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UniProtKB - Q4WK35 (AMDR_ASPFU)
Protein
Acetamidase regulatory protein
Gene
amdR
Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Status
Functioni
Positively regulates the expression of genes involved in the catabolism of certain amides, omega amino acids, and lactams.
By similarityRegions
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
DNA bindingi | 26 – 59 | Zn(2)-C6 fungal-typePROSITE-ProRule annotationAdd BLAST | 34 |
GO - Molecular functioni
- DNA binding Source: UniProtKB-KW
- DNA-binding transcription factor activity, RNA polymerase II-specific Source: InterPro
- zinc ion binding Source: InterPro
GO - Biological processi
- transcription, DNA-templated Source: InterPro
Keywordsi
Molecular function | DNA-binding |
Biological process | Transcription, Transcription regulation |
Ligand | Metal-binding, Zinc |
Names & Taxonomyi
Protein namesi | Recommended name: Acetamidase regulatory protein |
Gene namesi | Name:amdR ORF Names:AFUA_1G03860 |
Organismi | Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus) |
Taxonomic identifieri | 330879 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Aspergillaceae › Aspergillus › Aspergillus subgen. Fumigati › |
Proteomesi |
|
Organism-specific databases
VEuPathDBi | FungiDB:Afu1g03860 |
Subcellular locationi
Nucleus
- Nucleus PROSITE-ProRule annotation
Nucleus
- nucleus Source: UniProtKB-SubCell
Keywords - Cellular componenti
NucleusPTM / Processingi
Molecule processing
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
ChainiPRO_0000233115 | 1 – 772 | Acetamidase regulatory proteinAdd BLAST | 772 |
Family & Domainsi
Region
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Regioni | 1 – 23 | DisorderedSequence analysisAdd BLAST | 23 | |
Regioni | 78 – 99 | DisorderedSequence analysisAdd BLAST | 22 | |
Regioni | 114 – 148 | DisorderedSequence analysisAdd BLAST | 35 | |
Regioni | 627 – 690 | DisorderedSequence analysisAdd BLAST | 64 |
Compositional bias
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Compositional biasi | 1 – 20 | Polar residuesSequence analysisAdd BLAST | 20 | |
Compositional biasi | 123 – 147 | Polar residuesSequence analysisAdd BLAST | 25 | |
Compositional biasi | 630 – 662 | Polar residuesSequence analysisAdd BLAST | 33 | |
Compositional biasi | 676 – 690 | Polar residuesSequence analysisAdd BLAST | 15 |
Phylogenomic databases
HOGENOMi | CLU_006329_4_0_1 |
InParanoidi | Q4WK35 |
OMAi | QEDLRMA |
OrthoDBi | 917119at2759 |
Family and domain databases
CDDi | cd00067, GAL4, 1 hit |
Gene3Di | 4.10.240.10, 1 hit |
InterProi | View protein in InterPro IPR007219, Transcription_factor_dom_fun IPR001138, Zn2-C6_fun-type_DNA-bd IPR036864, Zn2-C6_fun-type_DNA-bd_sf |
Pfami | View protein in Pfam PF04082, Fungal_trans, 1 hit PF00172, Zn_clus, 1 hit |
SMARTi | View protein in SMART SM00906, Fungal_trans, 1 hit SM00066, GAL4, 1 hit |
SUPFAMi | SSF57701, SSF57701, 1 hit |
PROSITEi | View protein in PROSITE PS00463, ZN2_CY6_FUNGAL_1, 1 hit PS50048, ZN2_CY6_FUNGAL_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q4WK35-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MSSTAQKNSL SPTGNGVTKR KSGSAACVHC HRRKVRCDAR IVGLPCSNCR
60 70 80 90 100
SSGKTDCRIH EKKKRLAVRS ILNPVPIRCR PPSTSEHVPE ASPPSTISEP
110 120 130 140 150
TAFTTAFRGV QPEAAAPPAS VAPNVQSKAQ HLHSNSYSQT SPQAQECHLP
160 170 180 190 200
PASDRFAEQD AHADFEKRLV KLIDDEEGSG PREIQRGVRA IYVGHELSNM
210 220 230 240 250
SFLIRQQRDK DDDVYHFAGS EIPRRQLKTG HDQLLVDALT LPEPALVDEL
260 270 280 290 300
VQAYFTHVNP GYPIVEEDQF MSQYRNRDPS DPPPILLLQA ILLVGCHVTH
310 320 330 340 350
PKEERDALKA IFFRRAKWLF DNRIERNRDT LVQAALLLTW HSDSPDDDVS
360 370 380 390 400
ANAHYWVGVA ARIATGLGMH RNPVSSRFAP RDRRMWRRLW YILVQLDVMV
410 420 430 440 450
SLSYGRPQAI NLEDSDVSPL TASDFEGCGA RVQTDYVIHF SELCTMISYI
460 470 480 490 500
VRERFGLRVS SERRKAALQE ADEALANWSL RLPDHLRLRA SDMDPWSAML
510 520 530 540 550
HLTYNNFLIL LHRPHPRASA YSDDYGPHDA EICSAAAGVI TSIFEELRLN
560 570 580 590 600
DRLKYLWYSG VHTLFTAMIQ VRVELRFSNP VLAINALRRF DSASCSLREL
610 620 630 640 650
AKYWSHATTI LRLFEDSKRL QKDLRLATSE RSRPFSSTQD QPQAQALDQN
660 670 680 690 700
KNQHQHSSAD APVQPPQPDR LLPSYDSPTP DSTSLPQTAV SPHQNLTFDS
710 720 730 740 750
WIPSTNLATV DPMDQPREFL DWRQLFSFTD PDQPVLPMSM DGLPELEDEW
760 770
RQIYWQETPM SDLLQDGGWM HG
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AAHF01000007 Genomic DNA Translation: EAL88097.1 |
RefSeqi | XP_750135.1, XM_745042.1 |
Genome annotation databases
EnsemblFungii | EAL88097; EAL88097; AFUA_1G03860 |
GeneIDi | 3507372 |
KEGGi | afm:AFUA_1G03860 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AAHF01000007 Genomic DNA Translation: EAL88097.1 |
RefSeqi | XP_750135.1, XM_745042.1 |
3D structure databases
AlphaFoldDBi | Q4WK35 |
SMRi | Q4WK35 |
ModBasei | Search... |
Protein-protein interaction databases
STRINGi | 330879.Q4WK35 |
Genome annotation databases
EnsemblFungii | EAL88097; EAL88097; AFUA_1G03860 |
GeneIDi | 3507372 |
KEGGi | afm:AFUA_1G03860 |
Organism-specific databases
VEuPathDBi | FungiDB:Afu1g03860 |
Phylogenomic databases
HOGENOMi | CLU_006329_4_0_1 |
InParanoidi | Q4WK35 |
OMAi | QEDLRMA |
OrthoDBi | 917119at2759 |
Family and domain databases
CDDi | cd00067, GAL4, 1 hit |
Gene3Di | 4.10.240.10, 1 hit |
InterProi | View protein in InterPro IPR007219, Transcription_factor_dom_fun IPR001138, Zn2-C6_fun-type_DNA-bd IPR036864, Zn2-C6_fun-type_DNA-bd_sf |
Pfami | View protein in Pfam PF04082, Fungal_trans, 1 hit PF00172, Zn_clus, 1 hit |
SMARTi | View protein in SMART SM00906, Fungal_trans, 1 hit SM00066, GAL4, 1 hit |
SUPFAMi | SSF57701, SSF57701, 1 hit |
PROSITEi | View protein in PROSITE PS00463, ZN2_CY6_FUNGAL_1, 1 hit PS50048, ZN2_CY6_FUNGAL_2, 1 hit |
MobiDBi | Search... |
Entry informationi
Entry namei | AMDR_ASPFU | |
Accessioni | Q4WK35Primary (citable) accession number: Q4WK35 | |
Entry historyi | Integrated into UniProtKB/Swiss-Prot: | May 2, 2006 |
Last sequence update: | July 5, 2005 | |
Last modified: | May 25, 2022 | |
This is version 91 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Reviewed (UniProtKB/Swiss-Prot) | |
Annotation program | Fungal Protein Annotation Program |