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Entry version 84 (11 Dec 2019)
Sequence version 3 (23 Jan 2002)
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Protein

Probable arabinosyltransferase B

Gene

embB

Organism
Mycolicibacterium smegmatis (Mycobacterium smegmatis)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Arabinosyl transferase responsible for the polymerization of arabinose into the arabinan of arabinogalactan.

Miscellaneous

This is one of the targets of the anti-tuberculosis drug ethambutol [(S,S')-2,2'-(ethylenediimino)di-1-butanol; EMB]. EMB is a first-line drug used to treat tuberculosis. EMB inhibits the transfer of arabinogalactan into the cell wall.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionGlycosyltransferase, Transferase
Biological processAntibiotic resistance, Cell wall biogenesis/degradation

Protein family/group databases

Carbohydrate-Active enZymes

More...
CAZyi
GT53 Glycosyltransferase Family 53

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Probable arabinosyltransferase B (EC:2.4.2.-)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:embB
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMycolicibacterium smegmatis (Mycobacterium smegmatis)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri1772 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiBacteriaActinobacteriaCorynebacterialesMycobacteriaceaeMycolicibacterium

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei28 – 50HelicalSequence analysisAdd BLAST23
Transmembranei223 – 241HelicalSequence analysisAdd BLAST19
Transmembranei262 – 281HelicalSequence analysisAdd BLAST20
Transmembranei333 – 352HelicalSequence analysisAdd BLAST20
Transmembranei359 – 381HelicalSequence analysisAdd BLAST23
Transmembranei420 – 442HelicalSequence analysisAdd BLAST23
Transmembranei462 – 481HelicalSequence analysisAdd BLAST20
Transmembranei522 – 544HelicalSequence analysisAdd BLAST23
Transmembranei557 – 574HelicalSequence analysisAdd BLAST18
Transmembranei578 – 600HelicalSequence analysisAdd BLAST23
Transmembranei613 – 635HelicalSequence analysisAdd BLAST23
Transmembranei650 – 672HelicalSequence analysisAdd BLAST23
Transmembranei689 – 711HelicalSequence analysisAdd BLAST23

GO - Cellular componenti

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002205681 – 1082Probable arabinosyltransferase BAdd BLAST1082

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q50395

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the emb family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG4105J1Z Bacteria
ENOG410XSQE LUCA

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
2.60.120.610, 1 hit
2.60.120.940, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR032731 Arabino_trans_C
IPR042486 Arabino_trans_C_2
IPR007680 Arabino_trans_central
IPR040920 Arabino_trans_N
IPR027451 EmbABC_dom1

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF14896 Arabino_trans_C, 1 hit
PF17689 Arabino_trans_N, 1 hit
PF04602 Arabinose_trans, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q50395-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSGNMDEAVS GNMDEAVSAG KDVRIARWVA TIAGLLGFVL SVSIPLLPVT
60 70 80 90 100
QTTATLNWPQ QGRLDNVTAP LISQAPLELT ATVPCSVVRD LPPEGGLVFG
110 120 130 140 150
TAPAEGRDAA LNAMLVNVTE TRVDVIVRNV VVASVNRDRV AGPDCQRIEI
160 170 180 190 200
TSNLDGTYAD FVGLTQISGE DAGKLQRTGY PDPNLRPAIV GVFTDLTGPA
210 220 230 240 250
PQGLSVSAEI DTRFTTHPTA LKLAAMLLAI VSTVIALLAL WRLDRLDGRR
260 270 280 290 300
MHRLIPTRWR TVTAVDGVVV GGMAIWYVIG ANSSDDGYIL QMARTAEHAG
310 320 330 340 350
YMANYFRWFG SPEDPFGWYY NVLALMTKVS DASIWIRLPD LICALICWLL
360 370 380 390 400
LSREVLPRLG PAVAGSRAAM WAAGLVLLGA WMPFNNGLRP EGQIATGALI
410 420 430 440 450
TYVLIERAVT SGRLTPAALA ITTAAFTLGI QPTGLIAVAA LLAGGRPILR
460 470 480 490 500
IVIRRRRLDG TWPLIAPLLA AGTVILAVVF ADQTIATVLE ATRIRTAIGP
510 520 530 540 550
SQEWWTEKLR YYYLILPTTD GAISRRVAFV FTAMCLFPSL FMMLRRKHIA
560 570 580 590 600
GVARGPAWRL MGIIFATMFF LMFTPTKWTH HFGLFAAVGG AMAALATVLV
610 620 630 640 650
SPTVLRSARN RMAFLSLVLF VLAFCFASTN GWWYVSNFGA PFNNSVPKVG
660 670 680 690 700
GVQISAIFFA LSAIAALWAF WLHLTRRTES RVVDRLTAAP IPVAAGFMVV
710 720 730 740 750
VMMASMAIGV VRQYPTYSNG WANIRAFAGG CGLADDVLVE PDSNAGFLTP
760 770 780 790 800
LPGAYGPLGP LGGEDPQGFS PDGVPDRIIA EAIRLNNPQP GTDYDWNRPI
810 820 830 840 850
KLDEPGINGS TVPLPYGLDP KRVPVAGTYS TEAQQESRLS SAWYELPARD
860 870 880 890 900
ETERAAHPLV VITAAGTITG ESVANGLTTG QTVDLEYATR GPDGTLVPAG
910 920 930 940 950
RVTPYDVGPT PSWRNLRYPR SEIPDDAVAV RVVAEDLSLS QGDWIAVTPP
960 970 980 990 1000
RVPELQSVQE YVGSDQPVLM DWAVGLAFPC QQPMLHANGV TEVPKFRISP
1010 1020 1030 1040 1050
DYYAKLQSTD TWQDGINGGL LGITDLLLRA SVMSTYLSQD WGQDWGSLRK
1060 1070 1080
FDTVVEATPA ELDFGSQTHS GLYSPGPLRI RP
Length:1,082
Mass (Da):116,777
Last modified:January 23, 2002 - v3
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i10883EA54F72E0FE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti453I → M in AAB69157 (PubMed:9420031).Curated1
Sequence conflicti459D → V in AAB69157 (PubMed:9420031).Curated1
Sequence conflicti508K → N in AAB69157 (PubMed:9420031).Curated1
Sequence conflicti579T → I in AAB69157 (PubMed:9420031).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti289I → F Resistance to EMB. 1 Publication1
Natural varianti289I → M Resistance to EMB. 1 Publication1
Natural varianti292M → T Resistance to EMB. 1 Publication1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
U46844 Genomic DNA Translation: AAC45273.1
AF004289 Genomic DNA Translation: AAB69157.1

Protein sequence database of the Protein Information Resource

More...
PIRi
T45096

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U46844 Genomic DNA Translation: AAC45273.1
AF004289 Genomic DNA Translation: AAB69157.1
PIRiT45096

3D structure databases

SMRiQ50395
ModBaseiSearch...

Protein family/group databases

CAZyiGT53 Glycosyltransferase Family 53

Phylogenomic databases

eggNOGiENOG4105J1Z Bacteria
ENOG410XSQE LUCA

Family and domain databases

Gene3Di2.60.120.610, 1 hit
2.60.120.940, 1 hit
InterProiView protein in InterPro
IPR032731 Arabino_trans_C
IPR042486 Arabino_trans_C_2
IPR007680 Arabino_trans_central
IPR040920 Arabino_trans_N
IPR027451 EmbABC_dom1
PfamiView protein in Pfam
PF14896 Arabino_trans_C, 1 hit
PF17689 Arabino_trans_N, 1 hit
PF04602 Arabinose_trans, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiEMBB_MYCSM
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q50395
Secondary accession number(s): O30406
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: January 23, 2002
Last modified: December 11, 2019
This is version 84 of the entry and version 3 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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