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UniProtKB - Q4WYP0 (NRPS6_ASPFU)
Protein
Nonribosomal peptide synthetase 6
Gene
NRPS6
Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Status
Functioni
Nonribosomal peptide synthesis (NRPS) is a key mechanism responsible for the biosynthesis of bioactive metabolites which are potentially contributing to organismal virulence.
GO - Molecular functioni
- ligase activity Source: UniProtKB-KW
- phosphopantetheine binding Source: GO_Central
GO - Biological processi
- amino acid activation for nonribosomal peptide biosynthetic process Source: GO_Central
- nonribosomal peptide biosynthetic process Source: AspGD
- secondary metabolic process Source: AspGD
- secondary metabolite biosynthetic process Source: GO_Central
Keywordsi
Molecular function | Ligase |
Biological process | Virulence |
Names & Taxonomyi
Protein namesi | |
Gene namesi | Name:NRPS6 Synonyms:pesG ORF Names:AFUA_3G13730 |
Organismi | Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus) |
Taxonomic identifieri | 330879 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Aspergillaceae › Aspergillus › Aspergillus subgen. Fumigati › |
Proteomesi |
|
Organism-specific databases
VEuPathDBi | FungiDB:Afu3g13730 |
PTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000416547 | 1 – 1290 | Nonribosomal peptide synthetase 6Add BLAST | 1290 |
Amino acid modifications
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Modified residuei | 812 | O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation | 1 |
Keywords - PTMi
Phosphopantetheine, PhosphoproteinFamily & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 775 – 851 | CarrierPROSITE-ProRule annotationAdd BLAST | 77 |
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 27 | DisorderedSequence analysisAdd BLAST | 27 | |
Regioni | 260 – 657 | AdenylationAdd BLAST | 398 | |
Regioni | 846 – 870 | DisorderedSequence analysisAdd BLAST | 25 | |
Regioni | 914 – 1162 | CondensationAdd BLAST | 249 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 13 – 27 | Polar residuesSequence analysisAdd BLAST | 15 | |
Compositional biasi | 848 – 870 | Basic and acidic residuesSequence analysisAdd BLAST | 23 |
Domaini
NRP synthetases are composed of discrete domains (adenylation (A), thiolation (T) or peptidyl carrier protein (PCP) and condensation (C) domains) which when grouped together are referred to as a single module. Each module is responsible for the recognition (via the A domain) and incorporation of a single amino acid into the growing peptide product. Thus, an NRP synthetase is generally composed of one or more modules and can terminate in a thioesterase domain (TE) that releases the newly synthesized peptide from the enzyme. Occasionally, epimerase (E) domains (responsible for l- to d- amino acid conversion) are present within the NRP synthetase. NRPS6 has the following architecture: A-T-C.1 Publication
Sequence similaritiesi
Belongs to the NRP synthetase family.Curated
Keywords - Domaini
RepeatPhylogenomic databases
eggNOGi | KOG1178, Eukaryota |
HOGENOMi | CLU_000022_60_3_1 |
InParanoidi | Q4WYP0 |
OMAi | FTTTHRI |
OrthoDBi | 4243at2759 |
Family and domain databases
Gene3Di | 1.10.1200.10, 1 hit 3.30.300.30, 1 hit 3.30.559.10, 1 hit 3.40.50.12780, 1 hit |
InterProi | View protein in InterPro IPR036736, ACP-like_sf IPR045851, AMP-bd_C_sf IPR000873, AMP-dep_Synth/Lig IPR042099, ANL_N_sf IPR023213, CAT-like_dom_sf IPR001242, Condensatn IPR009081, PP-bd_ACP |
Pfami | View protein in Pfam PF00501, AMP-binding, 1 hit PF00668, Condensation, 1 hit PF00550, PP-binding, 1 hit |
SUPFAMi | SSF47336, SSF47336, 1 hit |
PROSITEi | View protein in PROSITE PS50075, CARRIER, 1 hit |
i Sequence
Sequence statusi: Complete.
Q4WYP0-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MTAIDVPWLS TPRRDNSHGT RSNSSCQPSC TQRIAVPISP DAVKYPLAVF
60 70 80 90 100
CFAWAVTLGA YLDSQELVIG FAFHGWDGDT SIPSAGTCRI RIRPEQEILP
110 120 130 140 150
ALDEVVADGD KGLRSWVAQG AGSETDIAIQ RKEVGDSLHP AVHGDEKLSP
160 170 180 190 200
EIIITPSGNQ GPYHVQGRFD PHIVAPALAH MMLHQFAFAV QGIVRGQSSI
210 220 230 240 250
ASSQVKDLQA ISPDGMAQLM RWNRQSAAEE DGACVQDLIQ RTCQQQPHAM
260 270 280 290 300
AVCAWDGSWS YQELDCQASH LASQLCDHGI EPEKFVGLLF EKSKWTTVAI
310 320 330 340 350
LAVLKAGGAF VLLDPTQPAA YLSAICTMTR TALLLCSSHN QRLAAELRQT
360 370 380 390 400
TIQVPRDPYH GAMPTSDFRR QSSPAVQPHH TLYACFTSGS TGRPKGFIID
410 420 430 440 450
HVAFNSGLQT YAHATGLGCD SRVFQFASYS FAPSITDQLA SLIVGASICV
460 470 480 490 500
PAEEELQNDV EGSISQLQAT WLKLTPSVAR TLDPGRLPCV KTLILVGEEA
510 520 530 540 550
QVSDVAAWQD HGITVLGLYG QSENAKGTMV SRKSSEDADP GNIGSPFCAV
560 570 580 590 600
GWVVDPDDYH RLMPIGATGE LLLESPCLCR GYIDNEDETK LAFVSKPSWL
610 620 630 640 650
TQVRGQGTAQ PLLRTGDIVR YNCVDGTFCL VGRKGNRVKL RGQRLELAQV
660 670 680 690 700
EHHLRSCLSS THPVLADVVQ PANENGRDPM LVAFVPWADS QSAADATDGF
710 720 730 740 750
FAPPTKDFQT QARAVLGRLR HLLPSFMVPS TLLAVRTIPR TGTGKIHRRR
760 770 780 790 800
LQEAASMLSR KQLMAYISPF IPYRAPETEL ERKLQRACGR LLNIEADQIS
810 820 830 840 850
MQDNFFDLGG NSLTARQLVA VARAEGLQVS VAQIFQQPTL AGLAQTHRHP
860 870 880 890 900
VRRAEVPRSS HDPDPFGRVR DDVRREGLPH IARGNIEDAL PVLYTQMTTA
910 920 930 940 950
RDHCVDFFPL RVIGGQLDPE QLRLAWTRVI QAFPILRTVF PRFRGRFIQL
960 970 980 990 1000
VVRDIGDSNF YRVVEAPSGQ TAEEWARALC TEAIQFRCPV DRPVAQLTLI
1010 1020 1030 1040 1050
QAAGSSALVL RLCHAQYDGS CLEHLVRSLM MAYHGRPLVV ESDFQAYTRT
1060 1070 1080 1090 1100
CLRLRIPEVL DFWRRFLAGS SPTQLASSMT GDREAARKIN RSFFRREVNS
1110 1120 1130 1140 1150
LAAPAGFTLA TVVKAAWSWV LRNETRSEDV VFGQLVSCRG SVPLPHADTI
1160 1170 1180 1190 1200
IGPCMNIIPV RVGRDLLGAV QAQHAQTMEF DMIGMDEIVR HCTSWPAGTE
1210 1220 1230 1240 1250
PDSIIIHENF HVDWEVHDGG VTIQKIAAVF NQQPSSLTFL ITIPTETGLI
1260 1270 1280 1290
AVLMAPANMS STHADRVLDL FCNTLTRLAW SPAAVLRRSE
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AAHF01000002 Genomic DNA Translation: EAL92213.1 |
RefSeqi | XP_754251.1, XM_749158.1 |
Genome annotation databases
EnsemblFungii | EAL92213; EAL92213; AFUA_3G13730 |
GeneIDi | 3512418 |
KEGGi | afm:AFUA_3G13730 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AAHF01000002 Genomic DNA Translation: EAL92213.1 |
RefSeqi | XP_754251.1, XM_749158.1 |
3D structure databases
SMRi | Q4WYP0 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 746128.CADAFUBP00003471 |
Genome annotation databases
EnsemblFungii | EAL92213; EAL92213; AFUA_3G13730 |
GeneIDi | 3512418 |
KEGGi | afm:AFUA_3G13730 |
Organism-specific databases
VEuPathDBi | FungiDB:Afu3g13730 |
Phylogenomic databases
eggNOGi | KOG1178, Eukaryota |
HOGENOMi | CLU_000022_60_3_1 |
InParanoidi | Q4WYP0 |
OMAi | FTTTHRI |
OrthoDBi | 4243at2759 |
Family and domain databases
Gene3Di | 1.10.1200.10, 1 hit 3.30.300.30, 1 hit 3.30.559.10, 1 hit 3.40.50.12780, 1 hit |
InterProi | View protein in InterPro IPR036736, ACP-like_sf IPR045851, AMP-bd_C_sf IPR000873, AMP-dep_Synth/Lig IPR042099, ANL_N_sf IPR023213, CAT-like_dom_sf IPR001242, Condensatn IPR009081, PP-bd_ACP |
Pfami | View protein in Pfam PF00501, AMP-binding, 1 hit PF00668, Condensation, 1 hit PF00550, PP-binding, 1 hit |
SUPFAMi | SSF47336, SSF47336, 1 hit |
PROSITEi | View protein in PROSITE PS50075, CARRIER, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | NRPS6_ASPFU | |
Accessioni | Q4WYP0Primary (citable) accession number: Q4WYP0 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | April 18, 2012 |
Last sequence update: | July 5, 2005 | |
Last modified: | February 23, 2022 | |
This is version 93 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |
Miscellaneousi
Keywords - Technical termi
Reference proteomeDocuments
- SIMILARITY comments
Index of protein domains and families