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Entry version 107 (07 Apr 2021)
Sequence version 1 (07 Jun 2005)
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Protein

Zinc finger CW-type PWWP domain protein 2

Gene

ZCWPW2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Histone methylation reader which binds to non-methylated (H3K4me0), monomethylated (H3K4me1), dimethylated (H3K4me2) and trimethylated (H3K4me3) 'Lys-4' on histone H3 (PubMed:26933034). The order of binding preference is H3K4me3 > H3K4me2 > H3K4me1 > H3K4me0 (PubMed:26933034).1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">Function</a> section specifies the position(s) and type(s) of zinc fingers within the protein.<p><a href='/help/zn_fing' target='_top'>More...</a></p>Zinc fingeri24 – 79CW-typePROSITE-ProRule annotationAdd BLAST56

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

  • methylated histone binding Source: UniProtKB
  • zinc ion binding Source: InterPro

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

LigandMetal-binding, Zinc

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q504Y3

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc finger CW-type PWWP domain protein 2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:ZCWPW2
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:23574, ZCWPW2

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q504Y3

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSG00000206559.7

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi30W → A, V, L, M, G, S, T, N or Q: Reduced histone H3K4me3 binding. 1 Publication1
Mutagenesisi30W → C, D, E, H, K or R: Significantly reduced histone H3K4me3 binding. 1 Publication1
Mutagenesisi30W → L: Loss of histone H3K4me3 binding; when associated with F-41. 1 Publication1
Mutagenesisi30W → M: Loss of histone H3K4me3 binding; when associated with F-41. 1 Publication1
Mutagenesisi30W → P: Loss of histone H3K4me3 binding. 1 Publication1
Mutagenesisi41W → F: Significantly reduced histone H3K4me3 binding. Loss of histone H3K4me3 binding; when associated with L-30 or M-30. 1 Publication1
Mutagenesisi78F → S, I, P, D, E, H, R or Q: Little effect on histone H3K4me3 binding. 1 Publication1
Mutagenesisi78Missing : Little effect on histone H3K4me3 binding. 1 Publication1

Organism-specific databases

DisGeNET

More...
DisGeNETi
152098

Open Targets

More...
OpenTargetsi
ENSG00000206559

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA134888742

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q504Y3, Tdark

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
ZCWPW2

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74740233

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002863481 – 356Zinc finger CW-type PWWP domain protein 2Add BLAST356

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q504Y3

PeptideAtlas

More...
PeptideAtlasi
Q504Y3

PRoteomics IDEntifications database

More...
PRIDEi
Q504Y3

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
62417

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000206559, Expressed in testis and 124 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q504Y3, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q504Y3, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000206559, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
127425, 4 interactors

Protein interaction database and analysis system

More...
IntActi
Q504Y3, 2 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000373278

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q504Y3, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

Secondary structure

1356
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q504Y3

Database of comparative protein structure models

More...
ModBasei
Search...

Protein Data Bank in Europe - Knowledge Base

More...
PDBe-KBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini98 – 162PWWPPROSITE-ProRule annotationAdd BLAST65

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

The CW-TYPE zinc finger mediates its binding to trimethylated histone H3K4me3.1 Publication

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri24 – 79CW-typePROSITE-ProRule annotationAdd BLAST56

Keywords - Domaini

Zinc-finger

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QS46, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00560000077278

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_077983_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q504Y3

Identification of Orthologs from Complete Genome Data

More...
OMAi
SPFENHY

Database of Orthologous Groups

More...
OrthoDBi
1159953at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q504Y3

TreeFam database of animal gene trees

More...
TreeFami
TF318885

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR000313, PWWP_dom
IPR042778, ZCWPW1/ZCWPW2
IPR011124, Znf_CW

The PANTHER Classification System

More...
PANTHERi
PTHR15999, PTHR15999, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00855, PWWP, 1 hit
PF07496, zf-CW, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50812, PWWP, 1 hit
PS51050, ZF_CW, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 4 potential isoforms that are computationally mapped.Show allAlign All

Q504Y3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MDKEKLDVKI EYCNYAMDSS VENMYVNKVW VQCENENCLK WRLLSSEDSA
60 70 80 90 100
KVDHDEPWYC FMNTDSRYNN CSISEEDFPE ESQLHQCGFK IVYSQLPLGS
110 120 130 140 150
LVLVKLQNWP SWPGILCPDR FKGKYVTYDP DGNVEEYHIE FLGDPHSRSW
160 170 180 190 200
IKATFVGHYS ITLKPEKCKN KKKWYKSALQ EACLLYGYSH EQRLEMCCLS
210 220 230 240 250
KLQDKSETHD KVAALVKKRK QTSKNNIEKK KPKFRKRKRK AILKCSFENV
260 270 280 290 300
YSDDALSKEN RVVCETEVLL KELEQMLQQA LQPTATPDES EEGHGEEINM
310 320 330 340 350
GEKLSKCSPE APAGSLFENH YEEDYLVIDG IKLKAGECIE DITNKFKEID

ALMSEF
Length:356
Mass (Da):41,376
Last modified:June 7, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i90CB5558C9801B1F
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H7C087H7C087_HUMAN
Zinc finger CW-type PWWP domain pro...
ZCWPW2
165Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JFK0C9JFK0_HUMAN
Zinc finger CW-type PWWP domain pro...
ZCWPW2
126Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C0K4H7C0K4_HUMAN
Zinc finger CW-type PWWP domain pro...
ZCWPW2
191Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
H7C0L9H7C0L9_HUMAN
Zinc finger CW-type PWWP domain pro...
ZCWPW2
241Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_051499202L → Q. Corresponds to variant dbSNP:rs1563656Ensembl.1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
BC094696 mRNA Translation: AAH94696.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS33723.1

NCBI Reference Sequences

More...
RefSeqi
NP_001035522.1, NM_001040432.3
NP_001311098.1, NM_001324169.1
XP_016861244.1, XM_017005755.1

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000383768; ENSP00000373278; ENSG00000206559

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
152098

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:152098

UCSC genome browser

More...
UCSCi
uc003ceh.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC094696 mRNA Translation: AAH94696.1
CCDSiCCDS33723.1
RefSeqiNP_001035522.1, NM_001040432.3
NP_001311098.1, NM_001324169.1
XP_016861244.1, XM_017005755.1

3D structure databases

Select the link destinations:

Protein Data Bank Europe

More...
PDBei

Protein Data Bank RCSB

More...
RCSB PDBi

Protein Data Bank Japan

More...
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4O62X-ray1.78A/B/C21-78[»]
4Z0OX-ray1.57A21-78[»]
4Z0RX-ray1.75A/B/C21-78[»]
SMRiQ504Y3
ModBaseiSearch...
PDBe-KBiSearch...

Protein-protein interaction databases

BioGRIDi127425, 4 interactors
IntActiQ504Y3, 2 interactors
STRINGi9606.ENSP00000373278

Genetic variation databases

BioMutaiZCWPW2
DMDMi74740233

Proteomic databases

PaxDbiQ504Y3
PeptideAtlasiQ504Y3
PRIDEiQ504Y3
ProteomicsDBi62417

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
27555, 29 antibodies

Genome annotation databases

EnsembliENST00000383768; ENSP00000373278; ENSG00000206559
GeneIDi152098
KEGGihsa:152098
UCSCiuc003ceh.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
152098
DisGeNETi152098

GeneCards: human genes, protein and diseases

More...
GeneCardsi
ZCWPW2
HGNCiHGNC:23574, ZCWPW2
HPAiENSG00000206559, Low tissue specificity
neXtProtiNX_Q504Y3
OpenTargetsiENSG00000206559
PharmGKBiPA134888742
VEuPathDBiHostDB:ENSG00000206559.7

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502QS46, Eukaryota
GeneTreeiENSGT00560000077278
HOGENOMiCLU_077983_1_0_1
InParanoidiQ504Y3
OMAiSPFENHY
OrthoDBi1159953at2759
PhylomeDBiQ504Y3
TreeFamiTF318885

Enzyme and pathway databases

PathwayCommonsiQ504Y3

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
152098, 15 hits in 981 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
ZCWPW2, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
152098
PharosiQ504Y3, Tdark

Protein Ontology

More...
PROi
PR:Q504Y3
RNActiQ504Y3, protein

Gene expression databases

BgeeiENSG00000206559, Expressed in testis and 124 other tissues
ExpressionAtlasiQ504Y3, baseline and differential
GenevisibleiQ504Y3, HS

Family and domain databases

InterProiView protein in InterPro
IPR000313, PWWP_dom
IPR042778, ZCWPW1/ZCWPW2
IPR011124, Znf_CW
PANTHERiPTHR15999, PTHR15999, 1 hit
PfamiView protein in Pfam
PF00855, PWWP, 1 hit
PF07496, zf-CW, 1 hit
PROSITEiView protein in PROSITE
PS50812, PWWP, 1 hit
PS51050, ZF_CW, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiZCPW2_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q504Y3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 1, 2007
Last sequence update: June 7, 2005
Last modified: April 7, 2021
This is version 107 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

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Keywords - Technical termi

3D-structure, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with genetic variants
    List of human entries with genetic variants
  3. Human variants curated from literature reports
    Index of human variants curated from literature reports
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
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