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UniProtKB - Q504L7 (ZN574_RAT)
Protein
Zinc finger protein 574
Gene
Znf574
Organism
Rattus norvegicus (Rat)
Status
Functioni
May be involved in transcriptional regulation.
Regions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 16 – 38 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 76 – 98 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 126 – 148 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 213 – 235 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 310 – 332 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 337 – 359 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 365 – 387 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 393 – 414 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 22 | |
Zinc fingeri | 467 – 490 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 496 – 518 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 524 – 546 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 552 – 574 | C2H2-type 12PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 580 – 602 | C2H2-type 13PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 608 – 631 | C2H2-type 14PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 637 – 660 | C2H2-type 15; degeneratePROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 668 – 690 | C2H2-type 16PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 740 – 762 | C2H2-type 17PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 768 – 790 | C2H2-type 18PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 796 – 818 | C2H2-type 19PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 824 – 846 | C2H2-type 20PROSITE-ProRule annotationAdd BLAST | 23 |
GO - Molecular functioni
- DNA-binding transcription activator activity, RNA polymerase II-specific Source: GO_Central
- metal ion binding Source: UniProtKB-KW
- RNA polymerase II cis-regulatory region sequence-specific DNA binding Source: GO_Central
GO - Biological processi
- regulation of transcription by RNA polymerase II Source: GO_Central
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: Zinc finger protein 574 |
Gene namesi | Name:Znf574 Synonyms:Zfp574 |
Organismi | Rattus norvegicus (Rat) |
Taxonomic identifieri | 10116 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Myomorpha › Muroidea › Muridae › Murinae › Rattus |
Proteomesi |
|
Organism-specific databases
RGDi | 1311420, Zfp574 |
Subcellular locationi
Nucleus
- Nucleus Curated
Nucleus
- nucleus Source: GO_Central
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000274865 | 1 – 898 | Zinc finger protein 574Add BLAST | 898 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 164 | PhosphoserineBy similarity | 1 | |
Modified residuei | 301 | PhosphoserineBy similarity | 1 | |
Modified residuei | 719 | PhosphoserineBy similarity | 1 | |
Modified residuei | 726 | PhosphothreonineBy similarity | 1 | |
Modified residuei | 834 | Asymmetric dimethylarginineBy similarity | 1 |
Keywords - PTMi
Methylation, PhosphoproteinProteomic databases
PaxDbi | Q504L7 |
Expressioni
Gene expression databases
Bgeei | ENSRNOG00000055761, Expressed in testis and 21 other tissues |
Genevisiblei | Q504L7, RN |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 243 – 305 | DisorderedSequence analysisAdd BLAST | 63 | |
Regioni | 417 – 460 | DisorderedSequence analysisAdd BLAST | 44 | |
Regioni | 691 – 735 | DisorderedSequence analysisAdd BLAST | 45 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 273 – 299 | Basic and acidic residuesSequence analysisAdd BLAST | 27 | |
Compositional biasi | 421 – 435 | Pro residuesSequence analysisAdd BLAST | 15 |
Sequence similaritiesi
Belongs to the krueppel C2H2-type zinc-finger protein family.Curated
Zinc finger
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Zinc fingeri | 16 – 38 | C2H2-type 1PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 76 – 98 | C2H2-type 2PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 126 – 148 | C2H2-type 3PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 213 – 235 | C2H2-type 4PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 310 – 332 | C2H2-type 5PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 337 – 359 | C2H2-type 6PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 365 – 387 | C2H2-type 7PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 393 – 414 | C2H2-type 8PROSITE-ProRule annotationAdd BLAST | 22 | |
Zinc fingeri | 467 – 490 | C2H2-type 9PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 496 – 518 | C2H2-type 10PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 524 – 546 | C2H2-type 11PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 552 – 574 | C2H2-type 12PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 580 – 602 | C2H2-type 13PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 608 – 631 | C2H2-type 14PROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 637 – 660 | C2H2-type 15; degeneratePROSITE-ProRule annotationAdd BLAST | 24 | |
Zinc fingeri | 668 – 690 | C2H2-type 16PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 740 – 762 | C2H2-type 17PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 768 – 790 | C2H2-type 18PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 796 – 818 | C2H2-type 19PROSITE-ProRule annotationAdd BLAST | 23 | |
Zinc fingeri | 824 – 846 | C2H2-type 20PROSITE-ProRule annotationAdd BLAST | 23 |
Keywords - Domaini
Repeat, Zinc-fingerPhylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000161799 |
HOGENOMi | CLU_002678_24_1_1 |
InParanoidi | Q504L7 |
OMAi | PQRFECG |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q504L7 |
TreeFami | TF350791 |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 5 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 20 hits |
SUPFAMi | SSF57667, SSF57667, 11 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 18 hits PS50157, ZINC_FINGER_C2H2_2, 19 hits |
i Sequence
Sequence statusi: Complete.
Q504L7-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTEESEETVL YIEHRYVCSE CNQLYGSLEE VLVHQNSHVP QQHFELVGVA
60 70 80 90 100
DPGVTVATEA TSGTGLYQTL IQESQYQCLE CGQLLLSPSQ LLEHQELHLK
110 120 130 140 150
MMAPQEAVPA EPPPKVPPLS SSTIHYECVD CKALFASQEM WLSHRQTHLR
160 170 180 190 200
ATPNKAPAPV VLGSPVVLGP PVGQARVAVE HSYRKAEEGG EGAAVPSVAA
210 220 230 240 250
ATEMVTEVEL LLYKCSECSQ LFQMPADFLE HQATHFPAPV PEAEEPATQQ
260 270 280 290 300
ETLVPSPTEA AVSQPDPLPA SDHSYELRNE LRNGEAMGRD RRGRKPRRSS
310 320 330 340 350
SGESGATQEL FCSACDQIFL SPHQLQQHLR SHREGVFKCP LCSRVFPSPS
360 370 380 390 400
SLDQHLGDHS SESHFLCVDC GLAFGTEALL LAHRRAHTPN PLHSCPCGKT
410 420 430 440 450
FVNLTKFLYH RRTHGAGGVP LPTTPVPPEE PAISFPEPAP AETGELEAPE
460 470 480 490 500
LPVSEESSAE PAAPGTYRCL LCSREFSKAL QLTRHQRFVH RLERRHKCSI
510 520 530 540 550
CGKMFKKKSH VRNHLRTHTG ERPFPCPDCS KPFNSPANLA RHRLTHTGER
560 570 580 590 600
PYRCGDCGKA FTQSSTLRQH RLVHAQHFPY RCQECGVRFH RPYRLLMHRY
610 620 630 640 650
HHTGEYPYKC RECPRSFLLR RLLEVHQLVV HAGRQPHRCP SCGAAFPSSL
660 670 680 690 700
RLREHRCAAA AAQAPRRFEC GTCGKKVGSA ARLQAHEAAH AAAGPGEVLA
710 720 730 740 750
KEPPAPRAAR ATRTPVAPSP TALGGTTSAA PAAPARRRGL ECSECKKLFS
760 770 780 790 800
TETSLQVHRR IHTGERPYPC PDCGKAFRQS THLKDHRRLH TGERPFACEV
810 820 830 840 850
CGKAFAISMR LAEHRRIHTG ERPYSCPDCG KSYRSFSNLW KHRKTHQQQH
860 870 880 890
QAAVRQQLAE AEAAVGLAVM ETAVEALPLV EAIEIYPLAE ADGVQISG
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC094953 mRNA Translation: AAH94953.1 |
RefSeqi | NP_001019429.1, NM_001024258.1 XP_008757152.1, XM_008758930.1 XP_008757153.1, XM_008758931.2 |
Genome annotation databases
Ensembli | ENSRNOT00000079847; ENSRNOP00000070796; ENSRNOG00000055761 |
GeneIDi | 308434 |
KEGGi | rno:308434 |
UCSCi | RGD:1311420, rat |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC094953 mRNA Translation: AAH94953.1 |
RefSeqi | NP_001019429.1, NM_001024258.1 XP_008757152.1, XM_008758930.1 XP_008757153.1, XM_008758931.2 |
3D structure databases
SMRi | Q504L7 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 10116.ENSRNOP00000061367 |
Proteomic databases
PaxDbi | Q504L7 |
Genome annotation databases
Ensembli | ENSRNOT00000079847; ENSRNOP00000070796; ENSRNOG00000055761 |
GeneIDi | 308434 |
KEGGi | rno:308434 |
UCSCi | RGD:1311420, rat |
Organism-specific databases
CTDi | 232976 |
RGDi | 1311420, Zfp574 |
Phylogenomic databases
eggNOGi | KOG1721, Eukaryota |
GeneTreei | ENSGT00940000161799 |
HOGENOMi | CLU_002678_24_1_1 |
InParanoidi | Q504L7 |
OMAi | PQRFECG |
OrthoDBi | 1318335at2759 |
PhylomeDBi | Q504L7 |
TreeFami | TF350791 |
Miscellaneous databases
PROi | PR:Q504L7 |
Gene expression databases
Bgeei | ENSRNOG00000055761, Expressed in testis and 21 other tissues |
Genevisiblei | Q504L7, RN |
Family and domain databases
InterProi | View protein in InterPro IPR036236, Znf_C2H2_sf IPR013087, Znf_C2H2_type |
Pfami | View protein in Pfam PF00096, zf-C2H2, 5 hits |
SMARTi | View protein in SMART SM00355, ZnF_C2H2, 20 hits |
SUPFAMi | SSF57667, SSF57667, 11 hits |
PROSITEi | View protein in PROSITE PS00028, ZINC_FINGER_C2H2_1, 18 hits PS50157, ZINC_FINGER_C2H2_2, 19 hits |
MobiDBi | Search... |
Entry informationi
Entry namei | ZN574_RAT | |
Accessioni | Q504L7Primary (citable) accession number: Q504L7 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | February 6, 2007 |
Last sequence update: | June 7, 2005 | |
Last modified: | February 23, 2022 | |
This is version 110 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families