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Protein

C-type lectin domain family 12 member A

Gene

Clec12a

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Cell surface receptor that modulates signaling cascades and mediates tyrosine phosphorylation of target MAP kinases.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionReceptor
LigandLectin

Names & Taxonomyi

Protein namesi
Recommended name:
C-type lectin domain family 12 member A
Alternative name(s):
C-type lectin-like molecule 1
Short name:
CLL-1
Myeloid inhibitory C-type lectin-like receptor
Short name:
MICL
CD_antigen: CD371
Gene namesi
Name:Clec12a
Synonyms:Micl
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:3040968 Clec12a

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 43CytoplasmicSequence analysisAdd BLAST43
Transmembranei44 – 64Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST21
Topological domaini65 – 267ExtracellularSequence analysisAdd BLAST203

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003135791 – 267C-type lectin domain family 12 member AAdd BLAST267

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi98N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi105N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi161 ↔ 246By similarity
Glycosylationi165N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi225 ↔ 238By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

MaxQBiQ504P2
PaxDbiQ504P2
PRIDEiQ504P2

PTM databases

iPTMnetiQ504P2
PhosphoSitePlusiQ504P2

Expressioni

Gene expression databases

CleanExiMM_CLEC12A

Interactioni

Subunit structurei

Interacts with PTPN6 and PTPN11.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000063627

Structurei

3D structure databases

ProteinModelPortaliQ504P2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini140 – 247C-type lectinAdd BLAST108

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi5 – 10ITIM motif6

Domaini

Keywords - Domaini

Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG4297 Eukaryota
ENOG410XPJ1 LUCA
HOGENOMiHOG000111777
HOVERGENiHBG107715
InParanoidiQ504P2
KOiK17516
PhylomeDBiQ504P2
TreeFamiTF336674

Family and domain databases

CDDicd03593 CLECT_NK_receptors_like, 1 hit
Gene3Di3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR016187 CTDL_fold
IPR033992 NKR-like_CTLD
PfamiView protein in Pfam
PF00059 Lectin_C, 1 hit
SMARTiView protein in SMART
SM00034 CLECT, 1 hit
SUPFAMiSSF56436 SSF56436, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q504P2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSEEIVYANL KIQDPDKKEE TQKSDKCGGK VSADASHSQQ KTVLILILLC
60 70 80 90 100
LLLFIGMGVL GGIFYTTLAT EMIKSNQLQR AKEELQENVF LQLKHNLNSS
110 120 130 140 150
KKIKNLSAML QSTATQLCRE LYSKEPEHKC KPCPKGSEWY KDSCYSQLNQ
160 170 180 190 200
YGTWQESVMA CSARNASLLK VKNKDVLEFI KYKKLRYFWL ALLPRKDRTQ
210 220 230 240 250
YPLSEKMFLS EESERSTDDI DKKYCGYIDR VNVYYTYCTD ENNIICEETA
260
SKVQLESVLN GLPEDSR
Length:267
Mass (Da):30,757
Last modified:June 7, 2005 - v1
Checksum:i2958572936E4A35D
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0R4J0T2A0A0R4J0T2_MOUSE
C-type lectin domain family 12 memb...
Clec12a mCG_142101
267Annotation score:
D3YXD8D3YXD8_MOUSE
C-type lectin domain family 12 memb...
Clec12a
179Annotation score:

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti90F → S in BAC39163 (PubMed:16141072).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK084335 mRNA Translation: BAC39163.1
BC094904 mRNA Translation: AAH94904.1
CCDSiCCDS20584.1
RefSeqiNP_808354.1, NM_177686.4
XP_011239625.1, XM_011241323.2
UniGeneiMm.90241

Genome annotation databases

GeneIDi232413
KEGGimmu:232413
UCSCiuc009efl.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK084335 mRNA Translation: BAC39163.1
BC094904 mRNA Translation: AAH94904.1
CCDSiCCDS20584.1
RefSeqiNP_808354.1, NM_177686.4
XP_011239625.1, XM_011241323.2
UniGeneiMm.90241

3D structure databases

ProteinModelPortaliQ504P2
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000063627

PTM databases

iPTMnetiQ504P2
PhosphoSitePlusiQ504P2

Proteomic databases

MaxQBiQ504P2
PaxDbiQ504P2
PRIDEiQ504P2

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi232413
KEGGimmu:232413
UCSCiuc009efl.2 mouse

Organism-specific databases

CTDi160364
MGIiMGI:3040968 Clec12a

Phylogenomic databases

eggNOGiKOG4297 Eukaryota
ENOG410XPJ1 LUCA
HOGENOMiHOG000111777
HOVERGENiHBG107715
InParanoidiQ504P2
KOiK17516
PhylomeDBiQ504P2
TreeFamiTF336674

Miscellaneous databases

PROiPR:Q504P2
SOURCEiSearch...

Gene expression databases

CleanExiMM_CLEC12A

Family and domain databases

CDDicd03593 CLECT_NK_receptors_like, 1 hit
Gene3Di3.10.100.10, 1 hit
InterProiView protein in InterPro
IPR001304 C-type_lectin-like
IPR016186 C-type_lectin-like/link_sf
IPR016187 CTDL_fold
IPR033992 NKR-like_CTLD
PfamiView protein in Pfam
PF00059 Lectin_C, 1 hit
SMARTiView protein in SMART
SM00034 CLECT, 1 hit
SUPFAMiSSF56436 SSF56436, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiCL12A_MOUSE
AccessioniPrimary (citable) accession number: Q504P2
Secondary accession number(s): Q8BN96
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: June 7, 2005
Last modified: October 10, 2018
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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