Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Ras-related protein Rab-26

Gene

Rab26

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

The small GTPases Rab are key regulators of intracellular membrane trafficking, from the formation of transport vesicles to their fusion with membranes. Rabs cycle between an inactive GDP-bound form and an active GTP-bound form that is able to recruit to membranes different set of downstream effectors directly responsible for vesicle formation, movement, tethering and fusion. Mediates transport of ADRA2A and ADRA2B from the Golgi to the cell membrane. Plays a role in the maturation of zymogenic granules and in pepsinogen secretion in the stomach (By similarity). Plays a role in the secretion of amylase from acinar granules in the parotid gland.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi74 – 82GTPBy similarity9
Nucleotide bindingi123 – 127GTPBy similarity5
Nucleotide bindingi181 – 184GTPBy similarity4
Nucleotide bindingi211 – 213GTPBy similarity3

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processProtein transport, Transport
LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-MMU-8873719 RAB geranylgeranylation

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-related protein Rab-26
Gene namesi
Name:Rab26
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:2443284 Rab26

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasmic vesicle, Golgi apparatus, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001212191 – 260Ras-related protein Rab-26Add BLAST260

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Lipidationi257S-geranylgeranyl cysteineBy similarity1
Lipidationi258S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Prenylation

Proteomic databases

MaxQBiQ504M8
PaxDbiQ504M8
PRIDEiQ504M8

PTM databases

iPTMnetiQ504M8
PhosphoSitePlusiQ504M8

Expressioni

Tissue specificityi

Detected in zymogenic cells in the stomach.1 Publication

Gene expression databases

BgeeiENSMUSG00000079657 Expressed in 80 organ(s), highest expression level in brain
CleanExiMM_RAB26
ExpressionAtlasiQ504M8 baseline and differential
GenevisibleiQ504M8 MM

Interactioni

Subunit structurei

Interacts with ADRA2B (By similarity). Interacts with RIMS1.By similarity1 Publication

Protein-protein interaction databases

BioGridi236652, 1 interactor
IntActiQ504M8, 2 interactors
STRINGi10090.ENSMUSP00000046089

Structurei

3D structure databases

ProteinModelPortaliQ504M8
SMRiQ504M8
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi97 – 105Effector regionBy similarity9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rab family.Curated

Phylogenomic databases

eggNOGiKOG0083 Eukaryota
ENOG410Z9H6 LUCA
GeneTreeiENSGT00900000140786
HOGENOMiHOG000233968
HOVERGENiHBG009351
InParanoidiQ504M8
KOiK07913
PhylomeDBiQ504M8
TreeFamiTF323428

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51419 RAB, 1 hit

Sequence (1+)i

Sequence statusi: Complete.

This entry has 1 described isoform and 2 potential isoforms that are computationally mapped.Show allAlign All

Q504M8-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSRKKTPKSK GGSEPATSTL PAAAAATNGP RLAHPRTVRP GPEAPPNGPP
60 70 80 90 100
QSIRPSLGST GDFYDVAFKV MLVGDSGVGK TCLLVRFKDG AFLAGTFIST
110 120 130 140 150
VGIDFRNKVL DVDGMKVKLQ IWDTAGQERF RSVTHAYYRD AHALLLLYDI
160 170 180 190 200
TNKDSFDNIQ AWLTEIQEYA QQDVVLMLLG NKVDSTQDRV VKREDGEKLA
210 220 230 240 250
KEYGLPFMET SARTGLNVDL AFTAIAKELK QRSAKAPSEP RFRLHDYVKR
260
EGRGVSCCRL
Length:260
Mass (Da):28,619
Last modified:June 7, 2005 - v1
Checksum:i3657E725B1D004E8
GO

Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
H3BLG3H3BLG3_MOUSE
Ras-related protein Rab-26
Rab26
295Annotation score:
Q8BNU1Q8BNU1_MOUSE
Ras-related protein Rab-26
Rab26
197Annotation score:

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC094931 mRNA Translation: AAH94931.1
CCDSiCCDS50016.1
RefSeqiNP_796349.1, NM_177375.1
UniGeneiMm.266033

Genome annotation databases

EnsembliENSMUST00000035797; ENSMUSP00000046089; ENSMUSG00000079657
GeneIDi328778
KEGGimmu:328778
UCSCiuc008awu.2 mouse

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC094931 mRNA Translation: AAH94931.1
CCDSiCCDS50016.1
RefSeqiNP_796349.1, NM_177375.1
UniGeneiMm.266033

3D structure databases

ProteinModelPortaliQ504M8
SMRiQ504M8
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi236652, 1 interactor
IntActiQ504M8, 2 interactors
STRINGi10090.ENSMUSP00000046089

PTM databases

iPTMnetiQ504M8
PhosphoSitePlusiQ504M8

Proteomic databases

MaxQBiQ504M8
PaxDbiQ504M8
PRIDEiQ504M8

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000035797; ENSMUSP00000046089; ENSMUSG00000079657
GeneIDi328778
KEGGimmu:328778
UCSCiuc008awu.2 mouse

Organism-specific databases

CTDi25837
MGIiMGI:2443284 Rab26

Phylogenomic databases

eggNOGiKOG0083 Eukaryota
ENOG410Z9H6 LUCA
GeneTreeiENSGT00900000140786
HOGENOMiHOG000233968
HOVERGENiHBG009351
InParanoidiQ504M8
KOiK07913
PhylomeDBiQ504M8
TreeFamiTF323428

Enzyme and pathway databases

ReactomeiR-MMU-8873719 RAB geranylgeranylation

Miscellaneous databases

ChiTaRSiRab26 mouse
PROiPR:Q504M8
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000079657 Expressed in 80 organ(s), highest expression level in brain
CleanExiMM_RAB26
ExpressionAtlasiQ504M8 baseline and differential
GenevisibleiQ504M8 MM

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51419 RAB, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiRAB26_MOUSE
AccessioniPrimary (citable) accession number: Q504M8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: June 7, 2005
Last modified: October 10, 2018
This is version 119 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again