UniProtKB - Q503L9 (NXN_DANRE)
Protein
Nucleoredoxin
Gene
nxn
Organism
Danio rerio (Zebrafish) (Brachydanio rerio)
Status
Functioni
Functions as a redox-dependent negative regulator of the Wnt signaling pathway.By similarity
Catalytic activityi
GO - Molecular functioni
- protein-disulfide reductase activity Source: UniProtKB-EC
GO - Biological processi
- cell differentiation Source: UniProtKB-KW
- circulatory system development Source: UniProtKB
- negative regulation of protein ubiquitination Source: UniProtKB
- negative regulation of Wnt signaling pathway Source: UniProtKB
- Wnt signaling pathway Source: UniProtKB-KW
Keywordsi
Molecular function | Developmental protein, Oxidoreductase |
Biological process | Differentiation, Wnt signaling pathway |
Ligand | NAD |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:nxn ORF Names:zgc:110449 |
Organismi | Danio rerio (Zebrafish) (Brachydanio rerio) |
Taxonomic identifieri | 7955 [NCBI] |
Taxonomic lineagei | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Actinopterygii › Neopterygii › Teleostei › Ostariophysi › Cypriniformes › Danionidae › Danioninae › Danio |
Proteomesi |
|
Organism-specific databases
ZFINi | ZDB-GENE-050522-75, nxn |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000332935 | 1 – 418 | NucleoredoxinAdd BLAST | 418 |
Proteomic databases
PaxDbi | Q503L9 |
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 109 – 309 | ThioredoxinPROSITE-ProRule annotationAdd BLAST | 201 |
Sequence similaritiesi
Belongs to the nucleoredoxin family.Curated
Phylogenomic databases
eggNOGi | KOG2501, Eukaryota |
InParanoidi | Q503L9 |
OrthoDBi | 1350271at2759 |
PhylomeDBi | Q503L9 |
Family and domain databases
Gene3Di | 3.40.30.10, 3 hits |
InterProi | View protein in InterPro IPR012336, Thioredoxin-like_fold IPR036249, Thioredoxin-like_sf IPR013766, Thioredoxin_domain |
Pfami | View protein in Pfam PF13905, Thioredoxin_8, 2 hits |
SUPFAMi | SSF52833, SSF52833, 3 hits |
PROSITEi | View protein in PROSITE PS51352, THIOREDOXIN_2, 1 hit |
(1+)i Sequence
Sequence statusi: Complete.
This entry has 1 described isoform and 3 potential isoforms that are computationally mapped.Show allAlign All
Q503L9-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSEFLVNLLG ERLVNGEKAE VDVQALGSRL SLLGLYFGCS LNGPCKQFNA
60 70 80 90 100
SLTEFYSKFK KSSEHKDKLE IVFISSDQDQ KQWQDFLQEM QWPALPFKDR
110 120 130 140 150
HKKMKLWNKY KVTSIPSLVF IDAATGKVVC RNGLLVVRDD PKGLEFPWGP
160 170 180 190 200
KPFAEVVSGP LLRNNRQTTD STALEGSYVG VYFSAHWCPP CRSLTRVLVE
210 220 230 240 250
SYRKVKETGQ KFEIVFVSAD RSEESFTQYF SEMPWLAVPY SDEARRSRLN
260 270 280 290 300
RLYGIQGIPT LILLDTEGHM ITRQGRVEIL NDPDCGLFPW HPRPVLELSE
310 320 330 340 350
SNAVQLHEGP CLVLFVDAEE EGELDPAKEL IQPIAEKIMA KYKAKEEETP
360 370 380 390 400
LLFFVAGEDD MSDSLRDYTN LPEAAPLLTI LDMSARAKYV KDVEEITPAV
410
VEQFVSGFLA EKLKPEPI
Computationally mapped potential isoform sequencesi
There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basketA0A2R8Q546 | A0A2R8Q546_DANRE | Nucleoredoxin | nxn | 316 | Annotation score: | ||
F1R5G2 | F1R5G2_DANRE | Nucleoredoxin | nxn | 418 | Annotation score: | ||
A0A2R8Q274 | A0A2R8Q274_DANRE | Nucleoredoxin | nxn | 366 | Annotation score: |
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC095273 mRNA Translation: AAH95273.1 |
RefSeqi | NP_001018431.1, NM_001020595.1 |
Genome annotation databases
GeneIDi | 553621 |
KEGGi | dre:553621 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | BC095273 mRNA Translation: AAH95273.1 |
RefSeqi | NP_001018431.1, NM_001020595.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 7955.ENSDARP00000037350 |
Proteomic databases
PaxDbi | Q503L9 |
Genome annotation databases
GeneIDi | 553621 |
KEGGi | dre:553621 |
Organism-specific databases
CTDi | 64359 |
ZFINi | ZDB-GENE-050522-75, nxn |
Phylogenomic databases
eggNOGi | KOG2501, Eukaryota |
InParanoidi | Q503L9 |
OrthoDBi | 1350271at2759 |
PhylomeDBi | Q503L9 |
Miscellaneous databases
PROi | PR:Q503L9 |
Family and domain databases
Gene3Di | 3.40.30.10, 3 hits |
InterProi | View protein in InterPro IPR012336, Thioredoxin-like_fold IPR036249, Thioredoxin-like_sf IPR013766, Thioredoxin_domain |
Pfami | View protein in Pfam PF13905, Thioredoxin_8, 2 hits |
SUPFAMi | SSF52833, SSF52833, 3 hits |
PROSITEi | View protein in PROSITE PS51352, THIOREDOXIN_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | NXN_DANRE | |
Accessioni | Q503L9Primary (citable) accession number: Q503L9 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 29, 2008 |
Last sequence update: | June 7, 2005 | |
Last modified: | December 2, 2020 | |
This is version 89 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Chordata Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families