Nr2c1

Functionⁱ

Orphan nuclear receptor. Binds the IR7 element in the promoter of its own gene in an autoregulatory negative feedback mechanism. Primarily repressor of a broad range of genes including ESR1 and RARB. Together with NR2C2, forms the core of the DRED (direct repeat erythroid-definitive) complex that represses embryonic and fetal globin transcription. Binds to hormone response elements (HREs) consisting of two 5'-AGGTCA-3' half site direct repeat consensus sequences (By similarity). Also activator of OCT4 gene expression. Plays a fundamental role in early embryogenesis and regulates embryonic stem cell proliferation and differentiation. Mediator of retinoic acid-regulated preadipocyte proliferation.By similarity13 Publications

Regions

Feature key	Position(s)	DescriptionActions	Length
DNA bindingⁱ	98 – 173	Nuclear receptorPROSITE-ProRule annotationAdd BLAST	76
Zinc fingerⁱ	101 – 121	NR C4-typePROSITE-ProRule annotationAdd BLAST	21
Zinc fingerⁱ	137 – 156	NR C4-typePROSITE-ProRule annotationAdd BLAST	20

GO - Molecular functionⁱ

DNA binding
Source: UniProtKB
Inferred from direct assayⁱ
histone deacetylase binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 11463856
protein homodimerization activity
Source: UniProtKB
Inferred from physical interactionⁱ
- 9369481
proximal promoter DNA-binding transcription repressor activity, RNA polymerase II-specific
Source: NTNU_SB
Inferred from direct assayⁱ
- 9369481
RNA polymerase II proximal promoter sequence-specific DNA binding
Source: NTNU_SB
Inferred from direct assayⁱ
- 9369481
steroid hormone receptor activity Source: InterPro
zinc ion binding Source: InterPro

View the complete GO annotation on QuickGO ...

GO - Biological processⁱ

View the complete GO annotation on QuickGO ...

Keywordsⁱ

Molecular function	Activator, DNA-binding, Receptor, Repressor
Biological process	Transcription, Transcription regulation
Ligand	Metal-binding, Zinc

Enzyme and pathway databases

Reactomeⁱ	R-MMU-383280 Nuclear Receptor transcription pathway

Reactomeⁱ

R-MMU-383280 Nuclear Receptor transcription pathway

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Nuclear receptor subfamily 2 group C member 1 Alternative name(s): Orphan nuclear receptor TR2 Testicular receptor 2 Short name: mTR2
Gene namesⁱ	Name:Nr2c1Imported Synonyms:Tr2, Tr2-11Imported
Organismⁱ	Mus musculus (Mouse)
Taxonomic identifierⁱ	10090 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Mus › Mus
Proteomesⁱ	UP000000589 Componentⁱ: Chromosome 10

Organism-specific databases

MGIⁱ	MGI:1352465 Nr2c1

Keywords - Cellular componentⁱ

Nucleus

Pathology & Biotechⁱ

Disruption phenotypeⁱ

No visible phenotype. Mice exhibit normal spermatogenesis and testis development, as well as normal central nervous system development. NR2C1 and NR2C2 double null mutants result in early embryonic lethality and increased apoptosis. Embryos die around 7.5 dpc.2 Publications

Mutagenesis

Feature key	Position(s)	DescriptionActions	Length
Mutagenesisⁱ	167	K → A: No effect on sumoylation. 1 Publication	1
Mutagenesisⁱ	170	S → A: No effect on sumoylation nor on DNA-binding and little effect on binding KAT2B. Greatly reduced DNA-binding, binding to KAT2B and activation of the RARB promoter; when associated with A-185. 2 Publications	1
Mutagenesisⁱ	185	S → A: No effect on sumoylation and little effect on binding KAT2B. Some reduced DNA-binding. Greatly reduced DNA-binding, binding to KAT2B and activation of the RARB promoter; when associated with A-170. 2 Publications	1
Mutagenesisⁱ	203	S → A: No effect on sumoylation. 1 Publication	1
Mutagenesisⁱ	208	T → A: No effect on sumoylation. 1 Publication	1
Mutagenesisⁱ	210	T → A: Abolishes sumoylation. No repression of OCT4 gene expression with or without retinoic acid and enhanced interaction with KAT2B and HDAC3. Abolishes interaction with HDAC3 and PML association; when associated with R-238. 1 Publication	1
Mutagenesisⁱ	210	T → E: Sumoylated. Repressed OCT4 gene expression. Enhanced interaction with KAT2B; when associated with R-238. 1 Publication	1
Mutagenesisⁱ	238	K → A: Abolishes sumoylation. Strongly associated with PML nuclear bodies. No effect on activation of OCT4 but activation not suppressed by additional SUMO1. Increased binding to KAT2B and reduced binding to NRIP1. Abolishes PML association; when associated with A-210. 2 Publications	1
Mutagenesisⁱ	238	K → R: Abolishes sumoylation. No effect on activation of OCT4 but activation not suppressed by additional SUMO1. Enhanced interaction with KAT2B; when associated with A-210 or E-210. 2 Publications	1
Mutagenesisⁱ	240	E → A: Abolishes sumoylation. 1 Publication	1
Mutagenesisⁱ	461	S → A: Little effect on PKC-stimulated protein stability nor on activation of RARB reporter. 1 Publication	1
Mutagenesisⁱ	461	S → A: No effect on sumoylation. 1 Publication	1
Mutagenesisⁱ	568	S → A: Greatly reduced PKC-stimulated protein stability and activation of RARB reporter. 1 Publication	1
Mutagenesisⁱ	568	S → A: No effect on sumoylation. 1 Publication	1
Mutagenesisⁱ	575	K → R: No effect on sumoylation. 1 Publication	1

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000053587	1 – 590	Nuclear receptor subfamily 2 group C member 1Add BLAST		590

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	185	Phosphoserine1 Publication	1
Modified residueⁱ	203	Phosphoserine1 Publication	1
Modified residueⁱ	208	Phosphothreonine1 Publication	1
Modified residueⁱ	210	Phosphothreonine; by MAPK11 Publication	1
Cross-linkⁱ	238	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO); alternate1 Publication
Cross-linkⁱ	238	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateBy similarity
Modified residueⁱ	461	Phosphoserine; by PKC1 Publication	1
Modified residueⁱ	568	Phosphoserine; by PKC1 Publication	1
Cross-linkⁱ	575	Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)By similarity

Post-translational modificationⁱ

Sumoylation requires both PIAS1 and UBE2I. Sumoylation appears to dissociate NR2C1 from the PML nuclear bodies. Enhances the interaction with NRIP1 but inhibits interaction with KAT2B. In proliferating cells, stimulation by all-trans retinoic acid, activation of MAPK1-mediated phosphorylation and recruitment to PML bodies with subsequent sumoylation, suppresses OCT4 expression.

Phosphorylated on several serine and threonine residues. Phosphorylation on Thr-210, stimulated by all-trans retinoic acid (atRA) mediates PML location and sumoylation in proliferating cells which then modulates its association with effector molecules, KAT2B and NRIP1. Phosphorylation on Ser-568 by PKC is important for protein stability and function as activator of RARB.2 Publications

Keywords - PTMⁱ

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

PaxDbⁱ	Q505F1
PeptideAtlas More...PeptideAtlasⁱ	Q505F1
PRIDEⁱ	Q505F1

PTM databases

iPTMnetⁱ	Q505F1
PhosphoSitePlusⁱ	Q505F1

Expressionⁱ

Tissue specificityⁱ

Isoform 1 is highly expressed in the adlumenal compartment of the seminiferous tubule of adult testes (at protein level) and in the eyes of newborn animals. Weakly expressed in other adult organs including the seminal vesicle, prostate, ovary, adrenal gland, heart, thymus, placenta and brain. Expressed during embryonic stages in developing eyes, brain and cartilage primordia (at protein level). Also expressed in the developing spinal motor neurons and in the sympathetic-, parasympathetic- and sensory ganglia of the embryonic PNS. Expressed in the developing neural epithelia of the inner ear, nasal cavity, tongue and retina. At day 16.5, expressed in various tissues including kidney and intestine. In contrast, isoform 2 is widely expressed at a low level throughout the adult testis.7 Publications

Manual assertion based on experiment inⁱ

Ref.1
"Genomic structure, promoter identification, and chromosomal mapping of a mouse nuclear orphan receptor expressed in embryos and adult testes."
Lee C.-H., Copeland N.G., Gilbert D.J., Jenkins N.A., Wei L.-N.
Genomics 30:46-52(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, VARIANTS MET-29; MET-145; 296-SER--LYS-304; ILE-361; ALA-377 AND ALA-456.
Ref.2
"Molecular cloning and characterization of a mouse nuclear orphan receptor expressed in embryos and testes."
Lee C.-H., Chang L., Wei L.N.
Mol. Reprod. Dev. 44:305-314(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, VARIANTS MET-29; MET-145; 296-SER--LYS-304; ILE-361; ALA-377 AND ALA-456.
Ref.3
"Distinct expression patterns and biological activities of two isoforms of the mouse orphan receptor TR2."
Lee C.-H., Chang L., Wei L.-N.
J. Endocrinol. 152:245-255(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2), FUNCTION, TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
Ref.4
"Polymorphism in the murine Tr2-11 gene encoding an orphan receptor, and its exclusion as a candidate gene for the cataract mutation Cat3."
Immervoll T., Adamski J., Graw J.
Biol. Chem. 379:83-85(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY.
Ref.5
"A bidirectional regulation between the TR2/TR4 orphan receptors (TR2/TR4) and the ciliary neurotrophic factor (CNTF) signaling pathway."
Young W.-J., Lee Y.-F., Smith S.M., Chang C.
J. Biol. Chem. 273:20877-20885(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), TISSUE SPECIFICITY, INDUCTION.
Ref.10
"Multiple functions of the TR2-11 orphan receptor in modulating activation of two key cis-acting elements involved in the retinoic acid signal transduction system."
Lin T.M., Young W.J., Chang C.
J. Biol. Chem. 270:30121-30128(1995) [PubMed] [Europe PMC] [Abstract]
Cited for: DNA-BINDING, FUNCTION, TISSUE SPECIFICITY.
Ref.15
"Spermatogenesis and testis development are normal in mice lacking testicular orphan nuclear receptor 2."
Shyr C.R., Collins L.L., Mu X.M., Platt K.A., Chang C.
Mol. Cell. Biol. 22:4661-4666(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: DISRUPTION PHENOTYPE, TISSUE SPECIFICITY.

Developmental stageⁱ

Isoform 1 is highly expressed in early to midgestation embryos, with expression leveling off at 15 dpc. Expressed in yolk sac erythrocytes at 9.5 dpc. After birth, expression in the testes remains at a basal level until puberty, begins to increase at postnatal day 16 (P16) and peaks at P20 to P24. Expression is maintained at a high level throughout adulthood. Isoform 2 peaks transiently at P24.4 Publications

Inductionⁱ

By ciliary neurotrophic factor (CNTF). Repressed by vitamin A. Induced by retinoic acid.2 Publications

Gene expression databases

Bgeeⁱ	ENSMUSG00000005897 Expressed in 255 organ(s), highest expression level in retina
CleanExⁱ	MM_NR2C1
Genevisibleⁱ	Q505F1 MM

Interactionⁱ

Subunit structureⁱ

Homodimer. Heterodimer; with NR2C2 which is required for chromatin remodeling and for binding to promoter regions such as globin DR1 repeats. Interacts with ESR1; the interaction prevents homodimerization of ESR1 and suppresses its transcriptional activity and cell growth (By similarity). Interacts with NRIP1 (via its LXXLL motifs); the interaction provides corepressor activity. Interacts with HDAC3 (via the DNA-binding domain); the interaction recruits phosphorylated NR2C1 to PML bodies for sumoylation. Interacts with HDAC4 (via the DNA-binding domain). Interacts with PIAS1; the interaction is required for sumoylation of NR2C1. Interacts with UBE2I; the interaction is required for sumoylation of NR2C1. Interacts with KAT2B; the interaction acts as a corepressor of gene expression.By similarity6 Publications

Binary interactionsⁱ

With	Entry	#Exp.	IntAct
Kat2b	Q9JHD1	3	EBI-15617004,EBI-2325611
Nrip1	Q8CBD1	3	EBI-15617004,EBI-1771626
Pias1	O88907	4	EBI-15617004,EBI-3508327
Pml	Q60953	2	EBI-15617004,EBI-3895605
Pml	Q8BSJ6	3	EBI-15617004,EBI-15719975
Sumo1	P63166	5	EBI-15617004,EBI-80152
Ube2i	P63280	3	EBI-15617004,EBI-80180

GO - Molecular functionⁱ

histone deacetylase binding
Source: UniProtKB
Inferred from physical interactionⁱ
- 11463856
protein homodimerization activity
Source: UniProtKB
Inferred from physical interactionⁱ
- 9369481

View the complete GO annotation on QuickGO ...

Protein-protein interaction databases

BioGridⁱ	204299, 2 interactors
Database of interacting proteins More...DIPⁱ	DIP-29275N
IntActⁱ	Q505F1, 7 interactors
STRINGⁱ	10090.ENSMUSP00000089858

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q505F1
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Domains and Repeats

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Domainⁱ	333 – 577	NR LBDPROSITE-ProRule annotationAdd BLAST		245

Region

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Regionⁱ	1 – 166	Required for interaction with KAT2BAdd BLAST		166
Regionⁱ	571 – 590	Required for interaction with NRIP1Add BLAST		20

Sequence similaritiesⁱ

Belongs to the nuclear hormone receptor family. NR2 subfamily.Sequence analysis

Zinc finger

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Zinc fingerⁱ	101 – 121	NR C4-typePROSITE-ProRule annotationAdd BLAST		21
Zinc fingerⁱ	137 – 156	NR C4-typePROSITE-ProRule annotationAdd BLAST		20

Keywords - Domainⁱ

Zinc-finger

Phylogenomic databases

eggNOGⁱ	KOG3575 Eukaryota ENOG410XRZC LUCA
Ensembl GeneTree More...GeneTreeⁱ	ENSGT00760000118948
HOVERGENⁱ	HBG008596
InParanoidⁱ	Q505F1
KEGG Orthology (KO) More...KOⁱ	K08543
OMAⁱ	KAYMEFQ
Database of Orthologous Groups More...OrthoDBⁱ	EOG091G099H
TreeFamⁱ	TF316650

Family and domain databases

Gene3Dⁱ	3.30.50.10, 1 hit
InterProⁱ	View protein in InterPro IPR035500 NHR_like_dom_sf IPR000536 Nucl_hrmn_rcpt_lig-bd IPR001723 Nuclear_hrmn_rcpt IPR001628 Znf_hrmn_rcpt IPR013088 Znf_NHR/GATA
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF00104 Hormone_recep, 1 hit PF00105 zf-C4, 1 hit
PRINTSⁱ	PR00398 STRDHORMONER PR00047 STROIDFINGER
SMARTⁱ	View protein in SMART SM00430 HOLI, 1 hit SM00399 ZnF_C4, 1 hit
SUPFAMⁱ	SSF48508 SSF48508, 1 hit
PROSITEⁱ	View protein in PROSITE PS51843 NR_LBD, 1 hit PS00031 NUCLEAR_REC_DBD_1, 1 hit PS51030 NUCLEAR_REC_DBD_2, 1 hit

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket

Isoform 13 Publications (identifier: Q505F1-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MATIEEIAHQ IIDQQMGEIV TEQQTGQKIQ IVTALDHSTQ GKQFILANHE 
        60         70         80         90        100
GSTPGKVFLT TPDAAGVNQL FFTSPDLSAP HLQLLTEKSP DQGPNKVFDL 
       110        120        130        140        150
CVVCGDKASG RHYGAITCEG CKGFFKRSIR KNLVYSCRGS KDCVINKHHR 
       160        170        180        190        200
NRCQYCRLQR CIAFGMKQDS VQCERKPIEV SREKSSNCAA STEKIYIRKD 
       210        220        230        240        250
LRSPLAATPT FVTDSETARS AGLLDSGMFV NIHPSGIKTE PAMLMAPDKA 
       260        270        280        290        300
ESCQGDLSTL ASVVTSLANL GKAKDLSHCG GDMPVVQSLR NGDTSFGAFH 
       310        320        330        340        350
HDIQTNGDVS RAFDTLAKAL TPGESSACQS PEEGMEGSPH LIAGEPSFVE 
       360        370        380        390        400
KEGPLLSESH VAFRLTMPSP MPEYLNVHYI GESASRLLFL SMHWALSIPS 
       410        420        430        440        450
FQALGQENSI SLVKAYWNEL FTLGLAQCWQ VMNVATILAT FVNCLHSSLQ 
       460        470        480        490        500
QDKMSPERRK SLMEHIFKLQ EFCNSMVKLC IDGHEYAYLK AIVLFSPDHP 
       510        520        530        540        550
GLENMELIER FQEKAYVEFQ DYITRTYPDD TYRLSRLLLR LPALRLMNAT 
       560        570        580        590
ITEELFFKGL IGNVRIDSVI PHILKMEPAD YNSQIIGHSL

Length:590

Mass (Da):65,476

Last modified:July 27, 2011 - v3

Checksum:ⁱE639AF3E5312918D

GO

Isoform 21 Publication (identifier: Q505F1-2) [UniParc]FASTA Add to basket

Also known as: TR2-11-t1 Publication, TR2-11-truncated1 Publication

The sequence of this isoform differs from the canonical sequence as follows:
220-256: SAGLLDSGMFVNIHPSGIKTEPAMLMAPDKAESCQGD → CPAAISASFASLPRSTETKTCASFVAGQLDCWIQECL
257-590: Missing.

« Hide

        10         20         30         40         50
MATIEEIAHQ IIDQQMGEIV TEQQTGQKIQ IVTALDHSTQ GKQFILANHE 
        60         70         80         90        100
GSTPGKVFLT TPDAAGVNQL FFTSPDLSAP HLQLLTEKSP DQGPNKVFDL 
       110        120        130        140        150
CVVCGDKASG RHYGAITCEG CKGFFKRSIR KNLVYSCRGS KDCVINKHHR 
       160        170        180        190        200
NRCQYCRLQR CIAFGMKQDS VQCERKPIEV SREKSSNCAA STEKIYIRKD 
       210        220        230        240        250
LRSPLAATPT FVTDSETARC PAAISASFAS LPRSTETKTC ASFVAGQLDC 

WIQECL

Note: Due to intron retention.1 Publication

Show »

Length:256

Mass (Da):28,225

Checksum:ⁱ53064D53EEB1C54A

GO

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	88	K → N in CAA72244 (PubMed:9504722).Curated	1
Sequence conflictⁱ	88	K → N in AAC29502 (PubMed:9694834).Curated	1
Sequence conflictⁱ	88	K → N in AAL31315 (Ref. 6) Curated	1
Sequence conflictⁱ	200	D → N in AAC29502 (PubMed:9694834).Curated	1
Sequence conflictⁱ	200	D → N in AAL31315 (Ref. 6) Curated	1
Sequence conflictⁱ	273	A → T in AAC29502 (PubMed:9694834).Curated	1
Sequence conflictⁱ	273	A → T in AAL31315 (Ref. 6) Curated	1
Sequence conflictⁱ	326 – 327	SA → TS in AAC52787 (PubMed:8595902).Curated	2
Sequence conflictⁱ	326 – 327	SA → TS in AAC53253 (PubMed:8595902).Curated	2
Sequence conflictⁱ	326 – 327	SA → TS in CAA72244 (PubMed:9504722).Curated	2
Sequence conflictⁱ	326 – 327	SA → TS in AAL31315 (Ref. 6) Curated	2
Sequence conflictⁱ	331	P → S in AAC29502 (PubMed:9694834).Curated	1
Sequence conflictⁱ	331	P → S in AAL31315 (Ref. 6) Curated	1
Sequence conflictⁱ	529	D → N in BAE27509 (PubMed:16141072).Curated	1

Natural variant

Feature key	Position(s)	DescriptionActions	Length
Natural variantⁱ	29	I → M in strain: CD-1. 2 Publications	1
Natural variantⁱ	145	I → M in strain: CD-1. 2 Publications	1
Natural variantⁱ	296 – 304	FGAFHHDIQ → SVLFIMIFK in strain: CD-1. 2 Publications	9
Natural variantⁱ	361	V → I in strain: CD-1. 2 Publications	1
Natural variantⁱ	377	V → A in strain: CD-1. 2 Publications	1
Natural variantⁱ	456	P → A in strain: CD-1. 2 Publications	1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_051921	220 – 256	SAGLL…SCQGD → CPAAISASFASLPRSTETKT CASFVAGQLDCWIQECL in isoform 2. 1 PublicationAdd BLAST		37
Alternative sequenceⁱVSP_051922	257 – 590	Missing in isoform 2. 1 PublicationAdd BLAST		334

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U28280 U28279 Genomic DNA Translation: AAC53253.1 U28265 mRNA Translation: AAC52787.1 Y11436 mRNA Translation: CAA72244.1 U30482 mRNA Translation: AAC29502.1 L26957 mRNA Translation: AAL31315.1 AK146891 mRNA Translation: BAE27509.1 AK149374 mRNA Translation: BAE28842.1 AC127596 Genomic DNA No translation available. AC138026 Genomic DNA No translation available. BC090662 mRNA Translation: AAH90662.1 BC094580 mRNA Translation: AAH94580.1
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS24131.1 [Q505F1-1]
NCBI Reference Sequences More...RefSeqⁱ	NP_035759.3, NM_011629.3 [Q505F1-1] XP_006513655.1, XM_006513592.2 [Q505F1-1]
UniGeneⁱ	Mm.107483

Genome annotation databases

Ensemblⁱ	ENSMUST00000092213; ENSMUSP00000089858; ENSMUSG00000005897 [Q505F1-1] ENSMUST00000099343; ENSMUSP00000096945; ENSMUSG00000005897 [Q505F1-1] ENSMUST00000105290; ENSMUSP00000100927; ENSMUSG00000005897 [Q505F1-1]
GeneIDⁱ	22025
KEGGⁱ	mmu:22025
UCSC genome browser More...UCSCⁱ	uc007gvo.2 mouse [Q505F1-1]

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

90% Identity
50% Identity

Protein	Similar proteins		Species	Score	Length	Source
Q505F1	Nuclear receptor subfamily 2 group C member 1		RAT		590	UniRef90_Q505F1
UPI0003334510		JACJA		611
UPI00038C4A48		MICOH		590
UPI000A318DDE		MUSCR		590
UPI000A310745		MUSPA		588
+1

Protein	Similar proteins		Species	Score	Length	Source
Q505F1	Nuclear receptor subfamily 2 group C member 1		RAT		590	UniRef50_Q505F1
Uncharacterized protein		SARHA		605
Uncharacterized protein		MONDO		605
Nr2c2 protein		MOUSE		501
Uncharacterized protein		LEPOC		612
+227
Q505F1-2	Nuclear receptor subfamily 2, group C, member 1		ASTMX		285	UniRef50_Q505F1-2

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U28280 U28279 Genomic DNA Translation: AAC53253.1 U28265 mRNA Translation: AAC52787.1 Y11436 mRNA Translation: CAA72244.1 U30482 mRNA Translation: AAC29502.1 L26957 mRNA Translation: AAL31315.1 AK146891 mRNA Translation: BAE27509.1 AK149374 mRNA Translation: BAE28842.1 AC127596 Genomic DNA No translation available. AC138026 Genomic DNA No translation available. BC090662 mRNA Translation: AAH90662.1 BC094580 mRNA Translation: AAH94580.1
CCDSⁱ	CCDS24131.1 [Q505F1-1]
RefSeqⁱ	NP_035759.3, NM_011629.3 [Q505F1-1] XP_006513655.1, XM_006513592.2 [Q505F1-1]
UniGeneⁱ	Mm.107483

3D structure databases

ProteinModelPortalⁱ	Q505F1
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	204299, 2 interactors
DIPⁱ	DIP-29275N
IntActⁱ	Q505F1, 7 interactors
STRINGⁱ	10090.ENSMUSP00000089858

PTM databases

iPTMnetⁱ	Q505F1
PhosphoSitePlusⁱ	Q505F1

Proteomic databases

PaxDbⁱ	Q505F1
PeptideAtlasⁱ	Q505F1
PRIDEⁱ	Q505F1

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

Ensemblⁱ	ENSMUST00000092213; ENSMUSP00000089858; ENSMUSG00000005897 [Q505F1-1] ENSMUST00000099343; ENSMUSP00000096945; ENSMUSG00000005897 [Q505F1-1] ENSMUST00000105290; ENSMUSP00000100927; ENSMUSG00000005897 [Q505F1-1]
GeneIDⁱ	22025
KEGGⁱ	mmu:22025
UCSCⁱ	uc007gvo.2 mouse [Q505F1-1]

Organism-specific databases

CTDⁱ	7181
MGIⁱ	MGI:1352465 Nr2c1

Phylogenomic databases

eggNOGⁱ	KOG3575 Eukaryota ENOG410XRZC LUCA
GeneTreeⁱ	ENSGT00760000118948
HOVERGENⁱ	HBG008596
InParanoidⁱ	Q505F1
KOⁱ	K08543
OMAⁱ	KAYMEFQ
OrthoDBⁱ	EOG091G099H
TreeFamⁱ	TF316650

Enzyme and pathway databases

Reactomeⁱ	R-MMU-383280 Nuclear Receptor transcription pathway

Reactomeⁱ

R-MMU-383280 Nuclear Receptor transcription pathway

Miscellaneous databases

ChiTaRSⁱ	Nr2c1 mouse
Protein Ontology More...PROⁱ	PR:Q505F1
SOURCEⁱ	Search...

Gene expression databases

Bgeeⁱ	ENSMUSG00000005897 Expressed in 255 organ(s), highest expression level in retina
CleanExⁱ	MM_NR2C1
Genevisibleⁱ	Q505F1 MM

Family and domain databases

Gene3Dⁱ	3.30.50.10, 1 hit
InterProⁱ	View protein in InterPro IPR035500 NHR_like_dom_sf IPR000536 Nucl_hrmn_rcpt_lig-bd IPR001723 Nuclear_hrmn_rcpt IPR001628 Znf_hrmn_rcpt IPR013088 Znf_NHR/GATA
Pfamⁱ	View protein in Pfam PF00104 Hormone_recep, 1 hit PF00105 zf-C4, 1 hit
PRINTSⁱ	PR00398 STRDHORMONER PR00047 STROIDFINGER
SMARTⁱ	View protein in SMART SM00430 HOLI, 1 hit SM00399 ZnF_C4, 1 hit
SUPFAMⁱ	SSF48508 SSF48508, 1 hit
PROSITEⁱ	View protein in PROSITE PS51843 NR_LBD, 1 hit PS00031 NUCLEAR_REC_DBD_1, 1 hit PS51030 NUCLEAR_REC_DBD_2, 1 hit
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	NR2C1_MOUSE
Accessionⁱ	Q505F1Primary (citable) accession number: Q505F1 Secondary accession number(s): P97763 Q8VIJ3
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	December 6, 2005
	Last sequence update:	July 27, 2011
	Last modified:	November 7, 2018
	This is version 125 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program

Miscellaneousⁱ

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

SIMILARITY comments
Index of protein domains and families
MGD cross-references
Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

UniProtKB

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UniRef

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Supporting data

UniProtKB - Q505F1 (NR2C1_MOUSE)

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Nuclear receptor subfamily 2 group C member 1

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<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regions

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Nucleus

Nucleus

Keywords - Cellular componenti

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Keywords - PTMi

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

GO - Molecular functioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Region

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Zinc finger

Keywords - Domaini

Phylogenomic databases

Family and domain databases

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

Keywords - Coding sequence diversityi

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Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

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<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

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Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Keywords - Cellular componentⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Keywords - PTMⁱ

Expressionⁱ

Interactionⁱ

GO - Molecular functionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Keywords - Domainⁱ

Keywords - Coding sequence diversityⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ

Keywords - Technical termⁱ