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Entry version 107 (23 Feb 2022)
Sequence version 2 (15 May 2007)
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Protein

Phosphatase and actin regulator 4

Gene

Phactr4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Regulator of protein phosphatase 1 (PP1) required for neural tube and optic fissure closure, and enteric neural crest cell (ENCCs) migration during development. Acts as an activator of PP1 by interacting with PPP1CA and preventing phosphorylation of PPP1CA at 'Thr-320'. During neural tube closure, localizes to the ventral neural tube and activates PP1, leading to down-regulate cell proliferation within cranial neural tissue and the neural retina. Also acts as a regulator of migration of enteric neural crest cells (ENCCs) by activating PP1, leading to dephosphorylation and subsequent activation of cofilin (COF1 or COF2) and repression of the integrin signaling through the RHO/ROCK pathway.

2 Publications

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionActin-binding, Developmental protein, Protein phosphatase inhibitor
Biological processNeurogenesis

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Phosphatase and actin regulator 4
Alternative name(s):
Protein Humpty dumpty
Short name:
Humdy
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:Phactr4
Synonyms:Kiaa4120
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiMus musculus (Mouse)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri10090 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000000589 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Mouse genome database (MGD) from Mouse Genome Informatics (MGI)

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MGIi
MGI:2140327, Phactr4

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
HostDB:ENSMUSG00000066043

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cell projection, Cytoplasm

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Neural tube and eye defects in embryos followed by death. By 9.25 dpc, mutant embryos show failure to close the cranial neural tube. About 15% of homozygous mutant embryos exhibit severe exencephaly, along with a wavy spinal neural tube and a shortened anterior/posterior body axis, and die around 10.5 dpc. Remaining embryos exhibit complete exencephaly from the forebrain to hindbrain. Most embryos die by 14.5 dpc, but a few survive to birth and die shortly thereafter. Embryos also have eye defects: they display overgrowth of the neural retina and retinal pigment epithelium. Embryos also display coloboma at 12.5 dpc and 16.5 dpc, due to defects in closure of optic fissure. Defects are due to elevated proliferation and abnormally phosphorylated, inactive PP1, resulting in RB1 hyperphosphorylation, derepression of E2F targets, and abnormal cell-cycle progression. Embryos also show embryonic gastrointestinal defects due to colon hypoganglionosis, which resembles human Hirschsprung disease: ENCCs within the embryonic gut display a collective cell migration defect and show undirected cellular protrusions and disrupted directional and chain migration.2 Publications

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/manual/pathology%5Fand%5Fbiotech%5Fsection">'Pathology and Biotech'</a> section describes the effect of the experimental mutation of one or more amino acid(s) on the biological properties of the protein.<p><a href='/help/mutagen' target='_top'>More...</a></p>Mutagenesisi650R → P in humdy; failure to close the neural tube and optic fissure, causing exencephaly and retinal coloboma and common birth defects. Specifically disrupts interaction with PPP1CA while it does not affect interaction with actin. 1 Publication1

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00002873071 – 694Phosphatase and actin regulator 4Add BLAST694

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei116PhosphoserineCombined sources1
Modified residuei118PhosphoserineCombined sources1
Modified residuei129PhosphoserineBy similarity1
Modified residuei145PhosphoserineBy similarity1
Modified residuei264PhosphoserineCombined sources1
Modified residuei285PhosphoserineCombined sources1
Modified residuei335PhosphoserineBy similarity1
Modified residuei337PhosphoserineBy similarity1
Modified residuei420PhosphoserineCombined sources1
Modified residuei425PhosphothreonineCombined sources1
Modified residuei436PhosphoserineCombined sources1
Modified residuei446PhosphoserineCombined sources1
Modified residuei457PhosphoserineCombined sources1
Modified residuei503PhosphoserineCombined sources1
Modified residuei505PhosphoserineCombined sources1
Modified residuei549PhosphoserineBy similarity1
Modified residuei582PhosphoserineBy similarity1
Modified residuei620PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q501J7

jPOST - Japan Proteome Standard Repository/Database

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jPOSTi
Q501J7

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q501J7

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q501J7

PeptideAtlas

More...
PeptideAtlasi
Q501J7

PRoteomics IDEntifications database

More...
PRIDEi
Q501J7

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
288137 [Q501J7-1]
288138 [Q501J7-2]
288139 [Q501J7-3]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q501J7

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q501J7

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section provides information on the expression of the gene product at various stages of a cell, tissue or organism development. By default, the information is derived from experiments at the mRNA level, unless specified 'at the protein level'.<p><a href='/help/developmental_stage' target='_top'>More...</a></p>Developmental stagei

During embryonic development, most strongly expressed in neural tissue. Expressed in a dynamic pattern during neurulation: from 8.5 dpc to 9.5 dpc, the period of cranial neural closure and spatially regulated proliferation, it is expressed strongly in the ventral region of the cranial neural tube. By 10.5 dpc, expressed more uniformly along the dorsal and ventral aspects of the cranial neural tube. Also expressed in the neural retina and lens.1 Publication

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSMUSG00000066043, Expressed in adult mammalian kidney and 244 other tissues

ExpressionAtlas, Differential and Baseline Expression

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ExpressionAtlasi
Q501J7, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q501J7, MM

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds PPP1CA and actin.

GO - Molecular functioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

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BioGRIDi
221393, 4 interactors

STRING: functional protein association networks

More...
STRINGi
10090.ENSMUSP00000099628

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...
RNActi
Q501J7, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q501J7

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section indicates the positions and types of repeated sequence motifs or repeated domains within the protein.<p><a href='/help/repeat' target='_top'>More...</a></p>Repeati63 – 88RPEL 1Add BLAST26
Repeati575 – 600RPEL 2Add BLAST26
Repeati613 – 638RPEL 3Add BLAST26

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 354DisorderedSequence analysisAdd BLAST354
Regioni375 – 405DisorderedSequence analysisAdd BLAST31
Regioni467 – 562DisorderedSequence analysisAdd BLAST96
Regioni589 – 608DisorderedSequence analysisAdd BLAST20

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi53 – 100Basic and acidic residuesSequence analysisAdd BLAST48
Compositional biasi121 – 143Basic and acidic residuesSequence analysisAdd BLAST23
Compositional biasi186 – 216Polar residuesSequence analysisAdd BLAST31
Compositional biasi265 – 282Polar residuesSequence analysisAdd BLAST18
Compositional biasi300 – 319Polar residuesSequence analysisAdd BLAST20
Compositional biasi329 – 353Pro residuesSequence analysisAdd BLAST25
Compositional biasi495 – 512Basic and acidic residuesSequence analysisAdd BLAST18
Compositional biasi526 – 543Basic and acidic residuesSequence analysisAdd BLAST18
Compositional biasi594 – 608Basic and acidic residuesSequence analysisAdd BLAST15

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
KOG4339, Eukaryota

Ensembl GeneTree

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GeneTreei
ENSGT00940000157582

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_015753_1_1_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q501J7

Identification of Orthologs from Complete Genome Data

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OMAi
XKNEADR

Database of Orthologous Groups

More...
OrthoDBi
1205245at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q501J7

TreeFam database of animal gene trees

More...
TreeFami
TF316316

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR029984, Phactr4
IPR004018, RPEL_repeat

The PANTHER Classification System

More...
PANTHERi
PTHR12751:SF4, PTHR12751:SF4, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF02755, RPEL, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

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SMARTi
View protein in SMART
SM00707, RPEL, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS51073, RPEL, 3 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 3 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 3 described isoforms and 2 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q501J7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MEDPSEEAEQ PSGDPGMGMD SVEAGDTTPP TKRKSKFSAL GKIFKPWKWR
60 70 80 90 100
KKKSSDKFKE TSEVLERKIS MRKPREELVK RGVLLEDPEQ DGEDSGKLSH
110 120 130 140 150
AALKNGHTTP IGSARSSSPV LVEEEPERSL RNLTPEEESK KRLGSTGSQP
160 170 180 190 200
NSEAEPGPEH APKQPLLPPK RPLSSSCEAK EVPAGSTARS VSSTSGSTTV
210 220 230 240 250
TSAATTAATD MTKTVKSFVG PTPAPAPAPR TLPAAPASAN TAATTTAPAK
260 270 280 290 300
QPPIPPPKPA QRNSNPIIAE LSQAMNSGTV LSKPSPPLPP KRGIPSTSIP
310 320 330 340 350
SLEPAASFTT KTANDQREKT VSLCLEPPLI IPPSSPSPPL PTHIPPEPPR
360 370 380 390 400
SPLVPAKTFQ IVPEVEFSSS SDLFQDISQQ EDQKTEVPKK IQDQSFGESH
410 420 430 440 450
IPSRLPPLPL HIRIQQALTS PLPVTPPLEG THRAHSLLFE NSDSFSEDTG
460 470 480 490 500
TLGRTRSLPI TIEMLKVPDD EEEEQTCPFV EDVTSTSATP SLPLCLREEE
510 520 530 540 550
KESDSDSEGP IKYRDEEEDD DDDESHQSAL ANRVKRKDTL AMKLSSRPSE
560 570 580 590 600
PETNLNSWPR KSKEEWNEIR HQIGNTLIRR LSQRPTAEEL EQRNILQPKN
610 620 630 640 650
EADRQAEKRE IKRRLTRKLS QRPTVAELLA RKILRFNEYV EVTDAHDYDR
660 670 680 690
RADKPWTKLT PADKAAIRKE LNEFKSSEME VHVDSKHFTR YHRP
Length:694
Mass (Da):76,632
Last modified:May 15, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3AEB17E6A390DD29
GO
Isoform 2 (identifier: Q501J7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     64-90: Missing.

Show »
Length:667
Mass (Da):73,401
Checksum:iC8792813A330F37A
GO
Isoform 3 (identifier: Q501J7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-5: MEDPS → MGQADVSRPVNPDAV

Show »
Length:704
Mass (Da):77,610
Checksum:i2A63C3E20DBAC762
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 2 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
A0A0A0MQJ4A0A0A0MQJ4_MOUSE
Phosphatase and actin regulator 4
Phactr4
298Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A0MQL5A0A0A0MQL5_MOUSE
Phosphatase and actin regulator 4
Phactr4
157Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAD90294 differs from that shown. Reason: Erroneous initiation. Extended N-terminus.Curated
The sequence CAM26520 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti212T → K in BAC33611 (PubMed:16141072).Curated1
Sequence conflicti224A → S in AAH96033 (PubMed:19468303).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0254391 – 5MEDPS → MGQADVSRPVNPDAV in isoform 3. Curated5
Alternative sequenceiVSP_02544064 – 90Missing in isoform 2. 1 PublicationAdd BLAST27

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AK049209 mRNA Translation: BAC33611.1
AK220496 mRNA Translation: BAD90294.1 Different initiation.
AL805897 Genomic DNA Translation: CAM26521.1
AL805897 Genomic DNA Translation: CAM26523.1
AL805897 Genomic DNA Translation: CAM26520.1 Sequence problems.
BC075672 mRNA Translation: AAH75672.1
BC096033 mRNA Translation: AAH96033.1

The Consensus CDS (CCDS) project

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CCDSi
CCDS18724.1 [Q501J7-1]
CCDS51318.1 [Q501J7-2]

NCBI Reference Sequences

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RefSeqi
NP_001155269.1, NM_001161797.1 [Q501J7-2]
NP_780515.2, NM_175306.4 [Q501J7-1]
XP_006538519.1, XM_006538456.3 [Q501J7-3]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...
Ensembli
ENSMUST00000084170; ENSMUSP00000081185; ENSMUSG00000066043 [Q501J7-2]
ENSMUST00000084249; ENSMUSP00000081270; ENSMUSG00000066043 [Q501J7-3]
ENSMUST00000102568; ENSMUSP00000099628; ENSMUSG00000066043 [Q501J7-1]

Database of genes from NCBI RefSeq genomes

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GeneIDi
100169

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
mmu:100169

UCSC genome browser

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UCSCi
uc008vbg.3, mouse [Q501J7-1]
uc008vbh.3, mouse [Q501J7-2]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK049209 mRNA Translation: BAC33611.1
AK220496 mRNA Translation: BAD90294.1 Different initiation.
AL805897 Genomic DNA Translation: CAM26521.1
AL805897 Genomic DNA Translation: CAM26523.1
AL805897 Genomic DNA Translation: CAM26520.1 Sequence problems.
BC075672 mRNA Translation: AAH75672.1
BC096033 mRNA Translation: AAH96033.1
CCDSiCCDS18724.1 [Q501J7-1]
CCDS51318.1 [Q501J7-2]
RefSeqiNP_001155269.1, NM_001161797.1 [Q501J7-2]
NP_780515.2, NM_175306.4 [Q501J7-1]
XP_006538519.1, XM_006538456.3 [Q501J7-3]

3D structure databases

SMRiQ501J7
ModBaseiSearch...

Protein-protein interaction databases

BioGRIDi221393, 4 interactors
STRINGi10090.ENSMUSP00000099628

PTM databases

iPTMnetiQ501J7
PhosphoSitePlusiQ501J7

Proteomic databases

EPDiQ501J7
jPOSTiQ501J7
MaxQBiQ501J7
PaxDbiQ501J7
PeptideAtlasiQ501J7
PRIDEiQ501J7
ProteomicsDBi288137 [Q501J7-1]
288138 [Q501J7-2]
288139 [Q501J7-3]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...
Antibodypediai
30935, 124 antibodies from 27 providers

Genome annotation databases

EnsembliENSMUST00000084170; ENSMUSP00000081185; ENSMUSG00000066043 [Q501J7-2]
ENSMUST00000084249; ENSMUSP00000081270; ENSMUSG00000066043 [Q501J7-3]
ENSMUST00000102568; ENSMUSP00000099628; ENSMUSG00000066043 [Q501J7-1]
GeneIDi100169
KEGGimmu:100169
UCSCiuc008vbg.3, mouse [Q501J7-1]
uc008vbh.3, mouse [Q501J7-2]

Organism-specific databases

Comparative Toxicogenomics Database

More...
CTDi
65979
MGIiMGI:2140327, Phactr4
VEuPathDBiHostDB:ENSMUSG00000066043

Rodent Unidentified Gene-Encoded large proteins database

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Rougei
Search...

Phylogenomic databases

eggNOGiKOG4339, Eukaryota
GeneTreeiENSGT00940000157582
HOGENOMiCLU_015753_1_1_1
InParanoidiQ501J7
OMAiXKNEADR
OrthoDBi1205245at2759
PhylomeDBiQ501J7
TreeFamiTF316316

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...
BioGRID-ORCSi
100169, 0 hits in 64 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...
ChiTaRSi
Phactr4, mouse

Protein Ontology

More...
PROi
PR:Q501J7
RNActiQ501J7, protein

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSMUSG00000066043, Expressed in adult mammalian kidney and 244 other tissues
ExpressionAtlasiQ501J7, baseline and differential
GenevisibleiQ501J7, MM

Family and domain databases

InterProiView protein in InterPro
IPR029984, Phactr4
IPR004018, RPEL_repeat
PANTHERiPTHR12751:SF4, PTHR12751:SF4, 1 hit
PfamiView protein in Pfam
PF02755, RPEL, 3 hits
SMARTiView protein in SMART
SM00707, RPEL, 3 hits
PROSITEiView protein in PROSITE
PS51073, RPEL, 3 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPHAR4_MOUSE
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q501J7
Secondary accession number(s): A2ALF7
, A2ALG0, F6QNZ3, Q5DTM4, Q6DI97, Q8C7U9
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: May 15, 2007
Last sequence update: May 15, 2007
Last modified: February 23, 2022
This is version 107 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families
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