UniProtKB - Q4WBR1 (Q4WBR1_ASPFU)
Protein
Submitted name:
AhpC/TSA family thioredoxin peroxidase, putative
Gene
AFUA_8G07130
Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Status
Functioni
Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively.UniRule annotation
Caution
The sequence shown here is derived from an EMBL/GenBank/DDBJ whole genome shotgun (WGS) entry which is preliminary data.Imported
Sites
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Active sitei | 98 | Cysteine sulfenic acid (-SOH) intermediateUniRule annotation | 1 |
GO - Molecular functioni
- peroxidase activity Source: GO_Central
- thioredoxin peroxidase activity Source: GO_Central
GO - Biological processi
- cell redox homeostasis Source: GO_Central
- cellular response to oxidative stress Source: GO_Central
Keywordsi
Molecular function | AntioxidantUniRule annotation, Oxidoreductase, PeroxidaseUniRule annotationImported |
Protein family/group databases
PeroxiBasei | 4438, Afum1CysPrx |
Names & Taxonomyi
Protein namesi | Submitted name: AhpC/TSA family thioredoxin peroxidase, putativeImported |
Gene namesi | ORF Names:AFUA_8G07130Imported |
Organismi | Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)Imported |
Taxonomic identifieri | 330879 [NCBI] |
Taxonomic lineagei | Eukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Aspergillaceae › Aspergillus › Aspergillus subgen. Fumigati › |
Proteomesi |
|
Organism-specific databases
VEuPathDBi | FungiDB:Afu8g07130 |
Subcellular locationi
Cytosol
- cytosol Source: GO_Central
Mitochondrion
- mitochondrion Source: GO_Central
Family & Domainsi
Domains and Repeats
Feature key | Position(s) | DescriptionActions | Graphical view | Length |
---|---|---|---|---|
Domaini | 56 – 219 | ThioredoxinInterPro annotationAdd BLAST | 164 |
Sequence similaritiesi
Belongs to the peroxiredoxin family.UniRule annotation
Keywords - Domaini
Redox-active centerUniRule annotationPhylogenomic databases
eggNOGi | KOG0854, Eukaryota |
HOGENOMi | CLU_042529_4_2_1 |
InParanoidi | Q4WBR1 |
OMAi | EKVMILP |
OrthoDBi | 1129256at2759 |
Family and domain databases
Gene3Di | 3.40.30.10, 1 hit |
InterProi | View protein in InterPro IPR000866, AhpC/TSA IPR024706, Peroxiredoxin_AhpC-typ IPR019479, Peroxiredoxin_C IPR036249, Thioredoxin-like_sf IPR013766, Thioredoxin_domain |
Pfami | View protein in Pfam PF10417, 1-cysPrx_C, 1 hit PF00578, AhpC-TSA, 1 hit |
PIRSFi | PIRSF000239, AHPC, 1 hit |
SUPFAMi | SSF52833, SSF52833, 1 hit |
PROSITEi | View protein in PROSITE PS51352, THIOREDOXIN_2, 1 hit |
i Sequence
Sequence statusi: Complete.
Q4WBR1-1 [UniParc]FASTAAdd to basket
10 20 30 40 50
MASILPRTGL RALSALPRAG PVSRVAFSRQ LPRAQPLVQP FGRRFLATVP
60 70 80 90 100
QEQPRLRLGS TAPNFKAQTT HGEIDFHEFI GDSWTILFSH PADFTPVCTT
110 120 130 140 150
ELGAFAKLKG EFDKRGVKMI GLSADDLSSH GDWVKDINEV ASTTVQFPII
160 170 180 190 200
ADPERKVAFL YDMIDQRDLD NIAEKGIPFT IRAVFIIDPA KKIRLTMLYP
210 220 230 240 250
ASTGRNSAEV LRVIDALQAA DKKGIATPID WTVGEDVIVP PSVSTEDAKK
260
KFGNVREVKP YLRYTKF
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AAHF01000013 Genomic DNA Translation: EAL85473.1 |
RefSeqi | XP_747511.1, XM_742418.1 |
Genome annotation databases
EnsemblFungii | EAL85473; EAL85473; AFUA_8G07130 |
GeneIDi | 3504965 |
KEGGi | afm:AFUA_8G07130 |
Similar proteinsi
Cross-referencesi
Sequence databases
Select the link destinations: EMBLi GenBanki DDBJi Links Updated | AAHF01000013 Genomic DNA Translation: EAL85473.1 |
RefSeqi | XP_747511.1, XM_742418.1 |
3D structure databases
ModBasei | Search... |
SWISS-MODEL-Workspacei | Submit a new modelling project... |
Protein-protein interaction databases
STRINGi | 746128.CADAFUBP00007856 |
Protein family/group databases
PeroxiBasei | 4438, Afum1CysPrx |
PTM databases
SwissPalmi | Q4WBR1 |
Genome annotation databases
EnsemblFungii | EAL85473; EAL85473; AFUA_8G07130 |
GeneIDi | 3504965 |
KEGGi | afm:AFUA_8G07130 |
Organism-specific databases
VEuPathDBi | FungiDB:Afu8g07130 |
Phylogenomic databases
eggNOGi | KOG0854, Eukaryota |
HOGENOMi | CLU_042529_4_2_1 |
InParanoidi | Q4WBR1 |
OMAi | EKVMILP |
OrthoDBi | 1129256at2759 |
Family and domain databases
Gene3Di | 3.40.30.10, 1 hit |
InterProi | View protein in InterPro IPR000866, AhpC/TSA IPR024706, Peroxiredoxin_AhpC-typ IPR019479, Peroxiredoxin_C IPR036249, Thioredoxin-like_sf IPR013766, Thioredoxin_domain |
Pfami | View protein in Pfam PF10417, 1-cysPrx_C, 1 hit PF00578, AhpC-TSA, 1 hit |
PIRSFi | PIRSF000239, AHPC, 1 hit |
SUPFAMi | SSF52833, SSF52833, 1 hit |
PROSITEi | View protein in PROSITE PS51352, THIOREDOXIN_2, 1 hit |
ProtoNeti | Search... |
MobiDBi | Search... |
Entry informationi
Entry namei | Q4WBR1_ASPFU | |
Accessioni | Q4WBR1Primary (citable) accession number: Q4WBR1 | |
Entry historyi | Integrated into UniProtKB/TrEMBL: | July 5, 2005 |
Last sequence update: | July 5, 2005 | |
Last modified: | February 10, 2021 | |
This is version 97 of the entry and version 1 of the sequence. See complete history. | ||
Entry statusi | Unreviewed (UniProtKB/TrEMBL) |