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Entry version 74 (11 Dec 2019)
Sequence version 2 (17 Apr 2007)
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Protein

7-dimethylallyltryptophan synthase

Gene

etpPT

Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the prenylation of L-tryptophan at the C-7 position of the indole moiety. The enzyme is specific for dimethylallyl diphosphate (DMAPP) as prenyl donor. Accepts also D-tryptophan, typtophan-derivatives with modifications at the side chain or the indole ring, and linear and cyclic dipeptides such as H-L-Trp-L-Gly-OH or cyclo-L-Trp-L-Gly as substrates, however with lower efficiency. Also has tryptophan aminopeptidase activity towards linear peptides with a tryptophanyl moiety at the N-terminus. Dipeptides are better substrates than peptides with 3 or more amino acids. Enzymatic rate constants however are much higher for the prenyltransferase activity than for the aminopeptidase activity.3 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the ‘Function’ section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=67 µM for dimethylallyl diphosphate1 Publication
  2. KM=137 µM for L-tryptophan1 Publication
  3. KM=350 µM for H-L-Trp-L-Gly-OH (for aminopeptidase activity)1 Publication
  1. Vmax=0.21 µmol/min/mg enzyme1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionAminopeptidase, Hydrolase, Protease, Transferase

Enzyme and pathway databases

BioCyc Collection of Pathway/Genome Databases

More...
BioCyci
MetaCyc:MONOMER-15368

BRENDA Comprehensive Enzyme Information System

More...
BRENDAi
2.5.1.34 508
2.5.1.80 508

Protein family/group databases

MEROPS protease database

More...
MEROPSi
M77.001

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
7-dimethylallyltryptophan synthase1 Publication (EC:2.5.1.802 Publications)
Short name:
7-DMATS1 Publication
Alternative name(s):
Tryptophan aminopeptidase1 Publication (EC:3.4.11.171 Publication)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:etpPT
ORF Names:AFUA_3G12930
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiNeosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri330879 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002530 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componentsi: Chromosome 3, Unassembled WGS sequence

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
FungiDB:Afu3g12930

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004185411 – 4727-dimethylallyltryptophan synthaseAdd BLAST472

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

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SMRi
Q4WYG3

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000217175

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q4WYG3

KEGG Orthology (KO)

More...
KOi
K14131

Identification of Orthologs from Complete Genome Data

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OMAi
EMISVDC

Database of Orthologous Groups

More...
OrthoDBi
1531660at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd13929 PT-DMATS_CymD, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR033964 Aro_prenylTrfase
IPR017795 Aro_prenylTrfase_DMATS
IPR012148 DMATS-type_fun

The PANTHER Classification System

More...
PANTHERi
PTHR40627 PTHR40627, 1 hit

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF11991 Trp_DMAT, 1 hit

PIRSF; a whole-protein classification database

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PIRSFi
PIRSF000509 Trp_DMAT, 1 hit

Structure-Function Linkage Database

More...
SFLDi
SFLDS00036 Aromatic_Prenyltransferase, 1 hit

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR03429 arom_pren_DMATS, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q4WYG3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSIGAEIDSL VPAPPGLNGT AAGYPAKTQK ELSNGDFDAH DGLSLAQLTP
60 70 80 90 100
YDVLTAALPL PAPASSTGFW WRETGPVMSK LLAKANYPLY THYKYLMLYH
110 120 130 140 150
THILPLLGPR PPLENSTHPS PSNAPWRSFL TDDFTPLEPS WNVNGNSEAQ
160 170 180 190 200
STIRLGIEPI GFEAGAAADP FNQAAVTQFM HSYEATEVGA TLTLFEHFRN
210 220 230 240 250
DMFVGPETYA ALRAKIPEGE HTTQSFLAFD LDAGRVTTKA YFFPILMSLK
260 270 280 290 300
TGQSTTKVVS DSILHLALKS EVWGVQTIAA MSVMEAWIGS YGGAAKTEMI
310 320 330 340 350
SVDCVNEADS RIKIYVRMPH TSLRKVKEAY CLGGRLTDEN TKEGLKLLDE
360 370 380 390 400
LWRTVFGIDD EDAELPQNSH RTAGTIFNFE LRPGKWFPEP KVYLPVRHYC
410 420 430 440 450
ESDMQIASRL QTFFGRLGWH NMEKDYCKHL EDLFPHHPLS SSTGTHTFLS
460 470
FSYKKQKGVY MTMYYNLRVY ST
Length:472
Mass (Da):52,688
Last modified:April 17, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i9FCA3EA23FB645DE
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Sequence’ section describes natural variant(s) of the protein sequence.<p><a href='/help/variant' target='_top'>More...</a></p>Natural varianti15P → Q in strain: B5233 / ATCC 13073. 1
Natural varianti271E → G in strain: B5233 / ATCC 13073. 1

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
EF539173 mRNA Translation: ABS89001.1
AAHF01000002 Genomic DNA Translation: EAL92290.2

NCBI Reference Sequences

More...
RefSeqi
XP_754328.2, XM_749235.2

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
EAL92290; EAL92290; AFUA_3G12930

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
3512456

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
afm:AFUA_3G12930

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
EF539173 mRNA Translation: ABS89001.1
AAHF01000002 Genomic DNA Translation: EAL92290.2
RefSeqiXP_754328.2, XM_749235.2

3D structure databases

SMRiQ4WYG3
ModBaseiSearch...

Protein family/group databases

MEROPSiM77.001

Genome annotation databases

EnsemblFungiiEAL92290; EAL92290; AFUA_3G12930
GeneIDi3512456
KEGGiafm:AFUA_3G12930

Organism-specific databases

EuPathDBiFungiDB:Afu3g12930

Phylogenomic databases

HOGENOMiHOG000217175
InParanoidiQ4WYG3
KOiK14131
OMAiEMISVDC
OrthoDBi1531660at2759

Enzyme and pathway databases

BioCyciMetaCyc:MONOMER-15368
BRENDAi2.5.1.34 508
2.5.1.80 508

Family and domain databases

CDDicd13929 PT-DMATS_CymD, 1 hit
InterProiView protein in InterPro
IPR033964 Aro_prenylTrfase
IPR017795 Aro_prenylTrfase_DMATS
IPR012148 DMATS-type_fun
PANTHERiPTHR40627 PTHR40627, 1 hit
PfamiView protein in Pfam
PF11991 Trp_DMAT, 1 hit
PIRSFiPIRSF000509 Trp_DMAT, 1 hit
SFLDiSFLDS00036 Aromatic_Prenyltransferase, 1 hit
TIGRFAMsiTIGR03429 arom_pren_DMATS, 1 hit

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry namei7DMAW_ASPFU
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q4WYG3
Secondary accession number(s): A8JY03
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 5, 2012
Last sequence update: April 17, 2007
Last modified: December 11, 2019
This is version 74 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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