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Protein

Mitochondrial import inner membrane translocase subunit TIM44

Gene

AFUA_1G09840

Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Status
Unreviewed-Annotation score: -Protein inferred from homologyi

Functioni

Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.UniRule annotation

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

GO - Molecular functioni

  • chaperone binding Source: GO_Central

GO - Biological processi

Keywordsi

Biological processProtein transport, TranslocationUniRule annotation, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Mitochondrial import inner membrane translocase subunit TIM44UniRule annotation
Gene namesi
ORF Names:AFUA_1G09840Imported
OrganismiNeosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)Imported
Taxonomic identifieri330879 [NCBI]
Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
Proteomesi
  • UP000002530 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiFungiDB:Afu1g09840

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cell wall Cytoskeleton Vacuole Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Membrane, Mitochondrion, Mitochondrion inner membraneUniRule annotation

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi5085.CADAFUBP00000911

Structurei

3D structure databases

ProteinModelPortaliQ4WTB9
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini363 – 517Tim44InterPro annotationAdd BLAST155

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili258 – 278Sequence analysisAdd BLAST21

Sequence similaritiesi

Belongs to the Tim44 family.UniRule annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

HOGENOMiHOG000208172
InParanoidiQ4WTB9
KOiK17804
OMAiRFLKQCE
OrthoDBiEOG092C2GAN

Family and domain databases

InterProiView protein in InterPro
IPR032710 NTF2-like_dom_sf
IPR017303 Tim44
IPR039544 Tim44-like
IPR007379 Tim44-like_dom
PANTHERiPTHR10721 PTHR10721, 1 hit
PfamiView protein in Pfam
PF04280 Tim44, 1 hit
PIRSFiPIRSF037871 TIM44, 1 hit
SMARTiView protein in SMART
SM00978 Tim44, 1 hit
SUPFAMiSSF54427 SSF54427, 1 hit

Sequencei

Sequence statusi: Complete.

Q4WTB9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MISASKMSAV ARAATLRSHV PGLRTTYSNA IASSRTLIHK SAYSTSIPTS
60 70 80 90 100
PTVLQRQQTS FPTGVQLISP YTALPLTRSF HIATARWQQQ QKEKHSEEPK
110 120 130 140 150
SEKSEEAKSE GGKEEGQKEA PPPPPPHGDK TPWQVFRETL QAEFKASKEW
160 170 180 190 200
NESTKALASS AQEFAENENI KRARAAYEAA SGAATSKTSA ALKKTGQAIG
210 220 230 240 250
KGAAWTWETP VVKGIRKGVS ATGAGLEKAT RPVRETEAYK NVKEAIDDGS
260 270 280 290 300
SSRYGGWIEK EERRRQRQLR EQKEMMKSGR RSTEPLVEDP KTLTIAWRSA
310 320 330 340 350
GTNLTIHKDS AWKESWREFK ESNPMMQKLF ALKETYNESE NPLISTARSI
360 370 380 390 400
SDRVASFFAE NETAQVIKKF REMDPNFQME SFLREMREYI LPEVLDAYVK
410 420 430 440 450
GDIETLKLWL SDAQFHVYAA LSKQYTTAGL KSDGRILDIR GVDVSHARML
460 470 480 490 500
EPGEIPVFVV TCRTQEVHVY RNVKTGELAA GMEDKVQLVT YAIGLTRIPE
510 520
DVNNPETRGW RLIELQKAAR DYI
Length:523
Mass (Da):58,688
Last modified:July 5, 2005 - v1
Checksum:i11823E2B9743A05C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAHF01000004 Genomic DNA Translation: EAL90313.1
RefSeqiXP_752351.1, XM_747258.1

Genome annotation databases

EnsemblFungiiEAL90313; EAL90313; AFUA_1G09840
GeneIDi3510473
KEGGiafm:AFUA_1G09840

Similar proteinsi

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAHF01000004 Genomic DNA Translation: EAL90313.1
RefSeqiXP_752351.1, XM_747258.1

3D structure databases

ProteinModelPortaliQ4WTB9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi5085.CADAFUBP00000911

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiEAL90313; EAL90313; AFUA_1G09840
GeneIDi3510473
KEGGiafm:AFUA_1G09840

Organism-specific databases

EuPathDBiFungiDB:Afu1g09840

Phylogenomic databases

HOGENOMiHOG000208172
InParanoidiQ4WTB9
KOiK17804
OMAiRFLKQCE
OrthoDBiEOG092C2GAN

Family and domain databases

InterProiView protein in InterPro
IPR032710 NTF2-like_dom_sf
IPR017303 Tim44
IPR039544 Tim44-like
IPR007379 Tim44-like_dom
PANTHERiPTHR10721 PTHR10721, 1 hit
PfamiView protein in Pfam
PF04280 Tim44, 1 hit
PIRSFiPIRSF037871 TIM44, 1 hit
SMARTiView protein in SMART
SM00978 Tim44, 1 hit
SUPFAMiSSF54427 SSF54427, 1 hit
ProtoNetiSearch...

Entry informationi

Entry nameiQ4WTB9_ASPFU
AccessioniPrimary (citable) accession number: Q4WTB9
Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2005
Last sequence update: July 5, 2005
Last modified: November 7, 2018
This is version 75 of the entry and version 1 of the sequence. See complete history.
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

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