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Protein

ATPase family AAA domain-containing protein 1-B

Gene

atad1b

Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

ATPase that plays a critical role in regulating the surface expression of AMPA receptors (AMPAR). Required for NMDA-stimulated AMPAR internalization in an ATPase-dependent manner (By similarity).By similarity

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi137 – 144ATPSequence analysis8

GO - Molecular functioni

Keywordsi

Molecular functionHydrolase
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ATPase family AAA domain-containing protein 1-B (EC:3.6.1.3)
Gene namesi
Name:atad1b
ORF Names:si:bz1g13.1, zgc:110042
OrganismiDanio rerio (Zebrafish) (Brachydanio rerio)
Taxonomic identifieri7955 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiActinopterygiiNeopterygiiTeleosteiOstariophysiCypriniformesCyprinidaeDanio
Proteomesi
  • UP000000437 Componenti: Chromosome 12

Organism-specific databases

ZFINiZDB-GENE-030616-44 atad1b

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell junction, Cell membrane, Membrane, Peroxisome, Postsynaptic cell membrane, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000847951 – 362ATPase family AAA domain-containing protein 1-BAdd BLAST362

Proteomic databases

PaxDbiQ503W7

Expressioni

Gene expression databases

BgeeiENSDARG00000056609

Interactioni

Protein-protein interaction databases

STRINGi7955.ENSDARP00000073585

Structurei

3D structure databases

ProteinModelPortaliQ503W7
SMRiQ503W7
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the AAA ATPase family.Curated

Phylogenomic databases

eggNOGiKOG0737 Eukaryota
COG0464 LUCA
GeneTreeiENSGT00550000074823
HOGENOMiHOG000225141
HOVERGENiHBG057074
InParanoidiQ503W7
KOiK22530
OMAiMPHLYSH
OrthoDBiEOG091G0CJ6
PhylomeDBiQ503W7
TreeFamiTF105016

Family and domain databases

InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR003959 ATPase_AAA_core
IPR003960 ATPase_AAA_CS
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00004 AAA, 1 hit
SMARTiView protein in SMART
SM00382 AAA, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS00674 AAA, 1 hit

Sequencei

Sequence statusi: Complete.

Q503W7-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVLKEIPTEN ITRPLGRNEV IGLLFRLTIF GAVTYFTIKW MVDAIDPTRK
60 70 80 90 100
QKVEAQKQAE KLMRQIGVQN VKLSEYEMSI AAHLVDPLTM QITWHDIAGL
110 120 130 140 150
DEVITELKDT VILPIQKRHL FEGSRLLQPP KGVLLYGPPG CGKTLIAKAT
160 170 180 190 200
AKEAGFRFIN LQPSTLTDKW YGESQKLAAA VFSLAIKLQP SIIFIDEIDS
210 220 230 240 250
FLRNRSSSDH EATAMMKAQF MSLWDGLDTD YNCQVIIMGA TNRPQDLDSA
260 270 280 290 300
ILRRMPTRFH INQPNVRQRK DILKLILENE NVESAVELSE IAKQTDGFSG
310 320 330 340 350
SDLREMCRDA ALLCVRDFVH QESPEEDFIR PIRQEDLQRA IEKMKKSKSA
360
GVHEAFMQVP LD
Length:362
Mass (Da):41,094
Last modified:September 13, 2005 - v2
Checksum:i70136A5CC5CF05EC
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti95H → Y in AAH95151 (PubMed:23594743).Curated1
Sequence conflicti266V → A in AAH95151 (PubMed:23594743).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
BC095151 mRNA Translation: AAH95151.1
AL731788 Genomic DNA Translation: CAI11460.1
RefSeqiNP_001019592.1, NM_001024421.2
XP_017213925.1, XM_017358436.1
UniGeneiDr.78224

Genome annotation databases

EnsembliENSDART00000079130; ENSDARP00000073585; ENSDARG00000056609
GeneIDi368412
KEGGidre:368412

Similar proteinsi

Entry informationi

Entry nameiATD1B_DANRE
AccessioniPrimary (citable) accession number: Q503W7
Secondary accession number(s): Q5SQM1
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 13, 2005
Last sequence update: September 13, 2005
Last modified: May 23, 2018
This is version 89 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

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