Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 110 (23 Feb 2022)
Sequence version 1 (05 Jul 2005)
Previous versions | rss
Add a publicationFeedback
Protein

Nonribosomal peptide synthetase fmqA

Gene

fmqA

Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at protein leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Nonribosomal peptide synthetase; part of the gene cluster that mediates the biosynthesis of the antitumor fumiquinazolines that confer a dual-usage capability to defend against phagocytes in the environment and animal hosts (PubMed:20225828, PubMed:20804163, PubMed:21899262, PubMed:24612080, PubMed:33705521).

The simplest member is fumiquinazoline F (FQF) with a 6-6-6 tricyclic core derived from anthranilic acid (Ant), tryptophan (Trp), and alanine (Ala) (PubMed:20225828).

The trimodular NRPS fmqA is responsible for FQF formation (PubMed:20225828).

Modules 1, 2 and 3 of fmqA are predicted to activate and load Ant, Trp and Ala, respectively, providing for the assembly of an Ant-Trp-Ala-S-enzyme intermediate that would undergo double cyclization for chain release and generation of the tricyclic 6-6-6 product fumiquinazoline F (PubMed:20225828).

The presence of an E domain predicted for module 2 of fmqA is consistent with epimerization of L-Trp to D-Trp during assembly to generate the R-stereocenter at C14 of FQF (PubMed:20225828).

The FAD-dependent monooxygenase fmqB and the monomodular NRPS fmqC then maturate FQF to FQA (PubMed:20804163).

FmqB oxidizes the 2',3'-double bond of the indole side chain of FQF, and fmqC activates L-Ala as the adenylate, installs it as the pantetheinyl thioester on its carrier protein domain, and acylates the oxidized indole for subsequent intramolecular cyclization to create the 6-5-5-imidazolindolone of FQA (PubMed:20804163).

The FAD-linked oxidoreductase fmqD introduces a third layer of scaffold complexity by converting FQA to the spirohemiaminal FQC, presumably by catalyzing the formation of a transient imine within the pyrazinone ring (PubMed:21899262).

FQC subsequently converts nonenzymatically to the known cyclic aminal FQD (PubMed:21899262).

5 Publications

<p>This subsection of the 'Function' section describes biophysical and chemical properties, such as maximal absorption, kinetic parameters, pH dependence, redox potentials and temperature dependence.<p><a href='/help/biophysicochemical_properties' target='_top'>More...</a></p>Kineticsi

  1. KM=18 µM for anthranilate1 Publication
  2. KM=230 µM for ATP1 Publication
  3. KM=17 µM for salicylic acid1 Publication
  4. KM=29 µM for 2-chlorobenzoic acid1 Publication
  5. KM=32 µM for 4-chlorobenzoic acid1 Publication
  6. KM=74 µM for benzoic acid1 Publication
  7. KM=416 µM for 3-aminobenzoic acidATP1 Publication
  8. KM=1900 µM for 4-aminobenzoic acid1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: Alkaloid biosynthesis

This protein is involved in Alkaloid biosynthesis.2 Publications
View all proteins of this organism that are known to be involved in Alkaloid biosynthesis.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • fumiquinazoline C biosynthetic process Source: AspGD
  • nonribosomal peptide biosynthetic process Source: AspGD
  • secondary metabolic process Source: AspGD

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionLigase
Biological processVirulence

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nonribosomal peptide synthetase fmqA1 Publication (EC:6.3.2.-1 Publication)
Alternative name(s):
Fumiquinazoline biosynthesis cluster protein A1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:fmqA1 Publication
Synonyms:NRPS121 Publication, pesM1 Publication
ORF Names:AFUA_6G12080
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiNeosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri330879 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillusAspergillus subgen. Fumigati
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002530 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 6

Organism-specific databases

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
FungiDB:Afu6g12080

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Keywords - Cellular componenti

Cytoplasmic vesicle

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Abolishes the production of all fumiquinazolines (PubMed:24612080).1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004165531 – 3955Nonribosomal peptide synthetase fmqAAdd BLAST3955

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei840O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1
Modified residuei1917O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1
Modified residuei3459O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1

Keywords - PTMi

Phosphopantetheine, Phosphoprotein

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q4WLW5

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Expression is positively regulated by brlA, a conidiation-specific transcription factor involved in the early stage of asexual development and necessary for conidiophore formation (PubMed:24612080). Expression is also induced by the cell wall integrity (CWI) signaling pathway that includes the mitogen-activated protein kinase mpkA and the transcription factor rlmA (PubMed:33705521). Expression is negatively regulated by the transcription factor sebA (PubMed:33705521).2 Publications

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction%5Fsection">'Interaction'</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structurei

Interacts with the mitogen-activated protein kinase mpkA.

1 Publication

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
746128.CADAFUBP00007610

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q4WLW5

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini806 – 879Carrier 1PROSITE-ProRule annotation2 PublicationsAdd BLAST74
Domaini1880 – 1956Carrier 2PROSITE-ProRule annotation2 PublicationsAdd BLAST77
Domaini3422 – 3498Carrier 3PROSITE-ProRule annotation2 PublicationsAdd BLAST77

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni293 – 691Adenylation 1Sequence analysis2 PublicationsAdd BLAST399
Regioni916 – 1187Condensation 1Sequence analysis2 PublicationsAdd BLAST272
Regioni1371 – 1766Adenylation 2Sequence analysis2 PublicationsAdd BLAST396
Regioni1970 – 2261EpimeraseSequence analysis2 PublicationsAdd BLAST292
Regioni2438 – 2724Condensation 2Sequence analysis2 PublicationsAdd BLAST287
Regioni2906 – 3299Adenylation 3Sequence analysis2 PublicationsAdd BLAST394
Regioni3541 – 3805Condensation 3Sequence analysis2 PublicationsAdd BLAST265

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

NRP synthetases are composed of discrete domains (adenylation (A), thiolation (T) or peptidyl carrier protein (PCP) and condensation (C) domains) which when grouped together are referred to as a single module (PubMed:17464044). Each module is responsible for the recognition (via the A domain) and incorporation of a single amino acid into the growing peptide product (PubMed:17464044). Thus, an NRP synthetase is generally composed of one or more modules and can terminate in a thioesterase domain (TE) that releases the newly synthesized peptide from the enzyme (PubMed:17464044). Occasionally, epimerase (E) domains (responsible for L- to D- amino acid conversion) are present within the NRP synthetase (PubMed:17464044). NRPS12 has the following architecture: A-T-C-A-T-E-C-A-T-C (PubMed:17464044, PubMed:20225828).1 Publication

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NRP synthetase family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1176, Eukaryota
KOG1178, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000022_60_4_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q4WLW5

Identification of Orthologs from Complete Genome Data

More...
OMAi
YEWLMAF

Database of Orthologous Groups

More...
OrthoDBi
4243at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1200.10, 3 hits
3.30.300.30, 3 hits
3.30.559.10, 4 hits
3.40.50.12780, 3 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR010071, AA_adenyl_domain
IPR036736, ACP-like_sf
IPR045851, AMP-bd_C_sf
IPR020845, AMP-binding_CS
IPR000873, AMP-dep_Synth/Lig
IPR042099, ANL_N_sf
IPR023213, CAT-like_dom_sf
IPR001242, Condensatn
IPR020806, PKS_PP-bd
IPR009081, PP-bd_ACP
IPR006162, Ppantetheine_attach_site

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00501, AMP-binding, 3 hits
PF00668, Condensation, 4 hits
PF00550, PP-binding, 3 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00823, PKS_PP, 3 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47336, SSF47336, 3 hits

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01733, AA-adenyl-dom, 3 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00455, AMP_BINDING, 2 hits
PS50075, CARRIER, 3 hits
PS00012, PHOSPHOPANTETHEINE, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q4WLW5-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MERLEAKNQT TKHGERMAPQ RYSVLRDEKC LFPVRNDGKL LVDEWRVTEL
60 70 80 90 100
AISSGEKGLK LCRTTCPTAG ADPRYLAAAA WALLLWRFAE VDTVQIGLQD
110 120 130 140 150
IPPGANEDIL EAGLKRGMKV LAASRRQVQL LNELWQGDTW SISDADPTCY
160 170 180 190 200
SYFDTGIVIC RGNSQDCLAK CRSPNQLRKA NGEACNVLLV LELDLDSNWR
210 220 230 240 250
KCFLAYKTTV LTDIQATHLK SSFEEVVELA RAGRGIPLSE ICLVSRRQLD
260 270 280 290 300
QIGKWNERAL VQPKFKAMHQ VVHDRATDRR HHPAVIAADR ALSYSELETL
310 320 330 340 350
SLKVAYRLRG SGVQPGDLIP VCFCKSSWAI VAMLAINKLG AAFVPLDPSQ
360 370 380 390 400
PVNRLKSITR QLDATLAVTS PENQSLVEDL VTTTVVVSET TVSELVDVHN
410 420 430 440 450
EIVLPACDPG APAYCLFTSG STGKPKGCVV DHAALASVAT HSHALHLGPT
460 470 480 490 500
SRVLQFASFT FGVSLIEVWC TLAAGGTVCL PSDSDRVSRL ADAIRSMGVD
510 520 530 540 550
WCILTPTVLA TLEPEAVPNL RTILVAGEPL KKAQFSLWAE RARLFQAYGF
560 570 580 590 600
TEWAGICCVS PQIRSIGDVG IIGTPANARC WLVEPGNPNQ LAPIGAVAEL
610 620 630 640 650
AVEGPSLAQG YLHDPEKTAA TLIPPPRWRA QYGHADGKRI YTTGDLVYYD
660 670 680 690 700
SNGMLRYVSR KDRQVKIRGQ RIDLAEPEYH IAQACCTIRN VVLDAIVPAD
710 720 730 740 750
SNGDAILVAF VLPSRDESSS NGGHDSPLFA VPDDHFTSSV RQLTSFLEDK
760 770 780 790 800
LPDYMVPRLF LQLKETPVTI TGKIARQKLR EAAEALRHDE LVALAGLETR
810 820 830 840 850
VLPPNTHKET LIHQLVVELL HLPPEMVGMN HNFFSLGGDS VSVMKLVSRA
860 870 880 890 900
KRVGLSFTVK DVFRSPQLGD LARLTDVVNS GAAQHMPPFS LLDRGAQPGL
910 920 930 940 950
LSMAAKICQV ESSMIQDIYP CTPLQEGMMT LSAAKAGSYI ARFVYRLEEH
960 970 980 990 1000
VDSPRFRRAW EMTVEATPIL RTRIISASDG RLYQVVIQEK FRWDDDGQPS
1010 1020 1030 1040 1050
GECVQNGQDR HMLLGEPLTH AALVRDRNQD GSLSTVFVLT MHHSVCDRWS
1060 1070 1080 1090 1100
VGLIMDSVET AYTGQTLTTN SMGPFLQYIQ QLQGGDAFWR SQFVGVKAEV
1110 1120 1130 1140 1150
FPSLPSPEYT PTPTETIDLS VELRDAVPGG HTIANAIRLA WALVISHYTS
1160 1170 1180 1190 1200
CSDVVFGVTI SGRAVPVPDI ERIIGPIIAT VPLRVRLKES STVLEALKAI
1210 1220 1230 1240 1250
QDQSMEMIPF EQLGLRQIRK LSPEAEEACN FQSQLVVQPA WGDENRSLFA
1260 1270 1280 1290 1300
TCEAGAAAEG GFAAYALSMI CQLVGSSQID VRTEFDPKVI QAPIMQRIVH
1310 1320 1330 1340 1350
HFVYTLQYLL AHPDARVAEI PVVSPGEKQL LRQWNGIVPP ASHQCVHEII
1360 1370 1380 1390 1400
QQRQIERPTS TAVWAWDGQL TYAELGELSD RLAEYLATKG VQPEVIVPVC
1410 1420 1430 1440 1450
LEKSYWTTVA MLGISKAGGA FALLDPSQPE QRLQSICHQL NSAVILTSEK
1460 1470 1480 1490 1500
NRDLAGKLAS HPIVLSLQSS RRWGHGPAKQ APATARPDHT LYVAFTSGST
1510 1520 1530 1540 1550
GTPKGVVIEH RSFCTSALAL NRITGVNSES RMLQFAGYSF DGSIMEMLSA
1560 1570 1580 1590 1600
LMAGACVCVP SEFQRRNELV AAAAKFELTH AHLTPSVARH LLRGNPEFTK
1610 1620 1630 1640 1650
TLVSVGEPMT ASDVADWASN GQCKVMNGYG PAECAVSTTI QAAVTSASDP
1660 1670 1680 1690 1700
KNIGFPVAGV CWVVHPENHD ILLPPGAVGE LLIEGPTLAR GYLNEPDKTA
1710 1720 1730 1740 1750
AAFIPLPAWI KDIRPEQPHG RLYKSGDLVR YNADGSFQYI GRRDSQIKLR
1760 1770 1780 1790 1800
GQRIELDEVE KHVYQCWPGV IAVVAVEMVS FTPATQTLVA FVVVEEHVDT
1810 1820 1830 1840 1850
TGDILAAPTQ EFTGQVAVAQ ARLREAIPAF MVPEIFIPLL VLPQSASGKT
1860 1870 1880 1890 1900
DRRRLRSIAT ACTREKLAAY GAVGTGTKRE PTSVAEREMQ AIWAQALNLP
1910 1920 1930 1940 1950
LAEIGMDDSF YQLGGDSITA MQVVAHARSK GLAVTMDSIL RLKSISKIMS
1960 1970 1980 1990 2000
HESSLSPAIV HIDEEEDVWF ALSPIQQMFF DRQPSGWDRF SQVFLLRVSQ
2010 2020 2030 2040 2050
PVTASQLQMA LHTLVSKHPM LRARFAKQHD GSWRQVITSK IQESYRCRSH
2060 2070 2080 2090 2100
RLNRRSSVDG VVSSGACSLS IQKGPLIAVD LMSREDGAQY LSIVIHHLVV
2110 2120 2130 2140 2150
DLVSWRIILA DLEAMLRGEN PMANHSTPFQ TWCRLQAEYA RQYLSPQHAF
2160 2170 2180 2190 2200
PTDLPDHYHQ DPSVFWGLAG QPNLVRDSRR QVFTLDEHTT RQLLGAANAA
2210 2220 2230 2240 2250
FATRTDEVLH AVLLYSFLKV FPHRIAPLTF SEGHGREPWD SAIDLSQTVG
2260 2270 2280 2290 2300
WFTTMWPVVA ELQQNHSFLE VVCRVKDARR AVPCNGWAYF VSRYLNPSGR
2310 2320 2330 2340 2350
QAFQQFHPVE LVFNYAGEYQ QFNQAGAFFI PDMPEYQGSL DAGEQIQRFG
2360 2370 2380 2390 2400
IFEVFASVVR GCLQFQFMYN RYMKHQLEIQ KWIESCRQTL IEGCSTLIAA
2410 2420 2430 2440 2450
KPSRTLSDFP LLPLTYSTLR ELLDVTLPTA GVSVENVEDI YPCSPSQRGM
2460 2470 2480 2490 2500
LIAQAKAAHN YNASVTWSIR SRIDSRPNVA RLKAAWCEVV KRHAILRTVF
2510 2520 2530 2540 2550
VESPWPESYM DQVVLQNVSP EFVFCRGSDS LPQSISSPGQ TRWSKGQCQH
2560 2570 2580 2590 2600
IMRVWERDNG DILCRLDLSH AIMDRTTLAI IQKDLSLAYD ERLLPGRAPL
2610 2620 2630 2640 2650
YRDYISYIYQ QDSESARQYW QGYLEGVEPC EFPTLNPVDP SITKEWGNLY
2660 2670 2680 2690 2700
RTLEDRRRLE EFCRTHSVTP WNVAGLAWAM VLRSFTRTDS VCFGYVKSGR
2710 2720 2730 2740 2750
DLPIDGIAGT AGPVFNPLPC RVHLTERLTV RETIGRLQEE YLQSLAHQSF
2760 2770 2780 2790 2800
PLSDIHRLAG VTSGVLFNTS VAVQTEVASE AEEAKRSLEF TTVAMEDGTE
2810 2820 2830 2840 2850
DDMVITLVPR GGELVLHLRH RSRTLTTDQA STVLATFEKA LCSILANAEA
2860 2870 2880 2890 2900
PMTSIDVFSD HDKAILWSRN RRVPDAVESC VHELIQKHCV ERPHSPAVNA
2910 2920 2930 2940 2950
WDGAFTYGQL DELSSRLAVY LAAQGVGPNV VVPLCFEKTR WTPIAMMGVM
2960 2970 2980 2990 3000
KAGGAFLLLD PSYPLQRLKD ICADIDCRLV VSSTTHEAMS RELASTVVVV
3010 3020 3030 3040 3050
GEDRHHWQLE NTSHTITMPK VRPADALYVV FTSGSTGKPK GVVIEHRSYC
3060 3070 3080 3090 3100
SGALDHIRSY NLTPQSRVLQ FSSYAFDISI VEQLSVLIAG GCICVISESQ
3110 3120 3130 3140 3150
RKNSLGEAAT ALQANHAMLI PSVARLVRHE DLSTITSLSL AGECMQETDV
3160 3170 3180 3190 3200
SYWAQHVRLM NGYGPAECSA LSLVQPCVLP HSDPHDIGYP VGSVAWVVDP
3210 3220 3230 3240 3250
HDHHKLVPNG AVGELLIEGP IVGRGYINNA EKTAEVFIEP PTWLRTLRGH
3260 3270 3280 3290 3300
CTSRLYKTGD LVRANPSGSL SILGRKDRQV KLRGQRLELG EVEANVQHCF
3310 3320 3330 3340 3350
PGALDVVADL LPSSRGGKPQ LVAMVFQNAE RAARIAPESD SKLIAEPSVD
3360 3370 3380 3390 3400
FMQSATTAET RLRQTVPNFM VPSMFLPLAQ IPRTHSDKVD RNSLLKAVAA
3410 3420 3430 3440 3450
MSSIELQAYK ASVDAGHCST RAPSTEEEKK LAEIWADVLK VPVEHIGADD
3460 3470 3480 3490 3500
NFLLSGGDSI DAMKAAAFCR AAGMALSVAD IFAHPVLSDL AKVAVPKSLN
3510 3520 3530 3540 3550
GSSTSHQPFS LSPVDSPKDL HMSLMEQGLV PPGSALADLL PGTQAQQFFI
3560 3570 3580 3590 3600
ERGTFHSYNF SIRGPLDRCR LQKTCTAILS RHSILRTKFL QYEGRLIQIV
3610 3620 3630 3640 3650
LDNLETPFTH YTTDGDLLEF CKSLWERDLA ALDGLGRLPC KFTLVSRSEQ
3660 3670 3680 3690 3700
EHVFTIQISH AQWDGVSIPR LFSDIAAIYN QIPLPSTTHF ADYVYHRSSR
3710 3720 3730 3740 3750
DERPAFDFWK KYLRGSSMPV PFPATNCQDR EHKTQWTFQG IKNPRLPAGI
3760 3770 3780 3790 3800
TMASLVKAAC GFHLCQLLSQ NDVVFGHTVN GRNLALDNVE ALLGCCLNFI
3810 3820 3830 3840 3850
PLRVMLQPSW TVLDLLAHVQ EQYTRALPHE HLELRDIFRH STPWPADTQL
3860 3870 3880 3890 3900
SFIVQHQNIE LHHNIALDGL QVQYSKFAQF DPLTEVWIFS EPHPDRLEIQ
3910 3920 3930 3940 3950
VCANTRVLSE DQARALCRRL CDLIEFFSAS PDCPLSKVVD HMDRPGLLAE

EKVLN
Length:3,955
Mass (Da):437,813
Last modified:July 5, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iC66E17E07E1F5296
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AAHF01000006 Genomic DNA Translation: EAL89049.1

NCBI Reference Sequences

More...
RefSeqi
XP_751087.1, XM_745994.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
EAL89049; EAL89049; AFUA_6G12080

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
3508392

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
afm:AFUA_6G12080

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAHF01000006 Genomic DNA Translation: EAL89049.1
RefSeqiXP_751087.1, XM_745994.1

3D structure databases

SMRiQ4WLW5
ModBaseiSearch...

Protein-protein interaction databases

STRINGi746128.CADAFUBP00007610

Proteomic databases

PRIDEiQ4WLW5

Genome annotation databases

EnsemblFungiiEAL89049; EAL89049; AFUA_6G12080
GeneIDi3508392
KEGGiafm:AFUA_6G12080

Organism-specific databases

VEuPathDBiFungiDB:Afu6g12080

Phylogenomic databases

eggNOGiKOG1176, Eukaryota
KOG1178, Eukaryota
HOGENOMiCLU_000022_60_4_1
InParanoidiQ4WLW5
OMAiYEWLMAF
OrthoDBi4243at2759

Family and domain databases

Gene3Di1.10.1200.10, 3 hits
3.30.300.30, 3 hits
3.30.559.10, 4 hits
3.40.50.12780, 3 hits
InterProiView protein in InterPro
IPR010071, AA_adenyl_domain
IPR036736, ACP-like_sf
IPR045851, AMP-bd_C_sf
IPR020845, AMP-binding_CS
IPR000873, AMP-dep_Synth/Lig
IPR042099, ANL_N_sf
IPR023213, CAT-like_dom_sf
IPR001242, Condensatn
IPR020806, PKS_PP-bd
IPR009081, PP-bd_ACP
IPR006162, Ppantetheine_attach_site
PfamiView protein in Pfam
PF00501, AMP-binding, 3 hits
PF00668, Condensation, 4 hits
PF00550, PP-binding, 3 hits
SMARTiView protein in SMART
SM00823, PKS_PP, 3 hits
SUPFAMiSSF47336, SSF47336, 3 hits
TIGRFAMsiTIGR01733, AA-adenyl-dom, 3 hits
PROSITEiView protein in PROSITE
PS00455, AMP_BINDING, 2 hits
PS50075, CARRIER, 3 hits
PS00012, PHOSPHOPANTETHEINE, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFMQA_ASPFU
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q4WLW5
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 18, 2012
Last sequence update: July 5, 2005
Last modified: February 23, 2022
This is version 110 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again