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Entry version 116 (23 Feb 2022)
Sequence version 1 (05 Jul 2005)
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Protein

Nonribosomal peptide synthetase 8

Gene

NRPS8

Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Status
Reviewed-Annotation score:

Annotation score:4 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Nonribosomal peptide synthesis (NRPS) is a key mechanism responsible for the biosynthesis of bioactive metabolites which are potentially contributing to organismal virulence. However, contarary to other nonribosomal peptide synthases, NRPS8 does not encode a secreted peptide, but has more a structural role since it is involved in germ tube formation.

1 Publication

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionLigase

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nonribosomal peptide synthetase 8 (EC:6.3.2.-)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NRPS8
Synonyms:pes3, pesI
ORF Names:AFUA_5G12730
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiNeosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri330879 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillusAspergillus subgen. Fumigati
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002530 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 5

Organism-specific databases

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
FungiDB:Afu5g12730

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

In contrast to other NRP synthetases, deletion of NRPS8 significantly increases the virulence, probably through aberrant innate immune recognition of the fungus.1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004165491 – 8515Nonribosomal peptide synthetase 8Add BLAST8515

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei652O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1
Modified residuei1769O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1
Modified residuei3323O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1
Modified residuei3894O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1
Modified residuei5422O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1
Modified residuei6519O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1
Modified residuei7612O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1

Keywords - PTMi

Phosphopantetheine, Phosphoprotein

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q4WVN4

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
746128.CADAFUBP00005903

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q4WVN4

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini615 – 691Carrier 1PROSITE-ProRule annotationAdd BLAST77
Domaini1732 – 1808Carrier 2PROSITE-ProRule annotationAdd BLAST77
Domaini3286 – 3362Carrier 3PROSITE-ProRule annotationAdd BLAST77
Domaini3857 – 3933Carrier 4PROSITE-ProRule annotationAdd BLAST77
Domaini5385 – 5461Carrier 5PROSITE-ProRule annotationAdd BLAST77
Domaini6482 – 6558Carrier 6PROSITE-ProRule annotationAdd BLAST77
Domaini7575 – 7651Carrier 7PROSITE-ProRule annotationAdd BLAST77

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni59 – 736Adenylation 1Add BLAST678
Regioni587 – 1159Condensation 1Add BLAST573
Regioni1163 – 1705Adenylation 2Add BLAST543
Regioni1830 – 2273Epimerase 1Add BLAST444
Regioni2301 – 2709Condensation 2Add BLAST409
Regioni2733 – 3266Adenylation 3Add BLAST534
Regioni3406 – 3819Condensation 3Add BLAST414
Regioni3953 – 4392Epimerase 2Add BLAST440
Regioni4420 – 4823Condensation 4Add BLAST404
Regioni4837 – 5363Adenylation 4Add BLAST527
Regioni5508 – 5923Condensation 5Add BLAST416
Regioni5941 – 6459Adenylation 5Add BLAST519
Regioni6606 – 6992Condensation 6Add BLAST387
Regioni7030 – 7544Adenylation 6Add BLAST515
Regioni7670 – 8119Epimerase 3Add BLAST450
Regioni8164 – 8504Condensation 7Add BLAST341
Regioni8488 – 8515DisorderedSequence analysisAdd BLAST28

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

NRP synthetases are composed of discrete domains (adenylation (A), thiolation (T) or peptidyl carrier protein (PCP) and condensation (C) domains) which when grouped together are referred to as a single module. Each module is responsible for the recognition (via the A domain) and incorporation of a single amino acid into the growing peptide product. Thus, an NRP synthetase is generally composed of one or more modules and can terminate in a thioesterase domain (TE) that releases the newly synthesized peptide from the enzyme. Occasionally, epimerase (E) domains (responsible for l- to d- amino acid conversion) are present within the NRP synthetase. NRPS8 has the following architecture: A-T-C-A-T-E-C-A-T-C-T-E-C-A-T-C-A-T-C-A-T-E-C.1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NRP synthetase family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1178, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_222660_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q4WVN4

Identification of Orthologs from Complete Genome Data

More...
OMAi
QYIEWLE

Database of Orthologous Groups

More...
OrthoDBi
4243at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1200.10, 7 hits
3.30.300.30, 6 hits
3.30.559.10, 10 hits
3.40.50.12780, 5 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR010071, AA_adenyl_domain
IPR036736, ACP-like_sf
IPR045851, AMP-bd_C_sf
IPR020845, AMP-binding_CS
IPR000873, AMP-dep_Synth/Lig
IPR042099, ANL_N_sf
IPR023213, CAT-like_dom_sf
IPR001242, Condensatn
IPR020806, PKS_PP-bd
IPR009081, PP-bd_ACP
IPR006162, Ppantetheine_attach_site

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00501, AMP-binding, 6 hits
PF00668, Condensation, 10 hits
PF00550, PP-binding, 7 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00823, PKS_PP, 7 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47336, SSF47336, 7 hits

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01733, AA-adenyl-dom, 6 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00455, AMP_BINDING, 6 hits
PS50075, CARRIER, 7 hits
PS00012, PHOSPHOPANTETHEINE, 2 hits
PS50007, PIPLC_X_DOMAIN, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q4WVN4-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MSNNTMVNMS IEMKYDNDDT TSPDQKLPGL EALEMVKGAA SVVAEIEPSS
60 70 80 90 100
SASSIMGSRE HHERMLGPLE VCVHDLVQEQ SRQHGQTIAV HSIEKDLTYA
110 120 130 140 150
ELERYADWMA KYLMVKRDIQ AGHIIPFCLK KSVWTMVAML AIMKTGAACA
160 170 180 190 200
ALDPSQPVSR IKRILDDTEA PLVIVHRDYL GLAETLDVPS IVLGPDLWEG
210 220 230 240 250
TSSGDTDKPL PVVDATQPAY IAFTSGSTGE PKGIVVPHRS IATSMREHGP
260 270 280 290 300
ATRVDTETRA LQFASYTFDM SFQEMFTTLT HGGCVCVPSE AERWNDLAGA
310 320 330 340 350
MERLGVNWAK LTPTVVRLLH PEQVPSLRTL VVGGEPITQD IIQTWAHRVD
360 370 380 390 400
LIVSYGPAEA SIMAAVSDPL APTALPRVIG RQVGGTLHVV DAGNHDRLVE
410 420 430 440 450
GSGEGELLIE GPILATGYLK DQSRTDATFI IDPKWVSCDS ENVTTAPRRF
460 470 480 490 500
LKTGDLVHRD EDGVLYHLGR KDFRLKLNGR LIDLAAIETC LLGSAQIASA
510 520 530 540 550
VVIATREDTF WQQSLVAVIS AKPTPSSRPD PHDAGHIRIQ TQHDLMLPLI
560 570 580 590 600
RDLKDVAQSA LPDYMVPTVW LVVDSVPRLP SGKIHRRRVV QWLENLDEFT
610 620 630 640 650
VQEIRSMQNH TPHCEPETAM ERRLRDIWAE VLNMPVSTVS TMASFTGLGG
660 670 680 690 700
DSVAAMRLAR RCAAQGLEID VQMILQNLSI TELAPRVKVA EHSTDTSADN
710 720 730 740 750
ERFSIGISLD QLCQSLPPRL RSSITLDDVV DTYRCSPMQE AILLSRSRFQ
760 770 780 790 800
GYYDVRWVAE VVSIDQDTPI SLQRVRDAWV DVVRRHPALR TFFVQDASTG
810 820 830 840 850
NRLLTQVILG SFPPLVSIDH SQATLDGIMG VNAAESSDPL HQEPHRLSLF
860 870 880 890 900
SLPTGQVFLK LELNHALSDG VSTALIFRDL SLAYSKALPS SPAPSFGGFI
910 920 930 940 950
RRLNLGEAEA SSTALKYWTD RLTGMVPCLF PVLREAAWTG PSAVQHVEIP
960 970 980 990 1000
IHGSQGALRR FCTQHGTTIA NVFQTAWALV LSIYTGTDDV SFCYLVSGRD
1010 1020 1030 1040 1050
ASVDNVDEIV GPLISIMVHR LTLSRSLALL QVLRQVQSDF TVALGHQHCS
1060 1070 1080 1090 1100
LAQIAHSLNL RGQPMSNTVV NVQRRFSQGG PDGVADVYIR GIDCCNPTEF
1110 1120 1130 1140 1150
AIAVDVEDWE TYMTARLSYW ESCISQTQAE GIAETLAEVI RNIQTNPLQT
1160 1170 1180 1190 1200
VGEVALVGDA VLAKLSTWNA VLPEANEACL PELVERQVIS QPSAVAIDTD
1210 1220 1230 1240 1250
AEQITYISLW NLSGLLAGRL IDSGVQPRDL VAVCVPQSSW AVIAMLAIQR
1260 1270 1280 1290 1300
AGGACVPLDP KAPAQRWWEI ISRTGISTVV TSETKKHIMS SQLPGLQVVS
1310 1320 1330 1340 1350
ADGTEIDQHH LQGSGRVLPV LSVDSTAYVL FTSGSTGSPK GIDVPHRAIC
1360 1370 1380 1390 1400
TSLCAHCPVL GITNETRSLQ FAAYTFDASI EETFGVLVHG GCVCIPSEDT
1410 1420 1430 1440 1450
KMNGLVDFIN RKAISWAFFT PSLVRLIDPD LVPSLQTIVL GGEAVGNDIF
1460 1470 1480 1490 1500
NTWSHRVDLI NGYGPAEASI CCAAAHLSLR QTQSPSTIGR AVGCRIWVVD
1510 1520 1530 1540 1550
PQNINRLLPP DCVGELLIEG HIVANGYWGD EERTASSFLP PPEFLQSLSL
1560 1570 1580 1590 1600
EYPADNFRRC FYRTGDLVRQ RHDGSLIYVG RSDWQTKVNG QRVEIGEVEA
1610 1620 1630 1640 1650
QLSFHMAKNH SNHLSMVCVP KSGPWMKRLV AILSLDPEEC TVGNRSNVVF
1660 1670 1680 1690 1700
CLDKPETAAM IRTISKGIES SLPPFMIPTV WIPVKQLPTL ASGKINRRCV
1710 1720 1730 1740 1750
QEWVETSNEG IFLSVSRINS EAFGTSSTET TRGLTPTETV IRAIWSRVLN
1760 1770 1780 1790 1800
IPLHSIGLDN TFLSLGGDSI SAMQVVYQAH REGLTISVQD IFHCKTVAKL
1810 1820 1830 1840 1850
GRHADHSSKN TSSSNLLAPP VDEVEVPFAL SPIQQWFFES VPHKPAILNH
1860 1870 1880 1890 1900
YNQSAHFRVM KEIDHSQLFK ALQHVVQRHA MLRSRFILDS WSWQQKITTD
1910 1920 1930 1940 1950
IEGSFRLEVE SIDAITAFRS CCERAQKMID IIHGPLLVAI LVKVAEPAQH
1960 1970 1980 1990 2000
FLVLIGHHLS MDVVSWSIIH RELEAFLAGG QVIAPLSSTS FQQWARLHYE
2010 2020 2030 2040 2050
PNIVPAEPRE VLPFSVLEAD LDYWGMRDTA NEYRHGEYIT TSVDEETTAS
2060 2070 2080 2090 2100
IFKEANIAIG TEPVELIMAA VLYSFGRIFH DRSLPALYME AHGREGDEFG
2110 2120 2130 2140 2150
LDLSGTVGWF TTICPLQLHR ESLHTWARAV AQVKDRRRSI PAKGWAYFAC
2160 2170 2180 2190 2200
RTVSPKGQAS FNHHQQMEIL FNFTGSTGDI NDEHDRFLSP VRLMEDSRSD
2210 2220 2230 2240 2250
FDPKTPRVAL FAIEASVENR QLRFSVSYHR SMRHVPRVKQ WIHSLPSTLQ
2260 2270 2280 2290 2300
EGVQMLSTIG RQPTLYDCPL AALNYSDLDS ILARIQQSQA DMVVEEIYPC
2310 2320 2330 2340 2350
SHIQEGILLS SMRNPGHYQV RWLVKVEARR GLPVSTQRLA KAWQSVVRKH
2360 2370 2380 2390 2400
SILRTIFVDD PSGTSSFLQV VVEDPRYPAS IVEVQHRDSV ASLDEDIDFT
2410 2420 2430 2440 2450
VGELPYRATI YQLHDGNVFF LLDISHAILD GTSMGILAHE LVRGYDGSLT
2460 2470 2480 2490 2500
GDEAPHYRDY IRLLQTMPRN ETLAHWKAYL QDIEPCKMIS RNNCVEKVIT
2510 2520 2530 2540 2550
PEVRKVAVQL PSTESLQQFC KTYEVTFANI LQAVWAVVLM HYSGSETVCF
2560 2570 2580 2590 2600
GYLSSGRDLP IPHVDRAVGP YINILPCAVR LQQSSSRLDV VKAIQADLYQ
2610 2620 2630 2640 2650
NLAHEHCSLW QIHKELGLKG TTLFNTLVNF QKTTAAVEDA SISLTTVASR
2660 2670 2680 2690 2700
DPSEYDLAFN VTDEGSSMTA ELAFWSSFMD EPDANDLSRA VSRVFNEFVR
2710 2720 2730 2740 2750
SPEAVLHDLS PIGPLNVEQI VRLMPSPISG EQQCLHWLIE QWVCRTPDAP
2760 2770 2780 2790 2800
AVCSTELEWS YAKLHQLTTS LSHHLCQLGV GRNDRAAICM EKSPWVIVAM
2810 2820 2830 2840 2850
LAVLQAGAAF VPLDPSHPRT RRESMISSLD AQVLLISLDA DEDAHLTMSS
2860 2870 2880 2890 2900
CRQVRVGSTR GAGSDTGVSS NLPKNEPDDA AYILFTSGST GQPKGVVVPH
2910 2920 2930 2940 2950
RAVCSSIKAW SDMLNIRSTT RSLQFAAYTF DAAIGEIFAV LANGGCVCVP
2960 2970 2980 2990 3000
SESERLNFLP ETITQLDVNW SFLTPSVIRQ IDPSSVPTLQ TLALGGEPLS
3010 3020 3030 3040 3050
KEVIETWCDR VHLINVYGPT ETCVFSHANP ITDSKQEPSL IGPPILGRSW
3060 3070 3080 3090 3100
VVSPFNIDIL VPRGCIGELV IESPAVAAGY FNNPEQTAKA FIAPPRWWKL
3110 3120 3130 3140 3150
AQDALSGSNK RTEDELPRFY LTGDMVRQNV DGSITYLGRR DTQTKINGQR
3160 3170 3180 3190 3200
VELGEIEYHI LRLPAVLHAF VGVPKGGPYE SRLVAVVSLR SEDGSGRGEA
3210 3220 3230 3240 3250
VLPEDFRLEV VEPQIAARYT SDLIVHLERN LPAYMVPAFL VVVRQLPLQP
3260 3270 3280 3290 3300
SGKINRRMIL SWLSEPTMAG LQKTQHNFTR REEEPTTLGP VEKQMREIWS
3310 3320 3330 3340 3350
EVLNLPVTRI RLDQSFFDLG GDSITAMQVV SRCRRSGLQL TVQDLLRWKT
3360 3370 3380 3390 3400
ITKVTPRTIS LSQVTGERVY SLTSAGSVVD MRSIASKLEA IGLPGRAGVK
3410 3420 3430 3440 3450
GVYACSPMQE GILLAALKSP GKYEVVLMLE IRATGSQDRV DLELLESAWL
3460 3470 3480 3490 3500
QVVDRHDMLR TVFLQEKTAT GVFSQVVYKH IDPPIEITTV DDLDTLRSAS
3510 3520 3530 3540 3550
FSAGHFDCIP YRVTLCKLSG SSLAYVRLDI SHAVVDGWSL SILSRDLQQA
3560 3570 3580 3590 3600
YDGQLPSQPV AQYCELIQYL ESQPQETSME FWRHLLTGMV PCHLPNMISN
3610 3620 3630 3640 3650
SGSHSTQEVK LHQTRLEVDR NQELRDFCAA HDITIANVFQ LAWAVVLYRY
3660 3670 3680 3690 3700
TGMEDVCFGY LISGRDAPID NLEDAVGPFI NILVARATLR QGISVKEFLG
3710 3720 3730 3740 3750
EIRDTFLAMS AHQHTSLTQI QHELAVGNLG LFNTALNVQH RALTQQNPHS
3760 3770 3780 3790 3800
DIEICELSGR DPSEFGAILN VIDAGNTLEF ALSYWSDLLS EETGREICSF
3810 3820 3830 3840 3850
LSCILSAVLD NSGCSVKTVS QTAADAARSF IDRKGDGDIS STPRGNPAPE
3860 3870 3880 3890 3900
CYRPLKEPTN LIALTVQQVC AEVLDLSVSS LSLDETFLSL GGDSLLAMKV
3910 3920 3930 3940 3950
VSRCREHGVA LTVQHMLQNQ TIREVFEHAR FSDSFSYRQL RHTPDPTGIP
3960 3970 3980 3990 4000
FPLSPIQKLH FHLMPTGQNY YNQSFFLRVT ERLEASAIER AVRLLVLRHS
4010 4020 4030 4040 4050
VLRARFNQQI DGAWAQVISP DIEGSYHFSA TSLISWDDLW PLVEGAQKRL
4060 4070 4080 4090 4100
NIRQGPLLSV DVLNLQGGDQ HIYLVGHHLV VDLVSWRIIL ADLEIILRGG
4110 4120 4130 4140 4150
ELSHDPPLSF QTWIRLATEY AQDNIDPATT LPFQLRPGNF AYWGMAGIPN
4160 4170 4180 4190 4200
LAKDVSSLSF TLPTDITSSL LGPANASLGT EPTDLMIAAL AHTFSLVFHD
4210 4220 4230 4240 4250
HSGLTIFQES HGREPWTPEI DLSATCGWFT VLTPLSVETD KVEFRNTLKR
4260 4270 4280 4290 4300
VKDLRRRIPG KGWPYFASRF ASRRRTGQKL DEKDEIEVLF NFVGLYQQFN
4310 4320 4330 4340 4350
RNDSLFVRPV ADVSLPPDFS PDSIRLALIE INSLVDGQGR MVMHVTYNSR
4360 4370 4380 4390 4400
MKRQEGLTAW LERSQQVLEE EMPKLLTAAP ERTPSDFQLL SLSYNELSAL
4410 4420 4430 4440 4450
ESHCHKQFGL DLNAVEDIYP CSPMQEGILL SQVRDPSLYR VEWVADVRCV
4460 4470 4480 4490 4500
GGEAVDLGQL KQAWGQVVRR HPILRTIFVE RDHDAGAYLQ LVLNQSLFPS
4510 4520 4530 4540 4550
SCNSASAYKV LLHLPYHITF QCLPETDTVR ITLQANHAII DGVTLAILAR
4560 4570 4580 4590 4600
DLGSAYGGEL PDVSGPPFSD FVKFLRTRTI DKDLQYWSEF LSDSQPTLFP
4610 4620 4630 4640 4650
SLGSQLGPTP GAEDDLFVEK HIHFADGAKM HEFCATFGVT VLNLFQVAWA
4660 4670 4680 4690 4700
LVLRLYTGQD DVCFGYLASG RDSNVSGIDD IAGPMINMLV CRLQPTRDKT
4710 4720 4730 4740 4750
PRELLKQAHK HLTLALSHQH VPLAEVQNRL RTHGTPLFNT LVNLQKSNVG
4760 4770 4780 4790 4800
QGISHLTIST IGANDPNEFT IGLQIADNGQ SIDVLFGHWL SRVSVDQADL
4810 4820 4830 4840 4850
LASLLSSTVN NIMARPRARL GTINFCNGVH AQKMAEWNEQ ARRPVVESTL
4860 4870 4880 4890 4900
HSIIQDQARQ RPSTIAIAST EAMWTYEELE RAADQTARYL LRQGVQPGTI
4910 4920 4930 4940 4950
LPFCMAKSPR AIVVMLAILK VGCACAALDP AHPPDRLKLI VQQTGAKFVI
4960 4970 4980 4990 5000
SEPVVMDSLI LDGTANILSL TDCGGSINEP GLTPCQLPSV KPTDIAFIMF
5010 5020 5030 5040 5050
TSGSTGTPKG VLIQHDSICT SIQYNGEAEM VTSSTRGLQF SSYAFDTSVD
5060 5070 5080 5090 5100
EIFTVLSRGG CVCVPTEAER MNHLAAFISR FDVNWLSITP TVARLIAPGE
5110 5120 5130 5140 5150
VPSVRTIVLG GEEIDPGVVN HWKDHAELVA SYGPAEASIA CAASPVTSVV
5160 5170 5180 5190 5200
GDALLGRPVA SSLWVVDPSD HDALMPIGTA GELVIGGPLV ARGYLNDPDR
5210 5220 5230 5240 5250
TSLAFVCPKW STELNLPFNR FYRTGDMARW NVDGTLSYVG RLDTQVKLNG
5260 5270 5280 5290 5300
QRVELGEVER HLLAQPCLQC STCAVPQSGL LANRLVGVIG LQTPQISAAD
5310 5320 5330 5340 5350
GFHCLEISQA RTLVPYASDA EESLRAKLPP YMVPTVWIGV QSLPLNASGK
5360 5370 5380 5390 5400
LDRRKVNKWL ESFQDEDTLN IFQLVGSEQE AEDEPPLTPI QQTIRNIWAD
5410 5420 5430 5440 5450
VLGRTSESIG LQRSFFALGG DSVAAIRVVA QCRQANLQLT VQDVFQARTI
5460 5470 5480 5490 5500
QSLAACATAI IEKPVETVSS LLEPSQCENP ESELAKLDSE VLSGLGGPEN
5510 5520 5530 5540 5550
IEEIYPCSPM QEGILFSRSS IGGSYDTRLV VEVLPRDGAE VDLDRLKNAW
5560 5570 5580 5590 5600
AAVVQRHPIL RTVFADRPSD DSAFIQVTFR KYRPVIMGCE TSEQSLDDMI
5610 5620 5630 5640 5650
AMPVQPFDDR RNPPHRFTIC TSSQQRVFIL LEISHVLTDA VSIDIIWRDL
5660 5670 5680 5690 5700
QLAYEGALTT SKAPRYSRFV SYLQGTSQKD HMAYWLKFLK DAEPCLFPHL
5710 5720 5730 5740 5750
GTGNQKGATR AVSVTISRAM TDHIRQFCAS LQITVANLIQ VMWSMVLRSY
5760 5770 5780 5790 5800
TGMDDVSFGY ITSGRDLPLD GIDDLVGPLI SMMISRVRYT PSMKVADVIK
5810 5820 5830 5840 5850
QVGQDTVASM AHQHCSLAAI HREVGLKSRS LFNTVLTVVR PHSTQSIDSS
5860 5870 5880 5890 5900
LQLTQIASSA GTSEFDVVLE VSDSGVELDT TLAYSESALR SEDATNLSQA
5910 5920 5930 5940 5950
IMCALNWIIA HPESLVDHLS LCSPDLISQM TAMNNASPEW ELRQCLHELI
5960 5970 5980 5990 6000
SLRAHRQPDS PALWTGQGTM TYSELDSKST MLARQLISLG VRPGSLVPIC
6010 6020 6030 6040 6050
LSKSTVAVLA MLAIMKAGGA FVPLDPLHPT QRLADLVQRT GAKLILSSAN
6060 6070 6080 6090 6100
TRNSAEFAGP RVVEVEQLLS RVTSVNEIDG VCPAPDPEGI AYVLFTSGST
6110 6120 6130 6140 6150
GVPKGVVVPH RAVCCSIRAH SEAMNINTTS RSLQFASYTF DACICEIFSV
6160 6170 6180 6190 6200
LVAGGTVCIP SEEERVHDLA GFITRSQANW AFFTPTVIRT LGLSPSQVPS
6210 6220 6230 6240 6250
LRTLVLGGEV VTVHDARTWA GHVSLFNGYG PTETCVFCAT TPIHPDGVTY
6260 6270 6280 6290 6300
GRIGRPIGCA AWVVRPDNHD ILLPPGCPGE LLIEGPIVSQ GYLNDPVRTQ
6310 6320 6330 6340 6350
EAFITHPAWA QNRKLSQNQS SARRFYKTGD LVRQSPDGTL VYMARLDSQV
6360 6370 6380 6390 6400
KINGQRLDLG EIRHQIHSVV SEDVQVFIDL LPPTCLPNEK ALLVAFLAST
6410 6420 6430 6440 6450
RFEPEQTSGF SPPIKALTSQ LEQDLPRLLP RYMIPSVYLP LSAIPLTSGG
6460 6470 6480 6490 6500
KVDRQALRRR VSRMSMKELL VYTGEEQGTK LPISTAEEQQ MQMLWAEVLR
6510 6520 6530 6540 6550
IPPETIGASD HFFRLGADSI DGMKLVALAQ RHGILITLAD IFRSPRLSDL
6560 6570 6580 6590 6600
ATLLESPAHP DDSKHDLKSI IPAFSLLNVH SRNTVLKEIK ADYALDVSQI
6610 6620 6630 6640 6650
EDIYPCTPLQ ESLMAASIQS HGAYVHHLVE KLPPSGEVPA IMSAWQSVIK
6660 6670 6680 6690 6700
MTPILRTRIV QTVSAGLLQV VLKESVQWLH RRQAIQEYLD EDARHSMTLG
6710 6720 6730 6740 6750
DPLLRLACLH DPGTPHTGHI VITIHHSIYD GWSLPHIRKL VYATQNGHPC
6760 6770 6780 6790 6800
STSLPFNRFI HYLERKSDSR ASDSFWQSFL YRSQPLAFPP LPSTGYQPVG
6810 6820 6830 6840 6850
TDSVQLSVHW PSTFPPSAFT LSTFVRVAWA LVLGSYSGTD DVIFGLSLSG
6860 6870 6880 6890 6900
RDTPIPGILD ILGPTICTVP FRVKFSGESI GALLERAHAD SAAMLPYQHI
6910 6920 6930 6940 6950
GLHHIRQLGP DCQLACDFQT LLVIQPARDP SDPEPHSELT FTSSGGLTYA
6960 6970 6980 6990 7000
FALICQPHPS GIELHGDFDS NCVSRPVAER LLSQMKSVMG TLIFGDRRKL
7010 7020 7030 7040 7050
AAEVDVIDIS QKATLATWQR EPLQPGEGRV EDLIISRAQQ APDDLAIHAW
7060 7070 7080 7090 7100
DGELTYNELV EESATLAENL KRRGIGPGML VPLCFVKSIY YVVTLLAVTR
7110 7120 7130 7140 7150
TGAAFVPIDP DAPIERMQKI LKLTNACCIL TSASLAEQTR AKAPARVAVF
7160 7170 7180 7190 7200
AIPLDRSARM STDSDLMPGQ SIVSHEAVYV LFTSGSTGIP KGVVVTHSSM
7210 7220 7230 7240 7250
KASLKAHGRR LGLSESSRVL QFSNHTFDVS LLEILTTLAY GGCVCIPSDG
7260 7270 7280 7290 7300
DRVNRLSEYM RDAKVNFAIL TPSVARILSP VSVPDLRTLA LAGEAWGQEI
7310 7320 7330 7340 7350
VNIWRDSVRL FNAYGPTEAT ILSAIGEVDA QCFRPNNIGS GSGALCWVTS
7360 7370 7380 7390 7400
PTDPTRLMAI GAAGELLLEG PILAQGYLGE EEKTRAAFID PPMWRRELSS
7410 7420 7430 7440 7450
HGAPPCRSSL YRTGDLARYE EDGSITYLGR MDGQVKIRGQ RTELSEIEHH
7460 7470 7480 7490 7500
ILASDAVRNA VVLLRKNKLV CVLSLQSTSL TPAPSRPGDI RPVSDDDRDA
7510 7520 7530 7540 7550
ALRICLSIRA GLARKVPEYM VPDLWVPVID LPLSSSGKLA RKGVDDWLAS
7560 7570 7580 7590 7600
VDTKHLINLS LQKIPLSTTS PSPNIASSSV ERAIRQVIAG ALQLPVQQVS
7610 7620 7630 7640 7650
VDAPFTALGG DSITAILVAS KLRNMGILLT MRDILEFPSI QHLASREDLT
7660 7670 7680 7690 7700
APSPANLPLD VEQVNVPFEL TPIQRFFFCF FPDGANHFNQ SILVRVARRF
7710 7720 7730 7740 7750
TYDQWITSLR ALVQRHGMLR ARFSNVDNNL QQRITDESEG ACCVKWHTLE
7760 7770 7780 7790 7800
AMDPSYISTA LDRCERRIDI FQGPICAVEI FDFPHEQIFF IAAHHLVMDF
7810 7820 7830 7840 7850
VSQQILLKDL DSLLAGEELS TPRPLSFQAW SLKQIEYGSN LALSPQAVLP
7860 7870 7880 7890 7900
HHENVPLANL NYWGIAAMDS CYADSAVRVL EFDSTVTSSL VGDANRAFNS
7910 7920 7930 7940 7950
EPIELFIASL LHSFANTFTD RSAPAIFKEG HGRQTREPRL DPSSTVGWFT
7960 7970 7980 7990 8000
TITPIALAVS PQLSTFEDTL RRVKDICRAI PANGFDYFTS RFLNASGSSA
8010 8020 8030 8040 8050
FQSHGPMMEI VLNYAGVLNN VQQGGTLFCP IATEEQRQMR YHDINPQLRR
8060 8070 8080 8090 8100
FAVFDIYAQV AGGKLSFTFA YSPSLNYQDR ISAWIESLRR LLEAISVDLP
8110 8120 8130 8140 8150
AKQPQKTLAD YPRARLDYTA LERLHKDIIP SLYPAKLDDV WECSPTQTVM
8160 8170 8180 8190 8200
LRARSYQPLF FSPHFIWKIA GTKASEGNRE RLTKAWKRIV ARHSVLRSVF
8210 8220 8230 8240 8250
TSQLTATYHQ IVLANPPFFI TWADMAGKES PSEALRRLPP LPSDELHLAF
8260 8270 8280 8290 8300
RLTASEDDEG DLFCRLDINH ALIDHVSINV ILSDVIAVYG GQPMDSDSAF
8310 8320 8330 8340 8350
STFRDYVEYS HLRLVDGEPY WQDRLHDACP CVLTQRPYRQ IPGVLFSKSV
8360 8370 8380 8390 8400
SVNASALKAL CLSSGFTLAS LFQACWAVLL QRYVGSDDVL FGYIASNRGL
8410 8420 8430 8440 8450
PIRGIDRMVG PLISILPRRV RLSPSASSVS EQVRAIAKHI HEQLHDDLEH
8460 8470 8480 8490 8500
HMSAGNTMAE VIQRGRCIEE LLFPFDTAIN FRSQPSAAVN SVSSDPTSPL
8510
QFADGQDPMP VSHQP
Length:8,515
Mass (Da):940,213
Last modified:July 5, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i3488DFADACA264D0
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AAHF01000003 Genomic DNA Translation: EAL91342.1

NCBI Reference Sequences

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RefSeqi
XP_753380.1, XM_748287.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
EAL91342; EAL91342; AFUA_5G12730

Database of genes from NCBI RefSeq genomes

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GeneIDi
3511687

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
afm:AFUA_5G12730

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAHF01000003 Genomic DNA Translation: EAL91342.1
RefSeqiXP_753380.1, XM_748287.1

3D structure databases

SMRiQ4WVN4
ModBaseiSearch...

Protein-protein interaction databases

STRINGi746128.CADAFUBP00005903

Proteomic databases

PRIDEiQ4WVN4

Genome annotation databases

EnsemblFungiiEAL91342; EAL91342; AFUA_5G12730
GeneIDi3511687
KEGGiafm:AFUA_5G12730

Organism-specific databases

VEuPathDBiFungiDB:Afu5g12730

Phylogenomic databases

eggNOGiKOG1178, Eukaryota
HOGENOMiCLU_222660_0_0_1
InParanoidiQ4WVN4
OMAiQYIEWLE
OrthoDBi4243at2759

Family and domain databases

Gene3Di1.10.1200.10, 7 hits
3.30.300.30, 6 hits
3.30.559.10, 10 hits
3.40.50.12780, 5 hits
InterProiView protein in InterPro
IPR010071, AA_adenyl_domain
IPR036736, ACP-like_sf
IPR045851, AMP-bd_C_sf
IPR020845, AMP-binding_CS
IPR000873, AMP-dep_Synth/Lig
IPR042099, ANL_N_sf
IPR023213, CAT-like_dom_sf
IPR001242, Condensatn
IPR020806, PKS_PP-bd
IPR009081, PP-bd_ACP
IPR006162, Ppantetheine_attach_site
PfamiView protein in Pfam
PF00501, AMP-binding, 6 hits
PF00668, Condensation, 10 hits
PF00550, PP-binding, 7 hits
SMARTiView protein in SMART
SM00823, PKS_PP, 7 hits
SUPFAMiSSF47336, SSF47336, 7 hits
TIGRFAMsiTIGR01733, AA-adenyl-dom, 6 hits
PROSITEiView protein in PROSITE
PS00455, AMP_BINDING, 6 hits
PS50075, CARRIER, 7 hits
PS00012, PHOSPHOPANTETHEINE, 2 hits
PS50007, PIPLC_X_DOMAIN, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiNRPS8_ASPFU
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q4WVN4
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 18, 2012
Last sequence update: July 5, 2005
Last modified: February 23, 2022
This is version 116 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
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