Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 111 (23 Feb 2022)
Sequence version 1 (05 Jul 2005)
Previous versions | rss
Add a publicationFeedback
Protein

Nonribosomal peptide synthetase sidC

Gene

NRPS2

Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Nonribosomal peptide synthase; part of the siderophore biosynthetic pathway (PubMed:17845073).

Aspergillus fumigatus produces four types of siderophores, low-molecular-mass iron chelators, including excreted fusarinine C (FsC) and triacetylfusarinine C (TAFC) for iron uptake; and intacellular ferricrocin (FC) for hyphal and hydroxyferricrocin (HFC) for conidial iron distribution and storage. TAFC consists of three N2-acetyl-N5-anhydromevalonyl-N5-hydroxyornithine residues cyclically linked by ester bonds; FC is a cyclic hexapeptide with the structure Gly-Ser-Gly-(N5-acetyl-N5-hydroxyornithine)x3. The biosynthesis of all four siderophores depends on the hydroxylation of ornithine, catalyzed by the monooxygenase sidA (PubMed:15504822, PubMed:16113265).

Subsequently, the pathways for biosynthesis of extra- and intracellular siderophores split (PubMed:17845073).

For biosynthesis of extracellular siderophores, the transacylase sidF transfers anhydromevalonyl to N5-hydroxyornithine (PubMed:17845073).

The required anhydromevalonyl-CoA moiety is derived from mevalonate by CoA ligation and dehydration catalyzed by sidI and sidH respectively (PubMed:22106303).

The acetylation of N5-hydroxyornithine for FC biosynthesis involves the constitutively expressed sidL (PubMed:21622789).

FC is hydroxylated to HFC by an as yet uncharacterized enzyme during conidiation (PubMed:17845073).

Assembly of fusarinine C (FsC) and FC is catalyzed by two different nonribosomal peptide synthetases (NRPS), sidD and sidC respectively (PubMed:15953695, PubMed:17845073, PubMed:17464044).

Subsequently, sidG catalyzes N2-acetylation of FsC for forming TAFC (PubMed:17845073).

Both extra- and intracellular siderophores are crucial for growth during iron limitation and virulence (PubMed:16113265).

7 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: Siderophore biosynthesis

This protein is involved in Siderophore biosynthesis.1 Publication
View all proteins of this organism that are known to be involved in Siderophore biosynthesis.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionLigase
Biological processVirulence

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nonribosomal peptide synthetase sidC1 Publication (EC:6.3.2.-1 Publication)
Short name:
NPRS sidC1 Publication
Alternative name(s):
Siderophore peptide synthetase C1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NRPS21 Publication
Synonyms:sidC1 Publication
ORF Names:AFUA_1G17200
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiNeosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri330879 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillusAspergillus subgen. Fumigati
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002530 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 1

Organism-specific databases

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
FungiDB:Afu1g17200

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Leads to a delay in both conidial swelling and germ tube production during iron-depleted conditions (PubMed:17845073).1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004165431 – 4763Nonribosomal peptide synthetase sidCAdd BLAST4763

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei890O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1
Modified residuei2016O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1
Modified residuei3136O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1
Modified residuei3681O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1
Modified residuei4238O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1

Keywords - PTMi

Phosphopantetheine, Phosphoprotein

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q4WR82

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Expression is induced during iron starvation (PubMed:15953695, PubMed:17845073).2 Publications

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
746128.CADAFUBP00001627

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q4WR82

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini853 – 930Carrier 1PROSITE-ProRule annotation1 PublicationAdd BLAST78
Domaini1979 – 2055Carrier 2PROSITE-ProRule annotation1 PublicationAdd BLAST77
Domaini3099 – 3175Carrier 3PROSITE-ProRule annotation1 PublicationAdd BLAST77
Domaini3647 – 3720Carrier 4PROSITE-ProRule annotation1 PublicationAdd BLAST74
Domaini4204 – 4277Carrier 5PROSITE-ProRule annotation1 PublicationAdd BLAST74

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 24DisorderedSequence analysisAdd BLAST24
Regioni296 – 815Adenylation 1Sequence analysis1 PublicationAdd BLAST520
Regioni1003 – 1396Condensation 1Sequence analysis1 PublicationAdd BLAST394
Regioni1398 – 1951Adenylation 2Sequence analysis1 PublicationAdd BLAST554
Regioni2092 – 2423Condensation 2Sequence analysis1 PublicationAdd BLAST332
Regioni2556 – 3070Adenylation 3Sequence analysis1 PublicationAdd BLAST515
Regioni3217 – 3626Condensation 3Sequence analysis1 PublicationAdd BLAST410
Regioni3761 – 4093Condensation 4Sequence analysis1 PublicationAdd BLAST333
Regioni4344 – 4593Condensation 5Sequence analysis1 PublicationAdd BLAST250

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

NRP synthetases are composed of discrete domains (adenylation (A), thiolation (T) or peptidyl carrier protein (PCP) and condensation (C) domains) which when grouped together are referred to as a single module. Each module is responsible for the recognition (via the A domain) and incorporation of a single amino acid into the growing peptide product. Thus, an NRP synthetase is generally composed of one or more modules and can terminate in a thioesterase domain (TE) that releases the newly synthesized peptide from the enzyme. Occasionally, epimerase (E) domains (responsible for L- to D- amino acid conversion) are present within the NRP synthetase. NRPS2 has the following architecture: A-T-C-A-T-C-A-T-C-T-C-T-C.2 Publications

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NRP synthetase family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1178, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000092_1_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q4WR82

Identification of Orthologs from Complete Genome Data

More...
OMAi
ITMIGEK

Database of Orthologous Groups

More...
OrthoDBi
4243at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1200.10, 5 hits
3.30.300.30, 3 hits
3.30.559.10, 5 hits
3.40.50.12780, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR036736, ACP-like_sf
IPR025110, AMP-bd_C
IPR045851, AMP-bd_C_sf
IPR020845, AMP-binding_CS
IPR000873, AMP-dep_Synth/Lig
IPR042099, ANL_N_sf
IPR023213, CAT-like_dom_sf
IPR001242, Condensatn
IPR020806, PKS_PP-bd
IPR009081, PP-bd_ACP
IPR006162, Ppantetheine_attach_site

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00501, AMP-binding, 3 hits
PF13193, AMP-binding_C, 1 hit
PF00668, Condensation, 5 hits
PF00550, PP-binding, 5 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00823, PKS_PP, 4 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47336, SSF47336, 5 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00455, AMP_BINDING, 3 hits
PS50075, CARRIER, 5 hits
PS00012, PHOSPHOPANTETHEINE, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q4WR82-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MAGTANPADE GLTGPTETTN HINSARSDVA LGSSLSGIVP MTKIPALNTI
60 70 80 90 100
DQFVAEGSPD DLIGQSPWRR IGQGDVSGEL ATGLIEGYAR FVSALTGVED
110 120 130 140 150
VAFAVLCQAS TRPSQALICA SVTLTDQGRE VPSAWQCAVR ELDFSYYNRS
160 170 180 190 200
EVQFALDLGL TGGPENRKAG LSTLAENDCL SLYVRGSTDG LCISFTYPRR
210 220 230 240 250
LIPEAAVSQL LKTITFHITQ TTGCLQSTGA WPDDPTPDLS ILNFPPLMIP
260 270 280 290 300
PSRDHDSATM PRHSKSFLLH SAFEGWAQKS PTSIALDFVH SLPSASTVAE
310 320 330 340 350
HSTLTYAALN AAATYLAIHI RSLLSDNTRN AGSRIIPVYM STSPELYISY
360 370 380 390 400
LGILKAGYAF CPIPTDAPPQ RVREIFQDID SSVILGDGEE PSSVSWFLSA
410 420 430 440 450
AGEATSKPTW VNVAEVSRWK HLSREDTEIA TEDRLFEPPD IDHNEIAYLL
460 470 480 490 500
FTSGSTGKPK GVQVSHLAVT CSIESHATAI PLPGTSAGDF RWFQFASPTF
510 520 530 540 550
DPSLMEIFVT LSSGGTLCSA SRSLTLTDLE GTINEARATV MMATPSLAAL
560 570 580 590 600
LRPAQLTTLQ YLWTMGEKLN RTVIENFTQK AHSNDLNGDS VPALRLLVNA
610 620 630 640 650
YGPTEAAINC TFFAPVEYHT RGSIIGEPLP TCSIFVLDPA SHTPKPIPAG
660 670 680 690 700
LAGELAIGGP QVSQGYLNRP EETANSFVHS PEYGYLYRTG DLARIVWDEK
710 720 730 740 750
GAQVIEFLGR ITSDQVKISG RRVELGEIES VLATLTGVRE VVAVVPKRDA
760 770 780 790 800
SVQGSEQIVA CIVADSLSED AAPEFVRLAD ECAHRHLAAY MCPSSYVFFD
810 820 830 840 850
SIPRTSSGKV DRNSISSMLQ QGKDSGMKFY MPSNDVPEAR GMARAEWDPL
860 870 880 890 900
EDEKALELRT LVLDLVAQTT GQDISVIKPN TSLYTLGLDS LGSMQFLQKL
910 920 930 940 950
RDKSLHNLSV GDVLQSNTVN GLLTLILNGK TNLRGLTNGQ LADDSRMSLA
960 970 980 990 1000
EHLQAFNDTN LSRCAKRLSI SPERIQTVLP TTETQSGMLT SFLRTSTDSS
1010 1020 1030 1040 1050
FATRSYIYHS VISLEPHVDI ERLKKAWESV IASYDSFRTR FCWIDDDMAP
1060 1070 1080 1090 1100
FAQCILKEDA ASAPMWAINH TFGDSMHEDS LTRALREAEN TISLDSPWKL
1110 1120 1130 1140 1150
SLLESSGDKV IILSMFHGIF DGGSLQLLLE NVSSVYDGQL PAPRTSLEHV
1160 1170 1180 1190 1200
VVNHFQANQT ATSNFWKEYL NKYSPIAFPS LTAYRPPAVN ATGCVEITPR
1210 1220 1230 1240 1250
TTHDILKQQS RTIGSTPLSV LQAAWASLLL AYTGTQDHDV VMGSVISGRF
1260 1270 1280 1290 1300
DPDSEICIGP TFTTIPTRLA LGQIPKAGGF WTNKSVVNHL ASLNAKALSH
1310 1320 1330 1340 1350
LQPRLGSLVT ADSKLPYDTV LAYQDFSAGS STSSIWKSID HPPMANDYAV
1360 1370 1380 1390 1400
MIEVWPARDS SLTLRASFAL SQMDRDGAKV MLHQLDDIIA FILQNPDGDF
1410 1420 1430 1440 1450
ENALLYTRPD LKASYNPMPK EADEVSDGDL IHTKFENHAN SHPDDMALLF
1460 1470 1480 1490 1500
KYDLEDDGNL QNISWTYGEL NARADNLAAY LCETYDKLTN KVVPICIEKS
1510 1520 1530 1540 1550
PAMYIAILGI LKAGGAWCPI DTFSPAQRRH DLIKRTGAGV LLVSSEDGEQ
1560 1570 1580 1590 1600
PKDAIPIGID VVDVKKYADP LVSWPSVGRW SSKKLSSPAG LAYLIWTSGT
1610 1620 1630 1640 1650
TGAPKGVPIT HSAAVSCFRS LKKDIPSDVS GGVVRCLQFS QYTFDVSIQD
1660 1670 1680 1690 1700
LFYTWSLGGV LISATREIML GSFAKLANTT RATHAHLTPA FAAGVPRNSC
1710 1720 1730 1740 1750
ETLEVITMIG EKLTQHVADD WGTDMRAYNT YGPAEVTIVS TVREFGNDCL
1760 1770 1780 1790 1800
NIKSANVGWP MESVSVFVTR NKQIVMKNAV GELALGGPQL SPGYLDQEDV
1810 1820 1830 1840 1850
TKAKYVWSEE AGQILYYTGD LVRMLADGSL EFMNRVDDLV KIGGIRIELS
1860 1870 1880 1890 1900
EISFALGGCH PLVENIETLY IDRPDRPSKV LVAFLSASNA TGADAGDDLL
1910 1920 1930 1940 1950
LLNDSALQIA LSTREKAHTA LPAYMVPSVY LVMKRIPRTQ SAKTDRRALQ
1960 1970 1980 1990 2000
AAYASVDIED WENRMNPENN ATGHPTDDLV ASDAMEKIVH MIASLINISP
2010 2020 2030 2040 2050
SIVAKASRLR SLGIDSIHAI RLASRLKEAG YRLSFIEVIN CVTVQDLARL
2060 2070 2080 2090 2100
CTSSSEVDAL PAAEFDINLF NDQWHDIVAS KVDGEFFTVR ATPIQESLLS
2110 2120 2130 2140 2150
ETMGTYNLYW SNHLFSLDKS VDVKRLKQAW LALCQKNEAL RTGFIPVAEV
2160 2170 2180 2190 2200
NNSSRKDDLD FSILQVLHDH PTLDWEYVMC EDHEWDRLLH SRIEDVMKAH
2210 2220 2230 2240 2250
QKTYFKQPPW AVTVLDNGVE RFMVLTMHHS IHDGPSLDLI ERDLRSAYID
2260 2270 2280 2290 2300
KPPSRYQLRS ALSKILPTDE MAAETRRFWS SELQKYSELD APAWPDLTGK
2310 2320 2330 2340 2350
RKPETAVQEH NLISEQMRMT EPLEKLQSIS AELGVSSIAS LIRAAWGFVS
2360 2370 2380 2390 2400
LSYLGVPAAV FAETVSDRIL HADLDNGIGP LISVVPVPFD PKGTAREVLA
2410 2420 2430 2440 2450
EQQRISTQSR KYRHIHAREV RRMLNRPRGE PLYPAVFAFH PAGAEADGTT
2460 2470 2480 2490 2500
NPGLWHELED RIGLHVEHPM AFNVLQNADS SLVLEVFSDA SLMSHEHLSI
2510 2520 2530 2540 2550
FVRQVDSLVS AMLANPDKEL RELINHLPPS LRSKSSQHVS EAVRNSVTLS
2560 2570 2580 2590 2600
PTHWLELNAR EHPEWTAVEV ASSISASGIE KQSMSYGTLN AAANCVAAFI
2610 2620 2630 2640 2650
ASVGYKNRMI AVCAGRNLPS YPVIVGVFKS GNTYLPIDNN LPNDRKTFLI
2660 2670 2680 2690 2700
EDGNCPLVFT ETAFAATFSD VPETCRVLCI DHPSFVDSLA GMPTDNRAYA
2710 2720 2730 2740 2750
SDPQDNAYLL YTSGSTGKPK GVMVSRANLS AFIESFSEFV CRVAPSTLEL
2760 2770 2780 2790 2800
GGRGRYLAQA SRAFDVHLLE MFFAWRHGMA SVTAERTMLL DDLQLTITKW
2810 2820 2830 2840 2850
GITHASMVPS LVDQTNLRPE LCPELKYLSV GGEKISKRVL DTWAGLPHVA
2860 2870 2880 2890 2900
LANAYGPTEV TIGCTFALVG KETTIRNIGP PLSACTCHVL IPGTMDYALR
2910 2920 2930 2940 2950
GQTGELCFTG DIVGNGYLNR PDATGFVQGP DGEKMYRTGD IGRLMSDDSV
2960 2970 2980 2990 3000
EYVGRGDDQT KIRGQRLELG EVSEVIRSSS PVQIGVVTTV TKHPGLARPQ
3010 3020 3030 3040 3050
LISFIARSGD KSRQRSGDAT IIHSDLATLG KELRDACQRK LPAYMVPEII
3060 3070 3080 3090 3100
LPITFIPLAP MSGKANIKEL HSMFSSLPLA SILQGNNPGT SDTAAFTDRP
3110 3120 3130 3140 3150
LSSDEEAVVS EICAVIKVER ENINPLTNIF EIGLDSLSAI SLSVKLRRIG
3160 3170 3180 3190 3200
YDATVALVMG NPVVEQLAQL PRKSTEAVAD PHSSDLTKRL AELETEYHKG
3210 3220 3230 3240 3250
YTRPANSGQV AVRPCLPLQE GLVARSINSE EDQLYVNHIA LSFGPGLDSG
3260 3270 3280 3290 3300
RLRFAWQDTA DNSEILRTCF APLEKEIVQV VLTPGGAISW TEDEYDSLED
3310 3320 3330 3340 3350
CIKEQRARQQ EISRGIIKNM TDVPPVRFHL ATLSSKRPLV LFIAIHHALY
3360 3370 3380 3390 3400
DGESFSMLLE DVAARYVGEP VTRRGSPAAF IDHVYGQNLE KAQQHWVNAL
3410 3420 3430 3440 3450
SDCQPTIFRV DTGVVEETTF INRKLHAGLA KLERHSADLH TTVPSLMQAL
3460 3470 3480 3490 3500
FALLLADRVN SSDVTYGLVL SGRAVAVPDA ESVLLPCITT IPARLNTSGL
3510 3520 3530 3540 3550
KTVSDVVRSV HQSTARSLEY QHTSLRHIQR WLKSEKPLFD CLFSYIRSTP
3560 3570 3580 3590 3600
APKNTLWGQL ESTMPSEYPL AVEIEANSEK DEMYVHCGFS PSFGSADRGQ
3610 3620 3630 3640 3650
EFLEKLDALL SAFLFEDDIA LDSFSLANSG NPGSRATEVK WDATTWSATE
3660 3670 3680 3690 3700
TKIRDLTATF CGLDVVNVSK GTSFISLGID SVTAIQFARK LRELQFEIVP
3710 3720 3730 3740 3750
SDIMRFPCVG ALAEHVDERS SEGRQSARVG DKKPRVSLAA HRDNVPLLDD
3760 3770 3780 3790 3800
GDSVAAIFES TPLQAGMITR TLGSDTQVYV HPHIVRLTEG VDIDRLSKAI
3810 3820 3830 3840 3850
SEVVAKNDIL RTSFHPIAEN GVTWVGAVHT NPPLQWKEIT LPSNADVIAE
3860 3870 3880 3890 3900
LTSLYSFREV ADFETPPVRF VLVHRKNEKL FVVIMHHALY DGVSLPLLFE
3910 3920 3930 3940 3950
ELAATYHGQT TVGRPQFSEI AHYIVEGQND SCDFWTKKLA GYEPVEIPAL
3960 3970 3980 3990 4000
SSSEATERML LSERKIGLDV EKVVESCKSM EVTVQSVALL AYAKVLACLG
4010 4020 4030 4040 4050
GKRDVVFGQV LAGRSLPVPG ADQTIGPLFN TVAQRVLFEP KFLSNREMAQ
4060 4070 4080 4090 4100
RVQQLTSESQ AFQHAPLKDV QRALRQEHGM NAASLFDTLF VFQKSADLTT
4110 4120 4130 4140 4150
DTPHEQQIWT PFETEGYAAQ AEHKLNVEID HGREAIIVSG SGDGRYICQQ
4160 4170 4180 4190 4200
ALDEFMADFC TAFQDIIEHP SRCATAAPER LGGLPLRLSN AEEPERGHSE
4210 4220 4230 4240 4250
SDAPAHESII RDVLAEVSGV SVDSITPSTS IYNIGLDSLS AIRIASICRS
4260 4270 4280 4290 4300
RGLKAGVADV LQGNTLRGIS ARIISPVEAP IQAREPLIKD HEAIEKAVLQ
4310 4320 4330 4340 4350
RLGLNKDEVE TILPCLSGQL YHLVSWLKSG RTLFEPAWSY YSIERIDSGK
4360 4370 4380 4390 4400
LEEAWNQLRQ RHHILRTCFV ATSPSMAVQA VLKDAPQNAE IFKVIESPAC
4410 4420 4430 4440 4450
IEEAAKAQAR EEGLNPSSLF VPPVRLRLLK ASDKDGIQIF INHAAYDAWT
4460 4470 4480 4490 4500
MPMFVSELAH LYREQPVEST PDFPSFVEYA TRSLREVDEQ TYWSSQVGSS
4510 4520 4530 4540 4550
LPTLIKPTNQ GLPKQFFVGV WEKVQNLSQL ERACRSACLS LQSVVLLAVS
4560 4570 4580 4590 4600
RSLARTTGVQ SPTIGLYQTG RSASFSNIEN LSGPCLNVTP FTFPSPGAKA
4610 4620 4630 4640 4650
ESNALDEVQA IQNSLAERVL YEQSCLRDIL TNWASTKGKG PLFNTWVNLL
4660 4670 4680 4690 4700
WMHQPSTRGD SKSHTDLDLF QPLRIGVPTD FIPATPLPDP SGETTSISAL
4710 4720 4730 4740 4750
DTSYLPDENL YIDIGPDYST DTIGFGVRVE GGLLTEKEVR GMVDDVSGEI
4760
EGIMAAIQQG KSR
Length:4,763
Mass (Da):522,418
Last modified:July 5, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i7C5F60213B253FC8
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AAHF01000004 Genomic DNA Translation: EAL91050.1

NCBI Reference Sequences

More...
RefSeqi
XP_753088.1, XM_747995.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
EAL91050; EAL91050; AFUA_1G17200

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
3510120

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
afm:AFUA_1G17200

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAHF01000004 Genomic DNA Translation: EAL91050.1
RefSeqiXP_753088.1, XM_747995.1

3D structure databases

SMRiQ4WR82
ModBaseiSearch...

Protein-protein interaction databases

STRINGi746128.CADAFUBP00001627

Proteomic databases

PRIDEiQ4WR82

Genome annotation databases

EnsemblFungiiEAL91050; EAL91050; AFUA_1G17200
GeneIDi3510120
KEGGiafm:AFUA_1G17200

Organism-specific databases

VEuPathDBiFungiDB:Afu1g17200

Phylogenomic databases

eggNOGiKOG1178, Eukaryota
HOGENOMiCLU_000092_1_0_1
InParanoidiQ4WR82
OMAiITMIGEK
OrthoDBi4243at2759

Family and domain databases

Gene3Di1.10.1200.10, 5 hits
3.30.300.30, 3 hits
3.30.559.10, 5 hits
3.40.50.12780, 3 hits
InterProiView protein in InterPro
IPR036736, ACP-like_sf
IPR025110, AMP-bd_C
IPR045851, AMP-bd_C_sf
IPR020845, AMP-binding_CS
IPR000873, AMP-dep_Synth/Lig
IPR042099, ANL_N_sf
IPR023213, CAT-like_dom_sf
IPR001242, Condensatn
IPR020806, PKS_PP-bd
IPR009081, PP-bd_ACP
IPR006162, Ppantetheine_attach_site
PfamiView protein in Pfam
PF00501, AMP-binding, 3 hits
PF13193, AMP-binding_C, 1 hit
PF00668, Condensation, 5 hits
PF00550, PP-binding, 5 hits
SMARTiView protein in SMART
SM00823, PKS_PP, 4 hits
SUPFAMiSSF47336, SSF47336, 5 hits
PROSITEiView protein in PROSITE
PS00455, AMP_BINDING, 3 hits
PS50075, CARRIER, 5 hits
PS00012, PHOSPHOPANTETHEINE, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSIDC_ASPFU
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q4WR82
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 18, 2012
Last sequence update: July 5, 2005
Last modified: February 23, 2022
This is version 111 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again