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Entry version 104 (12 Aug 2020)
Sequence version 1 (07 Jun 2005)
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Protein

Renal cancer differentiation gene 1 protein

Gene

C4orf46

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...
PathwayCommonsi
Q504U0

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Renal cancer differentiation gene 1 protein1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:C4orf46
Synonyms:RCDG1
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
HostDB:ENSG00000205208.4

Human Gene Nomenclature Database

More...
HGNCi
HGNC:27320, C4orf46

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
616210, gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q504U0

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
201725

Open Targets

More...
OpenTargetsi
ENSG00000205208

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA162379968

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q504U0, Tdark

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
C4orf46

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74740214

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003356891 – 113Renal cancer differentiation gene 1 proteinAdd BLAST113

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q504U0

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q504U0

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q504U0

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q504U0

PeptideAtlas

More...
PeptideAtlasi
Q504U0

PRoteomics IDEntifications database

More...
PRIDEi
Q504U0

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
62404

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q504U0

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q504U0

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified 'at protein level'.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in the kidney, in epithelial cells in both proximal tubules and distal convoluted tubules.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000205208, Expressed in testis and 180 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q504U0, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q504U0, HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
ENSG00000205208, Tissue enhanced (lymphoid)

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the '<a href="http://www.uniprot.org/help/interaction%5Fsection">Interaction</a>' section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="https://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated at every <a href="http://www.uniprot.org/help/synchronization">UniProt release</a>.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsi

Hide details

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...
BioGRIDi
128401, 8 interactors

Protein interaction database and analysis system

More...
IntActi
Q504U0, 10 interactors

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000368503

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q504U0, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q504U0

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502SUFC, Eukaryota

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000003125

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_171943_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q504U0

Identification of Orthologs from Complete Genome Data

More...
OMAi
FKCMENA

Database of Orthologous Groups

More...
OrthoDBi
1562931at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q504U0

TreeFam database of animal gene trees

More...
TreeFami
TF338687

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR031457, RCDG1

The PANTHER Classification System

More...
PANTHERi
PTHR31641, PTHR31641, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15725, RCDG1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequence (1+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry has 1 described isoform and 1 potential isoform that is computationally mapped.Show allAlign All

Q504U0-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MADPEELQVS SPPPPPPSSP SSSDASAASS PGGPVSLGWP VPSRSSGPTV
60 70 80 90 100
DQLEEVELQI GDAAFSLTKL LEATSAVSAQ VEELAFKCTE NARFLKTWRD
110
LLKEGYDSLK PDD
Length:113
Mass (Da):11,899
Last modified:June 7, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i6FE4325ED2C2CAB2
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There is 1 potential isoform mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
D6RFF4D6RFF4_HUMAN
Renal cancer differentiation gene 1...
C4orf46
65Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK027539 mRNA Translation: BAG51339.1
AK074948 mRNA Translation: BAG52038.1
CH471056 Genomic DNA Translation: EAX04855.1
BC065017 mRNA Translation: AAH65017.1
BC094775 mRNA Translation: AAH94775.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS34088.1

NCBI Reference Sequences

More...
RefSeqi
NP_001008394.1, NM_001008393.3

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENST00000379205; ENSP00000368503; ENSG00000205208

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
201725

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
hsa:201725

UCSC genome browser

More...
UCSCi
uc003iqa.4, human

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK027539 mRNA Translation: BAG51339.1
AK074948 mRNA Translation: BAG52038.1
CH471056 Genomic DNA Translation: EAX04855.1
BC065017 mRNA Translation: AAH65017.1
BC094775 mRNA Translation: AAH94775.1
CCDSiCCDS34088.1
RefSeqiNP_001008394.1, NM_001008393.3

3D structure databases

SMRiQ504U0
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi128401, 8 interactors
IntActiQ504U0, 10 interactors
STRINGi9606.ENSP00000368503

PTM databases

iPTMnetiQ504U0
PhosphoSitePlusiQ504U0

Polymorphism and mutation databases

BioMutaiC4orf46
DMDMi74740214

Proteomic databases

EPDiQ504U0
MassIVEiQ504U0
MaxQBiQ504U0
PaxDbiQ504U0
PeptideAtlasiQ504U0
PRIDEiQ504U0
ProteomicsDBi62404

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
53666, 131 antibodies

Genome annotation databases

EnsembliENST00000379205; ENSP00000368503; ENSG00000205208
GeneIDi201725
KEGGihsa:201725
UCSCiuc003iqa.4, human

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
201725
DisGeNETi201725
EuPathDBiHostDB:ENSG00000205208.4

GeneCards: human genes, protein and diseases

More...
GeneCardsi
C4orf46
HGNCiHGNC:27320, C4orf46
HPAiENSG00000205208, Tissue enhanced (lymphoid)
MIMi616210, gene
neXtProtiNX_Q504U0
OpenTargetsiENSG00000205208
PharmGKBiPA162379968

GenAtlas: human gene database

More...
GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG502SUFC, Eukaryota
GeneTreeiENSGT00390000003125
HOGENOMiCLU_171943_0_0_1
InParanoidiQ504U0
OMAiFKCMENA
OrthoDBi1562931at2759
PhylomeDBiQ504U0
TreeFamiTF338687

Enzyme and pathway databases

PathwayCommonsiQ504U0

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
201725, 11 hits in 861 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
C4orf46, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...
GenomeRNAii
201725
PharosiQ504U0, Tdark

Protein Ontology

More...
PROi
PR:Q504U0
RNActiQ504U0, protein

The Stanford Online Universal Resource for Clones and ESTs

More...
SOURCEi
Search...

Gene expression databases

BgeeiENSG00000205208, Expressed in testis and 180 other tissues
ExpressionAtlasiQ504U0, baseline and differential
GenevisibleiQ504U0, HS

Family and domain databases

InterProiView protein in InterPro
IPR031457, RCDG1
PANTHERiPTHR31641, PTHR31641, 1 hit
PfamiView protein in Pfam
PF15725, RCDG1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiCD046_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q504U0
Secondary accession number(s): B3KNH7
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 20, 2008
Last sequence update: June 7, 2005
Last modified: August 12, 2020
This is version 104 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  2. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
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