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UniProtKB - Q4WVN4 (NRPS8_ASPFU)

Entry version 116 (23 Feb 2022)
Sequence version 1 (05 Jul 2005)
Previous versions | rss
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Protein

Nonribosomal peptide synthetase 8

Gene

NRPS8

Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Nonribosomal peptide synthesis (NRPS) is a key mechanism responsible for the biosynthesis of bioactive metabolites which are potentially contributing to organismal virulence. However, contarary to other nonribosomal peptide synthases, NRPS8 does not encode a secreted peptide, but has more a structural role since it is involved in germ tube formation.

1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionLigase

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nonribosomal peptide synthetase 8 (EC:6.3.2.-)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NRPS8
Synonyms:pes3, pesI
ORF Names:AFUA_5G12730
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiNeosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri330879 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Aspergillaceae › Aspergillus › Aspergillus subgen. Fumigati ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002530 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		FungiDB:Afu5g12730

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

In contrast to other NRP synthetases, deletion of NRPS8 significantly increases the virulence, probably through aberrant innate immune recognition of the fungus.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004165491 – 8515Nonribosomal peptide synthetase 8Add BLAST8515

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei652O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1
Modified residuei1769O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1
Modified residuei3323O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1
Modified residuei3894O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1
Modified residuei5422O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1
Modified residuei6519O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1
Modified residuei7612O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1

Keywords - PTMi

Phosphopantetheine, Phosphoprotein

Proteomic databases

PRoteomics IDEntifications database

More...PRIDEi		Q4WVN4

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		746128.CADAFUBP00005903

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q4WVN4

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini615 – 691Carrier 1PROSITE-ProRule annotationAdd BLAST77
Domaini1732 – 1808Carrier 2PROSITE-ProRule annotationAdd BLAST77
Domaini3286 – 3362Carrier 3PROSITE-ProRule annotationAdd BLAST77
Domaini3857 – 3933Carrier 4PROSITE-ProRule annotationAdd BLAST77
Domaini5385 – 5461Carrier 5PROSITE-ProRule annotationAdd BLAST77
Domaini6482 – 6558Carrier 6PROSITE-ProRule annotationAdd BLAST77
Domaini7575 – 7651Carrier 7PROSITE-ProRule annotationAdd BLAST77

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni59 – 736Adenylation 1Add BLAST678
Regioni587 – 1159Condensation 1Add BLAST573
Regioni1163 – 1705Adenylation 2Add BLAST543
Regioni1830 – 2273Epimerase 1Add BLAST444
Regioni2301 – 2709Condensation 2Add BLAST409
Regioni2733 – 3266Adenylation 3Add BLAST534
Regioni3406 – 3819Condensation 3Add BLAST414
Regioni3953 – 4392Epimerase 2Add BLAST440
Regioni4420 – 4823Condensation 4Add BLAST404
Regioni4837 – 5363Adenylation 4Add BLAST527
Regioni5508 – 5923Condensation 5Add BLAST416
Regioni5941 – 6459Adenylation 5Add BLAST519
Regioni6606 – 6992Condensation 6Add BLAST387
Regioni7030 – 7544Adenylation 6Add BLAST515
Regioni7670 – 8119Epimerase 3Add BLAST450
Regioni8164 – 8504Condensation 7Add BLAST341
Regioni8488 – 8515DisorderedSequence analysisAdd BLAST28

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

NRP synthetases are composed of discrete domains (adenylation (A), thiolation (T) or peptidyl carrier protein (PCP) and condensation (C) domains) which when grouped together are referred to as a single module. Each module is responsible for the recognition (via the A domain) and incorporation of a single amino acid into the growing peptide product. Thus, an NRP synthetase is generally composed of one or more modules and can terminate in a thioesterase domain (TE) that releases the newly synthesized peptide from the enzyme. Occasionally, epimerase (E) domains (responsible for l- to d- amino acid conversion) are present within the NRP synthetase. NRPS8 has the following architecture: A-T-C-A-T-E-C-A-T-C-T-E-C-A-T-C-A-T-C-A-T-E-C.1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NRP synthetase family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1178, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_222660_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q4WVN4

Identification of Orthologs from Complete Genome Data

More...OMAi		QYIEWLE

Database of Orthologous Groups

More...OrthoDBi		4243at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.1200.10, 7 hits
3.30.300.30, 6 hits
3.30.559.10, 10 hits
3.40.50.12780, 5 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR010071, AA_adenyl_domain
IPR036736, ACP-like_sf
IPR045851, AMP-bd_C_sf
IPR020845, AMP-binding_CS
IPR000873, AMP-dep_Synth/Lig
IPR042099, ANL_N_sf
IPR023213, CAT-like_dom_sf
IPR001242, Condensatn
IPR020806, PKS_PP-bd
IPR009081, PP-bd_ACP
IPR006162, Ppantetheine_attach_site

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00501, AMP-binding, 6 hits
PF00668, Condensation, 10 hits
PF00550, PP-binding, 7 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00823, PKS_PP, 7 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47336, SSF47336, 7 hits

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR01733, AA-adenyl-dom, 6 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00455, AMP_BINDING, 6 hits
PS50075, CARRIER, 7 hits
PS00012, PHOSPHOPANTETHEINE, 2 hits
PS50007, PIPLC_X_DOMAIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q4WVN4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSNNTMVNMS IEMKYDNDDT TSPDQKLPGL EALEMVKGAA SVVAEIEPSS 
        60         70         80         90        100
SASSIMGSRE HHERMLGPLE VCVHDLVQEQ SRQHGQTIAV HSIEKDLTYA 
       110        120        130        140        150
ELERYADWMA KYLMVKRDIQ AGHIIPFCLK KSVWTMVAML AIMKTGAACA 
       160        170        180        190        200
ALDPSQPVSR IKRILDDTEA PLVIVHRDYL GLAETLDVPS IVLGPDLWEG 
       210        220        230        240        250
TSSGDTDKPL PVVDATQPAY IAFTSGSTGE PKGIVVPHRS IATSMREHGP 
       260        270        280        290        300
ATRVDTETRA LQFASYTFDM SFQEMFTTLT HGGCVCVPSE AERWNDLAGA 
       310        320        330        340        350
MERLGVNWAK LTPTVVRLLH PEQVPSLRTL VVGGEPITQD IIQTWAHRVD 
       360        370        380        390        400
LIVSYGPAEA SIMAAVSDPL APTALPRVIG RQVGGTLHVV DAGNHDRLVE 
       410        420        430        440        450
GSGEGELLIE GPILATGYLK DQSRTDATFI IDPKWVSCDS ENVTTAPRRF 
       460        470        480        490        500
LKTGDLVHRD EDGVLYHLGR KDFRLKLNGR LIDLAAIETC LLGSAQIASA 
       510        520        530        540        550
VVIATREDTF WQQSLVAVIS AKPTPSSRPD PHDAGHIRIQ TQHDLMLPLI 
       560        570        580        590        600
RDLKDVAQSA LPDYMVPTVW LVVDSVPRLP SGKIHRRRVV QWLENLDEFT 
       610        620        630        640        650
VQEIRSMQNH TPHCEPETAM ERRLRDIWAE VLNMPVSTVS TMASFTGLGG 
       660        670        680        690        700
DSVAAMRLAR RCAAQGLEID VQMILQNLSI TELAPRVKVA EHSTDTSADN 
       710        720        730        740        750
ERFSIGISLD QLCQSLPPRL RSSITLDDVV DTYRCSPMQE AILLSRSRFQ 
       760        770        780        790        800
GYYDVRWVAE VVSIDQDTPI SLQRVRDAWV DVVRRHPALR TFFVQDASTG 
       810        820        830        840        850
NRLLTQVILG SFPPLVSIDH SQATLDGIMG VNAAESSDPL HQEPHRLSLF 
       860        870        880        890        900
SLPTGQVFLK LELNHALSDG VSTALIFRDL SLAYSKALPS SPAPSFGGFI 
       910        920        930        940        950
RRLNLGEAEA SSTALKYWTD RLTGMVPCLF PVLREAAWTG PSAVQHVEIP 
       960        970        980        990       1000
IHGSQGALRR FCTQHGTTIA NVFQTAWALV LSIYTGTDDV SFCYLVSGRD 
      1010       1020       1030       1040       1050
ASVDNVDEIV GPLISIMVHR LTLSRSLALL QVLRQVQSDF TVALGHQHCS 
      1060       1070       1080       1090       1100
LAQIAHSLNL RGQPMSNTVV NVQRRFSQGG PDGVADVYIR GIDCCNPTEF 
      1110       1120       1130       1140       1150
AIAVDVEDWE TYMTARLSYW ESCISQTQAE GIAETLAEVI RNIQTNPLQT 
      1160       1170       1180       1190       1200
VGEVALVGDA VLAKLSTWNA VLPEANEACL PELVERQVIS QPSAVAIDTD 
      1210       1220       1230       1240       1250
AEQITYISLW NLSGLLAGRL IDSGVQPRDL VAVCVPQSSW AVIAMLAIQR 
      1260       1270       1280       1290       1300
AGGACVPLDP KAPAQRWWEI ISRTGISTVV TSETKKHIMS SQLPGLQVVS 
      1310       1320       1330       1340       1350
ADGTEIDQHH LQGSGRVLPV LSVDSTAYVL FTSGSTGSPK GIDVPHRAIC 
      1360       1370       1380       1390       1400
TSLCAHCPVL GITNETRSLQ FAAYTFDASI EETFGVLVHG GCVCIPSEDT 
      1410       1420       1430       1440       1450
KMNGLVDFIN RKAISWAFFT PSLVRLIDPD LVPSLQTIVL GGEAVGNDIF 
      1460       1470       1480       1490       1500
NTWSHRVDLI NGYGPAEASI CCAAAHLSLR QTQSPSTIGR AVGCRIWVVD 
      1510       1520       1530       1540       1550
PQNINRLLPP DCVGELLIEG HIVANGYWGD EERTASSFLP PPEFLQSLSL 
      1560       1570       1580       1590       1600
EYPADNFRRC FYRTGDLVRQ RHDGSLIYVG RSDWQTKVNG QRVEIGEVEA 
      1610       1620       1630       1640       1650
QLSFHMAKNH SNHLSMVCVP KSGPWMKRLV AILSLDPEEC TVGNRSNVVF 
      1660       1670       1680       1690       1700
CLDKPETAAM IRTISKGIES SLPPFMIPTV WIPVKQLPTL ASGKINRRCV 
      1710       1720       1730       1740       1750
QEWVETSNEG IFLSVSRINS EAFGTSSTET TRGLTPTETV IRAIWSRVLN 
      1760       1770       1780       1790       1800
IPLHSIGLDN TFLSLGGDSI SAMQVVYQAH REGLTISVQD IFHCKTVAKL 
      1810       1820       1830       1840       1850
GRHADHSSKN TSSSNLLAPP VDEVEVPFAL SPIQQWFFES VPHKPAILNH 
      1860       1870       1880       1890       1900
YNQSAHFRVM KEIDHSQLFK ALQHVVQRHA MLRSRFILDS WSWQQKITTD 
      1910       1920       1930       1940       1950
IEGSFRLEVE SIDAITAFRS CCERAQKMID IIHGPLLVAI LVKVAEPAQH 
      1960       1970       1980       1990       2000
FLVLIGHHLS MDVVSWSIIH RELEAFLAGG QVIAPLSSTS FQQWARLHYE 
      2010       2020       2030       2040       2050
PNIVPAEPRE VLPFSVLEAD LDYWGMRDTA NEYRHGEYIT TSVDEETTAS 
      2060       2070       2080       2090       2100
IFKEANIAIG TEPVELIMAA VLYSFGRIFH DRSLPALYME AHGREGDEFG 
      2110       2120       2130       2140       2150
LDLSGTVGWF TTICPLQLHR ESLHTWARAV AQVKDRRRSI PAKGWAYFAC 
      2160       2170       2180       2190       2200
RTVSPKGQAS FNHHQQMEIL FNFTGSTGDI NDEHDRFLSP VRLMEDSRSD 
      2210       2220       2230       2240       2250
FDPKTPRVAL FAIEASVENR QLRFSVSYHR SMRHVPRVKQ WIHSLPSTLQ 
      2260       2270       2280       2290       2300
EGVQMLSTIG RQPTLYDCPL AALNYSDLDS ILARIQQSQA DMVVEEIYPC 
      2310       2320       2330       2340       2350
SHIQEGILLS SMRNPGHYQV RWLVKVEARR GLPVSTQRLA KAWQSVVRKH 
      2360       2370       2380       2390       2400
SILRTIFVDD PSGTSSFLQV VVEDPRYPAS IVEVQHRDSV ASLDEDIDFT 
      2410       2420       2430       2440       2450
VGELPYRATI YQLHDGNVFF LLDISHAILD GTSMGILAHE LVRGYDGSLT 
      2460       2470       2480       2490       2500
GDEAPHYRDY IRLLQTMPRN ETLAHWKAYL QDIEPCKMIS RNNCVEKVIT 
      2510       2520       2530       2540       2550
PEVRKVAVQL PSTESLQQFC KTYEVTFANI LQAVWAVVLM HYSGSETVCF 
      2560       2570       2580       2590       2600
GYLSSGRDLP IPHVDRAVGP YINILPCAVR LQQSSSRLDV VKAIQADLYQ 
      2610       2620       2630       2640       2650
NLAHEHCSLW QIHKELGLKG TTLFNTLVNF QKTTAAVEDA SISLTTVASR 
      2660       2670       2680       2690       2700
DPSEYDLAFN VTDEGSSMTA ELAFWSSFMD EPDANDLSRA VSRVFNEFVR 
      2710       2720       2730       2740       2750
SPEAVLHDLS PIGPLNVEQI VRLMPSPISG EQQCLHWLIE QWVCRTPDAP 
      2760       2770       2780       2790       2800
AVCSTELEWS YAKLHQLTTS LSHHLCQLGV GRNDRAAICM EKSPWVIVAM 
      2810       2820       2830       2840       2850
LAVLQAGAAF VPLDPSHPRT RRESMISSLD AQVLLISLDA DEDAHLTMSS 
      2860       2870       2880       2890       2900
CRQVRVGSTR GAGSDTGVSS NLPKNEPDDA AYILFTSGST GQPKGVVVPH 
      2910       2920       2930       2940       2950
RAVCSSIKAW SDMLNIRSTT RSLQFAAYTF DAAIGEIFAV LANGGCVCVP 
      2960       2970       2980       2990       3000
SESERLNFLP ETITQLDVNW SFLTPSVIRQ IDPSSVPTLQ TLALGGEPLS 
      3010       3020       3030       3040       3050
KEVIETWCDR VHLINVYGPT ETCVFSHANP ITDSKQEPSL IGPPILGRSW 
      3060       3070       3080       3090       3100
VVSPFNIDIL VPRGCIGELV IESPAVAAGY FNNPEQTAKA FIAPPRWWKL 
      3110       3120       3130       3140       3150
AQDALSGSNK RTEDELPRFY LTGDMVRQNV DGSITYLGRR DTQTKINGQR 
      3160       3170       3180       3190       3200
VELGEIEYHI LRLPAVLHAF VGVPKGGPYE SRLVAVVSLR SEDGSGRGEA 
      3210       3220       3230       3240       3250
VLPEDFRLEV VEPQIAARYT SDLIVHLERN LPAYMVPAFL VVVRQLPLQP 
      3260       3270       3280       3290       3300
SGKINRRMIL SWLSEPTMAG LQKTQHNFTR REEEPTTLGP VEKQMREIWS 
      3310       3320       3330       3340       3350
EVLNLPVTRI RLDQSFFDLG GDSITAMQVV SRCRRSGLQL TVQDLLRWKT 
      3360       3370       3380       3390       3400
ITKVTPRTIS LSQVTGERVY SLTSAGSVVD MRSIASKLEA IGLPGRAGVK 
      3410       3420       3430       3440       3450
GVYACSPMQE GILLAALKSP GKYEVVLMLE IRATGSQDRV DLELLESAWL 
      3460       3470       3480       3490       3500
QVVDRHDMLR TVFLQEKTAT GVFSQVVYKH IDPPIEITTV DDLDTLRSAS 
      3510       3520       3530       3540       3550
FSAGHFDCIP YRVTLCKLSG SSLAYVRLDI SHAVVDGWSL SILSRDLQQA 
      3560       3570       3580       3590       3600
YDGQLPSQPV AQYCELIQYL ESQPQETSME FWRHLLTGMV PCHLPNMISN 
      3610       3620       3630       3640       3650
SGSHSTQEVK LHQTRLEVDR NQELRDFCAA HDITIANVFQ LAWAVVLYRY 
      3660       3670       3680       3690       3700
TGMEDVCFGY LISGRDAPID NLEDAVGPFI NILVARATLR QGISVKEFLG 
      3710       3720       3730       3740       3750
EIRDTFLAMS AHQHTSLTQI QHELAVGNLG LFNTALNVQH RALTQQNPHS 
      3760       3770       3780       3790       3800
DIEICELSGR DPSEFGAILN VIDAGNTLEF ALSYWSDLLS EETGREICSF 
      3810       3820       3830       3840       3850
LSCILSAVLD NSGCSVKTVS QTAADAARSF IDRKGDGDIS STPRGNPAPE 
      3860       3870       3880       3890       3900
CYRPLKEPTN LIALTVQQVC AEVLDLSVSS LSLDETFLSL GGDSLLAMKV 
      3910       3920       3930       3940       3950
VSRCREHGVA LTVQHMLQNQ TIREVFEHAR FSDSFSYRQL RHTPDPTGIP 
      3960       3970       3980       3990       4000
FPLSPIQKLH FHLMPTGQNY YNQSFFLRVT ERLEASAIER AVRLLVLRHS 
      4010       4020       4030       4040       4050
VLRARFNQQI DGAWAQVISP DIEGSYHFSA TSLISWDDLW PLVEGAQKRL 
      4060       4070       4080       4090       4100
NIRQGPLLSV DVLNLQGGDQ HIYLVGHHLV VDLVSWRIIL ADLEIILRGG 
      4110       4120       4130       4140       4150
ELSHDPPLSF QTWIRLATEY AQDNIDPATT LPFQLRPGNF AYWGMAGIPN 
      4160       4170       4180       4190       4200
LAKDVSSLSF TLPTDITSSL LGPANASLGT EPTDLMIAAL AHTFSLVFHD 
      4210       4220       4230       4240       4250
HSGLTIFQES HGREPWTPEI DLSATCGWFT VLTPLSVETD KVEFRNTLKR 
      4260       4270       4280       4290       4300
VKDLRRRIPG KGWPYFASRF ASRRRTGQKL DEKDEIEVLF NFVGLYQQFN 
      4310       4320       4330       4340       4350
RNDSLFVRPV ADVSLPPDFS PDSIRLALIE INSLVDGQGR MVMHVTYNSR 
      4360       4370       4380       4390       4400
MKRQEGLTAW LERSQQVLEE EMPKLLTAAP ERTPSDFQLL SLSYNELSAL 
      4410       4420       4430       4440       4450
ESHCHKQFGL DLNAVEDIYP CSPMQEGILL SQVRDPSLYR VEWVADVRCV 
      4460       4470       4480       4490       4500
GGEAVDLGQL KQAWGQVVRR HPILRTIFVE RDHDAGAYLQ LVLNQSLFPS 
      4510       4520       4530       4540       4550
SCNSASAYKV LLHLPYHITF QCLPETDTVR ITLQANHAII DGVTLAILAR 
      4560       4570       4580       4590       4600
DLGSAYGGEL PDVSGPPFSD FVKFLRTRTI DKDLQYWSEF LSDSQPTLFP 
      4610       4620       4630       4640       4650
SLGSQLGPTP GAEDDLFVEK HIHFADGAKM HEFCATFGVT VLNLFQVAWA 
      4660       4670       4680       4690       4700
LVLRLYTGQD DVCFGYLASG RDSNVSGIDD IAGPMINMLV CRLQPTRDKT 
      4710       4720       4730       4740       4750
PRELLKQAHK HLTLALSHQH VPLAEVQNRL RTHGTPLFNT LVNLQKSNVG 
      4760       4770       4780       4790       4800
QGISHLTIST IGANDPNEFT IGLQIADNGQ SIDVLFGHWL SRVSVDQADL 
      4810       4820       4830       4840       4850
LASLLSSTVN NIMARPRARL GTINFCNGVH AQKMAEWNEQ ARRPVVESTL 
      4860       4870       4880       4890       4900
HSIIQDQARQ RPSTIAIAST EAMWTYEELE RAADQTARYL LRQGVQPGTI 
      4910       4920       4930       4940       4950
LPFCMAKSPR AIVVMLAILK VGCACAALDP AHPPDRLKLI VQQTGAKFVI 
      4960       4970       4980       4990       5000
SEPVVMDSLI LDGTANILSL TDCGGSINEP GLTPCQLPSV KPTDIAFIMF 
      5010       5020       5030       5040       5050
TSGSTGTPKG VLIQHDSICT SIQYNGEAEM VTSSTRGLQF SSYAFDTSVD 
      5060       5070       5080       5090       5100
EIFTVLSRGG CVCVPTEAER MNHLAAFISR FDVNWLSITP TVARLIAPGE 
      5110       5120       5130       5140       5150
VPSVRTIVLG GEEIDPGVVN HWKDHAELVA SYGPAEASIA CAASPVTSVV 
      5160       5170       5180       5190       5200
GDALLGRPVA SSLWVVDPSD HDALMPIGTA GELVIGGPLV ARGYLNDPDR 
      5210       5220       5230       5240       5250
TSLAFVCPKW STELNLPFNR FYRTGDMARW NVDGTLSYVG RLDTQVKLNG 
      5260       5270       5280       5290       5300
QRVELGEVER HLLAQPCLQC STCAVPQSGL LANRLVGVIG LQTPQISAAD 
      5310       5320       5330       5340       5350
GFHCLEISQA RTLVPYASDA EESLRAKLPP YMVPTVWIGV QSLPLNASGK 
      5360       5370       5380       5390       5400
LDRRKVNKWL ESFQDEDTLN IFQLVGSEQE AEDEPPLTPI QQTIRNIWAD 
      5410       5420       5430       5440       5450
VLGRTSESIG LQRSFFALGG DSVAAIRVVA QCRQANLQLT VQDVFQARTI 
      5460       5470       5480       5490       5500
QSLAACATAI IEKPVETVSS LLEPSQCENP ESELAKLDSE VLSGLGGPEN 
      5510       5520       5530       5540       5550
IEEIYPCSPM QEGILFSRSS IGGSYDTRLV VEVLPRDGAE VDLDRLKNAW 
      5560       5570       5580       5590       5600
AAVVQRHPIL RTVFADRPSD DSAFIQVTFR KYRPVIMGCE TSEQSLDDMI 
      5610       5620       5630       5640       5650
AMPVQPFDDR RNPPHRFTIC TSSQQRVFIL LEISHVLTDA VSIDIIWRDL 
      5660       5670       5680       5690       5700
QLAYEGALTT SKAPRYSRFV SYLQGTSQKD HMAYWLKFLK DAEPCLFPHL 
      5710       5720       5730       5740       5750
GTGNQKGATR AVSVTISRAM TDHIRQFCAS LQITVANLIQ VMWSMVLRSY 
      5760       5770       5780       5790       5800
TGMDDVSFGY ITSGRDLPLD GIDDLVGPLI SMMISRVRYT PSMKVADVIK 
      5810       5820       5830       5840       5850
QVGQDTVASM AHQHCSLAAI HREVGLKSRS LFNTVLTVVR PHSTQSIDSS 
      5860       5870       5880       5890       5900
LQLTQIASSA GTSEFDVVLE VSDSGVELDT TLAYSESALR SEDATNLSQA 
      5910       5920       5930       5940       5950
IMCALNWIIA HPESLVDHLS LCSPDLISQM TAMNNASPEW ELRQCLHELI 
      5960       5970       5980       5990       6000
SLRAHRQPDS PALWTGQGTM TYSELDSKST MLARQLISLG VRPGSLVPIC 
      6010       6020       6030       6040       6050
LSKSTVAVLA MLAIMKAGGA FVPLDPLHPT QRLADLVQRT GAKLILSSAN 
      6060       6070       6080       6090       6100
TRNSAEFAGP RVVEVEQLLS RVTSVNEIDG VCPAPDPEGI AYVLFTSGST 
      6110       6120       6130       6140       6150
GVPKGVVVPH RAVCCSIRAH SEAMNINTTS RSLQFASYTF DACICEIFSV 
      6160       6170       6180       6190       6200
LVAGGTVCIP SEEERVHDLA GFITRSQANW AFFTPTVIRT LGLSPSQVPS 
      6210       6220       6230       6240       6250
LRTLVLGGEV VTVHDARTWA GHVSLFNGYG PTETCVFCAT TPIHPDGVTY 
      6260       6270       6280       6290       6300
GRIGRPIGCA AWVVRPDNHD ILLPPGCPGE LLIEGPIVSQ GYLNDPVRTQ 
      6310       6320       6330       6340       6350
EAFITHPAWA QNRKLSQNQS SARRFYKTGD LVRQSPDGTL VYMARLDSQV 
      6360       6370       6380       6390       6400
KINGQRLDLG EIRHQIHSVV SEDVQVFIDL LPPTCLPNEK ALLVAFLAST 
      6410       6420       6430       6440       6450
RFEPEQTSGF SPPIKALTSQ LEQDLPRLLP RYMIPSVYLP LSAIPLTSGG 
      6460       6470       6480       6490       6500
KVDRQALRRR VSRMSMKELL VYTGEEQGTK LPISTAEEQQ MQMLWAEVLR 
      6510       6520       6530       6540       6550
IPPETIGASD HFFRLGADSI DGMKLVALAQ RHGILITLAD IFRSPRLSDL 
      6560       6570       6580       6590       6600
ATLLESPAHP DDSKHDLKSI IPAFSLLNVH SRNTVLKEIK ADYALDVSQI 
      6610       6620       6630       6640       6650
EDIYPCTPLQ ESLMAASIQS HGAYVHHLVE KLPPSGEVPA IMSAWQSVIK 
      6660       6670       6680       6690       6700
MTPILRTRIV QTVSAGLLQV VLKESVQWLH RRQAIQEYLD EDARHSMTLG 
      6710       6720       6730       6740       6750
DPLLRLACLH DPGTPHTGHI VITIHHSIYD GWSLPHIRKL VYATQNGHPC 
      6760       6770       6780       6790       6800
STSLPFNRFI HYLERKSDSR ASDSFWQSFL YRSQPLAFPP LPSTGYQPVG 
      6810       6820       6830       6840       6850
TDSVQLSVHW PSTFPPSAFT LSTFVRVAWA LVLGSYSGTD DVIFGLSLSG 
      6860       6870       6880       6890       6900
RDTPIPGILD ILGPTICTVP FRVKFSGESI GALLERAHAD SAAMLPYQHI 
      6910       6920       6930       6940       6950
GLHHIRQLGP DCQLACDFQT LLVIQPARDP SDPEPHSELT FTSSGGLTYA 
      6960       6970       6980       6990       7000
FALICQPHPS GIELHGDFDS NCVSRPVAER LLSQMKSVMG TLIFGDRRKL 
      7010       7020       7030       7040       7050
AAEVDVIDIS QKATLATWQR EPLQPGEGRV EDLIISRAQQ APDDLAIHAW 
      7060       7070       7080       7090       7100
DGELTYNELV EESATLAENL KRRGIGPGML VPLCFVKSIY YVVTLLAVTR 
      7110       7120       7130       7140       7150
TGAAFVPIDP DAPIERMQKI LKLTNACCIL TSASLAEQTR AKAPARVAVF 
      7160       7170       7180       7190       7200
AIPLDRSARM STDSDLMPGQ SIVSHEAVYV LFTSGSTGIP KGVVVTHSSM 
      7210       7220       7230       7240       7250
KASLKAHGRR LGLSESSRVL QFSNHTFDVS LLEILTTLAY GGCVCIPSDG 
      7260       7270       7280       7290       7300
DRVNRLSEYM RDAKVNFAIL TPSVARILSP VSVPDLRTLA LAGEAWGQEI 
      7310       7320       7330       7340       7350
VNIWRDSVRL FNAYGPTEAT ILSAIGEVDA QCFRPNNIGS GSGALCWVTS 
      7360       7370       7380       7390       7400
PTDPTRLMAI GAAGELLLEG PILAQGYLGE EEKTRAAFID PPMWRRELSS 
      7410       7420       7430       7440       7450
HGAPPCRSSL YRTGDLARYE EDGSITYLGR MDGQVKIRGQ RTELSEIEHH 
      7460       7470       7480       7490       7500
ILASDAVRNA VVLLRKNKLV CVLSLQSTSL TPAPSRPGDI RPVSDDDRDA 
      7510       7520       7530       7540       7550
ALRICLSIRA GLARKVPEYM VPDLWVPVID LPLSSSGKLA RKGVDDWLAS 
      7560       7570       7580       7590       7600
VDTKHLINLS LQKIPLSTTS PSPNIASSSV ERAIRQVIAG ALQLPVQQVS 
      7610       7620       7630       7640       7650
VDAPFTALGG DSITAILVAS KLRNMGILLT MRDILEFPSI QHLASREDLT 
      7660       7670       7680       7690       7700
APSPANLPLD VEQVNVPFEL TPIQRFFFCF FPDGANHFNQ SILVRVARRF 
      7710       7720       7730       7740       7750
TYDQWITSLR ALVQRHGMLR ARFSNVDNNL QQRITDESEG ACCVKWHTLE 
      7760       7770       7780       7790       7800
AMDPSYISTA LDRCERRIDI FQGPICAVEI FDFPHEQIFF IAAHHLVMDF 
      7810       7820       7830       7840       7850
VSQQILLKDL DSLLAGEELS TPRPLSFQAW SLKQIEYGSN LALSPQAVLP 
      7860       7870       7880       7890       7900
HHENVPLANL NYWGIAAMDS CYADSAVRVL EFDSTVTSSL VGDANRAFNS 
      7910       7920       7930       7940       7950
EPIELFIASL LHSFANTFTD RSAPAIFKEG HGRQTREPRL DPSSTVGWFT 
      7960       7970       7980       7990       8000
TITPIALAVS PQLSTFEDTL RRVKDICRAI PANGFDYFTS RFLNASGSSA 
      8010       8020       8030       8040       8050
FQSHGPMMEI VLNYAGVLNN VQQGGTLFCP IATEEQRQMR YHDINPQLRR 
      8060       8070       8080       8090       8100
FAVFDIYAQV AGGKLSFTFA YSPSLNYQDR ISAWIESLRR LLEAISVDLP 
      8110       8120       8130       8140       8150
AKQPQKTLAD YPRARLDYTA LERLHKDIIP SLYPAKLDDV WECSPTQTVM 
      8160       8170       8180       8190       8200
LRARSYQPLF FSPHFIWKIA GTKASEGNRE RLTKAWKRIV ARHSVLRSVF 
      8210       8220       8230       8240       8250
TSQLTATYHQ IVLANPPFFI TWADMAGKES PSEALRRLPP LPSDELHLAF 
      8260       8270       8280       8290       8300
RLTASEDDEG DLFCRLDINH ALIDHVSINV ILSDVIAVYG GQPMDSDSAF 
      8310       8320       8330       8340       8350
STFRDYVEYS HLRLVDGEPY WQDRLHDACP CVLTQRPYRQ IPGVLFSKSV 
      8360       8370       8380       8390       8400
SVNASALKAL CLSSGFTLAS LFQACWAVLL QRYVGSDDVL FGYIASNRGL 
      8410       8420       8430       8440       8450
PIRGIDRMVG PLISILPRRV RLSPSASSVS EQVRAIAKHI HEQLHDDLEH 
      8460       8470       8480       8490       8500
HMSAGNTMAE VIQRGRCIEE LLFPFDTAIN FRSQPSAAVN SVSSDPTSPL 
      8510 
QFADGQDPMP VSHQP
Length:8,515
Mass (Da):940,213
Last modified:July 5, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3488DFADACA264D0
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AAHF01000003 Genomic DNA Translation: EAL91342.1

NCBI Reference Sequences

More...RefSeqi		XP_753380.1, XM_748287.1

Genome annotation databases

Ensembl fungal genome annotation project

More...EnsemblFungii		EAL91342; EAL91342; AFUA_5G12730

Database of genes from NCBI RefSeq genomes

More...GeneIDi		3511687

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		afm:AFUA_5G12730

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAHF01000003 Genomic DNA Translation: EAL91342.1
RefSeqiXP_753380.1, XM_748287.1

3D structure databases

SMRiQ4WVN4
ModBaseiSearch...

Protein-protein interaction databases

STRINGi746128.CADAFUBP00005903

Proteomic databases

PRIDEiQ4WVN4

Genome annotation databases

EnsemblFungiiEAL91342; EAL91342; AFUA_5G12730
GeneIDi3511687
KEGGiafm:AFUA_5G12730

Organism-specific databases

VEuPathDBiFungiDB:Afu5g12730

Phylogenomic databases

eggNOGiKOG1178, Eukaryota
HOGENOMiCLU_222660_0_0_1
InParanoidiQ4WVN4
OMAiQYIEWLE
OrthoDBi4243at2759

Family and domain databases

Gene3Di1.10.1200.10, 7 hits
3.30.300.30, 6 hits
3.30.559.10, 10 hits
3.40.50.12780, 5 hits
InterProiView protein in InterPro
IPR010071, AA_adenyl_domain
IPR036736, ACP-like_sf
IPR045851, AMP-bd_C_sf
IPR020845, AMP-binding_CS
IPR000873, AMP-dep_Synth/Lig
IPR042099, ANL_N_sf
IPR023213, CAT-like_dom_sf
IPR001242, Condensatn
IPR020806, PKS_PP-bd
IPR009081, PP-bd_ACP
IPR006162, Ppantetheine_attach_site
PfamiView protein in Pfam
PF00501, AMP-binding, 6 hits
PF00668, Condensation, 10 hits
PF00550, PP-binding, 7 hits
SMARTiView protein in SMART
SM00823, PKS_PP, 7 hits
SUPFAMiSSF47336, SSF47336, 7 hits
TIGRFAMsiTIGR01733, AA-adenyl-dom, 6 hits
PROSITEiView protein in PROSITE
PS00455, AMP_BINDING, 6 hits
PS50075, CARRIER, 7 hits
PS00012, PHOSPHOPANTETHEINE, 2 hits
PS50007, PIPLC_X_DOMAIN, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNRPS8_ASPFU
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q4WVN4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 18, 2012
Last sequence update: July 5, 2005
Last modified: February 23, 2022
This is version 116 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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