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Entry version 105 (03 Jul 2019)
Sequence version 1 (05 Jul 2005)
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Protein

ABC multidrug transporter atrI

Gene

atrI

Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Pleiotropic ABC efflux transporter that confers resistance to azoles such as itraconazole and voriconazole.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi864 – 871ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTransport
LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
ABC multidrug transporter atrI
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:atrI1 Publication
ORF Names:AFUA_3G07300
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiNeosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri330879 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002530 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componentsi: Chromosome 3, Unassembled WGS sequence

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
FungiDB:Afu3g07300

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte & Seán O’Donoghue; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei506 – 526HelicalSequence analysisAdd BLAST21
Transmembranei530 – 550HelicalSequence analysisAdd BLAST21
Transmembranei580 – 600HelicalSequence analysisAdd BLAST21
Transmembranei605 – 625HelicalSequence analysisAdd BLAST21
Transmembranei639 – 659HelicalSequence analysisAdd BLAST21
Transmembranei664 – 684HelicalSequence analysisAdd BLAST21
Transmembranei744 – 764HelicalSequence analysisAdd BLAST21
Transmembranei1168 – 1188HelicalSequence analysisAdd BLAST21
Transmembranei1204 – 1224HelicalSequence analysisAdd BLAST21
Transmembranei1244 – 1264HelicalSequence analysisAdd BLAST21
Transmembranei1282 – 1302HelicalSequence analysisAdd BLAST21
Transmembranei1309 – 1329HelicalSequence analysisAdd BLAST21
Transmembranei1337 – 1357HelicalSequence analysisAdd BLAST21
Transmembranei1433 – 1453HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Membrane

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Exhibits enhanced susceptibility to itraconazole, however voriconazole susceptibility is less affected.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004451011 – 1472ABC multidrug transporter atrIAdd BLAST1472

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi143N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi277N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi308N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi332N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi1402N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi1460N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1

Keywords - PTMi

Glycoprotein

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Expression is increased in clinical azole-resistant isolates.1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
746128.CADAFUBP00004094

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini134 – 384ABC transporter 1PROSITE-ProRule annotationAdd BLAST251
Domaini828 – 1070ABC transporter 2PROSITE-ProRule annotationAdd BLAST243

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000162078

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q4WWW3

Identification of Orthologs from Complete Genome Data

More...
OMAi
FTWRDVV

Database of Orthologous Groups

More...
OrthoDBi
56980at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd03232 ABCG_PDR_domain2, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003593 AAA+_ATPase
IPR013525 ABC_2_trans
IPR029481 ABC_trans_N
IPR003439 ABC_transporter-like
IPR034003 ABCG_PDR_2
IPR027417 P-loop_NTPase
IPR010929 PDR_CDR_ABC

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF01061 ABC2_membrane, 2 hits
PF00005 ABC_tran, 2 hits
PF14510 ABC_trans_N, 1 hit
PF06422 PDR_CDR, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00382 AAA, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50893 ABC_TRANSPORTER_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q4WWW3-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MRRSNVVPVH SLTSSTNTGR DSRGEKYDEL TPVATRRASI SPDEARYLTQ
60 70 80 90 100
LASRDNAVSR VSTVADISLD DPALNPENKD FDLYKWLRKV VHVLNEEGVP
110 120 130 140 150
RKEASIFFQH LRVSGTGAAL QLQKTVADII TAPFRRETWN FRNKTSKTIL
160 170 180 190 200
HDFNGMLHSG ELLIVLGRPG SGCSTFLKTL SGELHGLNVD EKTVLHYSGI
210 220 230 240 250
PQSTMIKEFK GEVVYNQEVD KHFPHLTVGQ TLEFAAAVRT PSKRLGGMSR
260 270 280 290 300
NEYAQMMTKV VMAVFGLSHT YNTKVGNDTV RGVPGGERKR VSIAEMALAG
310 320 330 340 350
APLAAWDNST RGLDSATALK FVESLRLAAD LNSSAHAVAI YQASQAIYDL
360 370 380 390 400
FDKAVVLYEG RQIYFGPASK AKAFFERQGW FCPPRQTTGD FLTSVTNPIE
410 420 430 440 450
RQARPGMESQ VPRTAAEFEA YWLESEEYKE LQREMAAFQG ETSSQGNEKL
460 470 480 490 500
LEFQQRKRLA QASHTRPKSP YLLSIPMQIK LNTKRAYQRV WNERTSTMTT
510 520 530 540 550
FIGNTILALI VGSVFYGTPT ATAGFYAKGA TLFYAVLLNA LTAMTEINSL
560 570 580 590 600
YSQRPIVEKH ASFAFYHPAT EAIAGVVSDI PVKFLMAIAF NIILYFLSGL
610 620 630 640 650
RREPSQFFIY FLITFIIMFV MSAVFRTMAA ITRTVSQAMT LAGVLILMLV
660 670 680 690 700
IYTGFVVPVN YMHPWFKWIH YLNPIFYAFE ILIANEFHGR EFTCSQFIPV
710 720 730 740 750
YPNLPGDSFV CSSRGAVAGR RTVSGDAYIE ASYSYSYSHV WRNFGILIAF
760 770 780 790 800
LIGFMVIYFV ATELNSATTS SAEVLVFRRG HEPAHLKNGH EPGADEEAGA
810 820 830 840 850
GKTVVSSSAE ENKQDQGITS IPPQQDIFTW RDVVYDIEIK GEPRRLLDHV
860 870 880 890 900
SGWVKPGTLT ALMGVSGAGK TTLLDVLAHR TTMGVITGDM FVNGKPLDSS
910 920 930 940 950
FQRKTGYVQQ QDLHLETATV RESLRFSAML RQPASVSKEE KYAYVEEVIK
960 970 980 990 1000
MLNMEDFAEA VVGVPGEGLN VEQRKLLTIG VELAAKPKLL LFLDEPTSGL
1010 1020 1030 1040 1050
DSQSSWAICN FLRKLADAGQ AILCTIHQPS AILFEQFDQL LFLARGGKTV
1060 1070 1080 1090 1100
YFGPIGENSQ TLLKYFESHG PRRCGDQENP AEYMLEVVNA GTNPRGENWF
1110 1120 1130 1140 1150
DLWKASKEAA GVQAEIDRIH ESKRGEAESK DSTNPKDREH EEFAMPFFKQ
1160 1170 1180 1190 1200
LPIVTVRVFQ QYWRLPMYIA AKMMLGICAG LFIGFSFFKA DTSLQGMQNV
1210 1220 1230 1240 1250
IFSVFMLCAI FSSLVQQIIP LFITQRALYE VRERPSKTYS WKAFMIANII
1260 1270 1280 1290 1300
VEIPYQILMG ILVFGCYYYA VNGVQSSDRQ GLVLLFCIQF FIYASTFADF
1310 1320 1330 1340 1350
VIAALPDAET AGAIVTLQFS MALTFNGVMQ TPEALPGFWI FMYRVSPFTY
1360 1370 1380 1390 1400
WVGGMAATQL HGRAVKCSAA ETAIFNPPSG LTCQEYMADY MAVAPGHLSN
1410 1420 1430 1440 1450
PNATSSCEFC SLSVADQYLA SVNIYWSERW RNFGIFWAYV VFDIAVAVML
1460 1470
YYCFRVKKWN FSFGKRKKSK AA
Length:1,472
Mass (Da):164,612
Last modified:July 5, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i88B4FFB72AA0C45E
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AAHF01000002 Genomic DNA Translation: EAL92840.1

NCBI Reference Sequences

More...
RefSeqi
XP_754878.1, XM_749785.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
EAL92840; EAL92840; AFUA_3G07300

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
3512111

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
afm:AFUA_3G07300

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAHF01000002 Genomic DNA Translation: EAL92840.1
RefSeqiXP_754878.1, XM_749785.1

3D structure databases

Database of comparative protein structure models

More...
ModBasei
Search...

SWISS-MODEL Interactive Workspace

More...
SWISS-MODEL-Workspacei
Submit a new modelling project...

Protein-protein interaction databases

STRINGi746128.CADAFUBP00004094

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiEAL92840; EAL92840; AFUA_3G07300
GeneIDi3512111
KEGGiafm:AFUA_3G07300

Organism-specific databases

EuPathDBiFungiDB:Afu3g07300

Phylogenomic databases

HOGENOMiHOG000162078
InParanoidiQ4WWW3
OMAiFTWRDVV
OrthoDBi56980at2759

Family and domain databases

CDDicd03232 ABCG_PDR_domain2, 1 hit
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR013525 ABC_2_trans
IPR029481 ABC_trans_N
IPR003439 ABC_transporter-like
IPR034003 ABCG_PDR_2
IPR027417 P-loop_NTPase
IPR010929 PDR_CDR_ABC
PfamiView protein in Pfam
PF01061 ABC2_membrane, 2 hits
PF00005 ABC_tran, 2 hits
PF14510 ABC_trans_N, 1 hit
PF06422 PDR_CDR, 2 hits
SMARTiView protein in SMART
SM00382 AAA, 2 hits
SUPFAMiSSF52540 SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS50893 ABC_TRANSPORTER_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiATRI_ASPFU
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q4WWW3
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 10, 2018
Last sequence update: July 5, 2005
Last modified: July 3, 2019
This is version 105 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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