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UniProtKB - Q4WAZ9 (PSOA_ASPFU)

Protein

PKS-NRPS hybrid synthetase psoA

Gene

NRPS14

Organism
Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
Status
Reviewed-Annotation score:

Annotation score:5 out of 5

<p>The annotation score provides a heuristic measure of the annotation content of a UniProtKB entry or proteome. This score <strong>cannot</strong> be used as a measure of the accuracy of the annotation as we cannot define the ‘correct annotation’ for any given protein.<p><a href='/help/annotation_score' target='_top'>More...</a></p>-Experimental evidence at transcript leveli <p>This indicates the type of evidence that supports the existence of the protein. Note that the ‘protein existence’ evidence does not give information on the accuracy or correctness of the sequence(s) displayed.<p><a href='/help/protein_existence' target='_top'>More...</a></p>

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

PKS-NRPS hybrid synthetase; part of the gene cluster that mediates the biosynthesis of pseurotin A, a competitive inhibitor of chitin synthase and an inducer of nerve-cell proliferation (PubMed:17722120, PubMed:17464044, PubMed:24082142, PubMed:24939566). The PKS-NRPS hybrid synthetase psoA is responsible for the biosynthesis of azaspirene, one of the first intermediates having the 1-oxa-7-azaspiro[4,4]-non-2-ene-4,6-dione core of pseurotin, via condensation of one acetyl-CoA, 4 malonyl-CoA, and a L-phenylalanine molecule (PubMed:24082142, PubMed:24939566). The dual-functional monooxygenase/methyltransferase psoF seems to be involved in the addition of the C3 methyl group onto the pseurotin scaffold (PubMed:24939566). Azaspirene is then converted to synerazol through 4 steps including oxidation of C17 by the cytochrome P450 monooxygenase psoD, O-methylation of the hydroxy group of C8 by the methyltransferase psoC, and the trans-to-cis isomerization of the C13 olefin by the glutathione S-transferase psoE (PubMed:24939566). The fourth step of synerazol production is performed by the dual-functional monooxygenase/methyltransferase psoF which seems to catalyze the epoxidation of the intermediate deepoxy-synerazol (PubMed:24939566). Synerazol can be attacked by a water molecule nonenzymatically at two different positions to yield two diol products, pseurotin A and pseurotin D (PubMed:24939566).4 Publications

<p>This subsection of the <a href="http://www.uniprot.org/help/function_section">'Function'</a> section describes the metabolic pathway(s) associated with a protein.<p><a href='/help/pathway' target='_top'>More...</a></p>Pathwayi: Secondary metabolite biosynthesis

This protein is involved in Secondary metabolite biosynthesis.2 Publications
View all proteins of this organism that are known to be involved in Secondary metabolite biosynthesis.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Function’ section is used for enzymes and indicates the residues directly involved in catalysis.<p><a href='/help/act_site' target='_top'>More...</a></p>Active sitei182PROSITE-ProRule annotation1

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

View the complete GO annotation on QuickGO ...

GO - Biological processi

  • nonribosomal peptide biosynthetic process Source: AspGD
  • pseurotin A biosynthetic process Source: AspGD
  • secondary metabolic process Source: AspGD
  • secondary metabolite biosynthetic process Source: AspGD
View the complete GO annotation on QuickGO ...

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsi

Molecular functionLigase, Transferase

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides an exhaustive list of all names of the protein, from commonly used to obsolete, to allow unambiguous identification of a protein.<p><a href='/help/protein_names' target='_top'>More...</a></p>Protein namesi
Recommended name:
PKS-NRPS hybrid synthetase psoA1 Publication (EC:2.3.1.-2 Publications, EC:6.3.2.-2 Publications)
Alternative name(s):
Nonribosomal peptide synthetase 141 Publication
Short name:
NRPS141 Publication
Pseurotin biosynthesis protein A1 Publication
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section indicates the name(s) of the gene(s) that code for the protein sequence(s) described in the entry. Four distinct tokens exist: ‘Name’, ‘Synonyms’, ‘Ordered locus names’ and ‘ORF names’.<p><a href='/help/gene_name' target='_top'>More...</a></p>Gene namesi
Name:NRPS141 Publication
Synonyms:pesO1 Publication
ORF Names:AFUA_8G00540
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section provides information on the name(s) of the organism that is the source of the protein sequence.<p><a href='/help/organism-name' target='_top'>More...</a></p>OrganismiNeosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100) (Aspergillus fumigatus)
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section shows the unique identifier assigned by the NCBI to the source organism of the protein. This is known as the ‘taxonomic identifier’ or ‘taxid’.<p><a href='/help/taxonomic_identifier' target='_top'>More...</a></p>Taxonomic identifieri330879 [NCBI]
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section contains the taxonomic hierarchical classification lineage of the source organism. It lists the nodes as they appear top-down in the taxonomic tree, with the more general grouping listed first.<p><a href='/help/taxonomic_lineage' target='_top'>More...</a></p>Taxonomic lineageiEukaryota › Fungi › Dikarya › Ascomycota › Pezizomycotina › Eurotiomycetes › Eurotiomycetidae › Eurotiales › Aspergillaceae › Aspergillus ›
<p>This subsection of the <a href="http://www.uniprot.org/help/names_and_taxonomy_section">Names and taxonomy</a> section is present for entries that are part of a <a href="http://www.uniprot.org/proteomes">proteome</a>, i.e. of a set of proteins thought to be expressed by organisms whose genomes have been completely sequenced.<p><a href='/help/proteomes_manual' target='_top'>More...</a></p>Proteomesi
  • UP000002530 <p>A UniProt <a href="http://www.uniprot.org/manual/proteomes_manual">proteome</a> can consist of several components. <br></br>The component name refers to the genomic component encoding a set of proteins.<p><a href='/help/proteome_component' target='_top'>More...</a></p> Componentsi: Chromosome 8, Unassembled WGS sequence

Organism-specific databases

Eukaryotic Pathogen Database Resources

More...EuPathDBi		FungiDB:Afu8g00540

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

<p>This subsection of the ‘Pathology and Biotech’ section describes the in vivo effects caused by ablation of the gene (or one or more transcripts) coding for the protein described in the entry. This includes gene knockout and knockdown, provided experiments have been performed in the context of a whole organism or a specific tissue, and not at the single-cell level.<p><a href='/help/disruption_phenotype' target='_top'>More...</a></p>Disruption phenotypei

Abolishes the production of pseurotin (PubMed:17722120, PubMed:24082142).2 Publications

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section describes the extent of a polypeptide chain in the mature protein following processing.<p><a href='/help/chain' target='_top'>More...</a></p>ChainiPRO_00004165551 – 4007PKS-NRPS hybrid synthetase psoAAdd BLAST4007

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘PTM / Processing’ section specifies the position and type of each modified residue excluding <a href="http://www.uniprot.org/manual/lipid">lipids</a>, <a href="http://www.uniprot.org/manual/carbohyd">glycans</a> and <a href="http://www.uniprot.org/manual/crosslnk">protein cross-links</a>.<p><a href='/help/mod_res' target='_top'>More...</a></p>Modified residuei2455O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1
Modified residuei3612O-(pantetheine 4'-phosphoryl)serinePROSITE-ProRule annotation1

Keywords - PTMi

Phosphopantetheine, Phosphoprotein

Proteomic databases

PRoteomics IDEntifications database

More...PRIDEi		Q4WAZ9

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

<p>This subsection of the ‘Expression’ section reports the experimentally proven effects of inducers and repressors (usually chemical compounds or environmental factors) on the level of protein (or mRNA) expression (up-regulation, down-regulation, constitutive expression).<p><a href='/help/induction' target='_top'>More...</a></p>Inductioni

Expression is under the control of StuA, which is responsible for transcriptional activation during acquisition of developmental competence (PubMed:16207816). Expression is also induced under hypoxic conditions (PubMed:21388144).2 Publications

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

STRING: functional protein association networks

More...STRINGi		5085.CADAFUBP00008381

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

Protein Model Portal of the PSI-Nature Structural Biology Knowledgebase

More...ProteinModelPortali		Q4WAZ9

SWISS-MODEL Repository - a database of annotated 3D protein structure models

More...SMRi		Q4WAZ9

Database of comparative protein structure models

More...ModBasei		Search...

MobiDB: a database of protein disorder and mobility annotations

More...MobiDBi		Search...

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the <a href="http://www.uniprot.org/help/family_and_domains_section">Family and Domains</a> section describes the position and type of a domain, which is defined as a specific combination of secondary structures organized into a characteristic three-dimensional structure or fold.<p><a href='/help/domain' target='_top'>More...</a></p>Domaini2418 – 2495Carrier 1PROSITE-ProRule annotationAdd BLAST78
Domaini3576 – 3652Carrier 2PROSITE-ProRule annotationAdd BLAST77

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
<p>This subsection of the ‘Family and Domains’ section describes a region of interest that cannot be described in other subsections.<p><a href='/help/region' target='_top'>More...</a></p>Regioni1 – 389Ketosynthase (KS) domainSequence analysisAdd BLAST389
Regioni575 – 897Malonyl-CoA:ACP transacylase (MAT) domainSequence analysisAdd BLAST323
Regioni969 – 1147Dehydratase (DH) domainSequence analysisAdd BLAST179
Regioni2131 – 2305Ketoreductase (KR) domainSequence analysisAdd BLAST175
Regioni2589 – 2885Condensation (C) domainSequence analysisAdd BLAST297
Regioni3076 – 3478Adenylation (A) domainSequence analysisAdd BLAST403
Regioni3696 – 3920Reductase (R) domainSequence analysisAdd BLAST225

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domaini

NRP synthetases are composed of discrete domains (adenylation (A), thiolation (T) or peptidyl carrier protein (PCP) and condensation (C) domains) which when grouped together are referred to as a single module (PubMed:17464044). Each module is responsible for the recognition (via the A domain) and incorporation of a single amino acid into the growing peptide product (PubMed:17464044). Thus, an NRP synthetase is generally composed of one or more modules and can terminate in a thioesterase domain (TE) that releases the newly synthesized peptide from the enzyme. Occasionally, epimerase (E) domains (responsible for l- to d- amino acid conversion) are present within the NRP synthetase (PubMed:17464044). NRPS14 contains also a ketoacyl synthase domain (KS), an acyl transferase domain (AT), a dehydratase domain (DH), and 2 ketoreductase domains (KR) (PubMed:17464044). NRPS14 has the following architecture: KS-AT-DH-KR-T-C-A-T-KR (PubMed:17464044).1 Publication

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Belongs to the NRP synthase family.Curated

Keywords - Domaini

Repeat

Phylogenomic databases

The HOGENOM Database of Homologous Genes from Fully Sequenced Organisms

More...HOGENOMi		HOG000162255

InParanoid: Eukaryotic Ortholog Groups

More...InParanoidi		Q4WAZ9

KEGG Orthology (KO)

More...KOi		K15390

Identification of Orthologs from Complete Genome Data

More...OMAi		GYPPISE

Database of Orthologous Groups

More...OrthoDBi		EOG092C013A

Family and domain databases

Gene3D Structural and Functional Annotation of Protein Families

More...Gene3Di		1.10.1200.10, 2 hits
3.30.559.10, 1 hit
3.40.366.10, 1 hit
3.40.47.10, 1 hit

Integrated resource of protein families, domains and functional sites

More...InterProi		View protein in InterPro
IPR001227 Ac_transferase_dom_sf
IPR036736 ACP-like_sf
IPR014043 Acyl_transferase
IPR016035 Acyl_Trfase/lysoPLipase
IPR020845 AMP-binding_CS
IPR000873 AMP-dep_Synth/Lig
IPR023213 CAT-like_dom_sf
IPR001242 Condensatn
IPR032821 KAsynt_C_assoc
IPR018201 Ketoacyl_synth_AS
IPR014031 Ketoacyl_synth_C
IPR014030 Ketoacyl_synth_N
IPR013120 Male_sterile_NAD-bd
IPR016036 Malonyl_transacylase_ACP-bd
IPR036291 NAD(P)-bd_dom_sf
IPR020801 PKS_acyl_transferase
IPR020841 PKS_Beta-ketoAc_synthase_dom
IPR020807 PKS_dehydratase
IPR013968 PKS_KR
IPR020806 PKS_PP-bd
IPR009081 PP-bd_ACP
IPR029063 SAM-dependent_MTases
IPR016039 Thiolase-like

Pfam protein domain database

More...Pfami		View protein in Pfam
PF00698 Acyl_transf_1, 1 hit
PF00501 AMP-binding, 1 hit
PF00668 Condensation, 1 hit
PF16197 KAsynt_C_assoc, 1 hit
PF00109 ketoacyl-synt, 1 hit
PF02801 Ketoacyl-synt_C, 1 hit
PF08659 KR, 1 hit
PF07993 NAD_binding_4, 1 hit
PF00550 PP-binding, 2 hits
PF14765 PS-DH, 1 hit

Simple Modular Architecture Research Tool; a protein domain database

More...SMARTi		View protein in SMART
SM00827 PKS_AT, 1 hit
SM00826 PKS_DH, 1 hit
SM00825 PKS_KS, 1 hit
SM00823 PKS_PP, 2 hits

Superfamily database of structural and functional annotation

More...SUPFAMi		SSF47336 SSF47336, 2 hits
SSF51735 SSF51735, 3 hits
SSF52151 SSF52151, 1 hit
SSF53335 SSF53335, 1 hit
SSF53901 SSF53901, 1 hit
SSF55048 SSF55048, 1 hit

PROSITE; a protein domain and family database

More...PROSITEi		View protein in PROSITE
PS00455 AMP_BINDING, 1 hit
PS00606 B_KETOACYL_SYNTHASE, 1 hit
PS50075 CARRIER, 2 hits

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including <a href="http://www.uniprot.org/help/sequence_length">length</a> and <a href="http://www.uniprot.org/help/sequences">molecular weight</a>.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequencei

<p>This subsection of the <a href="http://www.uniprot.org/help/sequences_section">Sequence</a> section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusi: Complete.

Q4WAZ9-1 [UniParc]FASTAAdd to basket
« Hide
        10         20         30         40         50
MVYTHSPKEP IAIIGTGCRF PGGSTSPSKL WDLLYSPRDL TREVPAESRF 
        60         70         80         90        100
NPKGFYNVDG EHHGASNATN AYFIEEDPRY FDAGFFSIAP REAESIDPQQ 
       110        120        130        140        150
RLLLETVYEA MENAGLTLNG MRGSATSAYM GAMSADYTDT QLRDIENVSK 
       160        170        180        190        200
YMITGTSRAL LANRLSYFFD WKGPSISVDT ACSSSLAAVH LGVQALRAGE 
       210        220        230        240        250
CTISCVGGSN IILNPDCYLA ATSLHLLSPT GRSQMWDQAA DGYARGEGVC 
       260        270        280        290        300
VFFMKTLSQA LRDGDRIDAL LRETCVNSDG RTQGIALPSA EAQVSLMRTA 
       310        320        330        340        350
YKNAGLDLSK AEDRPQYIEA HGTGTQAGDP REAYAIATTF FPPGEDHSHR 
       360        370        380        390        400
PKLVVGSVKT IIGHTEGCAG IAGILKAVLA MRHKTIPPNQ HFHNLNPSVK 
       410        420        430        440        450
PSFKHLSIAT SPQPWPVVPP DTPLRASVNG FGSGGTNCHA IVESYVPEIH 
       460        470        480        490        500
DNGPWGKPKE MTQVPNGVAA PETDFSPIPL IFSASSGTAL RAMLERYQEY 
       510        520        530        540        550
LERTEVSLLR LAMTLNSHRS TLPVRVSIPG TSKADVLAAI RTQLAKVGSN 
       560        570        580        590        600
PGAEIGTRSS VPEFDHVRRP KILGVFTGQG AQWAGMGQGL MAKSALFRQV 
       610        620        630        640        650
IEVMEEAMAQ LPDGPEWSLK EEIMKPPKTS RLGEAEISLP VCAALQVGLV 
       660        670        680        690        700
KVLRSAGITF SMVVGHSGGE IGSAYAAGKI SEVDAIKIAY YRGVYTKLAI 
       710        720        730        740        750
GKDGKKGGMI AVGFGYEDGL NFCAMEQFAD RLTVAASNSP KSVTLSGDLD 
       760        770        780        790        800
AVHEAKELLD AEGVFNRVLR LDTAYHSPHM YPCAAPYLAA IERCGLVAGK 
       810        820        830        840        850
SNGTAWASSV YDDNRMMTSA QDKDLEAAYW KDNLIGRVLF SQAVERALDE 
       860        870        880        890        900
GNGDFDLALE IGPHPSLKGP TLETIRHKIG SEIPYSGVLD RKADDILALS 
       910        920        930        940        950
TALGFSWLTL GSGVVDFAGY VSGFDPSNAS ILNAPALPDL PTYPWDHKKV 
       960        970        980        990       1000
LYRESRLNKN VRHRVDPPHP LLGSRTPDDT DYEPRWRNFL IMEELPWLRD 
      1010       1020       1030       1040       1050
HCVQGQIIVP AATYSVMALE AAKVLCRGKH VQSIELSDVA ILRPIVLDEA 
      1060       1070       1080       1090       1100
SDGTETLFSV RSDLDSNKKH EDEIHAQFTL SAGAMDDRHL RTAATGHIRI 
      1110       1120       1130       1140       1150
TLAAEAPSSF PNGPRPTELD LLPTSVDRFY ASMDEIGLSY SGPFRAMTSM 
      1160       1170       1180       1190       1200
KRRLNVASAT VAVDRDLAGT IPVHPTWLDA CFQTFLAAFA APRDGSLWTA 
      1210       1220       1230       1240       1250
FMPTAIGRMV FSPSSTSQVP GRSVTVDAHI TDFAPGYQVS LPTLTGDMSI 
      1260       1270       1280       1290       1300
FNSETNQLQI QIEDFVMSSF LPASEKDDRR FYLQNVWGQE MLSGALCAAA 
      1310       1320       1330       1340       1350
ERCVAPTESE SKIIDTCEKA VHYYLSKLKA AGLLDQWADK NPGLRSLMNE 
      1360       1370       1380       1390       1400
IEARVTSIPE QSDLVSMLGE VGEHIDLVLV RTIGESLLNS PSEGLGPITP 
      1410       1420       1430       1440       1450
SPMGALISRW HHEGLGFAQL QRHFVSAAKQ ISHQHANLRI LQVGPSSPGL 
      1460       1470       1480       1490       1500
VRSVCQELGR SLERYTLVDD SEQTIEEMKS ALAADQLRVD FTTASVENGI 
      1510       1520       1530       1540       1550
DAVNHLTSAG GFDLVIVHKA FTKQVTALKT VRNLLRPGGF MLMMAATGAQ 
      1560       1570       1580       1590       1600
LRFPFMLMST LPSLDDERLA QTKFINATRA ETHDLLRQIG FSGVDSIALD 
      1610       1620       1630       1640       1650
NVPDKHTFSV VVSQALDDHI AFLRSPLTSP SPVPLSGNLL VVGGFSADIA 
      1660       1670       1680       1690       1700
KLATAIQSLV STVWHGDIIN VRTLAELDDE ASTVEAVLSL TDLDRPVLED 
      1710       1720       1730       1740       1750
VRAPTFRGLQ RLFSEAKTVL WITHRAKADN PYHNATIGLG RSFQSENPQK 
      1760       1770       1780       1790       1800
VLQFLDVDTL DGVESAIAET FLKLIGGVNM RNSNPADPTR LWTIEPEVSL 
      1810       1820       1830       1840       1850
ENGKYLVPRL FPDTERNDRL NALRRKVQTQ VSVETQPISL SRSAQSDQVA 
      1860       1870       1880       1890       1900
YTAEAVHFHR DLADGATDPV TIQVELCSTE PVIPNIDNED LFCFVGRTSE 
      1910       1920       1930       1940       1950
GARLVGLSTS NSSVVKVPRE WTIPVDKHTS HDQGAFVLEL RNEIQSLVIA 
      1960       1970       1980       1990       2000
KSIPPGSTTL IYEPDPHLAA SLQRPGRPAT SSVSFRARST WSIPGSHILI 
      2010       2020       2030       2040       2050
DPHASRKDIQ AKVPPKTRML IHMEQGPETC EFLALRQALP PYATVVAFND 
      2060       2070       2080       2090       2100
LAADDVNPRE LLAEALSIIR GDSQSTKVPF DPSSVVKASA LVAGGTREHA 
      2110       2120       2130       2140       2150
NAAVVDWTGA QSITLSPRPV DTRNLFSPNK TYLLVGLTGH IGQSICRWMV 
      2160       2170       2180       2190       2200
QGGARHIVVT SRHPEKQGQL WREELLRQGV NIVIEAADVT KEHDLLDLRA 
      2210       2220       2230       2240       2250
RIVSSMPPVG GIANGAMVLD DKLFIDMPFE SFQAAMKPKV QGSIYLEEVF 
      2260       2270       2280       2290       2300
SADNLDFFLF FSSISVMTGQ RTQANYVAAN NFMVAMAERR RARGLPASVI 
      2310       2320       2330       2340       2350
DIGMVVGIGV IQRSQNDKGV SAMENSIRQM DYMPVSETDL HHLLAEAILV 
      2360       2370       2380       2390       2400
GQRDESPELI TGLETYKPVE GEAPFWHHNV RFSHLITDPD AAQAGADSAG 
      2410       2420       2430       2440       2450
SAQKSLKEML LSSGGPEEAR KVMENALLQY LASSLKLSRE TIYTDVPIID 
      2460       2470       2480       2490       2500
LGIDSLVAVQ IRNWTWAEAG YDLPVLKILG GSSVTQICDE VVASLSFDKS 
      2510       2520       2530       2540       2550
SIAAAKVDSQ AAPAHKLRPW DKPSADTKRT DSIAPVPRSQ IAANGPNGLP 
      2560       2570       2580       2590       2600
NGALKKASKL AVKVRPLWTT QAGGKDTKKG PRPAPIRIQP LSLGQSRLYF 
      2610       2620       2630       2640       2650
LSQYMDDDRV LNCTISYALS GKLDVSKLEQ SLIQVVQRHE ALRTSFYTDE 
      2660       2670       2680       2690       2700
KDGKPMQGLL EKSPFRLRVV PGVSASSDVE TEFNLIRYRP YDLEQADTFA 
      2710       2720       2730       2740       2750
ATLLSHSPDS HTLICGYHHI IMDGVSWQIF QKDLAMFYNN SGIADSAKHL 
      2760       2770       2780       2790       2800
PAQYSEFTRK QQEDLSCGAY AERLRFFQDQ FREPVESLPL FPFAKVGTRK 
      2810       2820       2830       2840       2850
VVKQYAVQEA TTHLNAKVVS AIKQASQTSR TTPFHFYLSA FQVLLHRLLE 
      2860       2870       2880       2890       2900
TDKMCIGVVD ANRSDQNFVN TIGFFLETIP LWFKVNSEQR FVELLKETRT 
      2910       2920       2930       2940       2950
KAYAALAQTG VPTEEILRAC GVASSTTETP LFQVCFNYRM GAGRTAALQG 
      2960       2970       2980       2990       3000
VEMKFLDYVD AQNPFDLVAT VDDLDDGTAM ITLYLQDYLY DQEGAQLLAT 
      3010       3020       3030       3040       3050
MYANVLQVLA ENPERLVGSV SISNATLEDE GVKLGTGPIL DLVAPSTPTL 
      3060       3070       3080       3090       3100
SKIFHTWVDK DPHALAVKDT TGKSKTYVQL AERANAIAAS LLNAGAAPSI 
      3110       3120       3130       3140       3150
PIGVLLDPGV DTIATILAIL RIGAAYVPLD TRSSDAVLSD ILQESQPGIV 
      3160       3170       3180       3190       3200
IHHSATAPRS QILLKASAKT KLVTLNAVPQ KTIRKIQDVS VPEGLAMILY 
      3210       3220       3230       3240       3250
TSGSTGSPKG IPLTNANIRT PILGVSERVP LGREVVLQQS GQGFDAAVYQ 
      3260       3270       3280       3290       3300
IFIALANGGT LIMVDNRDDP AKVAALMAQE SVTCTTHIVS EMQALLKYGY 
      3310       3320       3330       3340       3350
DELRNCSSWR IAMVAGEAFT VHLLDQFRAL NRPDLKVINA YGPTEASICS 
      3360       3370       3380       3390       3400
SLGEVSFNRI SSSETSIPIG KAIPNYGTYI VDQHCKPVPL GWPGEVAIAG 
      3410       3420       3430       3440       3450
PGVASGYLNL GELTQAKFRS AATLGEVFGS DCLYLTGDRG RMLSDGSIVL 
      3460       3470       3480       3490       3500
SGRVDGDDQV KIRGHRVQLG DVARALVQAS RGVFADAAVI LKGDDTSNPQ 
      3510       3520       3530       3540       3550
LVAYVVFSRT SNIQDQQTYL RQLNQDLPVP AYMRPAITIP LDTLPVTDRG 
      3560       3570       3580       3590       3600
KLDSKKLASL PLPSISVDYE EDEQLTPTEA RLRDVWKNVL GDIASSIPIR 
      3610       3620       3630       3640       3650
RSSDFFSVGG NSLILLALKA EIAQVFGVGL SVSELFQAST LELLAARLDG 
      3660       3670       3680       3690       3700
TSLLAQINWE EETAPDETQF TLPPPINGIN GHGSSNGHAQ GISVLLTGAT 
      3710       3720       3730       3740       3750
GFLGGHILRQ LVQLPSVEHV HCVAIRPNKV DVRRQLSVES PKIIRYSGDL 
      3760       3770       3780       3790       3800
ALPNMGMSES EFSDLFKSID VIVHNGAEVS HMKNYRSLRA ANFLSTVGLA 
      3810       3820       3830       3840       3850
RAAVSRGIPI HYISTGGVAR LSVADEQPEA SLAAFHPPID GSDGYVASKW 
      3860       3870       3880       3890       3900
ASEVFLEKVQ RRFQGQVWIH RPSSITGDDV PDNDIAHSLL KFSRELGAVP 
      3910       3920       3930       3940       3950
ELTGSGFFDF INVETVSNNI AASVVRSSEK SGGGLIYLHQ SGEQVIPVGD 
      3960       3970       3980       3990       4000
LQKYVEELEG RPLQVLPLKE WVDLSIRKGL DEVLGSYMLA SKGVIRAPLL 

QRGPHVE
Length:4,007
Mass (Da):435,726
Last modified:April 17, 2007 - v2
<p>The checksum is a form of redundancy check that is calculated from the sequence. It is useful for tracking sequence updates.</p> <p>It should be noted that while, in theory, two different sequences could have the same checksum value, the likelihood that this would happen is extremely low.</p> <p>However UniProtKB may contain entries with identical sequences in case of multiple genes (paralogs).</p> <p>The checksum is computed as the sequence 64-bit Cyclic Redundancy Check value (CRC64) using the generator polynomial: x<sup>64</sup> + x<sup>4</sup> + x<sup>3</sup> + x + 1. The algorithm is described in the ISO 3309 standard. </p> <p class="publication">Press W.H., Flannery B.P., Teukolsky S.A. and Vetterling W.T.<br /> <strong>Cyclic redundancy and other checksums</strong><br /> <a href="http://www.nrbook.com/b/bookcpdf.php">Numerical recipes in C 2nd ed., pp896-902, Cambridge University Press (1993)</a>)</p> Checksum:iD3E04435030E5CAD
GO

Sequence databases

Select the link destinations:

EMBL nucleotide sequence database

More...EMBLi

GenBank nucleotide sequence database

More...GenBanki

DNA Data Bank of Japan; a nucleotide sequence database

More...DDBJi
Links Updated
AAHF01000014 Genomic DNA Translation: EAL85113.2

NCBI Reference Sequences

More...RefSeqi		XP_747151.2, XM_742058.2

Genome annotation databases

Ensembl fungal genome annotation project

More...EnsemblFungii		EAL85113; EAL85113; AFUA_8G00540

Database of genes from NCBI RefSeq genomes

More...GeneIDi		3504510

KEGG: Kyoto Encyclopedia of Genes and Genomes

More...KEGGi		afm:AFUA_8G00540

<p>This section provides links to proteins that are similar to the protein sequence(s) described in this entry at different levels of sequence identity thresholds (100%, 90% and 50%) based on their membership in UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>).<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsi

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AAHF01000014 Genomic DNA Translation: EAL85113.2
RefSeqiXP_747151.2, XM_742058.2

3D structure databases

ProteinModelPortaliQ4WAZ9
SMRiQ4WAZ9
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi5085.CADAFUBP00008381

Proteomic databases

PRIDEiQ4WAZ9

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblFungiiEAL85113; EAL85113; AFUA_8G00540
GeneIDi3504510
KEGGiafm:AFUA_8G00540

Organism-specific databases

EuPathDBiFungiDB:Afu8g00540

Phylogenomic databases

HOGENOMiHOG000162255
InParanoidiQ4WAZ9
KOiK15390
OMAiGYPPISE
OrthoDBiEOG092C013A

Family and domain databases

Gene3Di1.10.1200.10, 2 hits
3.30.559.10, 1 hit
3.40.366.10, 1 hit
3.40.47.10, 1 hit
InterProiView protein in InterPro
IPR001227 Ac_transferase_dom_sf
IPR036736 ACP-like_sf
IPR014043 Acyl_transferase
IPR016035 Acyl_Trfase/lysoPLipase
IPR020845 AMP-binding_CS
IPR000873 AMP-dep_Synth/Lig
IPR023213 CAT-like_dom_sf
IPR001242 Condensatn
IPR032821 KAsynt_C_assoc
IPR018201 Ketoacyl_synth_AS
IPR014031 Ketoacyl_synth_C
IPR014030 Ketoacyl_synth_N
IPR013120 Male_sterile_NAD-bd
IPR016036 Malonyl_transacylase_ACP-bd
IPR036291 NAD(P)-bd_dom_sf
IPR020801 PKS_acyl_transferase
IPR020841 PKS_Beta-ketoAc_synthase_dom
IPR020807 PKS_dehydratase
IPR013968 PKS_KR
IPR020806 PKS_PP-bd
IPR009081 PP-bd_ACP
IPR029063 SAM-dependent_MTases
IPR016039 Thiolase-like
PfamiView protein in Pfam
PF00698 Acyl_transf_1, 1 hit
PF00501 AMP-binding, 1 hit
PF00668 Condensation, 1 hit
PF16197 KAsynt_C_assoc, 1 hit
PF00109 ketoacyl-synt, 1 hit
PF02801 Ketoacyl-synt_C, 1 hit
PF08659 KR, 1 hit
PF07993 NAD_binding_4, 1 hit
PF00550 PP-binding, 2 hits
PF14765 PS-DH, 1 hit
SMARTiView protein in SMART
SM00827 PKS_AT, 1 hit
SM00826 PKS_DH, 1 hit
SM00825 PKS_KS, 1 hit
SM00823 PKS_PP, 2 hits
SUPFAMiSSF47336 SSF47336, 2 hits
SSF51735 SSF51735, 3 hits
SSF52151 SSF52151, 1 hit
SSF53335 SSF53335, 1 hit
SSF53901 SSF53901, 1 hit
SSF55048 SSF55048, 1 hit
PROSITEiView protein in PROSITE
PS00455 AMP_BINDING, 1 hit
PS00606 B_KETOACYL_SYNTHASE, 1 hit
PS50075 CARRIER, 2 hits

ProtoNet; Automatic hierarchical classification of proteins

More...ProtoNeti		Search...

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This subsection of the ‘Entry information’ section provides a mnemonic identifier for a UniProtKB entry, but it is not a stable identifier. Each reviewed entry is assigned a unique entry name upon integration into UniProtKB/Swiss-Prot.<p><a href='/help/entry_name' target='_top'>More...</a></p>Entry nameiPSOA_ASPFU
<p>This subsection of the ‘Entry information’ section provides one or more accession number(s). These are stable identifiers and should be used to cite UniProtKB entries. Upon integration into UniProtKB, each entry is assigned a unique accession number, which is called ‘Primary (citable) accession number’.<p><a href='/help/accession_numbers' target='_top'>More...</a></p>AccessioniPrimary (citable) accession number: Q4WAZ9
<p>This subsection of the ‘Entry information’ section shows the date of integration of the entry into UniProtKB, the date of the last sequence update and the date of the last annotation modification (‘Last modified’). The version number for both the entry and the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> are also displayed.<p><a href='/help/entry_history' target='_top'>More...</a></p>Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 18, 2012
Last sequence update: April 17, 2007
Last modified: November 7, 2018
This is version 101 of the entry and version 2 of the sequence. See complete history.
<p>This subsection of the ‘Entry information’ section indicates whether the entry has been manually annotated and reviewed by UniProtKB curators or not, in other words, if the entry belongs to the Swiss-Prot section of UniProtKB (<strong>reviewed</strong>) or to the computer-annotated TrEMBL section (<strong>unreviewed</strong>).<p><a href='/help/entry_status' target='_top'>More...</a></p>Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programFungal Protein Annotation Program

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families
  2. PATHWAY comments
    Index of metabolic and biosynthesis pathways
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