Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Entry version 95 (23 Feb 2022)
Sequence version 1 (05 Jul 2005)
Previous versions | rss
Add a publicationFeedback
Protein

Nonribosomal peptide synthase sidD

Gene

NRPS4

Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the 'correct annotation' for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the 'protein existence' evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

Nonribosomal peptide synthase; part of the siderophore biosynthetic pathway (PubMed:15953695, PubMed:17845073, PubMed:17464044).

Aspergillus fumigatus produces four types of siderophores, low-molecular-mass iron chelators, including excreted fusarinine C (FsC) and triacetylfusarinine C (TAFC) for iron uptake; and intacellular ferricrocin (FC) for hyphal and hydroxyferricrocin (HFC) for conidial iron distribution and storage. TAFC consists of three N2-acetyl-N5-anhydromevalonyl-N5-hydroxyornithine residues cyclically linked by ester bonds; FC is a cyclic hexapeptide with the structure Gly-Ser-Gly-(N5-acetyl-N5-hydroxyornithine)x3. The biosynthesis of all four siderophores depends on the hydroxylation of ornithine, catalyzed by the monooxygenase sidA (PubMed:15504822, PubMed:16113265).

Subsequently, the pathways for biosynthesis of extra- and intracellular siderophores split (PubMed:17845073).

For biosynthesis of extracellular siderophores, the transacylase sidF transfers anhydromevalonyl to N5-hydroxyornithine (PubMed:17845073).

The required anhydromevalonyl-CoA moiety is derived from mevalonate by CoA ligation and dehydration catalyzed by sidI and sidH respectively (PubMed:22106303).

The acetylation of N5-hydroxyornithine for FC biosynthesis involves the constitutively expressed sidL (PubMed:21622789).

FC is hydroxylated to HFC by an as yet uncharacterized enzyme during conidiation (PubMed:17845073).

Assembly of fusarinine C (FsC) and FC is catalyzed by two different nonribosomal peptide synthetases (NRPS), sidD and sidC respectively (PubMed:15953695, PubMed:17845073, PubMed:17464044).

Subsequently, sidG catalyzes N2-acetylation of FsC for forming TAFC (PubMed:17845073).

Both extra- and intracellular siderophores are crucial for growth during iron limitation and virulence (PubMed:16113265).

7 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function%5Fsection">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: Siderophore biosynthesis

This protein is involved in Siderophore biosynthesis.1 Publication
View all proteins of this organism that are known to be involved in Siderophore biosynthesis.

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionLigase
Biological processVirulence

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
Nonribosomal peptide synthase sidD1 Publication (EC:6.3.2.-1 Publication)
Short name:
NPRS sidD1 Publication
Alternative name(s):
Siderophore synthetase D1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: 'Name', 'Synonyms', 'Ordered locus names' and 'ORF names'.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NRPS41 Publication
Synonyms:sidD1 Publication
ORF Names:AFUA_3G03420
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiNeosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the 'taxonomic identifier' or 'taxid'.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri330879 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillusAspergillus subgen. Fumigati
<p>This subsection of the <a href="http://www.uniprot.org/help/names%5Fand%5Ftaxonomy%5Fsection">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002530 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes%5Fmanual">proteome</a> can consist of several components.<br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componenti: Chromosome 3

Organism-specific databases

Eukaryotic Pathogen, Vector and Host Database Resources

More...
VEuPathDBi
FungiDB:Afu3g03420

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the 'Pathology and Biotech' section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Prevents synthesis of TAFC and FsC without affecting FC production (PubMed:17845073).1 Publication

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section describes the extent of a polypeptide chain in the mature protein following processing or proteolytic cleavage.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004165451 – 2083Nonribosomal peptide synthase sidDAdd BLAST2083

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'PTM / Processing' section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei801O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1
Modified residuei1594O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1

Keywords - PTMi

Phosphopantetheine, Phosphoprotein

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q4WF53

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the 'Expression' section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Expression is induced during iron starvation (PubMed:15953695, PubMed:17845073).2 Publications

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
746128.CADAFUBP00004398

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q4WF53

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family%5Fand%5Fdomains%5Fsection">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini764 – 840Carrier 1PROSITE-ProRule annotationAdd BLAST77
Domaini1557 – 1633Carrier 2PROSITE-ProRule annotationAdd BLAST77

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the 'Family and Domains' section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni251 – 650Adenylation 1Add BLAST400
Regioni876 – 1146Condensation 1Add BLAST271
Regioni1336 – 1421Adenylation 2Add BLAST86
Regioni1674 – 1946Condensation 2Add BLAST273

<p>This subsection of the 'Family and domains' section provides general information on the biological role of a domain. The term 'domain' is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

NRP synthetases are composed of discrete domains (adenylation (A), thiolation (T) or peptidyl carrier protein (PCP) and condensation (C) domains) which when grouped together are referred to as a single module. Each module is responsible for the recognition (via the A domain) and incorporation of a single amino acid into the growing peptide product. Thus, an NRP synthetase is generally composed of one or more modules and can terminate in a thioesterase domain (TE) that releases the newly synthesized peptide from the enzyme. Occasionally, epimerase (E) domains (responsible for l- to d- amino acid conversion) are present within the NRP synthetase. NRPS4 has the following architecture: A-T-C-A-C.2 Publications

<p>This subsection of the 'Family and domains' section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NRP synthetase family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

evolutionary genealogy of genes: Non-supervised Orthologous Groups

More...
eggNOGi
KOG1178, Eukaryota

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
CLU_000022_60_2_1

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q4WF53

Identification of Orthologs from Complete Genome Data

More...
OMAi
FNPYPLM

Database of Orthologous Groups

More...
OrthoDBi
4243at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1200.10, 2 hits
3.30.300.30, 2 hits
3.30.559.10, 2 hits
3.40.50.12780, 1 hit

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR010071, AA_adenyl_domain
IPR036736, ACP-like_sf
IPR045851, AMP-bd_C_sf
IPR020845, AMP-binding_CS
IPR000873, AMP-dep_Synth/Lig
IPR042099, ANL_N_sf
IPR023213, CAT-like_dom_sf
IPR001242, Condensatn
IPR020806, PKS_PP-bd
IPR009081, PP-bd_ACP

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00501, AMP-binding, 1 hit
PF00668, Condensation, 2 hits
PF00550, PP-binding, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00823, PKS_PP, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47336, SSF47336, 2 hits

TIGRFAMs; a protein family database

More...
TIGRFAMsi
TIGR01733, AA-adenyl-dom, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00455, AMP_BINDING, 1 hit
PS50075, CARRIER, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence%5Flength">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences%5Fsection">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q4WF53-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MGSIQQDDVH NQIDHCNQSD DLPAARLNCN DVELFEVAGL ACDETSSPTG
60 70 80 90 100
MRDEMVLLSW LIALLRTREG GQIRYEWAYR YPEEEPVPRC LAMNEVVAGL
110 120 130 140 150
QSSVKETAAA VSRHISADVS SPPAPASLLL STSSLSQTSD EAKDEGLLHL
160 170 180 190 200
EIAFENGLCK IRPTWHSENM LPFTVTRYAR TLIDTVRLCI SNCDAAIQDC
210 220 230 240 250
LRPTAYDLDE IWRWNHNLPP TYNFCMHEII SDQAQKFPDK EAIASWDGSL
260 270 280 290 300
TYRQIDQYSS FVARSLIGMG VGLHDVLPVC FEKSRWTIVA VLAVMKAGAT
310 320 330 340 350
FVLMDPTLPL ARLQNMAQQV GAKMMVSSRG QYNLATEIIP NANVLVVEEN
360 370 380 390 400
TFSSLSAEQN GEPLPTVPSS ALMYMIFTSG STGTPKGVKI SHETYTSSAI
410 420 430 440 450
PRANAVGYTE DSRVLDFASY AFDVSIDSML LTLGNGGCLC IPSDEDRLND
460 470 480 490 500
INGVIRRMKV NYAGLTPSVA RILDADVISS LSGLGLGGEA VSARDVNLWG
510 520 530 540 550
QDTRIIIGYG PCECTIGCTV NSSAATGRDY ISIGPGNGAV IWIVDPNDHE
560 570 580 590 600
SLVPLGAVGE LLVEGPIVGQ GYLNDPEKTA AAFIEDPSWL VAGHEGYPGR
610 620 630 640 650
RGRLYKTGDL GRYDPDGSGG IVFVGRKDTQ VKLRGQRVEL GEIESQLRAR
660 670 680 690 700
LPSETTVIAE VIVPQGSGGQ PTLVAFVAAQ TTKGHDHTGL EAAELPDELR
710 720 730 740 750
RALSEADAEL AKVLPRYMVP TAYIPVNHIP TLISGKTDRK RLRQFGATVD
760 770 780 790 800
LRQLDQDATN TAARELSDLE RRLRQAWSQT LKLQACSIRL QDNFFALGGD
810 820 830 840 850
SLTAMKLVSV CRSQGLDLSV TSMFSNPTLS AMASVVRICD VDVQRTVPAF
860 870 880 890 900
SMITSDMNSA CVEAAEPCGV GPADIEDIYP CTPTQESLFT FSLKSVKPYV
910 920 930 940 950
AQRVLCIPSH IDLNAWRKAW EDVVAALPIL RTRVAQLQEP GLQQVVLKNS
960 970 980 990 1000
ISWTQASDLA EYLENDRTQK MNLGESLARY AIVEDSADGK RYMVWTIHHV
1010 1020 1030 1040 1050
LYDGWSEPII LKQVSDALQG QPVEVKAQMR DFVRFVRDSD DAAVQEFWRR
1060 1070 1080 1090 1100
ELKGAVGPQF PRLPSRDFMP TPDALVERQV SLDTSSGSPF TMATLIRGAW
1110 1120 1130 1140 1150
ALVASQYTGS DDIVFGETLT GRDIPLPGVE SIVGPLIATV PIRVRILRGS
1160 1170 1180 1190 1200
TVESYLQAVQ QSVLARTPYQ HLGMQNIRKV SQDAQHACET GTGLVIQPEP
1210 1220 1230 1240 1250
EYVGSELGVE RGDVVLEALH FNPYPLMLAC GIRKGGFRVC ASFDSSLIET
1260 1270 1280 1290 1300
RQMERMLAQL ETACWQLSQG LSRKVDEISC LPEAELNQIW QWNRSPPLSL
1310 1320 1330 1340 1350
DETTSRLRAN ASTKPGSSYP PAVVPWVCSP RNSSLLSPIG CVGELWLEGA
1360 1370 1380 1390 1400
LLSGDTVDSP AWLVAGSSTC AGRTGKVQAT GDMVQLREDG SLVFVGRKEN
1410 1420 1430 1440 1450
VVPVQGHAVD ITEIERHLAE HLPPTIRAAA TVVRSSSDQE LVMFIEQPAA
1460 1470 1480 1490 1500
EEACIELLSE KREIVCDAPD KAFQTTICAT IPGSLAAVLK KLDKYMRDSL
1510 1520 1530 1540 1550
PSYMAPSAYI VVEKLPNTMD DIDHNLLNQI ASQVTPQILN ELRDGLSNAW
1560 1570 1580 1590 1600
TKATAPNHLS ASESILRSAW AKVLRVDPEQ IDVDDNFFRR GGDSVLAMKL
1610 1620 1630 1640 1650
VSSLRAQGYS LSVADIFRHM RLSDAARVMK VDERSTEKIN SYQPFSMLRL
1660 1670 1680 1690 1700
PDVQQFLANI VRPQLGDQHW PIRDVLPVTD SQDMDIRATI QPPRTSIQYT
1710 1720 1730 1740 1750
MLYFDNSVDR ERLFRSCSDL VKTHEILRTV FISHESSFLQ VVLNELEIPV
1760 1770 1780 1790 1800
RAHKTDKQLD QYVASLFRED IESNFQLGCP FLRLFYVEGN NGESCLVIGL
1810 1820 1830 1840 1850
SHAQYDGVSL PRLLQDLDAL YTGTQLATFS PFSLYMAQTS EEAIQNKAAA
1860 1870 1880 1890 1900
YWRNLLSSSS LSTLDGPSSD PTDKAIFHTR PVNIHPLKEI TTANLLTAAW
1910 1920 1930 1940 1950
AMVLARRLQT PDVTFGSVTS GRTLDIPNAE NFMGPCYQLT PVRVPFHPDW
1960 1970 1980 1990 2000
TASDLLNFVQ TQSAESAAHD FLGFEKIAKL AGWASGRQGF DSIVHHQDWE
2010 2020 2030 2040 2050
DFDMMPFGGG SCRVDIANPH GDAAYPVKAV SFVKEGEIHV GVVCSERDVM
2060 2070 2080
FVDEVLGELA AAVVELAGQS TEVLLDSKLF SGQ
Length:2,083
Mass (Da):228,752
Last modified:July 5, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i977306F5EA529610
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AAHF01000010 Genomic DNA Translation: EAL86624.1

NCBI Reference Sequences

More...
RefSeqi
XP_748662.1, XM_743569.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
EAL86624; EAL86624; AFUA_3G03420

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
3506154

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
afm:AFUA_3G03420

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAHF01000010 Genomic DNA Translation: EAL86624.1
RefSeqiXP_748662.1, XM_743569.1

3D structure databases

SMRiQ4WF53
ModBaseiSearch...

Protein-protein interaction databases

STRINGi746128.CADAFUBP00004398

Proteomic databases

PRIDEiQ4WF53

Genome annotation databases

EnsemblFungiiEAL86624; EAL86624; AFUA_3G03420
GeneIDi3506154
KEGGiafm:AFUA_3G03420

Organism-specific databases

VEuPathDBiFungiDB:Afu3g03420

Phylogenomic databases

eggNOGiKOG1178, Eukaryota
HOGENOMiCLU_000022_60_2_1
InParanoidiQ4WF53
OMAiFNPYPLM
OrthoDBi4243at2759

Family and domain databases

Gene3Di1.10.1200.10, 2 hits
3.30.300.30, 2 hits
3.30.559.10, 2 hits
3.40.50.12780, 1 hit
InterProiView protein in InterPro
IPR010071, AA_adenyl_domain
IPR036736, ACP-like_sf
IPR045851, AMP-bd_C_sf
IPR020845, AMP-binding_CS
IPR000873, AMP-dep_Synth/Lig
IPR042099, ANL_N_sf
IPR023213, CAT-like_dom_sf
IPR001242, Condensatn
IPR020806, PKS_PP-bd
IPR009081, PP-bd_ACP
PfamiView protein in Pfam
PF00501, AMP-binding, 1 hit
PF00668, Condensation, 2 hits
PF00550, PP-binding, 2 hits
SMARTiView protein in SMART
SM00823, PKS_PP, 2 hits
SUPFAMiSSF47336, SSF47336, 2 hits
TIGRFAMsiTIGR01733, AA-adenyl-dom, 1 hit
PROSITEiView protein in PROSITE
PS00455, AMP_BINDING, 1 hit
PS50075, CARRIER, 2 hits

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the 'Entry information' section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiSIDD_ASPFU
<p>This subsection of the 'Entry information' section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called 'Primary (citable) accession number'.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q4WF53
<p>This subsection of the 'Entry information' section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification ('Last modified'). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical%5Fand%5Fisoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 18, 2012
Last sequence update: July 5, 2005
Last modified: February 23, 2022
This is version 95 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the 'Entry information' section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn't fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again