich repeat-containing protein 47Add BLAST581

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei314PhosphoserineBy similarity1
Modified residuei430PhosphoserineBy similarity1
Modified residuei519PhosphoserineBy similarity1

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q505F5

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q505F5

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q505F5

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q505F5

PRoteomics IDEntifications database

More...
PRIDEi
Q505F5

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
252670

2D gel databases

REPRODUCTION-2DPAGE

More...
REPRODUCTION-2DPAGEi
Q505F5

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q505F5

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q505F5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000029028, Expressed in blastocyst and 267 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q505F5, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q505F5, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
215663, 11 interactors

Protein interaction database and analysis system

More...
IntActi
Q505F5, 4 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000133124

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q505F5, protein

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati78 – 97LRR 1Add BLAST20
Repeati102 – 123LRR 2Add BLAST22
Repeati132 – 154LRR 3Add BLAST23
Repeati156 – 177LRR 4Add BLAST22
Repeati182 – 204LRR 5Add BLAST23
Repeati205 – 227LRR 6Add BLAST23
Repeati228 – 248LRR 7Add BLAST21

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili401 – 436Sequence analysisAdd BLAST36

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi2 – 7Poly-Ala6

Keywords - Domaini

Coiled coil, Leucine-rich repeat, Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2472, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00530000063489

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_034522_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q505F5

Database of Orthologous Groups

More...
OrthoDBi
1021451at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q505F5

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.50.40.10, 1 hit
3.80.10.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR005146, B3/B4_tRNA-bd
IPR001611, Leu-rich_rpt
IPR003591, Leu-rich_rpt_typical-subtyp
IPR032675, LRR_dom_sf
IPR020825, Phe-tRNA_synthase_B3/B4

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF03483, B3_4, 1 hit
PF13855, LRR_8, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00873, B3_4, 1 hit
SM00369, LRR_TYP, 5 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51450, LRR, 6 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All

Q505F5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAAAAMAVSE AWPELELAER ERRRELLLTG PGLEERVKAA GGRLPPRLFT
60 70 80 90 100
LPLLHYLEVS GCGSLRAPGP GLAQGLPQLH SLVLRRNALG PGLSPELGPL
110 120 130 140 150
PALRVLDLSG NALETLPPGE GLGPAEPPGL PQLQSLNLSG NRLRELPADL
160 170 180 190 200
ARCAPRLQSL NLTGNRLDAF PPELFRPGAL PLLSELAAAD NCLRELSPDI
210 220 230 240 250
AHLASLKTLD LSNNQLTEIP AELADCPKLK EINFRGNRLR DKRLEKMVGG
260 270 280 290 300
CQTKSILEYL RAGGRGGRSK GRQEASEKED RKKRRERKQH RESGEGEEEV
310 320 330 340 350
ADSARLMLKV LHVSENPTPL TVRVSPEVKD VRPYIVGAIV RGMDLQPGNA
360 370 380 390 400
LRRFLNSQTK LHDDLCEKRT AATIATHDLQ AVRGPLLYAA RPPEDLKIVP
410 420 430 440 450
LGRKEAKAKE LVRQLQLEAE EQRKQKKRQS VSGLHRYLHL LDGKENYPCL
460 470 480 490 500
VDAEGDVISF PPITNSEKTK IKKTTCNLFL EVTSATSLQL CKDIMDSLIL
510 520 530 540 550
RMAELSKSTS ENKEEDMLSG TEADAGCGLS DPNLTLSSGK DGQCPLVVEQ
560 570 580
VRVVDLEGSL KVVYPSKTDL ITLPPHVTVV R
Length:581
Mass (Da):63,590
Last modified:June 7, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iA82B2503E1E41EF0
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
E9PV22E9PV22_MOUSE
Leucine-rich repeat-containing prot...
Lrrc47
603Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6YT33F6YT33_MOUSE
Leucine-rich repeat-containing prot...
Lrrc47
79Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
F6Z4L9F6Z4L9_MOUSE
Leucine-rich repeat-containing prot...
Lrrc47
123Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti312H → Y in BAE32909 (PubMed:16141072).Curated1
Sequence conflicti487S → N in BAC98116 (PubMed:14621295).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK013512 mRNA Translation: BAB28889.1
AK154897 mRNA Translation: BAE32909.1
BC094573 mRNA Translation: AAH94573.1
AK129306 mRNA Translation: BAC98116.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS19006.1

NCBI Reference Sequences

More...
RefSeqi
NP_957678.1, NM_201226.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000030894; ENSMUSP00000030894; ENSMUSG00000029028

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
72946

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
mmu:72946

UCSC genome browser

More...
UCSCi
uc008way.1, mouse

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK013512 mRNA Translation: BAB28889.1
AK154897 mRNA Translation: BAE32909.1
BC094573 mRNA Translation: AAH94573.1
AK129306 mRNA Translation: BAC98116.1
CCDSiCCDS19006.1
RefSeqiNP_957678.1, NM_201226.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi215663, 11 interactors
IntActiQ505F5, 4 interactors
STRINGi10090.ENSMUSP00000133124

PTM databases

iPTMnetiQ505F5
PhosphoSitePlusiQ505F5

2D gel databases

REPRODUCTION-2DPAGEiQ505F5

Proteomic databases

EPDiQ505F5
jPOSTiQ505F5
MaxQBiQ505F5
PaxDbiQ505F5
PRIDEiQ505F5
ProteomicsDBi252670

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
1623, 27 antibodies

Genome annotation databases

EnsembliENSMUST00000030894; ENSMUSP00000030894; ENSMUSG00000029028
GeneIDi72946
KEGGimmu:72946
UCSCiuc008way.1, mouse

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
57470
MGIiMGI:1920196, Lrrc47

Rodent Unidentified Gene-Encoded large proteins database

More...
Rougei
Search...

Phylogenomic databases

eggNOGiKOG2472, Eukaryota
GeneTreeiENSGT00530000063489
HOGENOMiCLU_034522_0_0_1
InParanoidiQ505F5
OrthoDBi1021451at2759
PhylomeDBiQ505F5

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
72946, 1 hit in 53 CRISPR screens

Protein Ontology

More...
PROi
PR:Q505F5
RNActiQ505F5, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000029028, Expressed in blastocyst and 267 other tissues
ExpressionAtlasiQ505F5, baseline and differential
GenevisibleiQ505F5, MM

Family and domain databases

Gene3Di3.50.40.10, 1 hit
3.80.10.10, 2 hits
InterProiView protein in InterPro
IPR005146, B3/B4_tRNA-bd
IPR001611, Leu-rich_rpt
IPR003591, Leu-rich_rpt_typical-subtyp
IPR032675, LRR_dom_sf
IPR020825, Phe-tRNA_synthase_B3/B4
PfamiView protein in Pfam
PF03483, B3_4, 1 hit
PF13855, LRR_8, 2 hits
SMARTiView protein in SMART
SM00873, B3_4, 1 hit
SM00369, LRR_TYP, 5 hits
PROSITEiView protein in PROSITE
PS51450, LRR, 6 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiLRC47_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q505F5
Secondary accession number(s): Q3U380, Q6ZPW2, Q9CUZ0
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 21, 2006
Last sequence update: June 7, 2005
Last modified: April 7, 2021
This is version 125 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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