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Entry version 96 (16 Oct 2019)
Sequence version 1 (07 Jun 2005)
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Protein

Protein GREB1

Gene

GREB1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

May play a role in estrogen-stimulated cell proliferation. Acts as a regulator of hormone-dependent cancer growth in breast and prostate cancers.

Enzyme and pathway databases

Reactome - a knowledgebase of biological pathways and processes

More...
Reactomei
R-HSA-9018519 Estrogen-dependent gene expression

SIGNOR Signaling Network Open Resource

More...
SIGNORi
Q4ZG55

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Protein GREB1
Alternative name(s):
Gene regulated in breast cancer 1 protein
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:GREB1
Synonyms:KIAA0575
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiHomo sapiens (Human)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri9606 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000005640 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 2

Organism-specific databases

Human Gene Nomenclature Database

More...
HGNCi
HGNC:24885 GREB1

Online Mendelian Inheritance in Man (OMIM)

More...
MIMi
611736 gene

neXtProt; the human protein knowledge platform

More...
neXtProti
NX_Q4ZG55

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei1868 – 1888HelicalSequence analysisAdd BLAST21

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componenti

Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

DisGeNET

More...
DisGeNETi
9687

Open Targets

More...
OpenTargetsi
ENSG00000196208

The Pharmacogenetics and Pharmacogenomics Knowledge Base

More...
PharmGKBi
PA164747489

Miscellaneous databases

Pharos NIH Druggable Genome Knowledgebase

More...
Pharosi
Q4ZG55

Polymorphism and mutation databases

BioMuta curated single-nucleotide variation and disease association database

More...
BioMutai
GREB1

Domain mapping of disease mutations (DMDM)

More...
DMDMi
74739248

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00003209441 – 1949Protein GREB1Add BLAST1949

Proteomic databases

Encyclopedia of Proteome Dynamics

More...
EPDi
Q4ZG55

jPOST - Japan Proteome Standard Repository/Database

More...
jPOSTi
Q4ZG55

MassIVE - Mass Spectrometry Interactive Virtual Environment

More...
MassIVEi
Q4ZG55

MaxQB - The MaxQuant DataBase

More...
MaxQBi
Q4ZG55

PaxDb, a database of protein abundance averages across all three domains of life

More...
PaxDbi
Q4ZG55

PeptideAtlas

More...
PeptideAtlasi
Q4ZG55

PRoteomics IDEntifications database

More...
PRIDEi
Q4ZG55

ProteomicsDB: a multi-organism proteome resource

More...
ProteomicsDBi
62378 [Q4ZG55-1]
62379 [Q4ZG55-2]
62380 [Q4ZG55-3]
62381 [Q4ZG55-4]

PTM databases

iPTMnet integrated resource for PTMs in systems biology context

More...
iPTMneti
Q4ZG55

Comprehensive resource for the study of protein post-translational modifications (PTMs) in human, mouse and rat.

More...
PhosphoSitePlusi
Q4ZG55

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’. <br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression">P92958</a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression">Q8TDN4</a>, <a href="http://www.uniprot.org/uniprot/O14734#expression">O14734</a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityi

Expressed in proliferating prostatic tissue and prostate cancer.1 Publication

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Estrogen-responsive; regulated by estrogen receptors. Regulated by androgens. The regulatory region of the gene contains 3 estrogen-responsive elements.5 Publications

Gene expression databases

Bgee dataBase for Gene Expression Evolution

More...
Bgeei
ENSG00000196208 Expressed in 167 organ(s), highest expression level in right ovary

ExpressionAtlas, Differential and Baseline Expression

More...
ExpressionAtlasi
Q4ZG55 baseline and differential

Genevisible search portal to normalized and curated expression data from Genevestigator

More...
Genevisiblei
Q4ZG55 HS

Organism-specific databases

Human Protein Atlas

More...
HPAi
HPA024616
HPA027843
HPA028416

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

The Biological General Repository for Interaction Datasets (BioGrid)

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BioGridi
115040, 18 interactors

Protein interaction database and analysis system

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IntActi
Q4ZG55, 15 interactors

Molecular INTeraction database

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MINTi
Q4ZG55

STRING: functional protein association networks

More...
STRINGi
9606.ENSP00000370896

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q4ZG55

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes the position of regions of compositional bias within the protein and the particular amino acids that are over-represented within those regions.<p><a href='/help/compbias' target='_top'>More...</a></p>Compositional biasi1109 – 1232Ser-richAdd BLAST124

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the GREB1 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

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eggNOGi
ENOG410IF9T Eukaryota
ENOG410Z1PN LUCA

Ensembl GeneTree

More...
GeneTreei
ENSGT00390000008041

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q4ZG55

Identification of Orthologs from Complete Genome Data

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OMAi
GRSDNFH

Database for complete collections of gene phylogenies

More...
PhylomeDBi
Q4ZG55

TreeFam database of animal gene trees

More...
TreeFami
TF329531

Family and domain databases

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR028422 GREB1

The PANTHER Classification System

More...
PANTHERi
PTHR15720 PTHR15720, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF15782 GREB1, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (4+)i

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

This entry describes 4 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsi produced by alternative splicing. AlignAdd to basket

This entry has 4 described isoforms and 3 potential isoforms that are computationally mapped.Show allAlign All

Isoform 1 (identifier: Q4ZG55-1) [UniParc]FASTAAdd to basket
Also known as: GREB1a

This isoform has been chosen as the <div> <p><b>What is the canonical sequence?</b><p><a href='/help/canonical_and_isoforms' target='_top'>More...</a></p>canonicali sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide
        10         20         30         40         50
MGNSYAGQLK TTRFEEVLHN SIEASLRSNN LVPRPIFSQL YLEAEQQLAA
60 70 80 90 100
LEGGSRVDNE EEEEEGEGGL ETNGPPNPFQ LHPLPEGCCT TDGFCQAGKD
110 120 130 140 150
LRLVSISNEP MDVPAGFLLV GVKSPSLPDH LLVCAVDKRF LPDDNGHNAL
160 170 180 190 200
LGFSGNCVGC GKKGFCYFTE FSNHINLKLT TQPKKQKHLK YYLVRNAQGT
210 220 230 240 250
LTKGPLICWK GSEFRSRQIP ASTCSSSLFP ALESTAAFPS EPVPGTNPSI
260 270 280 290 300
LMGAQQAGPA SDHPSLNAAM GPAVFNGKDS PKCQQLAKNN LLALPRPSAL
310 320 330 340 350
GILSNSGPPK KRHKGWSPES PSAPDGGCPQ GGGNRAKYES AGMSCVPQVG
360 370 380 390 400
LVGPASVTFP VVASGEPVSV PDNLLKICKA KPVIFKGHGN FPYLCGNLND
410 420 430 440 450
VVVSPLLYTC YQNSQSVSRA YEQYGASAIQ PISEEMQLLL TVYYLVQLAA
460 470 480 490 500
DQVPLMEDLE QIFLRSWRES HLTEIRQYQQ APPQPFPPAP SAAAPVTSAQ
510 520 530 540 550
LPWLASLAAS SCNDSVHVIE CAYSLAEGLS EMFRLLVEGK LAKTNYVVII
560 570 580 590 600
CACRSAAIDS CIAVTGKYQA RILSESLLTP AEYQKEVNYE LVTGKVDSLG
610 620 630 640 650
AFFSTLCPEG DIDILLDKFH QENQGHISSS LAASSVTKAA SLDVSGTPVC
660 670 680 690 700
TSYNLEPHSI RPFQLAVAQK LLSHVCSIAD SSTQNLDLGS FEKVDFLICI
710 720 730 740 750
PPSEVTYQQT LLHVWHSGVL LELGLKKEHM TKQRVEQYVL KLDTEAQTKF
760 770 780 790 800
KAFLQNSFQN PHTLFVLIHD HAHWDLVSST VHNLYSQSDP SVGLVDRLLN
810 820 830 840 850
CREVKEAPNI VTLHVTSFPY ALQTQHTLIS PYNEIHWPAS CSNGVDLYHE
860 870 880 890 900
NKKYFGLSEF IESTLSGHSL PLLRYDSSFE AMVTALGKRF PRLHSAVIRT
910 920 930 940 950
FVLVQHYAAA LMAVSGLPQM KNYTSVETLE ITQNLLNSPK QCPCGHGLMV
960 970 980 990 1000
LLRVPCSPLA VVAYERLAHV RARLALEEHF EIILGSPSSG VTVGKHFVKQ
1010 1020 1030 1040 1050
LRMWQKIEDV EWRPQTYLEL EGLPCILIFS GMDPHGESLP RSLRYCDLRL
1060 1070 1080 1090 1100
INSSCLVRTA LEQELGLAAY FVSNEVPLEK GARNEALESD AEKLSSTDNE
1110 1120 1130 1140 1150
DEELGTEGST SEKRSPMKRE RSRSHDSASS SLSSKASGSA LGGESSAQPT
1160 1170 1180 1190 1200
ALPQGEHARS PQPRGPAEEG RAPGEKQRPR ASQGPPSAIS RHSPGPTPQP
1210 1220 1230 1240 1250
DCSLRTGQRS VQVSVTSSCS QLSSSSGSSS SSVAPAAGTW VLQASQCSLT
1260 1270 1280 1290 1300
KACRQPPIVF LPKLVYDMVV STDSSGLPKA ASLLPSPSVM WASSFRPLLS
1310 1320 1330 1340 1350
KTMTSTEQSL YYRQWTVPRP SHMDYGNRAE GRVDGFHPRR LLLSGPPQIG
1360 1370 1380 1390 1400
KTGAYLQFLS VLSRMLVRLT EVDVYDEEEI NINLREESDW HYLQLSDPWP
1410 1420 1430 1440 1450
DLELFKKLPF DYIIHDPKYE DASLICSHYQ GIKSEDRGMS RKPEDLYVRR
1460 1470 1480 1490 1500
QTARMRLSKY AAYNTYHHCE QCHQYMGFHP RYQLYESTLH AFAFSYSMLG
1510 1520 1530 1540 1550
EEIQLHFIIP KSKEHHFVFS QPGGQLESMR LPLVTDKSHE YIKSPTFTPT
1560 1570 1580 1590 1600
TGRHEHGLFN LYHAMDGASH LHVLVVKEYE MAIYKKYWPN HIMLVLPSIF
1610 1620 1630 1640 1650
NSAGVGAAHF LIKELSYHNL ELERNRQEEL GIKPQDIWPF IVISDDSCVM
1660 1670 1680 1690 1700
WNVVDVNSAG ERSREFSWSE RNVSLKHIMQ HIEAAPDIMH YALLGLRKWS
1710 1720 1730 1740 1750
SKTRASEVQE PFSRCHVHNF IILNVDLTQN VQYNQNRFLC DDVDFNLRVH
1760 1770 1780 1790 1800
SAGLLLCRFN RFSVMKKQIV VGGHRSFHIT SKVSDNSAAV VPAQYICAPD
1810 1820 1830 1840 1850
SKHTFLAAPA QLLLEKFLQH HSHLFFPLSL KNHDHPVLSV DCYLNLGSQI
1860 1870 1880 1890 1900
SVCYVSSRPH SLNISCSDLL FSGLLLYLCD SFVGASFLKK FHFLKGATLC
1910 1920 1930 1940
VICQDRSSLR QTVVRLELED EWQFRLRDEF QTANAREDRP LFFLTGRHI
Length:1,949
Mass (Da):216,467
Last modified:June 7, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iBA12C0535B166BC4
GO
Isoform 2 (identifier: Q4ZG55-2) [UniParc]FASTAAdd to basket
Also known as: GREB1b

The sequence of this isoform differs from the canonical sequence as follows:
     450-457: ADQVPLME → HQIRNPDV
     458-1949: Missing.

Show »
Length:457
Mass (Da):48,935
Checksum:i2C0028B0ECC23CB4
GO
Isoform 3 (identifier: Q4ZG55-3) [UniParc]FASTAAdd to basket
Also known as: GREB1c

The sequence of this isoform differs from the canonical sequence as follows:
     387-409: GHGNFPYLCGNLNDVVVSPLLYT → VFVNGATQMVALGPAEPASPRSL
     410-1949: Missing.

Show »
Length:409
Mass (Da):43,253
Checksum:i0E03659DC466B4C0
GO
Isoform 4 (identifier: Q4ZG55-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1002: Missing.

Show »
Length:947
Mass (Da):107,227
Checksum:i21023519D9B054E9
GO

<p>In eukaryotic reference proteomes, unreviewed entries that are likely to belong to the same gene are computationally mapped, based on gene identifiers from Ensembl, EnsemblGenomes and model organism databases.<p><a href='/help/gene_centric_isoform_mapping' target='_top'>More...</a></p>Computationally mapped potential isoform sequencesi

There are 3 potential isoforms mapped to this entry.BLASTAlignShow allAdd to basket
EntryEntry nameProtein names
Gene namesLengthAnnotation
F8W6E5F8W6E5_HUMAN
Protein GREB1
GREB1
253Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
A0A0D9SG99A0A0D9SG99_HUMAN
Protein GREB1
GREB1
79Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
C9JIG0C9JIG0_HUMAN
Protein GREB1
GREB1
541Annotation score:

Annotation score:1 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

The sequence BAA25501 differs from that shown. Reason: Erroneous initiation.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section reports difference(s) between the canonical sequence (displayed by default in the entry) and the different sequence submissions merged in the entry. These various submissions may originate from different sequencing projects, different types of experiments, or different biological samples. Sequence conflicts are usually of unknown origin.<p><a href='/help/conflict' target='_top'>More...</a></p>Sequence conflicti829I → S in AAG39036 (PubMed:11103799).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural variantiVAR_03931377N → T2 PublicationsCorresponds to variant dbSNP:rs10929757Ensembl.1
Natural variantiVAR_039314122V → A. Corresponds to variant dbSNP:rs4669751Ensembl.1
Natural variantiVAR_039315346V → M. Corresponds to variant dbSNP:rs6744817Ensembl.1
Natural variantiVAR_061654359F → L. Corresponds to variant dbSNP:rs35188552Ensembl.1
Natural variantiVAR_061655632A → T. Corresponds to variant dbSNP:rs36030386Ensembl.1
Natural variantiVAR_039316973R → Q. Corresponds to variant dbSNP:rs3762579Ensembl.1
Natural variantiVAR_0393171463Y → C. Corresponds to variant dbSNP:rs11695925Ensembl.1
Natural variantiVAR_0393181687D → N2 PublicationsCorresponds to variant dbSNP:rs2304402Ensembl.1
Natural variantiVAR_0393191814L → V. Corresponds to variant dbSNP:rs34955282Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes the sequence of naturally occurring alternative protein isoform(s). The changes in the amino acid sequence may be due to alternative splicing, alternative promoter usage, alternative initiation, or ribosomal frameshifting.<p><a href='/help/var_seq' target='_top'>More...</a></p>Alternative sequenceiVSP_0317571 – 1002Missing in isoform 4. 2 PublicationsAdd BLAST1002
Alternative sequenceiVSP_031758387 – 409GHGNF…PLLYT → VFVNGATQMVALGPAEPASP RSL in isoform 3. 1 PublicationAdd BLAST23
Alternative sequenceiVSP_031759410 – 1949Missing in isoform 3. 1 PublicationAdd BLAST1540
Alternative sequenceiVSP_031760450 – 457ADQVPLME → HQIRNPDV in isoform 2. 1 Publication8
Alternative sequenceiVSP_031761458 – 1949Missing in isoform 2. 1 PublicationAdd BLAST1492

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AF245388 mRNA Translation: AAG39036.1
AF245389 mRNA Translation: AAG39037.1
AF245390 mRNA Translation: AAG39038.1
AB011147 mRNA Translation: BAA25501.2 Different initiation.
AC011994 Genomic DNA Translation: AAX88907.1
AC110754 Genomic DNA No translation available.
CH471053 Genomic DNA Translation: EAX00927.1
CH471053 Genomic DNA Translation: EAX00928.1
BC054502 mRNA Translation: AAH54502.1

The Consensus CDS (CCDS) project

More...
CCDSi
CCDS33146.1 [Q4ZG55-2]
CCDS33147.1 [Q4ZG55-3]
CCDS42655.1 [Q4ZG55-1]

Protein sequence database of the Protein Information Resource

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PIRi
T00340

NCBI Reference Sequences

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RefSeqi
NP_055483.2, NM_014668.3 [Q4ZG55-1]
NP_149081.1, NM_033090.2 [Q4ZG55-2]
NP_683701.2, NM_148903.2 [Q4ZG55-3]
XP_005246249.1, XM_005246192.4 [Q4ZG55-1]
XP_011508725.1, XM_011510423.2 [Q4ZG55-2]

Genome annotation databases

Ensembl eukaryotic genome annotation project

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Ensembli
ENST00000234142; ENSP00000234142; ENSG00000196208 [Q4ZG55-1]
ENST00000263834; ENSP00000263834; ENSG00000196208 [Q4ZG55-3]
ENST00000381483; ENSP00000370892; ENSG00000196208 [Q4ZG55-2]
ENST00000381486; ENSP00000370896; ENSG00000196208 [Q4ZG55-1]
ENST00000396123; ENSP00000379429; ENSG00000196208 [Q4ZG55-4]

Database of genes from NCBI RefSeq genomes

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GeneIDi
9687

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
hsa:9687

UCSC genome browser

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UCSCi
uc002rbk.2 human [Q4ZG55-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

<p>This subsection of the <a href="http://www.uniprot.org/manual/cross_references_section">Cross-references</a> section provides links to various web resources that are relevant for a specific protein.<p><a href='/help/web_resource' target='_top'>More...</a></p>Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF245388 mRNA Translation: AAG39036.1
AF245389 mRNA Translation: AAG39037.1
AF245390 mRNA Translation: AAG39038.1
AB011147 mRNA Translation: BAA25501.2 Different initiation.
AC011994 Genomic DNA Translation: AAX88907.1
AC110754 Genomic DNA No translation available.
CH471053 Genomic DNA Translation: EAX00927.1
CH471053 Genomic DNA Translation: EAX00928.1
BC054502 mRNA Translation: AAH54502.1
CCDSiCCDS33146.1 [Q4ZG55-2]
CCDS33147.1 [Q4ZG55-3]
CCDS42655.1 [Q4ZG55-1]
PIRiT00340
RefSeqiNP_055483.2, NM_014668.3 [Q4ZG55-1]
NP_149081.1, NM_033090.2 [Q4ZG55-2]
NP_683701.2, NM_148903.2 [Q4ZG55-3]
XP_005246249.1, XM_005246192.4 [Q4ZG55-1]
XP_011508725.1, XM_011510423.2 [Q4ZG55-2]

3D structure databases

SMRiQ4ZG55
ModBaseiSearch...

Protein-protein interaction databases

BioGridi115040, 18 interactors
IntActiQ4ZG55, 15 interactors
MINTiQ4ZG55
STRINGi9606.ENSP00000370896

PTM databases

iPTMnetiQ4ZG55
PhosphoSitePlusiQ4ZG55

Polymorphism and mutation databases

BioMutaiGREB1
DMDMi74739248

Proteomic databases

EPDiQ4ZG55
jPOSTiQ4ZG55
MassIVEiQ4ZG55
MaxQBiQ4ZG55
PaxDbiQ4ZG55
PeptideAtlasiQ4ZG55
PRIDEiQ4ZG55
ProteomicsDBi62378 [Q4ZG55-1]
62379 [Q4ZG55-2]
62380 [Q4ZG55-3]
62381 [Q4ZG55-4]

Protocols and materials databases

The DNASU plasmid repository

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DNASUi
9687

Genome annotation databases

EnsembliENST00000234142; ENSP00000234142; ENSG00000196208 [Q4ZG55-1]
ENST00000263834; ENSP00000263834; ENSG00000196208 [Q4ZG55-3]
ENST00000381483; ENSP00000370892; ENSG00000196208 [Q4ZG55-2]
ENST00000381486; ENSP00000370896; ENSG00000196208 [Q4ZG55-1]
ENST00000396123; ENSP00000379429; ENSG00000196208 [Q4ZG55-4]
GeneIDi9687
KEGGihsa:9687
UCSCiuc002rbk.2 human [Q4ZG55-1]

Organism-specific databases

Comparative Toxicogenomics Database

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CTDi
9687
DisGeNETi9687

GeneCards: human genes, protein and diseases

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GeneCardsi
GREB1
HGNCiHGNC:24885 GREB1
HPAiHPA024616
HPA027843
HPA028416
MIMi611736 gene
neXtProtiNX_Q4ZG55
OpenTargetsiENSG00000196208
PharmGKBiPA164747489

Human Unidentified Gene-Encoded large proteins database

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HUGEi
Search...

GenAtlas: human gene database

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GenAtlasi
Search...

Phylogenomic databases

eggNOGiENOG410IF9T Eukaryota
ENOG410Z1PN LUCA
GeneTreeiENSGT00390000008041
InParanoidiQ4ZG55
OMAiGRSDNFH
PhylomeDBiQ4ZG55
TreeFamiTF329531

Enzyme and pathway databases

ReactomeiR-HSA-9018519 Estrogen-dependent gene expression
SIGNORiQ4ZG55

Miscellaneous databases

ChiTaRS: a database of human, mouse and fruit fly chimeric transcripts and RNA-sequencing data

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ChiTaRSi
GREB1 human

Database of phenotypes from RNA interference screens in Drosophila and Homo sapiens

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GenomeRNAii
9687
PharosiQ4ZG55

Protein Ontology

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PROi
PR:Q4ZG55

The Stanford Online Universal Resource for Clones and ESTs

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SOURCEi
Search...

Gene expression databases

BgeeiENSG00000196208 Expressed in 167 organ(s), highest expression level in right ovary
ExpressionAtlasiQ4ZG55 baseline and differential
GenevisibleiQ4ZG55 HS

Family and domain databases

InterProiView protein in InterPro
IPR028422 GREB1
PANTHERiPTHR15720 PTHR15720, 1 hit
PfamiView protein in Pfam
PF15782 GREB1, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

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MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiGREB1_HUMAN
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q4ZG55
Secondary accession number(s): A6NHD0
, A6NKN0, B5MDA9, O60321, Q7Z5S2, Q9H2Q6, Q9H2Q7, Q9H2Q8
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 26, 2008
Last sequence update: June 7, 2005
Last modified: October 16, 2019
This is version 96 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  2. SIMILARITY comments
    Index of protein domains and families
  3. Human chromosome 2
    Human chromosome 2: entries, gene names and cross-references to MIM
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
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