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Entry version 116 (25 May 2022)
Sequence version 1 (07 Jun 2005)
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Protein

Protein IQ-DOMAIN 30

Gene

IQD30

Organism
Arabidopsis thaliana (Mouse-ear cress)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May be involved in cooperative interactions with calmodulins or calmodulin-like proteins (By similarity).

Recruits calmodulin proteins to microtubules, thus being a potential scaffold in cellular signaling and trafficking (By similarity).

May associate with nucleic acids and regulate gene expression at the transcriptional or post-transcriptional level (By similarity).

By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionCalmodulin-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein IQ-DOMAIN 301 Publication
Short name:
AtIQD301 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:IQD301 Publication
Ordered Locus Names:At1g18840Imported
ORF Names:F6A14.7Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiArabidopsis thaliana (Mouse-ear cress)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri3702 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaViridiplantaeStreptophytaEmbryophytaTracheophytaSpermatophytaMagnoliopsidaeudicotyledonsGunneridaePentapetalaerosidsmalvidsBrassicalesBrassicaceaeCamelineaeArabidopsis
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000006548 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Arabidopsis Information Portal

More...
Araporti
AT1G18840

The Arabidopsis Information Resource

More...
TAIRi
locus:2034929, AT1G18840

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton, Nucleus

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004531351 – 572Protein IQ-DOMAIN 30Add BLAST572

Proteomic databases

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q501D2

PRoteomics IDEntifications database

More...
PRIDEi
Q501D2

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
174847

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q501D2, baseline and differential

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Binds to multiple calmodulin (CaM) in the presence of Ca2+ and CaM-like proteins.

By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
3702.AT1G18840.1

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

AlphaFold Protein Structure Database

More...
AlphaFoldDBi
Q501D2

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini108 – 136IQ 1PROSITE-ProRule annotationAdd BLAST29
Domaini137 – 154IQ 2PROSITE-ProRule annotationAdd BLAST18

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni75 – 96DisorderedSequence analysisAdd BLAST22
Regioni159 – 178Calmodulin-binding1 PublicationAdd BLAST20
Regioni282 – 332DisorderedSequence analysisAdd BLAST51
Regioni399 – 572DisorderedSequence analysisAdd BLAST174

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi80 – 96Polar residuesSequence analysisAdd BLAST17
Compositional biasi290 – 307Polar residuesSequence analysisAdd BLAST18
Compositional biasi399 – 421Polar residuesSequence analysisAdd BLAST23
Compositional biasi428 – 453Basic and acidic residuesSequence analysisAdd BLAST26
Compositional biasi454 – 489Polar residuesSequence analysisAdd BLAST36
Compositional biasi497 – 561Polar residuesSequence analysisAdd BLAST65

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the IQD family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
ENOG502QTUQ, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_026881_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q501D2

Identification of Orthologs from Complete Genome Data

More...
OMAi
VPHIEVE

Database of Orthologous Groups

More...
OrthoDBi
533192at2759

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q501D2

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR025064, DUF4005
IPR000048, IQ_motif_EF-hand-BS
IPR027417, P-loop_NTPase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF13178, DUF4005, 1 hit
PF00612, IQ, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00015, IQ, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540, SSF52540, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50096, IQ, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q501D2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGKPARWLKS VLLGKKPSKS SGSKDKERIV NGKEVVVISK IEESDVVSDL
60 70 80 90 100
SSIGNAAVYT SGIVETQNLK HEDVSDDEIQ VSEVQPTDSQ DVASVPDDSL
110 120 130 140 150
SESEKIQQEI AAVTVQAAYR GYLARRAFKI LKGIIRLQAL IRGHMVRRQA
160 170 180 190 200
VSTLCCVMGI VRLQALARGR EIRHSDIGVE VQRKCHLHHQ PLENKANSVV
210 220 230 240 250
DTHSYLGINK LTGNAFAQKL LASSPNVLPL SLDNDSSNSI WLENWSASCF
260 270 280 290 300
WKPVPQPKKA SLRKSQKKFA SNPQIVEAEF ARPKKSVRKV PSSNLDNSSV
310 320 330 340 350
AQTSSELEKP KRSFRKVSTS QSVEPLPSMD NPQVDLEKVK RGLRKVHNPV
360 370 380 390 400
VENSIQPQLV PQIAVEKPNG SLEESVNAFD EEKEDEVAET VVQQPEELIQ
410 420 430 440 450
THTPLGTNES LDSTLVNQIE ESEENVMAEE KEDVKEERTP KQNHKENSAG
460 470 480 490 500
KENQKSGKKA SSVTATQTAE FQESGNGNQT SSPGIPSYMQ ATKSAKAKLR
510 520 530 540 550
LQGSSSPRQL GTTEKASRRY SLPSSGNSAK ITSHSPKTRV SNSSGKSGNK
560 570
TEKTLLSSRE GNGKATPVEW KR
Length:572
Mass (Da):62,732
Last modified:June 7, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i188936165BBB8BBC
GO

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAF27097 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti183R → G in BAH20070 (PubMed:19423640).Curated1
Sequence conflicti564K → R in BAH20070 (PubMed:19423640).Curated1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AC011809 Genomic DNA Translation: AAF27097.1 Sequence problems.
CP002684 Genomic DNA Translation: AEE29769.1
CP002684 Genomic DNA Translation: AEE29770.1
CP002684 Genomic DNA Translation: ANM60334.1
AK317400 mRNA Translation: BAH20070.1
BT022035 mRNA Translation: AAY25447.1
AY702666 mRNA Translation: AAW22636.1

Protein sequence database of the Protein Information Resource

More...
PIRi
C86322

NCBI Reference Sequences

More...
RefSeqi
NP_001031067.1, NM_001035990.2
NP_001322630.1, NM_001332375.1
NP_173318.2, NM_101741.4

Genome annotation databases

Ensembl plant genome annotation project

More...
EnsemblPlantsi
AT1G18840.1; AT1G18840.1; AT1G18840
AT1G18840.2; AT1G18840.2; AT1G18840
AT1G18840.3; AT1G18840.3; AT1G18840

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
838465

Gramene; a comparative resource for plants

More...
Gramenei
AT1G18840.1; AT1G18840.1; AT1G18840
AT1G18840.2; AT1G18840.2; AT1G18840
AT1G18840.3; AT1G18840.3; AT1G18840

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
ath:AT1G18840

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC011809 Genomic DNA Translation: AAF27097.1 Sequence problems.
CP002684 Genomic DNA Translation: AEE29769.1
CP002684 Genomic DNA Translation: AEE29770.1
CP002684 Genomic DNA Translation: ANM60334.1
AK317400 mRNA Translation: BAH20070.1
BT022035 mRNA Translation: AAY25447.1
AY702666 mRNA Translation: AAW22636.1
PIRiC86322
RefSeqiNP_001031067.1, NM_001035990.2
NP_001322630.1, NM_001332375.1
NP_173318.2, NM_101741.4

3D structure databases

AlphaFoldDBiQ501D2
ModBaseiSearch...
SWISS-MODEL-WorkspaceiSubmit a new modelling project...

Protein-protein interaction databases

STRINGi3702.AT1G18840.1

Proteomic databases

PaxDbiQ501D2
PRIDEiQ501D2
ProteomicsDBi174847

Genome annotation databases

EnsemblPlantsiAT1G18840.1; AT1G18840.1; AT1G18840
AT1G18840.2; AT1G18840.2; AT1G18840
AT1G18840.3; AT1G18840.3; AT1G18840
GeneIDi838465
GrameneiAT1G18840.1; AT1G18840.1; AT1G18840
AT1G18840.2; AT1G18840.2; AT1G18840
AT1G18840.3; AT1G18840.3; AT1G18840
KEGGiath:AT1G18840

Organism-specific databases

AraportiAT1G18840
TAIRilocus:2034929, AT1G18840

Phylogenomic databases

eggNOGiENOG502QTUQ, Eukaryota
HOGENOMiCLU_026881_0_0_1
InParanoidiQ501D2
OMAiVPHIEVE
OrthoDBi533192at2759
PhylomeDBiQ501D2

Gene expression databases

ExpressionAtlasiQ501D2, baseline and differential

Family and domain databases

InterProiView protein in InterPro
IPR025064, DUF4005
IPR000048, IQ_motif_EF-hand-BS
IPR027417, P-loop_NTPase
PfamiView protein in Pfam
PF13178, DUF4005, 1 hit
PF00612, IQ, 2 hits
SMARTiView protein in SMART
SM00015, IQ, 2 hits
SUPFAMiSSF52540, SSF52540, 1 hit
PROSITEiView protein in PROSITE
PS50096, IQ, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiIQD30_ARATH
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q501D2
Secondary accession number(s): B9DH53, Q2NND8, Q9M9V3
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: June 2, 2021
Last sequence update: June 7, 2005
Last modified: May 25, 2022
This is version 116 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programPlant Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Arabidopsis thaliana
    Arabidopsis thaliana: entries and gene names
  2. SIMILARITY comments
    Index of protein domains and families
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