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Entry version 99 (29 Sep 2021)
Sequence version 1 (05 Jul 2005)
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Protein

5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferase

Gene

AFUA_4G07360

Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Status
Unreviewed-Annotation score:

Annotation score:2 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Protein inferred from homologyi <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation.

ARBA annotation

Caution

The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes the catalytic activity of an enzyme, i.e. a chemical reaction that the enzyme catalyzes.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityi

<p>This subsection of the 'Function' section provides information relevant to cofactors. A cofactor is any non-protein substance required for a protein to be catalytically active. Some cofactors are inorganic, such as the metal atoms zinc, iron, and copper in various oxidation states. Others, such as most vitamins, are organic.<p><a href='/help/cofactor' target='_top'>More...</a></p>Cofactori

Zn2+ARBA annotation

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: L-methionine biosynthesis via de novo pathway

This protein is involved in step 1 of the subpathway that synthesizes L-methionine from L-homocysteine (MetE route).ARBA annotation This subpathway is part of the pathway L-methionine biosynthesis via de novo pathway, which is itself part of Amino-acid biosynthesis.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes L-methionine from L-homocysteine (MetE route), the pathway L-methionine biosynthesis via de novo pathway and in Amino-acid biosynthesis.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionMethyltransferaseImportedARBA annotation, Transferase
Biological processAmino-acid biosynthesis, Methionine biosynthesisARBA annotation
LigandMetal-bindingARBA annotation, ZincARBA annotation

Enzyme and pathway databases

UniPathway: a resource for the exploration and annotation of metabolic pathways

More...
UniPathwayi
UPA00051;UER00082

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
5-methyltetrahydropteroyltriglutamate--homocysteine S-methyltransferaseARBA annotation (EC:2.1.1.14ARBA annotation)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
ORF Names:AFUA_4G07360Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiNeosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)Imported
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri330879 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillusAspergillus subgen. Fumigati
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002530 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 4

Organism-specific databases

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
FungiDB:Afu4g07360

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

PTM databases

SwissPalm database of S-palmitoylation events

More...
SwissPalmi
Q4WNY2

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
746128.CADAFUBP00006270

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q4WNY2

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini4 – 325Meth_synt_1InterPro annotationAdd BLAST322
Domaini443 – 766Meth_synt_2InterPro annotationAdd BLAST324

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and domains' section denotes the positions of regions of coiled coil within the protein.<p><a href='/help/coiled' target='_top'>More...</a></p>Coiled coili385 – 405Sequence analysisAdd BLAST21
Coiled coili471 – 491Sequence analysisAdd BLAST21

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the vitamin-B12 independent methionine synthase family.ARBA annotation

Keywords - Domaini

Coiled coilSequence analysis

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG2263, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_013175_0_0_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q4WNY2

Identification of Orthologs from Complete Genome Data

More...
OMAi
KVMKGML

Database of Orthologous Groups

More...
OrthoDBi
237390at2759

Family and domain databases

Conserved Domains Database

More...
CDDi
cd03311, CIMS_C_terminal_like, 1 hit

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
3.20.20.210, 2 hits

HAMAP database of protein families

More...
HAMAPi
MF_00172, Meth_synth, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR013215, Cbl-indep_Met_Synth_N
IPR006276, Cobalamin-indep_Met_synthase
IPR002629, Met_Synth_C/arc
IPR038071, UROD/MetE-like_sf

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF08267, Meth_synt_1, 1 hit
PF01717, Meth_synt_2, 1 hit

PIRSF; a whole-protein classification database

More...
PIRSFi
PIRSF000382, MeTrfase_B12_ind, 1 hit

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF51726, SSF51726, 2 hits

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01371, met_syn_B12ind, 1 hit

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q4WNY2-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVQSAVLGFP RMGKLRDLKK ATEAYWGGKI SRDELLSEGK RLRAEHWKIQ
60 70 80 90 100
KDAGVDIIPS NDFAFYDQVL DHIQLFGVVP ERYSKYNLDP LDEYFAMGRG
110 120 130 140 150
LQKPASEGQP AIDVPSLEMV KWFDSNYHYV KPTLQENQVF KLASNPKPVA
160 170 180 190 200
QFLEAKEAGI ITRPVILGPV SFLTLAKADR GQKIDPIDKI NDLVPVYVDL
210 220 230 240 250
LAQLKAAGVE DVQIDEPVLV FDLPAKSKAA FKPVYEKIGA LGDKAPRIVL
260 270 280 290 300
ATYFGDIVHN IDVLPALHNL HGIHVDLVRN PEQLDAVIAA LGPKQVLSAG
310 320 330 340 350
VVDGRNIWKT NFKAAIEKVE HAIQKLGKDR VIVSTSSSLL HVPHTLESEK
360 370 380 390 400
NLDPEVREWF SFAVEKTHEV VVIAKAVTEG PAAVRDQLEA NAKSVQARAS
410 420 430 440 450
SARTNDPKVK ERQAAVTEEM HNRKSPFPVR LAEQSKSINL PLFPTTTIGS
460 470 480 490 500
FPQTKEIRIQ RNKFTKGEIT AEEYEKFIEQ EIAEVVKIQE ELDLDVLVHG
510 520 530 540 550
EPERNDMVQY FGERLTGYVF TTHAWVQSYG SRCVRPPIIV GDISRPAPMT
560 570 580 590 600
VKESKYAVSI SKKPMKGMLT GPITCLRWSF PRDDVHQSVQ AQQLALALRD
610 620 630 640 650
EVIDLEAAGV KVIQVDEPAL REGLPLRAGK EREDYLTWAV RAFRLATSGV
660 670 680 690 700
SDGTQIHSHF CYSEFQDFFH AIAALDADVL SIENSKSDAK LLKVFVEEAY
710 720 730 740 750
PRHIGPGVYD IHSPRVPSEQ EIKDRIEEML PYLRPDQLWI NPDCGLKTRQ
760 770
WPETKAALTN MVNAAKFYRQ KYTK
Length:774
Mass (Da):86,895
Last modified:July 5, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i2D7CCCFB4F4EC6BB
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AAHF01000005 Genomic DNA Translation: EAL90052.1

NCBI Reference Sequences

More...
RefSeqi
XP_752090.1, XM_746997.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
EAL90052; EAL90052; AFUA_4G07360

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
3509461

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
afm:AFUA_4G07360

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAHF01000005 Genomic DNA Translation: EAL90052.1
RefSeqiXP_752090.1, XM_746997.1

3D structure databases

SMRiQ4WNY2
ModBaseiSearch...

Protein-protein interaction databases

STRINGi746128.CADAFUBP00006270

PTM databases

SwissPalmiQ4WNY2

Genome annotation databases

EnsemblFungiiEAL90052; EAL90052; AFUA_4G07360
GeneIDi3509461
KEGGiafm:AFUA_4G07360

Organism-specific databases

VEuPathDBiFungiDB:Afu4g07360

Phylogenomic databases

eggNOGiKOG2263, Eukaryota
HOGENOMiCLU_013175_0_0_1
InParanoidiQ4WNY2
OMAiKVMKGML
OrthoDBi237390at2759

Enzyme and pathway databases

UniPathwayiUPA00051;UER00082

Family and domain databases

CDDicd03311, CIMS_C_terminal_like, 1 hit
Gene3Di3.20.20.210, 2 hits
HAMAPiMF_00172, Meth_synth, 1 hit
InterProiView protein in InterPro
IPR013215, Cbl-indep_Met_Synth_N
IPR006276, Cobalamin-indep_Met_synthase
IPR002629, Met_Synth_C/arc
IPR038071, UROD/MetE-like_sf
PfamiView protein in Pfam
PF08267, Meth_synt_1, 1 hit
PF01717, Meth_synt_2, 1 hit
PIRSFiPIRSF000382, MeTrfase_B12_ind, 1 hit
SUPFAMiSSF51726, SSF51726, 2 hits
TIGRFAMsiTIGR01371, met_syn_B12ind, 1 hit

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiQ4WNY2_ASPFU
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q4WNY2
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/TrEMBL: July 5, 2005
Last sequence update: July 5, 2005
Last modified: September 29, 2021
This is version 99 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiUnreviewed (UniProtKB/TrEMBL)

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteomeImported
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