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UniProtKB - Q4WLW5 (FMQA_ASPFU)

Entry version 110 (23 Feb 2022)
Sequence version 1 (05 Jul 2005)
Previous versions | rss
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Protein

Nonribosomal peptide synthetase fmqA

Gene

fmqA

Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Nonribosomal peptide synthetase; part of the gene cluster that mediates the biosynthesis of the antitumor fumiquinazolines that confer a dual-usage capability to defend against phagocytes in the environment and animal hosts (PubMed:20225828, PubMed:20804163, PubMed:21899262, PubMed:24612080, PubMed:33705521).

The simplest member is fumiquinazoline F (FQF) with a 6-6-6 tricyclic core derived from anthranilic acid (Ant), tryptophan (Trp), and alanine (Ala) (PubMed:20225828).

The trimodular NRPS fmqA is responsible for FQF formation (PubMed:20225828).

Modules 1, 2 and 3 of fmqA are predicted to activate and load Ant, Trp and Ala, respectively, providing for the assembly of an Ant-Trp-Ala-S-enzyme intermediate that would undergo double cyclization for chain release and generation of the tricyclic 6-6-6 product fumiquinazoline F (PubMed:20225828).

The presence of an E domain predicted for module 2 of fmqA is consistent with epimerization of L-Trp to D-Trp during assembly to generate the R-stereocenter at C14 of FQF (PubMed:20225828).

The FAD-dependent monooxygenase fmqB and the monomodular NRPS fmqC then maturate FQF to FQA (PubMed:20804163).

FmqB oxidizes the 2',3'-double bond of the indole side chain of FQF, and fmqC activates L-Ala as the adenylate, installs it as the pantetheinyl thioester on its carrier protein domain, and acylates the oxidized indole for subsequent intramolecular cyclization to create the 6-5-5-imidazolindolone of FQA (PubMed:20804163).

The FAD-linked oxidoreductase fmqD introduces a third layer of scaffold complexity by converting FQA to the spirohemiaminal FQC, presumably by catalyzing the formation of a transient imine within the pyrazinone ring (PubMed:21899262).

FQC subsequently converts nonenzymatically to the known cyclic aminal FQD (PubMed:21899262).

5 Publications

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=18 µM for anthranilate1 Publication
  2. KM=230 µM for ATP1 Publication
  3. KM=17 µM for salicylic acid1 Publication
  4. KM=29 µM for 2-chlorobenzoic acid1 Publication
  5. KM=32 µM for 4-chlorobenzoic acid1 Publication
  6. KM=74 µM for benzoic acid1 Publication
  7. KM=416 µM for 3-aminobenzoic acidATP1 Publication
  8. KM=1900 µM for 4-aminobenzoic acid1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: Alkaloid biosynthesis

This protein is involved in Alkaloid biosynthesis.2 Publications
View all proteins of this organism that are known to be involved in Alkaloid biosynthesis.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

Complete GO annotation on QuickGO ...

GO - Biological processi

  • fumiquinazoline C biosynthetic process Source: AspGD
  • nonribosomal peptide biosynthetic process Source: AspGD
  • secondary metabolic process Source: AspGD
Complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionLigase
Biological processVirulence

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nonribosomal peptide synthetase fmqA1 Publication (EC:6.3.2.-1 Publication)
Alternative name(s):
Fumiquinazoline biosynthesis cluster protein A1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:fmqA1 Publication
Synonyms:NRPS121 Publication, pesM1 Publication
ORF Names:AFUA_6G12080
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiNeosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri330879 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Aspergillaceae › Aspergillus › Aspergillus subgen. Fumigati ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002530 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Eukaryotic Pathogen, Vector and Host Database Resources

More...VEuPathDBi		FungiDB:Afu6g12080

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasmic vesicle

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Abolishes the production of all fumiquinazolines (PubMed:24612080).1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004165531 – 3955Nonribosomal peptide synthetase fmqAAdd BLAST3955

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei840O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1
Modified residuei1917O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1
Modified residuei3459O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1

Keywords - PTMi

Phosphopantetheine, Phosphoprotein

Proteomic databases

PRoteomics IDEntifications database

More...PRIDEi		Q4WLW5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Expression is positively regulated by brlA, a conidiation-specific transcription factor involved in the early stage of asexual development and necessary for conidiophore formation (PubMed:24612080). Expression is also induced by the cell wall integrity (CWI) signaling pathway that includes the mitogen-activated protein kinase mpkA and the transcription factor rlmA (PubMed:33705521). Expression is negatively regulated by the transcription factor sebA (PubMed:33705521).2 Publications

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with the mitogen-activated protein kinase mpkA.

1 Publication

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		746128.CADAFUBP00007610

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q4WLW5

Database of comparative protein structure models

More...ModBasei		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini806 – 879Carrier 1PROSITE-ProRule annotation2 PublicationsAdd BLAST74
Domaini1880 – 1956Carrier 2PROSITE-ProRule annotation2 PublicationsAdd BLAST77
Domaini3422 – 3498Carrier 3PROSITE-ProRule annotation2 PublicationsAdd BLAST77

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni293 – 691Adenylation 1Sequence analysis2 PublicationsAdd BLAST399
Regioni916 – 1187Condensation 1Sequence analysis2 PublicationsAdd BLAST272
Regioni1371 – 1766Adenylation 2Sequence analysis2 PublicationsAdd BLAST396
Regioni1970 – 2261EpimeraseSequence analysis2 PublicationsAdd BLAST292
Regioni2438 – 2724Condensation 2Sequence analysis2 PublicationsAdd BLAST287
Regioni2906 – 3299Adenylation 3Sequence analysis2 PublicationsAdd BLAST394
Regioni3541 – 3805Condensation 3Sequence analysis2 PublicationsAdd BLAST265

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

NRP synthetases are composed of discrete domains (adenylation (A), thiolation (T) or peptidyl carrier protein (PCP) and condensation (C) domains) which when grouped together are referred to as a single module (PubMed:17464044). Each module is responsible for the recognition (via the A domain) and incorporation of a single amino acid into the growing peptide product (PubMed:17464044). Thus, an NRP synthetase is generally composed of one or more modules and can terminate in a thioesterase domain (TE) that releases the newly synthesized peptide from the enzyme (PubMed:17464044). Occasionally, epimerase (E) domains (responsible for L- to D- amino acid conversion) are present within the NRP synthetase (PubMed:17464044). NRPS12 has the following architecture: A-T-C-A-T-E-C-A-T-C (PubMed:17464044, PubMed:20225828).1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NRP synthetase family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...eggNOGi		KOG1176, Eukaryota
KOG1178, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		CLU_000022_60_4_1

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q4WLW5

Identification of Orthologs from Complete Genome Data

More...OMAi		YEWLMAF

Database of Orthologous Groups

More...OrthoDBi		4243at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.1200.10, 3 hits
3.30.300.30, 3 hits
3.30.559.10, 4 hits
3.40.50.12780, 3 hits

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR010071, AA_adenyl_domain
IPR036736, ACP-like_sf
IPR045851, AMP-bd_C_sf
IPR020845, AMP-binding_CS
IPR000873, AMP-dep_Synth/Lig
IPR042099, ANL_N_sf
IPR023213, CAT-like_dom_sf
IPR001242, Condensatn
IPR020806, PKS_PP-bd
IPR009081, PP-bd_ACP
IPR006162, Ppantetheine_attach_site

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00501, AMP-binding, 3 hits
PF00668, Condensation, 4 hits
PF00550, PP-binding, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00823, PKS_PP, 3 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47336, SSF47336, 3 hits

TIGRFAMs; a protein family database

More...TIGRFAMsi		TIGR01733, AA-adenyl-dom, 3 hits

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00455, AMP_BINDING, 2 hits
PS50075, CARRIER, 3 hits
PS00012, PHOSPHOPANTETHEINE, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q4WLW5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MERLEAKNQT TKHGERMAPQ RYSVLRDEKC LFPVRNDGKL LVDEWRVTEL 
        60         70         80         90        100
AISSGEKGLK LCRTTCPTAG ADPRYLAAAA WALLLWRFAE VDTVQIGLQD 
       110        120        130        140        150
IPPGANEDIL EAGLKRGMKV LAASRRQVQL LNELWQGDTW SISDADPTCY 
       160        170        180        190        200
SYFDTGIVIC RGNSQDCLAK CRSPNQLRKA NGEACNVLLV LELDLDSNWR 
       210        220        230        240        250
KCFLAYKTTV LTDIQATHLK SSFEEVVELA RAGRGIPLSE ICLVSRRQLD 
       260        270        280        290        300
QIGKWNERAL VQPKFKAMHQ VVHDRATDRR HHPAVIAADR ALSYSELETL 
       310        320        330        340        350
SLKVAYRLRG SGVQPGDLIP VCFCKSSWAI VAMLAINKLG AAFVPLDPSQ 
       360        370        380        390        400
PVNRLKSITR QLDATLAVTS PENQSLVEDL VTTTVVVSET TVSELVDVHN 
       410        420        430        440        450
EIVLPACDPG APAYCLFTSG STGKPKGCVV DHAALASVAT HSHALHLGPT 
       460        470        480        490        500
SRVLQFASFT FGVSLIEVWC TLAAGGTVCL PSDSDRVSRL ADAIRSMGVD 
       510        520        530        540        550
WCILTPTVLA TLEPEAVPNL RTILVAGEPL KKAQFSLWAE RARLFQAYGF 
       560        570        580        590        600
TEWAGICCVS PQIRSIGDVG IIGTPANARC WLVEPGNPNQ LAPIGAVAEL 
       610        620        630        640        650
AVEGPSLAQG YLHDPEKTAA TLIPPPRWRA QYGHADGKRI YTTGDLVYYD 
       660        670        680        690        700
SNGMLRYVSR KDRQVKIRGQ RIDLAEPEYH IAQACCTIRN VVLDAIVPAD 
       710        720        730        740        750
SNGDAILVAF VLPSRDESSS NGGHDSPLFA VPDDHFTSSV RQLTSFLEDK 
       760        770        780        790        800
LPDYMVPRLF LQLKETPVTI TGKIARQKLR EAAEALRHDE LVALAGLETR 
       810        820        830        840        850
VLPPNTHKET LIHQLVVELL HLPPEMVGMN HNFFSLGGDS VSVMKLVSRA 
       860        870        880        890        900
KRVGLSFTVK DVFRSPQLGD LARLTDVVNS GAAQHMPPFS LLDRGAQPGL 
       910        920        930        940        950
LSMAAKICQV ESSMIQDIYP CTPLQEGMMT LSAAKAGSYI ARFVYRLEEH 
       960        970        980        990       1000
VDSPRFRRAW EMTVEATPIL RTRIISASDG RLYQVVIQEK FRWDDDGQPS 
      1010       1020       1030       1040       1050
GECVQNGQDR HMLLGEPLTH AALVRDRNQD GSLSTVFVLT MHHSVCDRWS 
      1060       1070       1080       1090       1100
VGLIMDSVET AYTGQTLTTN SMGPFLQYIQ QLQGGDAFWR SQFVGVKAEV 
      1110       1120       1130       1140       1150
FPSLPSPEYT PTPTETIDLS VELRDAVPGG HTIANAIRLA WALVISHYTS 
      1160       1170       1180       1190       1200
CSDVVFGVTI SGRAVPVPDI ERIIGPIIAT VPLRVRLKES STVLEALKAI 
      1210       1220       1230       1240       1250
QDQSMEMIPF EQLGLRQIRK LSPEAEEACN FQSQLVVQPA WGDENRSLFA 
      1260       1270       1280       1290       1300
TCEAGAAAEG GFAAYALSMI CQLVGSSQID VRTEFDPKVI QAPIMQRIVH 
      1310       1320       1330       1340       1350
HFVYTLQYLL AHPDARVAEI PVVSPGEKQL LRQWNGIVPP ASHQCVHEII 
      1360       1370       1380       1390       1400
QQRQIERPTS TAVWAWDGQL TYAELGELSD RLAEYLATKG VQPEVIVPVC 
      1410       1420       1430       1440       1450
LEKSYWTTVA MLGISKAGGA FALLDPSQPE QRLQSICHQL NSAVILTSEK 
      1460       1470       1480       1490       1500
NRDLAGKLAS HPIVLSLQSS RRWGHGPAKQ APATARPDHT LYVAFTSGST 
      1510       1520       1530       1540       1550
GTPKGVVIEH RSFCTSALAL NRITGVNSES RMLQFAGYSF DGSIMEMLSA 
      1560       1570       1580       1590       1600
LMAGACVCVP SEFQRRNELV AAAAKFELTH AHLTPSVARH LLRGNPEFTK 
      1610       1620       1630       1640       1650
TLVSVGEPMT ASDVADWASN GQCKVMNGYG PAECAVSTTI QAAVTSASDP 
      1660       1670       1680       1690       1700
KNIGFPVAGV CWVVHPENHD ILLPPGAVGE LLIEGPTLAR GYLNEPDKTA 
      1710       1720       1730       1740       1750
AAFIPLPAWI KDIRPEQPHG RLYKSGDLVR YNADGSFQYI GRRDSQIKLR 
      1760       1770       1780       1790       1800
GQRIELDEVE KHVYQCWPGV IAVVAVEMVS FTPATQTLVA FVVVEEHVDT 
      1810       1820       1830       1840       1850
TGDILAAPTQ EFTGQVAVAQ ARLREAIPAF MVPEIFIPLL VLPQSASGKT 
      1860       1870       1880       1890       1900
DRRRLRSIAT ACTREKLAAY GAVGTGTKRE PTSVAEREMQ AIWAQALNLP 
      1910       1920       1930       1940       1950
LAEIGMDDSF YQLGGDSITA MQVVAHARSK GLAVTMDSIL RLKSISKIMS 
      1960       1970       1980       1990       2000
HESSLSPAIV HIDEEEDVWF ALSPIQQMFF DRQPSGWDRF SQVFLLRVSQ 
      2010       2020       2030       2040       2050
PVTASQLQMA LHTLVSKHPM LRARFAKQHD GSWRQVITSK IQESYRCRSH 
      2060       2070       2080       2090       2100
RLNRRSSVDG VVSSGACSLS IQKGPLIAVD LMSREDGAQY LSIVIHHLVV 
      2110       2120       2130       2140       2150
DLVSWRIILA DLEAMLRGEN PMANHSTPFQ TWCRLQAEYA RQYLSPQHAF 
      2160       2170       2180       2190       2200
PTDLPDHYHQ DPSVFWGLAG QPNLVRDSRR QVFTLDEHTT RQLLGAANAA 
      2210       2220       2230       2240       2250
FATRTDEVLH AVLLYSFLKV FPHRIAPLTF SEGHGREPWD SAIDLSQTVG 
      2260       2270       2280       2290       2300
WFTTMWPVVA ELQQNHSFLE VVCRVKDARR AVPCNGWAYF VSRYLNPSGR 
      2310       2320       2330       2340       2350
QAFQQFHPVE LVFNYAGEYQ QFNQAGAFFI PDMPEYQGSL DAGEQIQRFG 
      2360       2370       2380       2390       2400
IFEVFASVVR GCLQFQFMYN RYMKHQLEIQ KWIESCRQTL IEGCSTLIAA 
      2410       2420       2430       2440       2450
KPSRTLSDFP LLPLTYSTLR ELLDVTLPTA GVSVENVEDI YPCSPSQRGM 
      2460       2470       2480       2490       2500
LIAQAKAAHN YNASVTWSIR SRIDSRPNVA RLKAAWCEVV KRHAILRTVF 
      2510       2520       2530       2540       2550
VESPWPESYM DQVVLQNVSP EFVFCRGSDS LPQSISSPGQ TRWSKGQCQH 
      2560       2570       2580       2590       2600
IMRVWERDNG DILCRLDLSH AIMDRTTLAI IQKDLSLAYD ERLLPGRAPL 
      2610       2620       2630       2640       2650
YRDYISYIYQ QDSESARQYW QGYLEGVEPC EFPTLNPVDP SITKEWGNLY 
      2660       2670       2680       2690       2700
RTLEDRRRLE EFCRTHSVTP WNVAGLAWAM VLRSFTRTDS VCFGYVKSGR 
      2710       2720       2730       2740       2750
DLPIDGIAGT AGPVFNPLPC RVHLTERLTV RETIGRLQEE YLQSLAHQSF 
      2760       2770       2780       2790       2800
PLSDIHRLAG VTSGVLFNTS VAVQTEVASE AEEAKRSLEF TTVAMEDGTE 
      2810       2820       2830       2840       2850
DDMVITLVPR GGELVLHLRH RSRTLTTDQA STVLATFEKA LCSILANAEA 
      2860       2870       2880       2890       2900
PMTSIDVFSD HDKAILWSRN RRVPDAVESC VHELIQKHCV ERPHSPAVNA 
      2910       2920       2930       2940       2950
WDGAFTYGQL DELSSRLAVY LAAQGVGPNV VVPLCFEKTR WTPIAMMGVM 
      2960       2970       2980       2990       3000
KAGGAFLLLD PSYPLQRLKD ICADIDCRLV VSSTTHEAMS RELASTVVVV 
      3010       3020       3030       3040       3050
GEDRHHWQLE NTSHTITMPK VRPADALYVV FTSGSTGKPK GVVIEHRSYC 
      3060       3070       3080       3090       3100
SGALDHIRSY NLTPQSRVLQ FSSYAFDISI VEQLSVLIAG GCICVISESQ 
      3110       3120       3130       3140       3150
RKNSLGEAAT ALQANHAMLI PSVARLVRHE DLSTITSLSL AGECMQETDV 
      3160       3170       3180       3190       3200
SYWAQHVRLM NGYGPAECSA LSLVQPCVLP HSDPHDIGYP VGSVAWVVDP 
      3210       3220       3230       3240       3250
HDHHKLVPNG AVGELLIEGP IVGRGYINNA EKTAEVFIEP PTWLRTLRGH 
      3260       3270       3280       3290       3300
CTSRLYKTGD LVRANPSGSL SILGRKDRQV KLRGQRLELG EVEANVQHCF 
      3310       3320       3330       3340       3350
PGALDVVADL LPSSRGGKPQ LVAMVFQNAE RAARIAPESD SKLIAEPSVD 
      3360       3370       3380       3390       3400
FMQSATTAET RLRQTVPNFM VPSMFLPLAQ IPRTHSDKVD RNSLLKAVAA 
      3410       3420       3430       3440       3450
MSSIELQAYK ASVDAGHCST RAPSTEEEKK LAEIWADVLK VPVEHIGADD 
      3460       3470       3480       3490       3500
NFLLSGGDSI DAMKAAAFCR AAGMALSVAD IFAHPVLSDL AKVAVPKSLN 
      3510       3520       3530       3540       3550
GSSTSHQPFS LSPVDSPKDL HMSLMEQGLV PPGSALADLL PGTQAQQFFI 
      3560       3570       3580       3590       3600
ERGTFHSYNF SIRGPLDRCR LQKTCTAILS RHSILRTKFL QYEGRLIQIV 
      3610       3620       3630       3640       3650
LDNLETPFTH YTTDGDLLEF CKSLWERDLA ALDGLGRLPC KFTLVSRSEQ 
      3660       3670       3680       3690       3700
EHVFTIQISH AQWDGVSIPR LFSDIAAIYN QIPLPSTTHF ADYVYHRSSR 
      3710       3720       3730       3740       3750
DERPAFDFWK KYLRGSSMPV PFPATNCQDR EHKTQWTFQG IKNPRLPAGI 
      3760       3770       3780       3790       3800
TMASLVKAAC GFHLCQLLSQ NDVVFGHTVN GRNLALDNVE ALLGCCLNFI 
      3810       3820       3830       3840       3850
PLRVMLQPSW TVLDLLAHVQ EQYTRALPHE HLELRDIFRH STPWPADTQL 
      3860       3870       3880       3890       3900
SFIVQHQNIE LHHNIALDGL QVQYSKFAQF DPLTEVWIFS EPHPDRLEIQ 
      3910       3920       3930       3940       3950
VCANTRVLSE DQARALCRRL CDLIEFFSAS PDCPLSKVVD HMDRPGLLAE 

EKVLN
Length:3,955
Mass (Da):437,813
Last modified:July 5, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC66E17E07E1F5296
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AAHF01000006 Genomic DNA Translation: EAL89049.1

NCBI Reference Sequences

More...RefSeqi		XP_751087.1, XM_745994.1

Genome annotation databases

Ensembl fungal genome annotation project

More...EnsemblFungii		EAL89049; EAL89049; AFUA_6G12080

Database of genes from NCBI RefSeq genomes

More...GeneIDi		3508392

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		afm:AFUA_6G12080

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAHF01000006 Genomic DNA Translation: EAL89049.1
RefSeqiXP_751087.1, XM_745994.1

3D structure databases

SMRiQ4WLW5
ModBaseiSearch...

Protein-protein interaction databases

STRINGi746128.CADAFUBP00007610

Proteomic databases

PRIDEiQ4WLW5

Genome annotation databases

EnsemblFungiiEAL89049; EAL89049; AFUA_6G12080
GeneIDi3508392
KEGGiafm:AFUA_6G12080

Organism-specific databases

VEuPathDBiFungiDB:Afu6g12080

Phylogenomic databases

eggNOGiKOG1176, Eukaryota
KOG1178, Eukaryota
HOGENOMiCLU_000022_60_4_1
InParanoidiQ4WLW5
OMAiYEWLMAF
OrthoDBi4243at2759

Family and domain databases

Gene3Di1.10.1200.10, 3 hits
3.30.300.30, 3 hits
3.30.559.10, 4 hits
3.40.50.12780, 3 hits
InterProiView protein in InterPro
IPR010071, AA_adenyl_domain
IPR036736, ACP-like_sf
IPR045851, AMP-bd_C_sf
IPR020845, AMP-binding_CS
IPR000873, AMP-dep_Synth/Lig
IPR042099, ANL_N_sf
IPR023213, CAT-like_dom_sf
IPR001242, Condensatn
IPR020806, PKS_PP-bd
IPR009081, PP-bd_ACP
IPR006162, Ppantetheine_attach_site
PfamiView protein in Pfam
PF00501, AMP-binding, 3 hits
PF00668, Condensation, 4 hits
PF00550, PP-binding, 3 hits
SMARTiView protein in SMART
SM00823, PKS_PP, 3 hits
SUPFAMiSSF47336, SSF47336, 3 hits
TIGRFAMsiTIGR01733, AA-adenyl-dom, 3 hits
PROSITEiView protein in PROSITE
PS00455, AMP_BINDING, 2 hits
PS50075, CARRIER, 3 hits
PS00012, PHOSPHOPANTETHEINE, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFMQA_ASPFU
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q4WLW5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 18, 2012
Last sequence update: July 5, 2005
Last modified: February 23, 2022
This is version 110 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
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