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UniProtKB - Q4ZIN3 (MBRL_HUMAN)

Entry version 132 (23 Feb 2022)
Sequence version 1 (07 Jun 2005)
Previous versions | rss
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Protein

Membralin

Gene

TMEM259

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May have a role in the ERAD pathway required for clearance of misfolded proteins in the endoplasmic reticulum (ER). Promotes survival of motor neurons, probably by protecting against ER stress.

By similarity

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Complete GO annotation on QuickGO ...

Enzyme and pathway databases

Pathway Commons web resource for biological pathway data

More...PathwayCommonsi		Q4ZIN3

SignaLink: a signaling pathway resource with multi-layered regulatory networks

More...SignaLinki		Q4ZIN3

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Membralin
Alternative name(s):
Transmembrane protein 259
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:TMEM259
Synonyms:C19orf6
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 19

Organism-specific databases

Human Gene Nomenclature Database

More...HGNCi		HGNC:17039, TMEM259

Online Mendelian Inheritance in Man (OMIM)

More...MIMi		611011, gene

neXtProt; the human protein knowledge platform

More...neXtProti		NX_Q4ZIN3

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		HostDB:ENSG00000182087

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular%5Flocation%5Fsection">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei70 – 90HelicalSequence analysisAdd BLAST21
Transmembranei302 – 322HelicalSequence analysisAdd BLAST21
Transmembranei346 – 366HelicalSequence analysisAdd BLAST21
Transmembranei426 – 446HelicalSequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Endoplasmic reticulum, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...DisGeNETi		91304

Open Targets

More...OpenTargetsi		ENSG00000182087

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...PharmGKBi		PA134936083

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...Pharosi		Q4ZIN3, Tbio

Genetic variation databases

BioMuta curated single-nucleotide variation and disease association database

More...BioMutai		TMEM259

Domain mapping of disease mutations (DMDM)

More...DMDMi		68565394

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section indicates that the initiator methionine is cleaved from the mature protein.<p><a href='/help/init_met' target='_top'>More...</a></p>Initiator methionineiRemovedCombined sources
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00000962732 – 620MembralinAdd BLAST619

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2N-acetylserineCombined sources1
Modified residuei29PhosphothreonineCombined sources1
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm%5Fprocessing%5Fsection">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi189N-linked (GlcNAc...) asparagine1 Publication1

Keywords - PTMi

Acetylation, Glycoprotein, Phosphoprotein

Proteomic databases

Encyclopedia of Proteome Dynamics

More...EPDi		Q4ZIN3

jPOST - Japan Proteome Standard Repository/Database

More...jPOSTi		Q4ZIN3

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...MassIVEi		Q4ZIN3

MaxQB - The MaxQuant DataBase

More...MaxQBi		Q4ZIN3

PaxDb, a database of protein abundance averages across all three domains of life

More...PaxDbi		Q4ZIN3

PeptideAtlas

More...PeptideAtlasi		Q4ZIN3

PRoteomics IDEntifications database

More...PRIDEi		Q4ZIN3

ProteomicsDB: a multi-organism proteome resource

More...ProteomicsDBi		62384 [Q4ZIN3-1]
62385 [Q4ZIN3-2]

PTM databases

GlyGen: Computational and Informatics Resources for Glycoscience

More...GlyGeni		Q4ZIN3, 1 site

iPTMnet integrated resource for PTMs in systems biology context

More...iPTMneti		Q4ZIN3

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...PhosphoSitePlusi		Q4ZIN3

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...Bgeei		ENSG00000182087, Expressed in left lobe of thyroid gland and 213 other tissues

ExpressionAtlas, Differential and Baseline Expression

More...ExpressionAtlasi		Q4ZIN3, baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...Genevisiblei		Q4ZIN3, HS

Organism-specific databases

Human Protein Atlas

More...HPAi		ENSG00000182087, Low tissue specificity

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with ERLIN2.

By similarity

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGRID)

More...BioGRIDi		124814, 94 interactors

Protein interaction database and analysis system

More...IntActi		Q4ZIN3, 20 interactors

Molecular INTeraction database

More...MINTi		Q4ZIN3

STRING: functional protein association networks

More...STRINGi		9606.ENSP00000349087

Miscellaneous databases

RNAct, Protein-RNA interaction predictions for model organisms.

More...RNActi		Q4ZIN3, protein

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 33DisorderedSequence analysisAdd BLAST33
Regioni474 – 517DisorderedSequence analysisAdd BLAST44
Regioni568 – 620DisorderedSequence analysisAdd BLAST53

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes the position of regions of compositional bias within the protein and the particular type of amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi478 – 492Polar residuesSequence analysisAdd BLAST15

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the membralin family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG2092, Eukaryota

Ensembl GeneTree

More...GeneTreei		ENSGT00390000013329

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_019069_2_1_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q4ZIN3

Identification of Orthologs from Complete Genome Data

More...OMAi		MTVDMFE

Database of Orthologous Groups

More...OrthoDBi		426985at2759

Database for complete collections of gene phylogenies

More...PhylomeDBi		Q4ZIN3

TreeFam database of animal gene trees

More...TreeFami		TF313323

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR019144, Membralin

The PANTHER Classification System

More...PANTHERi		PTHR21650:SF4, PTHR21650:SF4, 1 hit

Pfam protein domain database

More...Pfami		View protein in Pfam
PF09746, Membralin, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is in its mature form or if it represents the precursor.<p><a href='/help/sequence_processing' target='_top'>More...</a></p>Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 <p>This subsection of the 'Sequence' section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 2 described isoforms and 4 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q4ZIN3-1) [UniParc]FASTAAdd to basket
Also known as: Long, Membralin-1

This isoform has been chosen as the <p><strong>What is the canonical sequence?</strong><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MSEHVEPAAP GPGPNGGGGG PAPARGPRTP NLNPNPLINV RDRLFHALFF 
        60         70         80         90        100
KMAVTYSRLF PPAFRRLFEF FVLLKALFVL FVLAYIHIVF SRSPINCLEH 
       110        120        130        140        150
VRDKWPREGI LRVEVRHNSS RAPVFLQFCD SGGRGSFPGL AVEPGSNLDM 
       160        170        180        190        200
EDEEEEELTM EMFGNSSIKF ELDIEPKVFK PPSSTEALND SQEFPFPETP 
       210        220        230        240        250
TKVWPQDEYI VEYSLEYGFL RLSQATRQRL SIPVMVVTLD PTRDQCFGDR 
       260        270        280        290        300
FSRLLLDEFL GYDDILMSSV KGLAENEENK GFLRNVVSGE HYRFVSMWMA 
       310        320        330        340        350
RTSYLAAFAI MVIFTLSVSM LLRYSHHQIF VFIVDLLQML EMNMAIAFPA 
       360        370        380        390        400
APLLTVILAL VGMEAIMSEF FNDTTTAFYI ILIVWLADQY DAICCHTSTS 
       410        420        430        440        450
KRHWLRFFYL YHFAFYAYHY RFNGQYSSLA LVTSWLFIQH SMIYFFHHYE 
       460        470        480        490        500
LPAILQQVRI QEMLLQAPPL GPGTPTALPD DMNNNSGAPA TAPDSAGQPP 
       510        520        530        540        550
ALGPVSPGAS GSPGPVAAAP SSLVAAAASV AAAAGGDLGW MAETAAIITD 
       560        570        580        590        600
ASFLSGLSAS LLERRPASPL GPAGGLPHAP QDSVPPSDSA ASDTTPLGAA 
       610        620
VGGPSPASMA PTEAPSEVGS
Length:620
Mass (Da):67,889
Last modified:June 7, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7403EBF121ACD8A4
GO
Isoform 2 (identifier: Q4ZIN3-2) [UniParc]FASTAAdd to basket
Also known as: Short, Membralin-2, Membralin-3

The sequence of this isoform differs from the canonical sequence as follows:
     407-408: FF → IP
     409-620: Missing.

Show »
Length:408
Mass (Da):46,431
Checksum:iE57802391CF26F39
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 4 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
U3KPY4U3KPY4_HUMAN
Membralin
TMEM259
421Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
U3KPU1U3KPU1_HUMAN
Membralin
TMEM259
209Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0A0MTU3A0A0A0MTU3_HUMAN
Membralin
TMEM259
406Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
U3KQQ5U3KQQ5_HUMAN
Membralin
TMEM259
139Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the 'Sequence' section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence AAC12681 differs from that shown. Reason: Erroneous gene model prediction.Curated

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Sequence' section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_014377407 – 408FF → IP in isoform 2. 3 Publications2
Alternative sequenceiVSP_014378409 – 620Missing in isoform 2. 3 PublicationsAdd BLAST212

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
DQ005958 mRNA Translation: AAY27747.1
AC004528 Genomic DNA Translation: AAC12681.1 Sequence problems.
BC008957 mRNA Translation: AAH08957.1
AK090400 mRNA Translation: BAC03381.1

The Consensus CDS (CCDS) project

More...CCDSi		CCDS12052.1 [Q4ZIN3-2]
CCDS32862.1 [Q4ZIN3-1]

NCBI Reference Sequences

More...RefSeqi		NP_001028198.1, NM_001033026.1 [Q4ZIN3-1]
NP_219488.1, NM_033420.3 [Q4ZIN3-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

More...Ensembli		ENST00000333175; ENSP00000331423; ENSG00000182087 [Q4ZIN3-2]
ENST00000356663; ENSP00000349087; ENSG00000182087

Database of genes from NCBI RefSeq genomes

More...GeneIDi		91304

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		hsa:91304

Matched Annotation from NCBI and EMBL-EBI (MANE) - Phase one

More...MANE-Selecti		ENST00000356663.8; ENSP00000349087.2; NM_001033026.2; NP_001028198.1

UCSC genome browser

More...UCSCi		uc002lqr.2, human [Q4ZIN3-1]

Keywords - Coding sequence diversityi

Alternative splicing

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
DQ005958 mRNA Translation: AAY27747.1
AC004528 Genomic DNA Translation: AAC12681.1 Sequence problems.
BC008957 mRNA Translation: AAH08957.1
AK090400 mRNA Translation: BAC03381.1
CCDSiCCDS12052.1 [Q4ZIN3-2]
CCDS32862.1 [Q4ZIN3-1]
RefSeqiNP_001028198.1, NM_001033026.1 [Q4ZIN3-1]
NP_219488.1, NM_033420.3 [Q4ZIN3-2]

3D structure databases

Database of comparative protein structure models

More...ModBasei		Search...

SWISS-MODEL Interactive Workspace

More...SWISS-MODEL-Workspacei		Submit a new modelling project...

Protein-protein interaction databases

BioGRIDi124814, 94 interactors
IntActiQ4ZIN3, 20 interactors
MINTiQ4ZIN3
STRINGi9606.ENSP00000349087

PTM databases

GlyGeniQ4ZIN3, 1 site
iPTMnetiQ4ZIN3
PhosphoSitePlusiQ4ZIN3

Genetic variation databases

BioMutaiTMEM259
DMDMi68565394

Proteomic databases

EPDiQ4ZIN3
jPOSTiQ4ZIN3
MassIVEiQ4ZIN3
MaxQBiQ4ZIN3
PaxDbiQ4ZIN3
PeptideAtlasiQ4ZIN3
PRIDEiQ4ZIN3
ProteomicsDBi62384 [Q4ZIN3-1]
62385 [Q4ZIN3-2]

Protocols and materials databases

Antibodypedia a portal for validated antibodies

More...Antibodypediai		10308, 74 antibodies from 17 providers

The DNASU plasmid repository

More...DNASUi		91304

Genome annotation databases

EnsembliENST00000333175; ENSP00000331423; ENSG00000182087 [Q4ZIN3-2]
ENST00000356663; ENSP00000349087; ENSG00000182087
GeneIDi91304
KEGGihsa:91304
MANE-SelectiENST00000356663.8; ENSP00000349087.2; NM_001033026.2; NP_001028198.1
UCSCiuc002lqr.2, human [Q4ZIN3-1]

Organism-specific databases

Comparative Toxicogenomics Database

More...CTDi		91304
DisGeNETi91304

GeneCards: human genes, protein and diseases

More...GeneCardsi		TMEM259
HGNCiHGNC:17039, TMEM259
HPAiENSG00000182087, Low tissue specificity
MIMi611011, gene
neXtProtiNX_Q4ZIN3
OpenTargetsiENSG00000182087
PharmGKBiPA134936083
VEuPathDBiHostDB:ENSG00000182087

GenAtlas: human gene database

More...GenAtlasi		Search...

Phylogenomic databases

eggNOGiKOG2092, Eukaryota
GeneTreeiENSGT00390000013329
HOGENOMiCLU_019069_2_1_1
InParanoidiQ4ZIN3
OMAiMTVDMFE
OrthoDBi426985at2759
PhylomeDBiQ4ZIN3
TreeFamiTF313323

Enzyme and pathway databases

PathwayCommonsiQ4ZIN3
SignaLinkiQ4ZIN3

Miscellaneous databases

BioGRID ORCS database of CRISPR phenotype screens

More...BioGRID-ORCSi		91304, 22 hits in 1048 CRISPR screens

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

More...ChiTaRSi		TMEM259, human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

More...GenomeRNAii		91304
PharosiQ4ZIN3, Tbio

Protein Ontology

More...PROi		PR:Q4ZIN3
RNActiQ4ZIN3, protein

The Stanford Online Universal Resource for Clones and ESTs

More...SOURCEi		Search...

Gene expression databases

BgeeiENSG00000182087, Expressed in left lobe of thyroid gland and 213 other tissues
ExpressionAtlasiQ4ZIN3, baseline and differential
GenevisibleiQ4ZIN3, HS

Family and domain databases

InterProiView protein in InterPro
IPR019144, Membralin
PANTHERiPTHR21650:SF4, PTHR21650:SF4, 1 hit
PfamiView protein in Pfam
PF09746, Membralin, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiMBRL_HUMAN
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q4ZIN3
Secondary accession number(s): O60392, Q8NF79, Q96H30
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 5, 2005
Last sequence update: June 7, 2005
Last modified: February 23, 2022
This is version 132 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families
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