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Protein

Optic atrophy 3 protein homolog

Gene

Opa3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May play some role in mitochondrial processes.By similarity

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Optic atrophy 3 protein homolog
Gene namesi
Name:Opa3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 7

Organism-specific databases

MGIiMGI:2686271 Opa3

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Mitochondrion

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi122L → P: Homozygous mice have their visual function which is severely reduced, consistent with significant loss of retinal ganglion cells and degeneration of axons in the optic nerve. They also display a severe multi-systemic disease characterized by reduced lifespan (<4 months), decreased weight, dilated cardiomyopathy, extrapyramidal dysfunction and gross neuro-muscular defects. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003265471 – 179Optic atrophy 3 protein homologAdd BLAST179

Proteomic databases

MaxQBiQ505D7
PaxDbiQ505D7
PeptideAtlasiQ505D7
PRIDEiQ505D7

PTM databases

iPTMnetiQ505D7
PhosphoSitePlusiQ505D7

Expressioni

Gene expression databases

BgeeiENSMUSG00000052214 Expressed in 273 organ(s), highest expression level in interventricular septum
ExpressionAtlasiQ505D7 baseline and differential
GenevisibleiQ505D7 MM

Interactioni

Protein-protein interaction databases

BioGridi240079, 1 interactor
STRINGi10090.ENSMUSP00000069965

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili120 – 143Sequence analysisAdd BLAST24

Sequence similaritiesi

Belongs to the OPA3 family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG3335 Eukaryota
ENOG4111J9C LUCA
GeneTreeiENSGT00390000009795
HOGENOMiHOG000007385
HOVERGENiHBG019109
InParanoidiQ505D7
OMAiHWIEMRT
OrthoDBiEOG091G0W1R
PhylomeDBiQ505D7
TreeFamiTF314653

Family and domain databases

InterProiView protein in InterPro
IPR010754 OPA3-like
PANTHERiPTHR12499 PTHR12499, 1 hit
PfamiView protein in Pfam
PF07047 OPA3, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q505D7-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVVGAFPMAK LFYLGIRQVS KPLANRIKDA ARRSEFFKTY ICLPPAQLYH
60 70 80 90 100
WVEMRTKMRI MGFRGTTIKP LNEEAAAELG AELLGEATIF IVGGGCLVLE
110 120 130 140 150
YWRHQTQQRN KEEEQRAAWN ALQDEVGRLA LALEALQAQA QAMPSLSALE
160 170
ELREELQEVR GQVCNAHCTS KCQAASSKK
Length:179
Mass (Da):20,110
Last modified:June 7, 2005 - v1
Checksum:iFF948407D52F742E
GO

Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0U1RPB1A0A0U1RPB1_MOUSE
Optic atrophy 3 (Human), isoform CR...
Opa3 mCG_130075
208Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti56T → A in BAC35141 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK052774 mRNA Translation: BAC35141.1
AK133480 mRNA Translation: BAE21678.1
AK154960 mRNA Translation: BAE32955.1
AK164755 mRNA Translation: BAE37900.1
AK170977 mRNA Translation: BAE42155.1
BC094601 mRNA Translation: AAH94601.1
BC132309 mRNA Translation: AAI32310.1
BC132311 mRNA Translation: AAI32312.1
CCDSiCCDS20894.1
RefSeqiNP_997408.2, NM_207525.3
UniGeneiMm.239583

Genome annotation databases

EnsembliENSMUST00000063976; ENSMUSP00000069965; ENSMUSG00000052214
GeneIDi403187
KEGGimmu:403187
UCSCiuc009flc.1 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK052774 mRNA Translation: BAC35141.1
AK133480 mRNA Translation: BAE21678.1
AK154960 mRNA Translation: BAE32955.1
AK164755 mRNA Translation: BAE37900.1
AK170977 mRNA Translation: BAE42155.1
BC094601 mRNA Translation: AAH94601.1
BC132309 mRNA Translation: AAI32310.1
BC132311 mRNA Translation: AAI32312.1
CCDSiCCDS20894.1
RefSeqiNP_997408.2, NM_207525.3
UniGeneiMm.239583

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi240079, 1 interactor
STRINGi10090.ENSMUSP00000069965

PTM databases

iPTMnetiQ505D7
PhosphoSitePlusiQ505D7

Proteomic databases

MaxQBiQ505D7
PaxDbiQ505D7
PeptideAtlasiQ505D7
PRIDEiQ505D7

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000063976; ENSMUSP00000069965; ENSMUSG00000052214
GeneIDi403187
KEGGimmu:403187
UCSCiuc009flc.1 mouse

Organism-specific databases

CTDi80207
MGIiMGI:2686271 Opa3

Phylogenomic databases

eggNOGiKOG3335 Eukaryota
ENOG4111J9C LUCA
GeneTreeiENSGT00390000009795
HOGENOMiHOG000007385
HOVERGENiHBG019109
InParanoidiQ505D7
OMAiHWIEMRT
OrthoDBiEOG091G0W1R
PhylomeDBiQ505D7
TreeFamiTF314653

Miscellaneous databases

ChiTaRSiOpa3 mouse
PROiPR:Q505D7
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000052214 Expressed in 273 organ(s), highest expression level in interventricular septum
ExpressionAtlasiQ505D7 baseline and differential
GenevisibleiQ505D7 MM

Family and domain databases

InterProiView protein in InterPro
IPR010754 OPA3-like
PANTHERiPTHR12499 PTHR12499, 1 hit
PfamiView protein in Pfam
PF07047 OPA3, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiOPA3_MOUSE
AccessioniPrimary (citable) accession number: Q505D7
Secondary accession number(s): Q8C6Z9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 8, 2008
Last sequence update: June 7, 2005
Last modified: November 7, 2018
This is version 93 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
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Main funding by: National Institutes of Health

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