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Protein

PKS-NRPS hybrid synthetase psoA

Gene

NRPS14

Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>
-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

PKS-NRPS hybrid synthetase; part of the gene cluster that mediates the biosynthesis of pseurotin A, a competitive inhibitor of chitin synthase and an inducer of nerve-cell proliferation (PubMed:17722120, PubMed:17464044, PubMed:24082142, PubMed:24939566). The PKS-NRPS hybrid synthetase psoA is responsible for the biosynthesis of azaspirene, one of the first intermediates having the 1-oxa-7-azaspiro[4,4]-non-2-ene-4,6-dione core of pseurotin, via condensation of one acetyl-CoA, 4 malonyl-CoA, and a L-phenylalanine molecule (PubMed:24082142, PubMed:24939566). The dual-functional monooxygenase/methyltransferase psoF seems to be involved in the addition of the C3 methyl group onto the pseurotin scaffold (PubMed:24939566). Azaspirene is then converted to synerazol through 4 steps including oxidation of C17 by the cytochrome P450 monooxygenase psoD, O-methylation of the hydroxy group of C8 by the methyltransferase psoC, and the trans-to-cis isomerization of the C13 olefin by the glutathione S-transferase psoE (PubMed:24939566). The fourth step of synerazol production is performed by the dual-functional monooxygenase/methyltransferase psoF which seems to catalyze the epoxidation of the intermediate deepoxy-synerazol (PubMed:24939566). Synerazol can be attacked by a water molecule nonenzymatically at two different positions to yield two diol products, pseurotin A and pseurotin D (PubMed:24939566).4 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: Secondary metabolite biosynthesis

This protein is involved in Secondary metabolite biosynthesis.2 Publications
View all proteins of this organism that are known to be involved in Secondary metabolite biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei182PROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

GO - Biological processi

  • nonribosomal peptide biosynthetic process Source: AspGD
  • pseurotin A biosynthetic process Source: AspGD
  • secondary metabolic process Source: AspGD
  • secondary metabolite biosynthetic process Source: AspGD

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionLigase, Transferase

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
PKS-NRPS hybrid synthetase psoA1 Publication (EC:2.3.1.-2 Publications, EC:6.3.2.-2 Publications)
Alternative name(s):
Nonribosomal peptide synthetase 141 Publication
Short name:
NRPS141 Publication
Pseurotin biosynthesis protein A1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NRPS141 Publication
Synonyms:pesO1 Publication
ORF Names:AFUA_8G00540
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiNeosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri330879 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryotaFungiDikaryaAscomycotaPezizomycotinaEurotiomycetesEurotiomycetidaeEurotialesAspergillaceaeAspergillus
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002530 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componentsi: Chromosome 8, Unassembled WGS sequence

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...
EuPathDBi
FungiDB:Afu8g00540

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Abolishes the production of pseurotin (PubMed:17722120, PubMed:24082142).2 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004165551 – 4007PKS-NRPS hybrid synthetase psoAAdd BLAST4007

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2455O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1
Modified residuei3612O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1

Keywords - PTMi

Phosphopantetheine, Phosphoprotein

Proteomic databases

PRoteomics IDEntifications database

More...
PRIDEi
Q4WAZ9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Expression is under the control of StuA, which is responsible for transcriptional activation during acquisition of developmental competence (PubMed:16207816). Expression is also induced under hypoxic conditions (PubMed:21388144).2 Publications

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...
STRINGi
5085.CADAFUBP00008381

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...
ProteinModelPortali
Q4WAZ9

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...
SMRi
Q4WAZ9

Database of comparative protein structure models

More...
ModBasei
Search...

MobiDB: a database of protein disorder and mobility annotations

More...
MobiDBi
Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini2418 – 2495Carrier 1PROSITE-ProRule annotationAdd BLAST78
Domaini3576 – 3652Carrier 2PROSITE-ProRule annotationAdd BLAST77

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 389Ketosynthase (KS) domainSequence analysisAdd BLAST389
Regioni575 – 897Malonyl-CoA:ACP transacylase (MAT) domainSequence analysisAdd BLAST323
Regioni969 – 1147Dehydratase (DH) domainSequence analysisAdd BLAST179
Regioni2131 – 2305Ketoreductase (KR) domainSequence analysisAdd BLAST175
Regioni2589 – 2885Condensation (C) domainSequence analysisAdd BLAST297
Regioni3076 – 3478Adenylation (A) domainSequence analysisAdd BLAST403
Regioni3696 – 3920Reductase (R) domainSequence analysisAdd BLAST225

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

NRP synthetases are composed of discrete domains (adenylation (A), thiolation (T) or peptidyl carrier protein (PCP) and condensation (C) domains) which when grouped together are referred to as a single module (PubMed:17464044). Each module is responsible for the recognition (via the A domain) and incorporation of a single amino acid into the growing peptide product (PubMed:17464044). Thus, an NRP synthetase is generally composed of one or more modules and can terminate in a thioesterase domain (TE) that releases the newly synthesized peptide from the enzyme. Occasionally, epimerase (E) domains (responsible for l- to d- amino acid conversion) are present within the NRP synthetase (PubMed:17464044). NRPS14 contains also a ketoacyl synthase domain (KS), an acyl transferase domain (AT), a dehydratase domain (DH), and 2 ketoreductase domains (KR) (PubMed:17464044). NRPS14 has the following architecture: KS-AT-DH-KR-T-C-A-T-KR (PubMed:17464044).1 Publication

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NRP synthase family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...
HOGENOMi
HOG000162255

InParanoid: Eukaryotic Ortholog Groups

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InParanoidi
Q4WAZ9

KEGG Orthology (KO)

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KOi
K15390

Identification of Orthologs from Complete Genome Data

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OMAi
GYPPISE

Database of Orthologous Groups

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OrthoDBi
EOG092C013A

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...
Gene3Di
1.10.1200.10, 2 hits
3.30.559.10, 1 hit
3.40.366.10, 1 hit
3.40.47.10, 1 hit

Integrated resource of protein families, domains and functional sites

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InterProi
View protein in InterPro
IPR001227 Ac_transferase_dom_sf
IPR036736 ACP-like_sf
IPR014043 Acyl_transferase
IPR016035 Acyl_Trfase/lysoPLipase
IPR020845 AMP-binding_CS
IPR000873 AMP-dep_Synth/Lig
IPR023213 CAT-like_dom_sf
IPR001242 Condensatn
IPR032821 KAsynt_C_assoc
IPR018201 Ketoacyl_synth_AS
IPR014031 Ketoacyl_synth_C
IPR014030 Ketoacyl_synth_N
IPR013120 Male_sterile_NAD-bd
IPR016036 Malonyl_transacylase_ACP-bd
IPR036291 NAD(P)-bd_dom_sf
IPR020801 PKS_acyl_transferase
IPR020841 PKS_Beta-ketoAc_synthase_dom
IPR020807 PKS_dehydratase
IPR013968 PKS_KR
IPR020806 PKS_PP-bd
IPR009081 PP-bd_ACP
IPR029063 SAM-dependent_MTases
IPR016039 Thiolase-like

Pfam protein domain database

More...
Pfami
View protein in Pfam
PF00698 Acyl_transf_1, 1 hit
PF00501 AMP-binding, 1 hit
PF00668 Condensation, 1 hit
PF16197 KAsynt_C_assoc, 1 hit
PF00109 ketoacyl-synt, 1 hit
PF02801 Ketoacyl-synt_C, 1 hit
PF08659 KR, 1 hit
PF07993 NAD_binding_4, 1 hit
PF00550 PP-binding, 2 hits
PF14765 PS-DH, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...
SMARTi
View protein in SMART
SM00827 PKS_AT, 1 hit
SM00826 PKS_DH, 1 hit
SM00825 PKS_KS, 1 hit
SM00823 PKS_PP, 2 hits

Superfamily database of structural and functional annotation

More...
SUPFAMi
SSF47336 SSF47336, 2 hits
SSF51735 SSF51735, 3 hits
SSF52151 SSF52151, 1 hit
SSF53335 SSF53335, 1 hit
SSF53901 SSF53901, 1 hit
SSF55048 SSF55048, 1 hit

PROSITE; a protein domain and family database

More...
PROSITEi
View protein in PROSITE
PS00455 AMP_BINDING, 1 hit
PS00606 B_KETOACYL_SYNTHASE, 1 hit
PS50075 CARRIER, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q4WAZ9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVYTHSPKEP IAIIGTGCRF PGGSTSPSKL WDLLYSPRDL TREVPAESRF
60 70 80 90 100
NPKGFYNVDG EHHGASNATN AYFIEEDPRY FDAGFFSIAP REAESIDPQQ
110 120 130 140 150
RLLLETVYEA MENAGLTLNG MRGSATSAYM GAMSADYTDT QLRDIENVSK
160 170 180 190 200
YMITGTSRAL LANRLSYFFD WKGPSISVDT ACSSSLAAVH LGVQALRAGE
210 220 230 240 250
CTISCVGGSN IILNPDCYLA ATSLHLLSPT GRSQMWDQAA DGYARGEGVC
260 270 280 290 300
VFFMKTLSQA LRDGDRIDAL LRETCVNSDG RTQGIALPSA EAQVSLMRTA
310 320 330 340 350
YKNAGLDLSK AEDRPQYIEA HGTGTQAGDP REAYAIATTF FPPGEDHSHR
360 370 380 390 400
PKLVVGSVKT IIGHTEGCAG IAGILKAVLA MRHKTIPPNQ HFHNLNPSVK
410 420 430 440 450
PSFKHLSIAT SPQPWPVVPP DTPLRASVNG FGSGGTNCHA IVESYVPEIH
460 470 480 490 500
DNGPWGKPKE MTQVPNGVAA PETDFSPIPL IFSASSGTAL RAMLERYQEY
510 520 530 540 550
LERTEVSLLR LAMTLNSHRS TLPVRVSIPG TSKADVLAAI RTQLAKVGSN
560 570 580 590 600
PGAEIGTRSS VPEFDHVRRP KILGVFTGQG AQWAGMGQGL MAKSALFRQV
610 620 630 640 650
IEVMEEAMAQ LPDGPEWSLK EEIMKPPKTS RLGEAEISLP VCAALQVGLV
660 670 680 690 700
KVLRSAGITF SMVVGHSGGE IGSAYAAGKI SEVDAIKIAY YRGVYTKLAI
710 720 730 740 750
GKDGKKGGMI AVGFGYEDGL NFCAMEQFAD RLTVAASNSP KSVTLSGDLD
760 770 780 790 800
AVHEAKELLD AEGVFNRVLR LDTAYHSPHM YPCAAPYLAA IERCGLVAGK
810 820 830 840 850
SNGTAWASSV YDDNRMMTSA QDKDLEAAYW KDNLIGRVLF SQAVERALDE
860 870 880 890 900
GNGDFDLALE IGPHPSLKGP TLETIRHKIG SEIPYSGVLD RKADDILALS
910 920 930 940 950
TALGFSWLTL GSGVVDFAGY VSGFDPSNAS ILNAPALPDL PTYPWDHKKV
960 970 980 990 1000
LYRESRLNKN VRHRVDPPHP LLGSRTPDDT DYEPRWRNFL IMEELPWLRD
1010 1020 1030 1040 1050
HCVQGQIIVP AATYSVMALE AAKVLCRGKH VQSIELSDVA ILRPIVLDEA
1060 1070 1080 1090 1100
SDGTETLFSV RSDLDSNKKH EDEIHAQFTL SAGAMDDRHL RTAATGHIRI
1110 1120 1130 1140 1150
TLAAEAPSSF PNGPRPTELD LLPTSVDRFY ASMDEIGLSY SGPFRAMTSM
1160 1170 1180 1190 1200
KRRLNVASAT VAVDRDLAGT IPVHPTWLDA CFQTFLAAFA APRDGSLWTA
1210 1220 1230 1240 1250
FMPTAIGRMV FSPSSTSQVP GRSVTVDAHI TDFAPGYQVS LPTLTGDMSI
1260 1270 1280 1290 1300
FNSETNQLQI QIEDFVMSSF LPASEKDDRR FYLQNVWGQE MLSGALCAAA
1310 1320 1330 1340 1350
ERCVAPTESE SKIIDTCEKA VHYYLSKLKA AGLLDQWADK NPGLRSLMNE
1360 1370 1380 1390 1400
IEARVTSIPE QSDLVSMLGE VGEHIDLVLV RTIGESLLNS PSEGLGPITP
1410 1420 1430 1440 1450
SPMGALISRW HHEGLGFAQL QRHFVSAAKQ ISHQHANLRI LQVGPSSPGL
1460 1470 1480 1490 1500
VRSVCQELGR SLERYTLVDD SEQTIEEMKS ALAADQLRVD FTTASVENGI
1510 1520 1530 1540 1550
DAVNHLTSAG GFDLVIVHKA FTKQVTALKT VRNLLRPGGF MLMMAATGAQ
1560 1570 1580 1590 1600
LRFPFMLMST LPSLDDERLA QTKFINATRA ETHDLLRQIG FSGVDSIALD
1610 1620 1630 1640 1650
NVPDKHTFSV VVSQALDDHI AFLRSPLTSP SPVPLSGNLL VVGGFSADIA
1660 1670 1680 1690 1700
KLATAIQSLV STVWHGDIIN VRTLAELDDE ASTVEAVLSL TDLDRPVLED
1710 1720 1730 1740 1750
VRAPTFRGLQ RLFSEAKTVL WITHRAKADN PYHNATIGLG RSFQSENPQK
1760 1770 1780 1790 1800
VLQFLDVDTL DGVESAIAET FLKLIGGVNM RNSNPADPTR LWTIEPEVSL
1810 1820 1830 1840 1850
ENGKYLVPRL FPDTERNDRL NALRRKVQTQ VSVETQPISL SRSAQSDQVA
1860 1870 1880 1890 1900
YTAEAVHFHR DLADGATDPV TIQVELCSTE PVIPNIDNED LFCFVGRTSE
1910 1920 1930 1940 1950
GARLVGLSTS NSSVVKVPRE WTIPVDKHTS HDQGAFVLEL RNEIQSLVIA
1960 1970 1980 1990 2000
KSIPPGSTTL IYEPDPHLAA SLQRPGRPAT SSVSFRARST WSIPGSHILI
2010 2020 2030 2040 2050
DPHASRKDIQ AKVPPKTRML IHMEQGPETC EFLALRQALP PYATVVAFND
2060 2070 2080 2090 2100
LAADDVNPRE LLAEALSIIR GDSQSTKVPF DPSSVVKASA LVAGGTREHA
2110 2120 2130 2140 2150
NAAVVDWTGA QSITLSPRPV DTRNLFSPNK TYLLVGLTGH IGQSICRWMV
2160 2170 2180 2190 2200
QGGARHIVVT SRHPEKQGQL WREELLRQGV NIVIEAADVT KEHDLLDLRA
2210 2220 2230 2240 2250
RIVSSMPPVG GIANGAMVLD DKLFIDMPFE SFQAAMKPKV QGSIYLEEVF
2260 2270 2280 2290 2300
SADNLDFFLF FSSISVMTGQ RTQANYVAAN NFMVAMAERR RARGLPASVI
2310 2320 2330 2340 2350
DIGMVVGIGV IQRSQNDKGV SAMENSIRQM DYMPVSETDL HHLLAEAILV
2360 2370 2380 2390 2400
GQRDESPELI TGLETYKPVE GEAPFWHHNV RFSHLITDPD AAQAGADSAG
2410 2420 2430 2440 2450
SAQKSLKEML LSSGGPEEAR KVMENALLQY LASSLKLSRE TIYTDVPIID
2460 2470 2480 2490 2500
LGIDSLVAVQ IRNWTWAEAG YDLPVLKILG GSSVTQICDE VVASLSFDKS
2510 2520 2530 2540 2550
SIAAAKVDSQ AAPAHKLRPW DKPSADTKRT DSIAPVPRSQ IAANGPNGLP
2560 2570 2580 2590 2600
NGALKKASKL AVKVRPLWTT QAGGKDTKKG PRPAPIRIQP LSLGQSRLYF
2610 2620 2630 2640 2650
LSQYMDDDRV LNCTISYALS GKLDVSKLEQ SLIQVVQRHE ALRTSFYTDE
2660 2670 2680 2690 2700
KDGKPMQGLL EKSPFRLRVV PGVSASSDVE TEFNLIRYRP YDLEQADTFA
2710 2720 2730 2740 2750
ATLLSHSPDS HTLICGYHHI IMDGVSWQIF QKDLAMFYNN SGIADSAKHL
2760 2770 2780 2790 2800
PAQYSEFTRK QQEDLSCGAY AERLRFFQDQ FREPVESLPL FPFAKVGTRK
2810 2820 2830 2840 2850
VVKQYAVQEA TTHLNAKVVS AIKQASQTSR TTPFHFYLSA FQVLLHRLLE
2860 2870 2880 2890 2900
TDKMCIGVVD ANRSDQNFVN TIGFFLETIP LWFKVNSEQR FVELLKETRT
2910 2920 2930 2940 2950
KAYAALAQTG VPTEEILRAC GVASSTTETP LFQVCFNYRM GAGRTAALQG
2960 2970 2980 2990 3000
VEMKFLDYVD AQNPFDLVAT VDDLDDGTAM ITLYLQDYLY DQEGAQLLAT
3010 3020 3030 3040 3050
MYANVLQVLA ENPERLVGSV SISNATLEDE GVKLGTGPIL DLVAPSTPTL
3060 3070 3080 3090 3100
SKIFHTWVDK DPHALAVKDT TGKSKTYVQL AERANAIAAS LLNAGAAPSI
3110 3120 3130 3140 3150
PIGVLLDPGV DTIATILAIL RIGAAYVPLD TRSSDAVLSD ILQESQPGIV
3160 3170 3180 3190 3200
IHHSATAPRS QILLKASAKT KLVTLNAVPQ KTIRKIQDVS VPEGLAMILY
3210 3220 3230 3240 3250
TSGSTGSPKG IPLTNANIRT PILGVSERVP LGREVVLQQS GQGFDAAVYQ
3260 3270 3280 3290 3300
IFIALANGGT LIMVDNRDDP AKVAALMAQE SVTCTTHIVS EMQALLKYGY
3310 3320 3330 3340 3350
DELRNCSSWR IAMVAGEAFT VHLLDQFRAL NRPDLKVINA YGPTEASICS
3360 3370 3380 3390 3400
SLGEVSFNRI SSSETSIPIG KAIPNYGTYI VDQHCKPVPL GWPGEVAIAG
3410 3420 3430 3440 3450
PGVASGYLNL GELTQAKFRS AATLGEVFGS DCLYLTGDRG RMLSDGSIVL
3460 3470 3480 3490 3500
SGRVDGDDQV KIRGHRVQLG DVARALVQAS RGVFADAAVI LKGDDTSNPQ
3510 3520 3530 3540 3550
LVAYVVFSRT SNIQDQQTYL RQLNQDLPVP AYMRPAITIP LDTLPVTDRG
3560 3570 3580 3590 3600
KLDSKKLASL PLPSISVDYE EDEQLTPTEA RLRDVWKNVL GDIASSIPIR
3610 3620 3630 3640 3650
RSSDFFSVGG NSLILLALKA EIAQVFGVGL SVSELFQAST LELLAARLDG
3660 3670 3680 3690 3700
TSLLAQINWE EETAPDETQF TLPPPINGIN GHGSSNGHAQ GISVLLTGAT
3710 3720 3730 3740 3750
GFLGGHILRQ LVQLPSVEHV HCVAIRPNKV DVRRQLSVES PKIIRYSGDL
3760 3770 3780 3790 3800
ALPNMGMSES EFSDLFKSID VIVHNGAEVS HMKNYRSLRA ANFLSTVGLA
3810 3820 3830 3840 3850
RAAVSRGIPI HYISTGGVAR LSVADEQPEA SLAAFHPPID GSDGYVASKW
3860 3870 3880 3890 3900
ASEVFLEKVQ RRFQGQVWIH RPSSITGDDV PDNDIAHSLL KFSRELGAVP
3910 3920 3930 3940 3950
ELTGSGFFDF INVETVSNNI AASVVRSSEK SGGGLIYLHQ SGEQVIPVGD
3960 3970 3980 3990 4000
LQKYVEELEG RPLQVLPLKE WVDLSIRKGL DEVLGSYMLA SKGVIRAPLL

QRGPHVE
Length:4,007
Mass (Da):435,726
Last modified:April 17, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD3E04435030E5CAD
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

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EMBLi

GenBank nucleotide sequence database

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GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

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DDBJi
Links Updated
AAHF01000014 Genomic DNA Translation: EAL85113.2

NCBI Reference Sequences

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RefSeqi
XP_747151.2, XM_742058.2

Genome annotation databases

Ensembl fungal genome annotation project

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EnsemblFungii
EAL85113; EAL85113; AFUA_8G00540

Database of genes from NCBI RefSeq genomes

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GeneIDi
3504510

KEGG: Kyoto Encyclopedia of Genes and Genomes

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KEGGi
afm:AFUA_8G00540

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAHF01000014 Genomic DNA Translation: EAL85113.2
RefSeqiXP_747151.2, XM_742058.2

3D structure databases

ProteinModelPortaliQ4WAZ9
SMRiQ4WAZ9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi5085.CADAFUBP00008381

Proteomic databases

PRIDEiQ4WAZ9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiEAL85113; EAL85113; AFUA_8G00540
GeneIDi3504510
KEGGiafm:AFUA_8G00540

Organism-specific databases

EuPathDBiFungiDB:Afu8g00540

Phylogenomic databases

HOGENOMiHOG000162255
InParanoidiQ4WAZ9
KOiK15390
OMAiGYPPISE
OrthoDBiEOG092C013A

Family and domain databases

Gene3Di1.10.1200.10, 2 hits
3.30.559.10, 1 hit
3.40.366.10, 1 hit
3.40.47.10, 1 hit
InterProiView protein in InterPro
IPR001227 Ac_transferase_dom_sf
IPR036736 ACP-like_sf
IPR014043 Acyl_transferase
IPR016035 Acyl_Trfase/lysoPLipase
IPR020845 AMP-binding_CS
IPR000873 AMP-dep_Synth/Lig
IPR023213 CAT-like_dom_sf
IPR001242 Condensatn
IPR032821 KAsynt_C_assoc
IPR018201 Ketoacyl_synth_AS
IPR014031 Ketoacyl_synth_C
IPR014030 Ketoacyl_synth_N
IPR013120 Male_sterile_NAD-bd
IPR016036 Malonyl_transacylase_ACP-bd
IPR036291 NAD(P)-bd_dom_sf
IPR020801 PKS_acyl_transferase
IPR020841 PKS_Beta-ketoAc_synthase_dom
IPR020807 PKS_dehydratase
IPR013968 PKS_KR
IPR020806 PKS_PP-bd
IPR009081 PP-bd_ACP
IPR029063 SAM-dependent_MTases
IPR016039 Thiolase-like
PfamiView protein in Pfam
PF00698 Acyl_transf_1, 1 hit
PF00501 AMP-binding, 1 hit
PF00668 Condensation, 1 hit
PF16197 KAsynt_C_assoc, 1 hit
PF00109 ketoacyl-synt, 1 hit
PF02801 Ketoacyl-synt_C, 1 hit
PF08659 KR, 1 hit
PF07993 NAD_binding_4, 1 hit
PF00550 PP-binding, 2 hits
PF14765 PS-DH, 1 hit
SMARTiView protein in SMART
SM00827 PKS_AT, 1 hit
SM00826 PKS_DH, 1 hit
SM00825 PKS_KS, 1 hit
SM00823 PKS_PP, 2 hits
SUPFAMiSSF47336 SSF47336, 2 hits
SSF51735 SSF51735, 3 hits
SSF52151 SSF52151, 1 hit
SSF53335 SSF53335, 1 hit
SSF53901 SSF53901, 1 hit
SSF55048 SSF55048, 1 hit
PROSITEiView protein in PROSITE
PS00455 AMP_BINDING, 1 hit
PS00606 B_KETOACYL_SYNTHASE, 1 hit
PS50075 CARRIER, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

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ProtoNeti
Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPSOA_ASPFU
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q4WAZ9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 18, 2012
Last sequence update: April 17, 2007
Last modified: November 7, 2018
This is version 101 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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