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UniProtKB - Q504Y0 (S39AC_HUMAN)

Entry version 106 (16 Oct 2019)
Sequence version 3 (30 Nov 2010)
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Protein

Zinc transporter ZIP12

Gene

SLC39A12

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Acts as a zinc-influx transporter (Potential). May be partly involved in the outbreak of schizophrenia.Curated

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processIon transport, Transport, Zinc transport
LigandZinc

Protein family/group databases

Transport Classification Database

More...TCDBi		2.A.5.4.14 the zinc (zn(2+))-iron (fe(2+)) permease (zip) family

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Zinc transporter ZIP12
Alternative name(s):
LIV-1 subfamily of ZIP zinc transporter 8
Short name:
LZT-Hs8
Solute carrier family 39 member 12
Zrt- and Irt-like protein 12
Short name:
ZIP-12
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:SLC39A12
Synonyms:ZIP12
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 10

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:20860 SLC39A12

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		608734 gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q504Y0

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the subcellular compartment where each non-membrane region of a membrane-spanning protein is found.<p><a href='/help/topo_dom' target='_top'>More...</a></p>Topological domaini1 – 202ExtracellularSequence analysisAdd BLAST202
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei203 – 223HelicalSequence analysisAdd BLAST21
Topological domaini224 – 369CytoplasmicSequence analysisAdd BLAST146
Transmembranei370 – 390HelicalSequence analysisAdd BLAST21
Topological domaini391 – 398ExtracellularSequence analysis8
Transmembranei399 – 419HelicalSequence analysisAdd BLAST21
Topological domaini420 – 448CytoplasmicSequence analysisAdd BLAST29
Transmembranei449 – 469HelicalSequence analysisAdd BLAST21
Topological domaini470 – 538ExtracellularSequence analysisAdd BLAST69
Transmembranei539 – 559HelicalSequence analysisAdd BLAST21
Topological domaini560 – 602CytoplasmicSequence analysisAdd BLAST43
Transmembranei603 – 623HelicalSequence analysisAdd BLAST21
Topological domaini624 – 631ExtracellularSequence analysis8
Transmembranei632 – 652HelicalSequence analysisAdd BLAST21
Topological domaini653 – 663CytoplasmicSequence analysisAdd BLAST11
Transmembranei664 – 684HelicalSequence analysisAdd BLAST21
Topological domaini685 – 691ExtracellularSequence analysis7

Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		221074

Open Targets

More...OpenTargetsi		ENSG00000148482

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134956205

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q504Y0

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		SLC39A12

Domain mapping of disease mutations (DMDM)

More...DMDMi		313104190

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003124971 – 691Zinc transporter ZIP12Add BLAST691

Proteomic databases

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q504Y0

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q504Y0

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q504Y0

PeptideAtlas

More...PeptideAtlasi		Q504Y0

PRoteomics IDEntifications database

More...PRIDEi		Q504Y0

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		24332
62411 [Q504Y0-1]
62412 [Q504Y0-2]
62413 [Q504Y0-3]
62414 [Q504Y0-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q504Y0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q504Y0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in brain and eye.2 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000148482 Expressed in 60 organ(s), highest expression level in pigmented layer of retina

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q504Y0 HS

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

More...BioGridi		128681, 81 interactors

Protein interaction database and analysis system

More...IntActi		Q504Y0, 70 interactors

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000366586

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q504Y0

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a short (usually not more than 20 amino acids) conserved sequence motif of biological significance.<p><a href='/help/motif' target='_top'>More...</a></p>Motifi580 – 585XEXPHE-motif6

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi116 – 119Poly-Leu4
Compositional biasi564 – 569Poly-Ser6
Compositional biasi677 – 682Poly-Leu6

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the ZIP transporter (TC 2.A.5) family. [View classification]Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2693 Eukaryota
COG0428 LUCA

Ensembl GeneTree

More...GeneTreei		ENSGT00940000157914

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q504Y0

KEGG Orthology (KO)

More...KOi		K14718

Identification of Orthologs from Complete Genome Data

More...OMAi		FFNSCQE

Database of Orthologous Groups

More...OrthoDBi		657777at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q504Y0

TreeFam database of animal gene trees

More...TreeFami		TF318470

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR003689 ZIP
IPR041137 ZIP4_N

Pfam protein domain database

More...Pfami		View protein in Pfam
PF02535 Zip, 1 hit
PF18292 ZIP4_domain, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (5)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 5 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket
Isoform 1 (identifier: Q504Y0-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MCFRTKLSVS WVPLFLLLSR VFSTETDKPS AQDSRSRGSS GQPADLLQVL 
        60         70         80         90        100
SAGDHPPHNH SRSLIKTLLE KTGCPRRRNG MQGDCNLCFE PDALLLIAGG 
       110        120        130        140        150
NFEDQLREEV VQRVSLLLLY YIIHQEEICS SKLNMSNKEY KFYLHSLLSL 
       160        170        180        190        200
RQDEDSSFLS QNETEDILAF TRQYFDTSQS QCMETKTLQK KSGIVSSEGA 
       210        220        230        240        250
NESTLPQLAA MIITLSLQGV CLGQGNLPSP DYFTEYIFSS LNRTNTLRLS 
       260        270        280        290        300
ELDQLLNTLW TRSTCIKNEK IHQFQRKQNN IITHDQDYSN FSSSMEKESE 
       310        320        330        340        350
DGPVSWDQTC FSARQLVEIF LQKGLSLISK EDFKQMSPGI IQQLLSCSCH 
       360        370        380        390        400
LPKDQQAKLP PTTLEKYGYS TVAVTLLTLG SMLGTALVLF HSCEENYRLI 
       410        420        430        440        450
LQLFVGLAVG TLSGDALLHL IPQVLGLHKQ EAPEFGHFHE SKGHIWKLMG 
       460        470        480        490        500
LIGGIHGFFL IEKCFILLVS PNDKQGLSLV NGHVGHSHHL ALNSELSDQA 
       510        520        530        540        550
GRGKSASTIQ LKSPEDSQAA EMPIGSMTAS NRKCKAISLL AIMILVGDSL 
       560        570        580        590        600
HNFADGLAIG AAFSSSSESG VTTTIAILCH EIPHEMGDFA VLLSSGLSMK 
       610        620        630        640        650
TAILMNFISS LTAFMGLYIG LSVSADPCVQ DWIFTVTAGM FLYLSLVEML 
       660        670        680        690 
PEMTHVQTQR PWMMFLLQNF GLILGWLSLL LLAIYEQNIK I
Length:691
Mass (Da):76,666
Last modified:November 30, 2010 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iEB5959BDFD229D04
GO
Isoform 2 (identifier: Q504Y0-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     343-407: QLLSCSCHLP...RLILQLFVGL → RWSFSIAVRR...SMKAKVIFGN
     408-691: Missing.

Note: No experimental confirmation available.
Show »
Length:404
Mass (Da):45,813
Checksum:i4B36E204882F93B2
GO
Isoform 3 (identifier: Q504Y0-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     475-511: Missing.

Note: No experimental confirmation available.
Show »
Length:654
Mass (Da):72,864
Checksum:i13C4765D5F82A708
GO
Isoform 4 (identifier: Q504Y0-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     475-475: Missing.

Note: No experimental confirmation available.
Show »
Length:690
Mass (Da):76,538
Checksum:iEBFE5BE2E8F4C877
GO
Isoform 5 (identifier: Q504Y0-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-134: Missing.

Show »
Length:557
Mass (Da):61,643
Checksum:iE3C90A4E5412F2F3
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti287D → G in BAB70848 (PubMed:14702039).Curated1
Sequence conflicti316L → R in AAH47635 (PubMed:15489334).Curated1
Sequence conflicti423Q → R in BAH12025 (PubMed:14702039).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03751636S → G2 PublicationsCorresponds to variant dbSNP:rs10764176Ensembl.1
Natural variantiVAR_037517244T → M. Corresponds to variant dbSNP:rs7899328Ensembl.1
Natural variantiVAR_037518304V → I1 PublicationCorresponds to variant dbSNP:rs2478568Ensembl.1
Natural variantiVAR_037519435F → L. Corresponds to variant dbSNP:rs11011935Ensembl.1
Natural variantiVAR_037520471P → T in a breast cancer sample; somatic mutation. 1 Publication1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0575941 – 134Missing in isoform 5. Add BLAST134
Alternative sequenceiVSP_029847343 – 407QLLSC…LFVGL → RWSFSIAVRRTTGLSYSCLW AWPSGHCLGTLCSTLSLRFL VYISRKPQNLGISMKAKVIF GN in isoform 2. 1 PublicationAdd BLAST65
Alternative sequenceiVSP_029848408 – 691Missing in isoform 2. 1 PublicationAdd BLAST284
Alternative sequenceiVSP_029849475 – 511Missing in isoform 3. 1 PublicationAdd BLAST37
Alternative sequenceiVSP_029850475Missing in isoform 4. Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AK055061 mRNA Translation: BAB70848.1
AK295294 mRNA Translation: BAH12025.1
AC069023 Genomic DNA No translation available.
AL360231 Genomic DNA No translation available.
AL590111 Genomic DNA No translation available.
BC035118 mRNA Translation: AAH35118.1
BC047635 mRNA Translation: AAH47635.1
BC065917 mRNA Translation: AAH65917.1
BC094700 mRNA Translation: AAH94700.1
BC117323 mRNA Translation: AAI17324.1
BC143551 mRNA Translation: AAI43552.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS44362.1 [Q504Y0-1]
CCDS60493.1 [Q504Y0-4]
CCDS60494.1 [Q504Y0-5]
CCDS7124.1 [Q504Y0-3]

NCBI Reference Sequences

More...RefSeqi		NP_001138667.1, NM_001145195.1 [Q504Y0-1]
NP_001269662.1, NM_001282733.1 [Q504Y0-4]
NP_001269663.1, NM_001282734.1 [Q504Y0-5]
NP_689938.2, NM_152725.3 [Q504Y0-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000377369; ENSP00000366586; ENSG00000148482 [Q504Y0-1]
ENST00000377371; ENSP00000366588; ENSG00000148482 [Q504Y0-4]
ENST00000377374; ENSP00000366591; ENSG00000148482 [Q504Y0-3]
ENST00000539911; ENSP00000440445; ENSG00000148482 [Q504Y0-5]

Database of genes from NCBI RefSeq genomes

More...GeneIDi		221074

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:221074

UCSC genome browser

More...UCSCi		uc001ipn.3 human [Q504Y0-1]
uc010qck.1 human

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK055061 mRNA Translation: BAB70848.1
AK295294 mRNA Translation: BAH12025.1
AC069023 Genomic DNA No translation available.
AL360231 Genomic DNA No translation available.
AL590111 Genomic DNA No translation available.
BC035118 mRNA Translation: AAH35118.1
BC047635 mRNA Translation: AAH47635.1
BC065917 mRNA Translation: AAH65917.1
BC094700 mRNA Translation: AAH94700.1
BC117323 mRNA Translation: AAI17324.1
BC143551 mRNA Translation: AAI43552.1
CCDSiCCDS44362.1 [Q504Y0-1]
CCDS60493.1 [Q504Y0-4]
CCDS60494.1 [Q504Y0-5]
CCDS7124.1 [Q504Y0-3]
RefSeqiNP_001138667.1, NM_001145195.1 [Q504Y0-1]
NP_001269662.1, NM_001282733.1 [Q504Y0-4]
NP_001269663.1, NM_001282734.1 [Q504Y0-5]
NP_689938.2, NM_152725.3 [Q504Y0-3]

3D structure databases

SMRiQ504Y0
ModBaseiSearch...

Protein-protein interaction databases

BioGridi128681, 81 interactors
IntActiQ504Y0, 70 interactors
STRINGi9606.ENSP00000366586

Protein family/group databases

TCDBi2.A.5.4.14 the zinc (zn(2+))-iron (fe(2+)) permease (zip) family

PTM databases

iPTMnetiQ504Y0
PhosphoSitePlusiQ504Y0

Polymorphism and mutation databases

BioMutaiSLC39A12
DMDMi313104190

Proteomic databases

jPOSTiQ504Y0
MassIVEiQ504Y0
PaxDbiQ504Y0
PeptideAtlasiQ504Y0
PRIDEiQ504Y0
ProteomicsDBi24332
62411 [Q504Y0-1]
62412 [Q504Y0-2]
62413 [Q504Y0-3]
62414 [Q504Y0-4]

Protocols and materials databases

The DNASU plasmid repository

More...DNASUi		221074

Genome annotation databases

EnsembliENST00000377369; ENSP00000366586; ENSG00000148482 [Q504Y0-1]
ENST00000377371; ENSP00000366588; ENSG00000148482 [Q504Y0-4]
ENST00000377374; ENSP00000366591; ENSG00000148482 [Q504Y0-3]
ENST00000539911; ENSP00000440445; ENSG00000148482 [Q504Y0-5]
GeneIDi221074
KEGGihsa:221074
UCSCiuc001ipn.3 human [Q504Y0-1]
uc010qck.1 human

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		221074
DisGeNETi221074

GeneCards: human genes, protein and diseases

More...GeneCardsi		SLC39A12
HGNCiHGNC:20860 SLC39A12
MIMi608734 gene
neXtProtiNX_Q504Y0
OpenTargetsiENSG00000148482
PharmGKBiPA134956205

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG2693 Eukaryota
COG0428 LUCA
GeneTreeiENSGT00940000157914
InParanoidiQ504Y0
KOiK14718
OMAiFFNSCQE
OrthoDBi657777at2759
PhylomeDBiQ504Y0
TreeFamiTF318470

Miscellaneous databases

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		221074
PharosiQ504Y0

Protein Ontology

More...PROi		PR:Q504Y0

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000148482 Expressed in 60 organ(s), highest expression level in pigmented layer of retina
GenevisibleiQ504Y0 HS

Family and domain databases

InterProiView protein in InterPro
IPR003689 ZIP
IPR041137 ZIP4_N
PfamiView protein in Pfam
PF02535 Zip, 1 hit
PF18292 ZIP4_domain, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiS39AC_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q504Y0
Secondary accession number(s): B7Z2Y9
, B7ZL35, C9JJL4, F5GX72, Q49AN8, Q4G0L3, Q5VWV8, Q5VWV9, Q6NZY5, Q96NN4
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 4, 2007
Last sequence update: November 30, 2010
Last modified: October 16, 2019
This is version 106 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. Human chromosome 10
    Human chromosome 10: entries, gene names and cross-references to MIM
  5. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
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