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Entry version 108 (16 Oct 2019)
Sequence version 1 (05 Jul 2005)
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Protein

ABC transporter fmpD

Gene

fmpD

Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Status
Reviewed-Annotation score:

Annotation score:3 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

ABC transporter; part of the gene cluster that mediates the biosynthesis of fumipyrrole, a brown pigment that is involved in growth and conidiation (PubMed:25582336).1 Publication

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: Secondary metabolite biosynthesis

This protein is involved in Secondary metabolite biosynthesis.1 Publication
View all proteins of this organism that are known to be involved in Secondary metabolite biosynthesis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">Function</a> section describes a region in the protein which binds nucleotide phosphates. It always involves more than one amino acid and includes all residues involved in nucleotide-binding.<p><a href='/help/np_bind' target='_top'>More...</a></p>Nucleotide bindingi413 – 420ATPPROSITE-ProRule annotation8
Nucleotide bindingi1078 – 1085ATPPROSITE-ProRule annotation8

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Biological processTransport
LigandATP-binding, Nucleotide-binding

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
ABC transporter fmpD1 Publication
Alternative name(s):
Fumipyrrole biosynthesis protein D1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:fmpD1 Publication
ORF Names:AFUA_6G03470
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiNeosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri330879 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002530 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componentsi: Chromosome 6, Unassembled WGS sequence

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
FungiDB:Afu6g03470

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/subcellular_location_section">'Subcellular location'</a> section describes the extent of a membrane-spanning region of the protein. It denotes the presence of both alpha-helical transmembrane regions and the membrane spanning regions of beta-barrel transmembrane proteins.<p><a href='/help/transmem' target='_top'>More...</a></p>Transmembranei57 – 77HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei102 – 122HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei176 – 196HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei203 – 223HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei281 – 301HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei312 – 332HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei707 – 727HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei753 – 773HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei831 – 851HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei855 – 875HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei931 – 951HelicalPROSITE-ProRule annotationAdd BLAST21
Transmembranei968 – 988HelicalPROSITE-ProRule annotationAdd BLAST21

Keywords - Cellular componenti

Membrane

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004388721 – 1285ABC transporter fmpDAdd BLAST1285

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section">PTM / Processing</a> section specifies the position and type of each covalently attached glycan group (mono-, di-, or polysaccharide).<p><a href='/help/carbohyd' target='_top'>More...</a></p>Glycosylationi467N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi1037N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1
Glycosylationi1138N-linked (GlcNAc...) asparaginePROSITE-ProRule annotation1

Keywords - PTMi

Glycoprotein

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Expression is positively regulated by the fumipyrrole biosynthesis specific transcription factor fmpR (PubMed:25582336).1 Publication

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
746128.CADAFUBP00009216

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q4WD46

Database of comparative protein structure models

More...
ModBasei
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini54 – 343ABC transmembrane type-1 1PROSITE-ProRule annotationAdd BLAST290
Domaini380 – 622ABC transporter 1PROSITE-ProRule annotationAdd BLAST243
Domaini713 – 996ABC transmembrane type-1 2PROSITE-ProRule annotationAdd BLAST284
Domaini1043 – 1281ABC transporter 2PROSITE-ProRule annotationAdd BLAST239

Keywords - Domaini

Repeat, Transmembrane, Transmembrane helix

Phylogenomic databases

InParanoid: Eukaryotic Ortholog Groups

More...
InParanoidi
Q4WD46

KEGG Orthology (KO)

More...
KOi
K05658

Identification of Orthologs from Complete Genome Data

More...
OMAi
GVFQAKM

Database of Orthologous Groups

More...
OrthoDBi
186078at2759

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.20.1560.10, 2 hits

Integrated resource of protein families, domains and functional sites

More...
InterProi
View protein in InterPro
IPR003593 AAA+_ATPase
IPR011527 ABC1_TM_dom
IPR036640 ABC1_TM_sf
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR027417 P-loop_NTPase

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00664 ABC_membrane, 2 hits
PF00005 ABC_tran, 2 hits

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00382 AAA, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF52540 SSF52540, 2 hits
SSF90123 SSF90123, 2 hits

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS50929 ABC_TM1F, 2 hits
PS00211 ABC_TRANSPORTER_1, 2 hits
PS50893 ABC_TRANSPORTER_2, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>. The information is filed in different subsections. The current subsections and their content are listed below:<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q4WD46-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MTPPQMVSQL DDARLDERQR AILDRQLHGL GGETKQRKNV FAYATVSDRI
60 70 80 90 100
VLSVSSICAV LAGALNPLVP VIYGLLVSVY DGFAAGTVSA SELRSKTATF
110 120 130 140 150
SLYYVYLSIG LFAFTYVATV GFYYTGERMA RALRTTYLAA ILRQNMAFFD
160 170 180 190 200
LLGPGEITSR IMSDMGTVQE AVTSKLAVML TAIATFCAAF VVAFIMYWKT
210 220 230 240 250
ALIISPFFVI MIVTETLGGA YMVRHHKRAM ELYSQAAGIA EEAIAAIKHV
260 270 280 290 300
TAFGIQTLLS QRYLSVLEQA AKADRKAENM VAGMIAWMNA MPNLIYALAF
310 320 330 340 350
WAGSIYLTRG QMSVAEVSAT TLAVTIGSFA IIRIAPSAQA LLSGIAITGE
360 370 380 390 400
ILKSIARRSP QDPLVKEGDE PSTVVGDIVL DRVGLIYPSR DDVDILQDVS
410 420 430 440 450
LRCAAMKKTA IVGSSGSGKS SILGLVERFY EPTSGTVLLD GRDIQSLNLR
460 470 480 490 500
WLRRQIALVD QMPVLFNATI LENILYGCSD MVSQWSESEQ LDRVVQASKK
510 520 530 540 550
ANAHDFISAL PDGYHTHVGE KGLQLSGGQR QRVAIARALI RDPKILLLDE
560 570 580 590 600
ATSALDSKSE AMVQEALDAA AEHRTTIIVA HRLSTIQNAD HIIVLDHGKV
610 620 630 640 650
VEEGTHHALV AQNGAYAALV QKQQIGDTHD HKAPDGARLS IEDDDDEDSR
660 670 680 690 700
YGGNTEYVDE KDIRTEEVAL SSAAHDEGTQ RDSLKLSALQ TIAFIARLSK
710 720 730 740 750
RDWKVLLFGL ANAILAGLTI PVQSVFFAKI LTVIGFPPPQ YPQLRSEVDF
760 770 780 790 800
WSGLYVMLTG TTFLFWMGVE IALSYATQKL ARRVREVCFR SILVQDMAFF
810 820 830 840 850
DVPGNSPSAL SSVLSKSTND LAGLGGPVMG GILTFLSTIL AGIVLALAIG
860 870 880 890 900
WKLALVCTAT IPIVVACGWL RLQVLSTFDS KVRQSGIESA AYAGELVRTV
910 920 930 940 950
RTVASLGLEE HALARYEGIL AKQAAKSLRS ILLASALYAA SASVVYLCAA
960 970 980 990 1000
LAFWYGGTLI ASHEYSTFQV YICFVSLISG SQIAGSIFTY APDASKAMHA
1010 1020 1030 1040 1050
SREIQDIMNL KPSINKVAPT GPPPAHEGTE KNQPQQNLSA CRVEFEHVSF
1060 1070 1080 1090 1100
TYPSRPTRRA LDNLHITVEP GQTLALVGQS GSGKSTCVSL LERFYDPDQG
1110 1120 1130 1140 1150
RILIDGQDIK LRDVDEYRRD ISLVSQETII FSGTIRDNIT VGLAGQEVSD
1160 1170 1180 1190 1200
DEILEACKQA NILEFVQSLP DGLSTLVGTG GSMLSGGQKQ RIAIARAFLR
1210 1220 1230 1240 1250
KPKILLLDEA TSALDSQSEA IVQEAMDAIR KDRTTIMVAH RLSTVQNADV
1260 1270 1280
ICVLQDGKLL EIGTHEQLLG KRGKYWEMVS MQSLH
Length:1,285
Mass (Da):139,635
Last modified:July 5, 2005 - v1
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:i8F5B46138F8B610B
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...
EMBLi

GenBank nucleotide sequence database

More...
GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...
DDBJi
Links Updated
AAHF01000012 Genomic DNA Translation: EAL85692.1

NCBI Reference Sequences

More...
RefSeqi
XP_747730.1, XM_742637.1

Genome annotation databases

Ensembl fungal genome annotation project

More...
EnsemblFungii
EAL85692; EAL85692; AFUA_6G03470

Database of genes from NCBI RefSeq genomes

More...
GeneIDi
3505177

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...
KEGGi
afm:AFUA_6G03470

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAHF01000012 Genomic DNA Translation: EAL85692.1
RefSeqiXP_747730.1, XM_742637.1

3D structure databases

SMRiQ4WD46
ModBaseiSearch...

Protein-protein interaction databases

STRINGi746128.CADAFUBP00009216

Genome annotation databases

EnsemblFungiiEAL85692; EAL85692; AFUA_6G03470
GeneIDi3505177
KEGGiafm:AFUA_6G03470

Organism-specific databases

EuPathDBiFungiDB:Afu6g03470

Phylogenomic databases

InParanoidiQ4WD46
KOiK05658
OMAiGVFQAKM
OrthoDBi186078at2759

Family and domain databases

Gene3Di1.20.1560.10, 2 hits
InterProiView protein in InterPro
IPR003593 AAA+_ATPase
IPR011527 ABC1_TM_dom
IPR036640 ABC1_TM_sf
IPR003439 ABC_transporter-like
IPR017871 ABC_transporter_CS
IPR027417 P-loop_NTPase
PfamiView protein in Pfam
PF00664 ABC_membrane, 2 hits
PF00005 ABC_tran, 2 hits
SMARTiView protein in SMART
SM00382 AAA, 2 hits
SUPFAMiSSF52540 SSF52540, 2 hits
SSF90123 SSF90123, 2 hits
PROSITEiView protein in PROSITE
PS50929 ABC_TM1F, 2 hits
PS00211 ABC_TRANSPORTER_1, 2 hits
PS50893 ABC_TRANSPORTER_2, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...
ProtoNeti
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiFMPD_ASPFU
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q4WD46
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: February 15, 2017
Last sequence update: July 5, 2005
Last modified: October 16, 2019
This is version 108 of the entry and version 1 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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