Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Midnolin

Gene

MIDN

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Facilitates ubiquitin-independent proteasomal degradation of polycomb protein CBX4. Plays a role in inhibiting the activity of glucokinase GCK and both glucose-induced and basal insulin secretion.By similarity

GO - Molecular functioni

  • kinase binding Source: UniProtKB

GO - Biological processi

Names & Taxonomyi

Protein namesi
Recommended name:
Midnolin
Alternative name(s):
Midbrain nucleolar protein
Gene namesi
Name:MIDN
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

EuPathDBiHostDB:ENSG00000167470.12
HGNCiHGNC:16298 MIDN
MIMi606700 gene
neXtProtiNX_Q504T8

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000167470
PharmGKBiPA30818

Polymorphism and mutation databases

BioMutaiMIDN
DMDMi296437369

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002875361 – 468MidnolinAdd BLAST468

Proteomic databases

EPDiQ504T8
PaxDbiQ504T8
PeptideAtlasiQ504T8
PRIDEiQ504T8
ProteomicsDBi62403

PTM databases

iPTMnetiQ504T8
PhosphoSitePlusiQ504T8

Expressioni

Gene expression databases

BgeeiENSG00000167470 Expressed in 197 organ(s), highest expression level in heart left ventricle
CleanExiHS_MIDN
ExpressionAtlasiQ504T8 baseline and differential
GenevisibleiQ504T8 HS

Organism-specific databases

HPAiHPA042018
HPA049432

Interactioni

Subunit structurei

Interacts with GCK; the interaction occurs preferentially at low glucose levels.1 Publication

GO - Molecular functioni

Protein-protein interaction databases

BioGridi124652, 9 interactors
IntActiQ504T8, 8 interactors
MINTiQ504T8
STRINGi9606.ENSP00000300952

Structurei

3D structure databases

ProteinModelPortaliQ504T8
SMRiQ504T8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini31 – 105Ubiquitin-likePROSITE-ProRule annotationAdd BLAST75

Phylogenomic databases

eggNOGiENOG410IE7U Eukaryota
ENOG410XNUB LUCA
GeneTreeiENSGT00510000049027
HOGENOMiHOG000072693
HOVERGENiHBG098000
InParanoidiQ504T8
OMAiMEPQPGG
OrthoDBiEOG091G0X8V
PhylomeDBiQ504T8
TreeFamiTF329735

Family and domain databases

InterProiView protein in InterPro
IPR039336 Midnolin
IPR029071 Ubiquitin-like_domsf
IPR000626 Ubiquitin_dom
PANTHERiPTHR23010 PTHR23010, 1 hit
PfamiView protein in Pfam
PF00240 ubiquitin, 1 hit
SMARTiView protein in SMART
SM00213 UBQ, 1 hit
SUPFAMiSSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS50053 UBIQUITIN_2, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q504T8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MEPQPGGARS CRRGAPGGAC ELGPAAEAAP MSLAIHSTTG TRYDLAVPPD
60 70 80 90 100
ETVEGLRKRL SQRLKVPKER LALLHKDTRL SSGKLQEFGV GDGSKLTLVP
110 120 130 140 150
TVEAGLMSQA SRPEQSVMQA LESLTETQVS DFLSGRSPLT LALRVGDHMM
160 170 180 190 200
FVQLQLAAQH APLQHRHVLA AAAAAAAARG DPSIASPVSS PCRPVSSAAR
210 220 230 240 250
VPPVPTSPSP ASPSPITAGS FRSHAASTTC PEQMDCSPTA SSSASPGAST
260 270 280 290 300
TSTPGASPAP RSRKPGAVIE SFVNHAPGVF SGTFSGTLHP NCQDSSGRPR
310 320 330 340 350
RDIGTILQIL NDLLSATRHY QGMPPSLAQL RCHAQCSPAS PAPDLAPRTT
360 370 380 390 400
SCEKLTAAPS ASLLQGQSQI RMCKPPGDRL RQTENRATRC KVERLQLLLQ
410 420 430 440 450
QKRLRRKARR DARGPYHWSP SRKAGRSDSS SSGGGGSPSE ASGLGLDFED
460
SVWKPEVNPD IKSEFVVA
Length:468
Mass (Da):49,213
Last modified:May 18, 2010 - v2
Checksum:iE4086F3B6E16C4C2
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
K7END3K7END3_HUMAN
Midnolin
MIDN
216Annotation score:
K7EN89K7EN89_HUMAN
Midnolin
MIDN
139Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti457V → A in AAH94778 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC015089 mRNA Translation: AAH15089.2
BC094778 mRNA Translation: AAH94778.1
CCDSiCCDS32864.1
RefSeqiNP_796375.3, NM_177401.4
UniGeneiHs.465529

Genome annotation databases

EnsembliENST00000300952; ENSP00000300952; ENSG00000167470
ENST00000591446; ENSP00000467679; ENSG00000167470
GeneIDi90007
KEGGihsa:90007
UCSCiuc002lrp.4 human

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC015089 mRNA Translation: AAH15089.2
BC094778 mRNA Translation: AAH94778.1
CCDSiCCDS32864.1
RefSeqiNP_796375.3, NM_177401.4
UniGeneiHs.465529

3D structure databases

ProteinModelPortaliQ504T8
SMRiQ504T8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi124652, 9 interactors
IntActiQ504T8, 8 interactors
MINTiQ504T8
STRINGi9606.ENSP00000300952

PTM databases

iPTMnetiQ504T8
PhosphoSitePlusiQ504T8

Polymorphism and mutation databases

BioMutaiMIDN
DMDMi296437369

Proteomic databases

EPDiQ504T8
PaxDbiQ504T8
PeptideAtlasiQ504T8
PRIDEiQ504T8
ProteomicsDBi62403

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000300952; ENSP00000300952; ENSG00000167470
ENST00000591446; ENSP00000467679; ENSG00000167470
GeneIDi90007
KEGGihsa:90007
UCSCiuc002lrp.4 human

Organism-specific databases

CTDi90007
EuPathDBiHostDB:ENSG00000167470.12
GeneCardsiMIDN
HGNCiHGNC:16298 MIDN
HPAiHPA042018
HPA049432
MIMi606700 gene
neXtProtiNX_Q504T8
OpenTargetsiENSG00000167470
PharmGKBiPA30818
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IE7U Eukaryota
ENOG410XNUB LUCA
GeneTreeiENSGT00510000049027
HOGENOMiHOG000072693
HOVERGENiHBG098000
InParanoidiQ504T8
OMAiMEPQPGG
OrthoDBiEOG091G0X8V
PhylomeDBiQ504T8
TreeFamiTF329735

Miscellaneous databases

ChiTaRSiMIDN human
GenomeRNAii90007
PROiPR:Q504T8
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000167470 Expressed in 197 organ(s), highest expression level in heart left ventricle
CleanExiHS_MIDN
ExpressionAtlasiQ504T8 baseline and differential
GenevisibleiQ504T8 HS

Family and domain databases

InterProiView protein in InterPro
IPR039336 Midnolin
IPR029071 Ubiquitin-like_domsf
IPR000626 Ubiquitin_dom
PANTHERiPTHR23010 PTHR23010, 1 hit
PfamiView protein in Pfam
PF00240 ubiquitin, 1 hit
SMARTiView protein in SMART
SM00213 UBQ, 1 hit
SUPFAMiSSF54236 SSF54236, 1 hit
PROSITEiView protein in PROSITE
PS50053 UBIQUITIN_2, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiMIDN_HUMAN
AccessioniPrimary (citable) accession number: Q504T8
Secondary accession number(s): Q96BW8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: May 18, 2010
Last modified: September 12, 2018
This is version 100 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again